更新于：2024-09-21
N-acetyl-D-mannosamine
更新于：2024-09-21
概要
基本信息
最高研发阶段临床3期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
结构
分子式C8H15NO6 |
InChIKeyMBLBDJOUHNCFQT-WCTZXXKLSA-N |
CAS号3615-17-6 |
关联
8
项与 N-acetyl-D-mannosamine 相关的临床试验An open-label, randomised, three-arm crossover study to examine the comparative pharmacokinetics of ManNAc administered as an oral solution and as two novel oral tablet formulations in healthy adult males
An open-label, randomised, two-arm crossover study to determine the absolute oral bioavailability of ManNAc in healthy adult males
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Efficacy of ManNAc in Subjects With GNE Myopathy
100 项与 N-acetyl-D-mannosamine 相关的临床结果
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100 项与 N-acetyl-D-mannosamine 相关的转化医学
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100 项与 N-acetyl-D-mannosamine 相关的专利（医药）
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159
项与 N-acetyl-D-mannosamine 相关的文献（医药）2024-12-31Gut microbes
Integrative analysis with microbial modelling and machine learning uncovers potential alleviators for ulcerative colitis
Article
作者: Zhu, Jinlin ; Chen, Wei ; Lu, Wenwei ; Zhang, Hao ; Hu, Mingyi ; Chen, Jing ; Yin, Jialin ; Wang, Hongchao
Ulcerative colitis (UC) is a challenging form of inflammatory bowel disease, and its etiology is intricately linked to disturbances in the gut microbiome. To identify the potential alleviators of UC, we employed an integrative analysis combining microbial community modeling with advanced machine learning techniques. Using metagenomics data sourced from the Integrated Human Microbiome Project, we constructed individualized microbiome community models for each participant. Our analysis highlighted a significant decline in both α and β-diversity of strain-level microbial populations in UC subjects compared to controls. Distinct differences were also observed in the predicted fecal metabolite profiles and strain-to-metabolite contributions between the two groups. Using tree-based machine learning models, we successfully identified specific microbial strains and their associated metabolites as potential alleviators of UC. Notably, our experimental validation using a dextran sulfate sodium-induced UC mouse model demonstrated that the administration of Parabacteroides merdae ATCC 43,184 and N-acetyl-D-mannosamine provided notable relief from colitis symptoms. In summary, our study underscores the potential of an integrative approach to identify novel therapeutic avenues for UC, paving the way for future targeted interventions.
2024-09-04RSC Advances
Soft X-ray spectromicroscopy of human fibroblasts with impaired sialin function.
Article
作者: Miinalainen, Ilkka ; Darin, Niklas ; Kangas, Salla M ; Uusimaa, Johanna ; Patanen, Minna ; Angervaniva, Pia ; Blomqvist, Maria ; Huttula, Marko ; Hinttala, Reetta ; Mansikkala, Tuomas
Salla disease (SD) is a lysosomal storage disease where free sialic acid (SA) accumulates in lysosomes due to the impaired function of a membrane protein, sialin. Synchrotron radiation-based scanning transmission soft X-ray spectromicroscopy (STXM) was used to analyze both SD patients' fibroblasts and normal human dermal fibroblasts (NHDF) from healthy controls. Both cell lines were also cultured with N-acetyl-d-mannosamine monohydrate (ManNAc) to see if it increased SA concentration in the cells. The STXM technique was chosen to simultaneously observe the morphological and chemical changes in cells. It was observed that free SA did not remain in the lysosomes during the sample processing, leaving empty vacuoles to the fibroblasts. The total cytosol and entire cell spectra, however, showed systematic differences between the SD and NHDF samples, indicating changes in the relative macromolecular concentrations of the cells. The NHDF cell lines contained a higher relative protein concentration compared to the SD cell lines, and the addition of ManNAc increased the relative protein concentration in both cell lines. In this study, two sample preparation methods were compared, resin-embedded thin sections and cells grown directly on sample analysis grids. While the samples grown on the grids exhibited clean, well-resolved spectra not masked by embedding resin, the low penetration depth of soft X-rays hindered the analysis to only the thin region of the microfilaments away from the thick nucleus.
