Randomized, Double-blind, Placebo-controlled, Multi-center Phase III Study to Evaluate the Efficacy and Safety of Mocravimod As Adjunctive and Maintenance Treatment in Adult AML Patients Undergoing Allogeneic HCT

This is a multi-center, randomized, double-blinded, placebo controlled trial.

开始日期2022-06-16

申办/合作机构

Priothera SAS

NCT01830010 / Completed临床1期

A Two-part, Single- and Two Arm Randomized, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy (in Part 2 Only) of KRP203 in Patients Undergoing Stem Cell Transplant for Hematological Malignancies

Two part study to evaluate the safety, tolerability, pharmacokinetics, and efficacy (in Part 2 only) of KRP203 in patients undergoing allogeneic hemopoietic stem cell transplant for hematological malignancies

开始日期2013-06-28

申办/合作机构

Novartis Pharmaceuticals Corp.

JPRN-JapicCTI-132108 / Unknown status临床2期

Exploratory Phase II Study of KRP-203 -A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of KRP-203 in Patients with Crohn's Disease in Active Phase-

开始日期2013-05-01

申办/合作机构

KYORIN Pharmaceutical Co., Ltd.

100 项与 Mocravimod hydrochloride 相关的临床结果

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100 项与 Mocravimod hydrochloride 相关的转化医学

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100 项与 Mocravimod hydrochloride 相关的专利（医药）

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项与 Mocravimod hydrochloride 相关的文献（医药）

2024-07-01·BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion

Article

作者: Hirota, Yoshihisa ; Senda, Toshiya ; Ogawa-Iio, Aki ; Edinger, Aimee L ; Kofuji, Satoshi ; Boxer, Matthew B ; Nigorikawa, Kiyomi ; Kanoh, Hirotaka ; Sasaki, Takehiko ; Pragani, Rajan ; Kageyama, Shun ; Kofuji, Kaori ; Sasaki, Mika ; Sasaki, Atsuo T ; Yoshino, Hirofumi ; Takeuchi, Koh ; Davis, Mindy I ; Shen, Min ; Sumita, Kazutaka ; Simeonov, Anton ; Kim, Seong M ; Wolfe, Kara ; Nakatsu, Fubito

In animal cells, vacuoles are absent, but can be induced by diseases and drugs. While phosphoinositides are critical for membrane trafficking, their role in the formation of these vacuoles remains unclear. The immunosuppressive KRP203/Mocravimod, which antagonizes sphingosine-1-phosphate receptors, has been identified as having novel multimodal activity against phosphoinositide kinases. However, the impact of this novel KRP203 activity is unknown. Here, we show that KRP203 disrupts the spatial organization of phosphoinositides and induces extensive vacuolization in tumor cells and immortalized fibroblasts. The KRP203-induced vacuoles are primarily from endosomes, and augmented by inhibition of PIKFYVE and VPS34. Conversely, overexpression of PTEN decreased KRP203-induced vacuole formation. Furthermore, V-ATPase inhibition completely blunted KRP203-induced vacuolization, pointing to a critical requirement of the endosomal maturation process. Importantly, nearly a half of KRP203-induced vacuoles are significantly decorated with PI4P, a phosphoinositide typically enriched at the plasma membrane and Golgi. These results suggest a model that noncanonical spatial reorganization of phosphoinositides by KRP203 alters the endosomal maturation process, leading to vacuolization. Taken together, this study reveals a previously unrecognized bioactivity of KRP203 as a vacuole-inducing agent and its unique mechanism of phosphoinositide modulation, providing a new insight of phosphoinositide regulation into vacuolization-associated diseases and their molecular pathologies.

2023-10-01·Biochemical and biophysical research communications

Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells

Article

作者: Takeuchi, Koh ; Boxer, Matthew B ; Hirota, Yoshihisa ; Shen, Min ; Simeonov, Anton ; Davis, Mindy I ; Senda, Toshiya ; Sasaki, Atsuo T ; Pragani, Rajan ; Zheng, Yuxiang ; Kofuji, Satoshi ; Sasaki, Mika ; Sumita, Kazutaka ; Ikeda, Yoshiki

