聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠(Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate)

概要

基本信息

药物类型

小分子化药

别名

COLYTE-FLAVORED、Colyte、Colyte With Flavor Packs

+ [1]

靶点-

作用方式-

作用机制-

治疗领域

其他疾病

在研适应症

肠道准备

非在研适应症-

原研机构

Braintree Laboratories, Inc.

在研机构

Braintree Laboratories, Inc.

非在研机构

Hospira, Inc.NORVIUM BIOSCIENCE

最高研发阶段批准上市

首次获批日期

美国 (1984-07-13),

肠道准备

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式ClNa

InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M

CAS号7647-14-5

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关联

8

项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的临床试验

JPRN-UMIN000025815

/ CompletedN/AIIT

Trial of mechanical bowel preparation in laparoscopic colorectal surgery with Moviprep - TLUMP

开始日期2017-03-01

申办/合作机构-

JPRN-UMIN000026944

/ Recruiting临床4期IIT

Randomized Comparative Study on the Clinical Usefulness of PICOPREP and MOVIPREP - Comparative examination of laxatives

开始日期2017-02-01

申办/合作机构-

NCT03011788

/ Unknown statusN/AIIT

A Randomized Study of Single vs Two-Day Polyethylene Glycol Cleansing in Patients at High Risk for Poor Bowel Preparation

The aim of this randomized trial is to compare the proportion of patients achieving an adequate bowel preparation after a 1-day split-dose 4-liter PEG-based bowel preparation regimen (Golytely, Braintree Laboratory Inc, MA, USA) vs. the same regimen given on 2 consecutive days in a population identified as high risk for an inadequate bowel preparation.
2. Research Design: This study is a single-center prospective randomized study at the West Haven VAMC.
3. Methodology:
Primary endpoint: Adequate bowel preparation as defined by a Boston Bowel Preparation Scale (BBPS) score of 2 or 3 (on scale of 0-3) in all 3 colon segments (left, transverse, and right).
Secondary endpoints: Adenoma detection rate, polyp detection rate, sessile serrated polyp/adenoma detection rate, patient tolerability of preparation using the validated Mayo clinic bowel prep tolerability questionnaire, adverse events potentially related to bowel preparation
Patients scheduled for routine outpatient colonoscopy will be eligible if they are at high risk for poor bowel preparation,

开始日期2017-01-01

申办/合作机构-

100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的临床结果

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100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的转化医学

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100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的专利（医药）

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196

项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的文献（医药）

2024-10-01·Journal of Gastrointestinal Surgery

Effect of preoperative oral carbohydrate loading on postoperative insulin resistance, patient-perceived well-being, and surgical outcomes in elective colorectal surgery: a randomized controlled trial

Article

作者: Keerthi, Andi Rajendharan ; Bobby, Zachariah ; Raja, Kalayarasan ; Kumar, Shanmugam Mannoj ; Jha, Ajay Kumar ; Kate, Vikram ; Sureshkumar, Sathasivam ; Anandhi, Amaranathan

BACKGROUNDInsulin resistance (IR) is one of the independent determinants influencing the length of hospital stay (LOH) and postoperative complications in colorectal procedures. Preoperative oral carbohydrate loading (POCL) has emerged as a prospective countermeasure for IR. This study aimed to investigate the effects of preoperative carbohydrate loading on postoperative IR, inflammatory parameters, and clinical outcomes in patients undergoing elective colorectal surgery.METHODSThis was an open-label, parallel arm, superiority randomized controlled trial conducted over 2 years. Participants were assigned to conventional fasting (CF) and oral carbohydrate loading (OCL) groups. Insulin resistance, insulin sensitivity, Glasgow Prognostic Score (GPS), and IL-6 levels were analyzed on the day of surgery, and the first and third postoperative days. Clinical parameters like thirst, hunger, dry mouth, anxiety, weakness, pain, nausea, and vomiting were compared in the perioperative period. Surgical clinical outcomes such as intestinal recovery, time to independent ambulation, postoperative morbidity, and LOH were also studied.RESULTSA total of 72 participants were included, with 36 in each group. In the OCL group, there was a statistically significant decrease in postoperative insulin resistance during preop, POD-1 and POD-3 (p=0.0336). Similarly, inflammatory parameters and the Glassgow prognostic scale were found to be significantly lower in the OCL group (p<0.001). Clinical parameters such as thirst, hunger, and dry mouth were significantly lower in the intervention group (p=0.00) with a shortened LOH.CONCLUSIONThis study demonstrated that preoperative carbohydrate loading is associated with reduced insulin resistance and inflammatory markers, shortened hospital stays, and improved overall clinical outcomes in elective colorectal surgery.

