A Phase 2, Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of 1.0% and 2.5% Cis-UCA Ophthalmic Solutions in Subjects With Dry Eye

The objective of the Phase 2 study is to compare the safety and efficacy of cis-UCA Ophthalmic Solutions to placebo for the treatment of the signs and symptoms of dry eye.

开始日期2014-12-01

申办/合作机构

Herantis Pharma Oyj

[+1]

NCT01476332 / Completed临床1期

A Single Dose (Part 1) and Multiple Dose (Part 2) Phase I, Double-blind, Placebo-controlled, Safety, Tolerability and Pharmacokinetic Study of 0.5% and 2.5% Cis-UCA Eye Drops in Adult Healthy Volunteers

The purpose of this two-part study is to evaluate safety, tolerability and pharmacokinetics of 0.5% and 2.5% cis-UCA eye drops in comparison to placebo in adult healthy volunteers.

开始日期2011-11-01

申办/合作机构

Laurantis Pharma Oy

NCT01320579 / Completed临床2期

Phase II Study to Investigate the Properties of Topical Twice Daily Doses of 2.5% and 5% Cis-urocanic Acid in Comparison to Active Comparator 0.1% Protopic® for up to 28 Days in Patients With Moderate or Severe Atopic Dermatitis

The purpose of this study is to evaluate dose response, safety, tolerability and efficacy of 2.5% and 5% cis-UCA in comparison to placebo and active comparator in the treatment of adult patients with moderate or severe chronic atopic dermatitis.

开始日期2011-03-01

申办/合作机构

BioCis Pharma Oy

100 项与 Cis-urocanic acid 相关的临床结果

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100 项与 Cis-urocanic acid 相关的转化医学

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100 项与 Cis-urocanic acid 相关的专利（医药）

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602

项与 Cis-urocanic acid 相关的文献（医药）

2024-10-01·BIOPHYSICAL JOURNAL

Structure and function of skin barrier lipids: Effects of hydration and natural moisturizers in vitro

Article

作者: Björklund, Sebastian ; Kováčik, Andrej ; Hrdinová, Iva ; Sagrafena, Irene ; Nilsson, Emelie J ; Paraskevopoulos, Georgios ; Morin, Maxim ; Vávrová, Kateřina

Lipid membranes play a crucial role in regulating the body's water balance by adjusting their properties in response to hydration. The intercellular lipid matrix of the stratum corneum (SC), the outermost skin layer, serves as the body's primary defense against environmental factors. Osmolytes, including urocanic acid (UCA) and glycerol, are key components of the natural moisturizing factor that help the SC resist osmotic stress from dry environments. This study examines the effects of UCA and glycerol (each at 5 mol %) on isolated human SC lipids. For this, different techniques were employed, offering complementary information of the system's multiscale characteristics, including humidity-scanning quartz crystal microbalance with dissipation monitoring, infrared spectroscopy, x-ray diffraction, electrical impedance spectroscopy, and studies of water loss and permeability. Our results show that UCA increases water sorption and makes lipid films more liquid-like at high relative humidity, without significantly altering the lipid lamellar structure, chain order, or orthorhombic chain packing. Lipid films containing UCA exhibited higher water loss and significantly higher model drug permeability compared to lipid films without UCA. Further, incorporation of UCA resulted in kinetically faster changes in electrical properties upon contact with aqueous solution compared with control lipids. These observations suggest that UCA reduces lipid cohesion in regions other than the acyl chain-rich leaflets, which may impact SC desquamation. In contrast, glycerol did not influence the hydration or permeability of the SC lipid matrix. However, it increased the proportion of orthorhombic domains at high humidities and slowed the kinetics of the hydration process, as evidenced by slower changes in the dielectric properties of the lipid film. These findings suggest that glycerol enhances lipid cohesion rather than increasing water uptake, which is typically the expected function of humectants. Consequently, UCA and glycerol appear to have distinct roles in maintaining epidermal homeostasis.

2024-10-01·Journal of medical ultrasonics (2001)

Sentinel lymph node identification using contrast-enhanced ultrasound in breast cancer: review of the literature.

