黑种草种子提取物(Nigella sativa seed extract)

概要

基本信息

药物类型

中药

别名

Nigella sativa seeds extract containing ointment intervention

靶点-

作用机制-

治疗领域

感染呼吸系统疾病内分泌与代谢疾病+ [2]

在研适应症-

非在研适应症

砷性角化病新型冠状病毒感染糖尿病+ [4]

原研机构-

在研机构-

非在研机构

University of Indonesia

Aga Khan University

Bangabandhu Sheikh Mujib Medical University

+ [2]

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

7

项与黑种草种子提取物相关的临床试验

NCT04767087

/ Unknown status临床2/3期IIT

Honey and Nigella Sativa in the Prophylaxis of COVID-19: A Randomized Controlled Trial

Honey and Nigella sativa has established antiviral, antibacterial, anti-inflammatory, and immunomodulatory roles. So it is planned to test for its prophylaxis

开始日期2021-03-05

申办/合作机构

Sheikh Zayed Federal Postgraduate Medical Institute

NCT04914767

/ Completed临床1期IIT

The Effectiveness of Nigella Sativa in the Treatment of SARS COV2 (COVID-19)

The world is currently facing a crisis because of this potentially fatal situation of the COVID-19 epidemic without proven efficacy for any drug treatment, while the vaccination is not yet.
This epidemic is caused by a new betacorona virus, now called SARS-CoV-2. The most common symptoms reported are fever, cough or chest tightness, and dyspnea. Most cases have a mild course

开始日期2021-03-01

申办/合作机构

Hôpital Universitaire Sahloul

NCT04686461

/ Unknown statusN/AIIT

Effect of Thymoquinone Extracted From Nigella Sativa in the Treatment of Arsenical Keratosis

Prepare an ointment from Nigella sativa seeds extract and apply it over palmer arsenical keratosis patient for 12 weeks. After than the effect of the ointment will be observed by measuring the keratotic nodular size before and after the intervention.

开始日期2019-10-20

申办/合作机构

Bangabandhu Sheikh Mujib Medical University

100 项与黑种草种子提取物相关的临床结果

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100 项与黑种草种子提取物相关的转化医学

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100 项与黑种草种子提取物相关的专利（医药）

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213

项与黑种草种子提取物相关的文献（医药）

2024-10-01·PROSTAGLANDINS & OTHER LIPID MEDIATORS

The effect of Nigella sativa supplementation on glycemic status in adults: An updated systematic review and meta-analysis of randomized controlled trials

Review

作者: Jamali, Mehrdad ; Shakarami, Mehrnaz ; Pam, Pedram

This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of Nigella sativa (N. sativa) consumption on glycemic index in adults. A systematic literature search up to December 2023 was completed in PubMed, Scopus, and Web of Science, to identify eligible RCTs. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as weighted mean differences with a 95 % confidence interval. Finally, a total of 30 studies were found to be eligible for this meta-analysis. The pooled results using random effects model indicated that N. sativa supplementation significantly reduced FBS (SMD: -1.71; 95 % CI: -2.11, -1.31, p <0.001; I²= 92.7 %, p-heterogeneity <0.001) and HA1c levels (SMD: -2.16; 95 % CI: -3.04, -1.29, p <0.001; I²= 95.7 %, p-heterogeneity <0.001) but not effect on insulin (SMD = 0.48; 95 % CI: -0.53, 1.48, P = 0.353; I²= 96.1 %, p-heterogeneity <0.001), and HOMA-IR (SMD: -0.56; 95 % CI: -1.47, 0.35, p=0.229; I²= 95.0 %, p-heterogeneity <0.001).Overall, the evidence supports the consumption of N. sativa to reduce FBS and HA1c levels. Additional research, featuring extended durations and robust study designs, is necessary to determine the ideal dosage and duration of N. sativa supplementation for achieving a positive impact on glycemic markers.

