聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠(Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate)

概要

基本信息

药物类型

小分子化药

别名

COLYTE-FLAVORED、Colyte、Colyte With Flavor Packs

+ [1]

靶点-

作用方式-

作用机制-

治疗领域

其他疾病

在研适应症

肠道准备

非在研适应症-

原研机构

Braintree Laboratories, Inc.

在研机构

Braintree Laboratories, Inc.

非在研机构

Hospira, Inc.NORVIUM BIOSCIENCE

权益机构-

最高研发阶段批准上市

首次获批日期

美国 (1984-07-13),

肠道准备

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式ClNa

InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M

CAS号7647-14-5

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关联

8

项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的临床试验

NCT03198221

/ Terminated临床4期IIT

Randomized Comparison of the Impact of Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Versus Polyethylene Glycol Bowel Preparation on Inpatient Colonoscopy Quality Parameters

This is a prospective randomized study which will be done at main campus Cleveland Clinic. The investigators will be comparing the colon cleansing by the Boston Bowel Preparation Scale in participants undergoing colonoscopy as an inpatient at our hospital. Participants will be randomized to the the standard of care (4 Liter polyethylene glycol based preparation) or a low volume bowel preparation (sodium picosulfate, a stimulant laxative, magnesium oxide and anhydrous citric acid (SP/MC)). Both agents will either be administered as full dose the evening before or as split-dose on the evening before and on the day of the procedure.

开始日期2018-07-11

申办/合作机构

The Cleveland Clinic Foundation

[+1]

JPRN-UMIN000025815

/ CompletedN/AIIT

Trial of mechanical bowel preparation in laparoscopic colorectal surgery with Moviprep - TLUMP

开始日期2017-03-01

申办/合作机构-

JPRN-UMIN000026944

/ Recruiting临床4期IIT

Randomized Comparative Study on the Clinical Usefulness of PICOPREP and MOVIPREP - Comparative examination of laxatives

开始日期2017-02-01

申办/合作机构-

100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的临床结果

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100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的转化医学

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100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的专利（医药）

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197

项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的文献（医药）

2025-03-01·Gastroenterology Nursing

Impact of the Magnesium Citrate Recall on Gastroenterology Nursing Procedural Process

Article

作者: Mena, Alicia S ; Shaffer, Rebekah ; Pan, Jennifer Y

At a gastrointestinal endoscopy unit in a large, urban hospital system, the standard preparation (prep) for colonoscopy procedures was a combination of polyethylene glycol 3350 with electrolytes (Golytely) in addition to magnesium citrate until magnesium citrate underwent a national recall in July 2022. At the time of the recall, the facility had over 800 patients scheduled who had already received the recalled medication. The methods used in this project include collaboration with the interdisciplinary team to handle all aspects of the recall with a systematic approach and utilization of this unforeseen event to initiate tracking bowel prep compliance and prep quality with varied types of bowel preps utilizing a bowel prep rating scale. Of the over 800 patients scheduled at the time of the recall, 99.6% were prevented from ingesting the recalled medication. The colonoscopy prep compliance rate was 82.3%, and bowel prep quality was considered adequate in 97.7% of completed outpatient colonoscopies. This article highlights the importance of working with an interdisciplinary team during unplanned large-scale events to provide safe and effective care to patients, as well as finding positives in a challenging situation. This project includes the following commercial content: magnesium citrate, Golytely, MoviPrep, and Boston Bowel Preparation Score.

2024-10-01·Journal of Gastrointestinal Surgery

Effect of preoperative oral carbohydrate loading on postoperative insulin resistance, patient-perceived well-being, and surgical outcomes in elective colorectal surgery: a randomized controlled trial

Article

作者: Keerthi, Andi Rajendharan ; Bobby, Zachariah ; Raja, Kalayarasan ; Kumar, Shanmugam Mannoj ; Jha, Ajay Kumar ; Kate, Vikram ; Sureshkumar, Sathasivam ; Anandhi, Amaranathan