Review

作者: Omoto, Kiyoka ; Watanabe, Tamami ; Futsuhara, Kazushige

Abstract:

Before breast cancer surgery, sentinel lymph node (SLN) identification and biopsy using blue dye, radioisotope (RI) with a gamma probe, or a combination of the two are mainly performed. The dye-guided method requires skilled technique to make an incision in the skin and identify SLNs without damaging the lymphatic vessels. In addition, dye-induced anaphylactic shock has been reported. To use the γ-probe-guided method, the facility must be able to handle RI. However, to overcome the drawbacks of these methods, Omoto et al. developed a new identification modality using contrast-enhanced ultrasound with an ultrasound contrast agent (UCA) in 2002. Since then, many basic experiments and clinical studies using various UCA have been reported. In particular, a number of studies in SLN detection using Sonazoid have been reported and are herein reviewed.

2024-09-01·Minerva Obstetrics and Gynecology

Utero-cervical angle to predict the risk of spontaneous preterm birth: a review of literature

Review

作者: Manzo, Luigi ; Raffone, Antonio ; Mari, Sara ; Mollo, Antonio ; Giorno, Alice ; Rispoli, Enrico M ; Saccone, Gabriele ; Cipullo, Lucio M

BACKGROUND:

The aim of this paper was to evaluate the predictive role of the uterocervical angle (UCA) in spontaneous preterm birth (sPTB).

METHODS:

A systematic review of the literature was performed including all studies reporting the association between UCA and sPTB. Searches were performed with the use of a combination of keywords: "cervical length," "uterocervical angle," and "preterm birth" from inception of each database to March 2022. The statistical evaluations were carried out using the Comprehensive Meta-Analysis version 3 (Biostat Inc. USA).

RESULTS:

Sixteen studies all conducted on the second trimester UCA as well as its association with sPTB were included in this study. In all studies the measurements of cervical length (CL) and UCA were performer in the second trimester, except in one that in the third trimester. In most studies the CL is greater than 30 mm and the UCA is greater than 110 °. In seven studies women with symptoms were considered while in 8 studies the women were asymptomatic.

CONCLUSIONS:

It is too early for it to reach a firm conclusion on UCA utilization in clinical settings. A higher UCA measurement (greater than 150°) is an important risk factor for deliveries before 37 weeks' gestation. It provides a higher diagnostic performance in high risk patients than the CL measurement. However, the most relevant ultrasound parameter for the prediction of delivery within the next few data in women with preterm delivery remains the cervical length. There is a need to consider both markers and create protocols so that the values obtained with UCA and those with CL can make a real contribution to decisions to be made rather than using only CL.

项与 Cis-urocanic acid 相关的新闻（医药）

2022-12-13

·Abbott

Abbott and the Brain Injury Association of America launch Concussion Awareness Now coalition; team up with Rebel Wilson to raise awareness on seriousness of concussions