2024-07-01·Heliyon

Manuka combinations with nigella sativa and hydroxyurea in treating iron overload of pediatric β-thalassemia major, randomized clinical trial

Article

作者: Hussein, Raghda R S ; Gamaleldin, Mohamed M ; Meabed, Mohamed Hussein ; Abraham, Ivo L ; Elberry, Ahmed A ; Abdelhalim, Shaimaa M ; Mahmoud Hussein, Ahmed F

Background:

β-thalassemia major is microcytic hypochromic anemia disorder inherited from parents, resulting from a mutation in the β-globin locus. As a result, a quantitative defective hemoglobin synthesis and relative excess in α-globin is occurred. As such, frequent blood transfusion is required, that leads to iron overload. Iron overload results in several pathological complications, including cell death, tissue injury, organ dysfunction, and liver fibrosis. The present study examined the effectiveness of nigella Sativa and manuka honey combination or manuka honey alone to the conventional therapy (Deferasirox + blood transfusion) used for preventing and managing iron overload in pediatric β-thalassemia major patients.

Methods:

One hundred sixty-five patients participated in this randomized, double-blind, standard therapy-controlled, parallel-design multisite trial. The patients were randomly allocated into three groups, receiving either 500 mg nigella sativa oil combined with manuka honey lozenge (344 mg) daily or manuka honey alone plus the conventional therapy for ten treatment months. Ferritin level, serum iron, transferrin saturation, total iron binding capacity, alanine transaminase, and aspartate transaminase were determined at baseline and month 10.

Results:

Eventually, serum ferritin and iron were decreased significantly in the nigella sativa + manuka honey group as compared with the control group. Other clinical parameters were significantly impacted. The level of alanine transaminase and aspartate transaminase were significantly decreased in the nigella sativa plus manuka honey group compared with the control group.

Conclusion:

Results showed that nigella sativa plus manuka honey was more effective than manuka alone or the conventional treatment alone in managing iron overload of β-thalassemia major patients.

2024-06-01·Clinical Nutrition ESPEN

Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials

Review

作者: Musazadeh, Vali ; Kavyani, Zeynab ; Vajdi, Mahdi ; Hosseininejad-Mohebati, Ali ; Rostami, Reza Bijan ; Rounagh, Mahsa ; Falahatzadeh, Maryam

BACKGROUND AND AIM:

Several experiments have suggested that Nigella sativa (N. sativa) supplementation may have a beneficial effect on the lipid profile. However, the results from these trials have been inconclusive. Therefore, this study aimed to explore the impact of N. sativa supplementation on the lipid profile of adult participants.

METHODS:

We searched Scopus, Web of Science, PubMed, Cochrane, and Web of Science databases until December 2022. Random effects models were used, and pooled data were determined as standardized mean differences with a 95% confidence interval.

RESULTS:

The findings of 34 studies with 2278 participants revealed that N. sativa supplementation significantly reduced total cholesterol (TC) (SMD: -1.78; 95% CI: -2.20, -1.37, p < 0.001), triglycerides (TG) (SMD: -1.2725; 95% CI: -1.67, -0.83, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD: -2.45; 95% CI: -3.06, -1.85; p < 0.001) compared to control groups. However, a significant increase was found in high-density lipoprotein cholesterol (HDL-C) (SMD: 0.79; 95% CI: 0.38, 1.20, p < 0.001).

CONCLUSION:

N. sativa has improved effects on TG, LDL-C, TC, and HDL-C levels. Overall, N. sativa may be suggested as an adjuvant anti-hyperlipidemic agent.

100 项与黑种草种子提取物相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
新型冠状病毒感染	临床3期	巴基斯坦	Sheikh Zayed Federal Postgraduate Medical Institute	2021-03-05
高血压	临床3期	印尼	University of Indonesia	2011-07-01
血脂障碍	临床2期	印尼	University of Indonesia	2011-09-01
糖尿病	临床2期	巴基斯坦	Aga Khan University	2006-02-01
高胆固醇血症	临床2期	巴基斯坦	Aga Khan University	2006-02-01
代谢综合征	临床2期	巴基斯坦	Aga Khan University	2006-02-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


Pubmed \| Saudi J Gastroenterol	N/A	消化不良	88	Triple therapy (clarithromycin, amoxicillin, omeprazole)	觸衊構願憲膚餘鑰網淵(艱夢簾蓋鹽廠網鑰蓋製) = 製齋簾構製壓遞觸膚壓醖鏇鏇醖構簾鬱觸簾餘 (廠積鏇糧範獵範餘繭願 )	-	2010-01-01
				1 g Nigella sativa + 40 mg omeprazole	觸衊構願憲膚餘鑰網淵(艱夢簾蓋鹽廠網鑰蓋製) = 糧鬱憲餘遞醖鬱餘餘淵醖鏇鏇醖構簾鬱觸簾餘 (廠積鏇糧範獵範餘繭願 )