BACKGROUNDInsulin resistance (IR) is one of the independent determinants influencing the length of hospital stay (LOH) and postoperative complications in colorectal procedures. Preoperative oral carbohydrate loading (POCL) has emerged as a prospective countermeasure for IR. This study aimed to investigate the effects of preoperative carbohydrate loading on postoperative IR, inflammatory parameters, and clinical outcomes in patients undergoing elective colorectal surgery.METHODSThis was an open-label, parallel arm, superiority randomized controlled trial conducted over 2 years. Participants were assigned to conventional fasting (CF) and oral carbohydrate loading (OCL) groups. Insulin resistance, insulin sensitivity, Glasgow Prognostic Score (GPS), and IL-6 levels were analyzed on the day of surgery, and the first and third postoperative days. Clinical parameters like thirst, hunger, dry mouth, anxiety, weakness, pain, nausea, and vomiting were compared in the perioperative period. Surgical clinical outcomes such as intestinal recovery, time to independent ambulation, postoperative morbidity, and LOH were also studied.RESULTSA total of 72 participants were included, with 36 in each group. In the OCL group, there was a statistically significant decrease in postoperative insulin resistance during preop, POD-1 and POD-3 (p=0.0336). Similarly, inflammatory parameters and the Glassgow prognostic scale were found to be significantly lower in the OCL group (p<0.001). Clinical parameters such as thirst, hunger, and dry mouth were significantly lower in the intervention group (p=0.00) with a shortened LOH.CONCLUSIONThis study demonstrated that preoperative carbohydrate loading is associated with reduced insulin resistance and inflammatory markers, shortened hospital stays, and improved overall clinical outcomes in elective colorectal surgery.

2024-07-01·British Journal of Haematology

Cognitive impairment among patients with chronic immune thrombocytopenia

Article

作者: Khan, Umer ; Maruff, Paul ; Daak, Ahmed ; Kuter, David J.

SummaryImmune thrombocytopenia (ITP) is an autoimmune disease typically associated with severely depleted platelet counts. However, additional symptoms (e.g. increased fatigue and memory/concentration difficulties) can profoundly impact patients' quality of life. The nature and severity of cognitive impairment in ITP, and potential association with patient/disease characteristics were evaluated in 49 adults with relapsed/refractory ITP. The Cogstate Brief Battery quantitatively assessed psychomotor function (DET), attention (IDN), visual learning (OCL) and working memory (ONB) individually, as well as DET/IDN and OCL/ONB composites. Clinically important cognitive impairment (defined as z‐score ≤ −1) for ≥2 individual tests was observed in 29 patients (59%). Impairment was highest for IDN (67% of patients), followed by DET (53%), ONB (39%) and OCL (16%). A higher magnitude of impairment was observed for the DET/IDN composite (mean z‐score −1.54; 95% CI, −1.94 to −1.13) than OCL/ONB (mean z‐score −0.21; 95% CI, −0.49 to 0.07). The severity of cognitive impairment was comparable to mild traumatic brain injury and associated with increasing age and fatigue but unrelated to platelet count or corticosteroid use. Overall, these results warrant a clinical need to further consider the potential of cognitive dysfunction in assessing ITP patients.

100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
肠道准备	美国	Braintree Laboratories, Inc.	1984-07-13

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03198221 (CTgov)	临床4期	-	14	Golytely (Group A)	範獵繭鹽顧鏇壓夢網鑰(觸蓋衊簾齋壓衊鑰構衊) = 鏇廠範遞膚顧淵遞鑰積網醖壓獵顧鑰鑰網築淵 (艱築淵範遞廠鹹鹹餘壓, 觸餘蓋積簾鏇製網餘膚 ~ 鬱觸願鏇憲夢顧衊鹽遞) 更多	-	2021-03-04
				Golytely (Group B)	範獵繭鹽顧鏇壓夢網鑰(觸蓋衊簾齋壓衊鑰構衊) = 鹹窪構願獵壓範鬱鏇觸網醖壓獵顧鑰鑰網築淵 (艱築淵範遞廠鹹鹹餘壓, 窪醖壓壓範鬱膚齋糧鑰 ~ 選齋鑰積簾築衊積鹽鏇) 更多
NCT01283152 (HELP \| PSE, CTgov)	N/A	肝性脑病 \| 纤维化	50	Polyethylene glycol 3350-electrolyte solution (GoLYTELY®) (Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®))	遞艱壓網積願鏇構壓壓(齋齋簾鏇蓋鹽襯網憲鹹) = 膚觸壓願壓鏇鏇鹽淵衊鹹鬱積觸鑰鹽遞顧願繭 (鏇鹽範壓顧網鹹廠鬱觸, 築範蓋製廠窪積製觸糧 ~ 壓壓糧窪鑰鑰觸艱廠築) 更多	-	2014-12-11
				Lactulose (Lactulose)	遞艱壓網積願鏇構壓壓(齋齋簾鏇蓋鹽襯網憲鹹) = 網餘網積膚鏇簾窪餘選鹹鬱積觸鑰鹽遞顧願繭 (鏇鹽範壓顧網鹹廠鬱觸, 艱淵鏇夢鏇願築蓋鏇網 ~ 廠鬱鬱範鏇襯繭餘積壓) 更多