Concussion Awareness Now is comprised of nearly 20 advocacy groups focused on brain injury and will work to raise awareness about the importance of diagnosis and treatment for concussionsThe vast majority of concussions happen in everyday accidents, and over half of people who suspect they have a concussion never get it checkedRebel Wilson sustained a concussion while on set producing and acting in a movie and is sharing her personal story to help raise awarenessABBOTT PARK, Ill., and WASHINGTON, Dec. 13, 2022 /PRNewswire/ -- Abbott (NYSE: ABT) and the Brain Injury Association of America announced today they have cofounded a coalition of nearly 20 advocacy groups, and are teaming up with acclaimed actress, comedian, writer and producer Rebel Wilson to raise awareness of the seriousness of concussions. The coalition, called Concussion Awareness Now, will produce educational campaigns and other awareness efforts focused on seeking care for a possible concussion. According to a recent coalition survey, over half of people who suspect they have a concussion never get it checked. With blows to the head, phrases like "tough it out" and "walk it off" are the norm. And while that kind of direction may be appropriate for a skinned knee, it's never the answer for a potential brain injury. Wilson is sharing her personal concussion story as part of the coalition's debut campaign. She suffered a concussion after slipping on wet grass while filming a movie. "People often believe only athletes and stunt doubles get concussions," Wilson said. "But in reality, concussions are almost always everyday accidents like whacking my head when I fell down a hill." Wilson did seek care after her injury on set and is passionate about raising awareness about the importance of concussion care. "Concussions can be invisible injuries, with the true impact hidden beneath," said Dr. Beth McQuiston, medical director in Abbott's diagnostics business and board-certified neurologist. "Your brain impacts every aspect of who you are, which is why it's so important to understand that concussions are serious injuries, and that they require a diagnosis and care." There are many misconceptions around concussions. In a coalition survey of 3,000 people conducted last month, 84% of people falsely believed athletes are most at risk for concussion (about 3% of concussions that present to the emergency room are a result of sports injuries). Furthermore, 56% indicated that they believed you have to hit your head to sustain a concussion, when in fact concussions can occur after blasts or whiplash (commonly in car accidents) as well. Concussion Awareness Now brings together nearly 20 groups in the brain injury space. They represent people who have sustained brain injuries, their caregivers and those who treat brain injury, from veterans, older adults and victims of domestic violence to emergency care physicians, physicians' assistants and urgent care centers to athletic trainers. "With Concussion Awareness Now, we have no small goal," said Susan Connors, chief executive officer of the Brain Injury Association of America. "We want to change the societal norm about concussions so that when you sustain a potentially serious hit or jolt to your head, or your loved one does, you won't hesitate to get it checked and get on the right path to the best possible care." To learn more about the coalition and its cause, please visit ConcussionAwarenessNow.org. Concussion Awareness Now members include: Abbott (Co-Chair)Brain Injury Association of America (BIAA) (Co-Chair)American Academy of Physician Assistants (AAPA)American Physical Therapy Association (APTA)American Therapeutic Recreation Association (ATRA)American Speech-Language-Hearing Association (ASHA)Center on Partner-Inflicted Brain Injury (part of Ohio Domestic Violence Network)International Sports Vision Association (ISVA)Missouri Athletic Trainers Association (MOATA)National Association of State Head Injury Administrators (NASHIA)National Athletic Trainers Association (NATA)National Council on Aging (NCOA)National Neurotrauma Society (NNS)Neuro-Optometric Rehabilitation Association (NORA)Pink ConcussionsSafe Living Space (SLS)United States Brain Injury Alliance (USBIA)Urgent Care Association/College of Urgent Care Medicine (UCA/CUCM)Wounded Warrior Project (WWP)About the Brain Injury Association of America The Brain Injury Association of America is the country's oldest and largest nationwide brain injury advocacy organization. Our mission is to advance awareness, research, treatment, and education and to improve the quality of life for all people affected by brain injury. We are dedicated to increasing access to quality health care and raising awareness and understanding of brain injury. Learn more at www.biausa.org, on Facebook at www.facebook.com/BrainInjuryAssociationofAmerica, on Instagram at @bia_usa, and on LinkedIn at www.linkedin.com/company/brain-injury-association-of-america. About Abbott Abbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals and branded generic medicines. Our 113,000 colleagues serve people in more than 160 countries. Connect with us at www.abbott.com, on LinkedIn at www.linkedin.com/company/abbott-/, on Facebook at www.facebook.com/Abbott and on Twitter @AbbottNews. SOURCE Abbott

100 项与 Cis-urocanic acid 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB01971

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
干眼综合征	临床2期	美国	Herantis Pharma Oyj	2014-12-01
中度特应性皮炎	临床2期	芬兰	BioCis Pharma Oy	2011-03-01
重度特应性皮炎	临床2期	芬兰	BioCis Pharma Oy	2011-03-01
斑块状银屑病	临床2期	芬兰	Herantis Pharma Oyj	-
干眼症	临床2期	-	Herantis Pharma Oyj	-
非肌层浸润性膀胱肿瘤	临床1期	芬兰	BioCis Pharma Oy	2009-10-01
间质性膀胱炎	临床前	芬兰	Herantis Pharma Oyj	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01320579 (Pubmed) 人工标引	临床2期	特应性皮炎	-	cis-urocanic acid	衊製廠鑰壓積築醖憲網(鬱夢遞鹹簾鹽餘鹽淵糧) = Study treatments were well tolerated. 壓製壓範壓餘廠壓蓋鑰 (壓壓顧顧鹽築艱壓廠艱 ) 更多	积极	2014-01-01