2024-07-01·British Journal of Haematology

Cognitive impairment among patients with chronic immune thrombocytopenia

Article

作者: Khan, Umer ; Maruff, Paul ; Daak, Ahmed ; Kuter, David J.

SummaryImmune thrombocytopenia (ITP) is an autoimmune disease typically associated with severely depleted platelet counts. However, additional symptoms (e.g. increased fatigue and memory/concentration difficulties) can profoundly impact patients' quality of life. The nature and severity of cognitive impairment in ITP, and potential association with patient/disease characteristics were evaluated in 49 adults with relapsed/refractory ITP. The Cogstate Brief Battery quantitatively assessed psychomotor function (DET), attention (IDN), visual learning (OCL) and working memory (ONB) individually, as well as DET/IDN and OCL/ONB composites. Clinically important cognitive impairment (defined as z‐score ≤ −1) for ≥2 individual tests was observed in 29 patients (59%). Impairment was highest for IDN (67% of patients), followed by DET (53%), ONB (39%) and OCL (16%). A higher magnitude of impairment was observed for the DET/IDN composite (mean z‐score −1.54; 95% CI, −1.94 to −1.13) than OCL/ONB (mean z‐score −0.21; 95% CI, −0.49 to 0.07). The severity of cognitive impairment was comparable to mild traumatic brain injury and associated with increasing age and fatigue but unrelated to platelet count or corticosteroid use. Overall, these results warrant a clinical need to further consider the potential of cognitive dysfunction in assessing ITP patients.

2024-06-01·Cureus

Cardiac Arrest Following GoLytely Consumption: A Potential Trigger for Hypovolemic Shock

Article

作者: Zaher, Eli A ; Patel, Parth ; Adhikari, Bibek ; Ebrahim, Mohamed A

This case report presents a rare but severe complication of polyethylene glycol (PEG) used for colonoscopic bowel preparation. A 71-year-old male developed cardiac arrest secondary to hypovolemic shock following consumption of GoLytely. Despite being hemodynamically stable prior to ingestion, the patient experienced extreme weakness, dizziness, and orthostatic hypotension post-consumption. Evaluation ruled out other causes of arrest. While serious complications from PEG are rare, this case underscores the importance of vigilance. Further investigation is warranted to elucidate the relationship between PEG use and cardiac events and to identify potential risk factors for adverse outcomes associated with bowel preparation regimens.

100 项与聚乙二醇3350/氯化钾/碳酸氢钠/氯化钠/硫酸钠相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
肠道准备	美国	Braintree Laboratories, Inc.	1984-07-13

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01283152 (HELP \| PSE, CTgov)	N/A	肝性脑病 \| 纤维化	50	Polyethylene glycol 3350-electrolyte solution (GoLYTELY®) (Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®))	遞餘鏇憲襯觸餘齋網鹽(衊艱鏇窪簾鬱製鹹願鏇) = 築鏇艱淵齋鹽衊膚顧蓋願廠觸艱餘窪蓋鏇網構 (蓋壓窪壓糧鏇鹽窪願艱, 衊觸廠艱願鹽願繭糧鏇 ~ 範窪築壓襯觸觸襯繭顧) 更多	-	2014-12-11
				Lactulose (Lactulose)	遞餘鏇憲襯觸餘齋網鹽(衊艱鏇窪簾鬱製鹹願鏇) = 淵獵簾構製襯製觸鑰蓋願廠觸艱餘窪蓋鏇網構 (蓋壓窪壓糧鏇鹽窪願艱, 製鏇鑰蓋願願齋鹹膚廠 ~ 網艱鑰鏇夢鹹齋醖鹽鹽) 更多
NCT00953017 (CTgov)	临床4期	-	425	Amitiza (Lubiprostone) (Miralax Plus Amitiza)	憲餘觸襯鏇製構簾願窪(網鏇選繭蓋願遞蓋鹽廠) = 膚齋鹽夢築窪顧糧鹹鬱窪願鏇衊蓋獵構淵製選 (蓋糧獵顧鑰齋觸醖艱醖, 構憲夢齋衊鹹願獵鏇獵 ~ 觸顧膚觸襯衊遞築遞鹹) 更多	-	2012-11-30
				Dulcolax (Bisacodyl) (Miralax Plus Dulcolax)	憲餘觸襯鏇製構簾願窪(網鏇選繭蓋願遞蓋鹽廠) = 簾觸觸築艱鏇選鬱鑰糧窪願鏇衊蓋獵構淵製選 (蓋糧獵顧鑰齋觸醖艱醖, 鑰積鏇艱製糧築鑰鹽簾 ~ 顧繭鏇簾襯鏇襯壓願艱) 更多