2024-08-01Clinical Pharmacology in Drug Development
Impact of Food on the Oral Absorption of N‐Acetyl‐D‐Mannosamine in Healthy Men and Women
Article
作者: Gahl, William A. ; Meola, Tahlia R. ; Fornasini, Gianfranco ; Reuter, Stephanie E. ; Evans, Allan M. ; Polasek, Thomas M. ; Huizing, Marjan
Abstract:
N‐Acetyl‐D‐mannosamine (ManNAc) is an endogenous monosaccharide and precursor of N‐acetylneuraminic acid (Neu5Ac), a critical sialic acid. ManNAc is currently under clinical development to treat GNE myopathy, a rare muscle‐wasting disease. In this randomized, open‐label, 2‐sequence, crossover study, 16 healthy women and men were administered a single oral dose of ManNAc under fasting and fed conditions. Blood samples were collected for 48 hours after dosing for quantification of plasma ManNAc and Neu5Ac concentrations. Noncompartmental pharmacokinetic and deconvolution analyses were performed using baseline‐corrected plasma concentration data. Administration of ManNAc in the fed state resulted in a 1.6‐fold increase in ManNAc exposure, compared to fasting conditions. A concurrent increase in Neu5Ac exposure was observed in the presence of food. Deconvolution analysis indicated that the findings were attributed to prolonged absorption rather than an enhanced rate of absorption. The impact of food on ManNAc pharmacokinetics was greater in women than men (fed/fasted area under the concentration‐time curve from time 0 to infinity mean ratio: 198% compared to 121%). It is hypothesized that the presence of food slows gastric emptying, allowing a gradual release of ManNAc into the small intestine, translating into improved ManNAc absorption. The results suggest that taking ManNAc with food may enhance its therapeutic activity and/or reduce the daily dosage requirement.
1
项与 N-acetyl-D-mannosamine 相关的新闻（医药）100 项与 N-acetyl-D-mannosamine 相关的药物交易
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研发状态
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 远端性肌病 | 临床3期 | - | - | |
| 远端性肌病 | 临床3期 | - | - | |
| 遗传性包涵体肌病 | 临床2期 | 美国 | 2015-02-05 | |
| 肾脏疾病 | 临床1期 | 美国 | 2016-07-07 |
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临床结果
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适应症
分期
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临床2期 | 12 | 鑰簾選廠遞願鹹構積鬱(襯襯餘鹹壓鑰鑰膚範築) = 壓廠獵醖夢選構觸範鹽 鑰築製遞夢選選壓壓觸 (獵範鏇鏇簾構築顧憲選 ) | 积极 | 2021-11-01 | |||
临床1期 | 7 | ManNAc 3g single dose | 獵範繭選顧鹽糧鑰遞膚(遞蓋鬱鬱範憲鏇窪夢壓) = There were no serious adverse events. Most subjects (5 of 6) that received ManNAc twice daily showed a marked reduction in urine PCR (26-54%), which correlated with the degree of glomerular hyposialylation 衊鏇觸膚簾鬱壓繭製繭 (顧積膚艱鑰糧糧廠齋鏇 ) 更多 | 积极 | 2020-10-19 | ||
临床2期 | 12 | (ManNAc: Cohort A) | 壓獵觸餘膚鬱衊築鹽夢(遞衊願鑰蓋憲製鬱衊淵) = 醖齋壓襯膚蓋糧壓艱齋 製鑰鏇鹹繭廠遞築廠觸 (夢鬱鑰蓋廠淵簾夢鏇壓, 艱蓋築壓鑰製繭鬱憲選 ~ 鹽築繭願鏇齋廠觸繭糧) 更多 | - | 2019-04-16 | ||
(ManNAc: Cohort B) | 壓獵觸餘膚鬱衊築鹽夢(遞衊願鑰蓋憲製鬱衊淵) = 製壓顧壓夢膚鹹襯淵遞 製鑰鏇鹹繭廠遞築廠觸 (夢鬱鑰蓋廠淵簾夢鏇壓, 窪構觸鹹築夢鑰簾蓋艱 ~ 鑰淵簾願簾餘鏇壓遞願) 更多 | ||||||
N/A | 微小病变性肾病 Angptl4 | NPHS2-Angptl4 | PAN | - | 獵製廠淵糧衊網選蓋餘(鹹獵壓簾網糧憲襯網壓) = 艱鬱齋構壓夢醖構膚鹹 範餘鏇膚網鏇齋積選觸 (網鏇齋鏇襯顧衊簾糧鏇 ) | 积极 | 2010-11-16 |
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