Increased phosphoinositide signaling is commonly associated with cancers. While "one-drug one-target" has been a major drug discovery strategy for cancer therapy, a "one-drug multi-targets" approach for phosphoinositide enzymes has the potential to offer a new therapeutic approach. In this study, we sought a new way to target phosphoinositides metabolism. Using a high-throughput phosphatidylinositol 5-phosphate 4-kinase-alpha (PI5P4Kα) assay, we have identified that the immunosuppressor KRP203/Mocravimod induces a significant perturbation in phosphoinositide metabolism in U87MG glioblastoma cells. Despite high sequence similarity of PI5P4K and PI4K isozymes, in vitro kinase assays showed that KRP203 activates some (e.g., PI5P4Kα, PI4KIIβ) while inhibiting other phosphoinositide kinases (e.g., PI5P4Kβ, γ, PI4KIIα, class I PI3K-p110α, δ, γ). Furthermore, KRP203 enhances PI3P5K/PIKFYVE's substrate selectivity for phosphatidylinositol (PI) while preserving its selectivity for PI(3)P. At cellular levels, 3 h of KRP203 treatment induces a prominent increase of PI(3)P and moderate increase of PI(5)P, PI(3,5)P_2, and PI(3,4,5)P₃ levels in U87MG cells. Collectively, the finding of multimodal activity of KRP203 towards multi-phosphoinositide kinases may open a novel basis to modulate cellular processes, potentially leading to more effective treatments for diseases associated with phosphoinositide signaling pathways.

2023-07-01·Cellular immunology

Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation.

Article

作者: Bucher, Christoph ; Passweg, Jakob ; Tzankov, Alexandar ; Medinger, Michael ; Dertschnig, Simone

Graft-versus-leukemia (GvL) effects are critical to prevent relapses after allogeneic hematopoietic cell transplantation (allo-HCT). However, the success of allo-HCT is limited by graft-versus-host disease (GvHD). Both, CD4⁺ and CD8⁺ T cells contribute to GvHD and GvL. The sphingosine-1-phosphate receptor (S1PR) signaling plays a crucial role in lymphocyte trafficking. Mocravimod is an S1PR modulator and its administration leads to blocking lymphocyte egress from lymphoid organs. We hypothesized that this applies to the bone marrow (BM) too, and analyzed BM biopsies from the clinical study with mocravimod (phase I trial in allo-HCT patients; NCT01830010) by immunohistochemical staining for CD3, CD4, CD8, TIA1, FoxP3, PD1, T-Bet, GATA3, and ROR-γt to identify and quantify T cell subsets in situ. Allo-HCT patients without receiving mocravimod were used as controls. BM from 9 patients in the mocravimod group and 10 patients in the control group were examined. CD3⁺ T cells were found to accumulate in the BM of mocravimod-treated patients compared to controls, both on day 30 and 90 post-transplant. The effect was stronger for CD4⁺ T cells, than CD8⁺ T cells, which is in line with data from murine studies showing that CD4⁺ T cells are more sensitive to mocravimod treatment than CD8⁺ T cells. Clinically-relevant acute GvHD events (grade II-IV) were slightly lower, but comparable to controls when mocravimod was administered. Taken together, data are supportive of mocravimod's mode of action and bring additional evidence of fewer relapses for allo-HCT patients treated with S1PR modulators.

项与 Mocravimod hydrochloride 相关的新闻（医药）

2023-11-27

·GlobeNewswire-Health Care

Priothera – US FDA grants Orphan Drug Designation to mocravimod to improve the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with hematologic malignancies

Mocravimod is the only S1P receptor modulator being developed as an adjunctive and maintenance treatment for blood cancers Mocravimod is being investigated in a global registration-enabling Phase 3 trial This is the second Orphan Drug designation for mocravimod Priothera Ltd., a Phase 3 clinical stage biotechnology company pioneering the development of its S1P receptor modulator compound mocravimod, today announced that the US Food and Drug Administration (FDA) has granted Orphan Drug designation (ODD) to mocravimod for the ‘treatment to improve outcome following hematopoietic stem cell transplantation in hematologic malignancies’. This ODD aims to potentially increase leukemia-free survival by enhancing a graft-versus-leukemia (GvL) response. Florent Gros, Co-Founder and CEO of Priothera, commented: “We are very pleased that the US FDA granted mocravimod this Orphan Drug designation. This designation emphasizes the importance of developing novel therapeutic options to improve the outcome and success of maintenance therapy following allo-HSCT in blood cancer patients. This is an important milestone as this ODD complements the first ODD granted for prevention of graft-versus-host disease. “The two ODDs highlight mocravimod’s dual mode of action which for the first time is being leveraged to improve the allo-HSCT treatment outcomes in hematological malignancies to potentially increase the leukemia free survival – graft-versus-leukemia response - while reducing tissue damage resulting from the graft-versus-host disease.” The first ODD granted for mocravimod by the US FDA was for the ‘prevention of graft-versus-host disease (GvHD)’ – see press release here. Mocravimod, a sphingosine-1-phosphate (S1P) receptor modulator, is being investigated in a pivotal global Phase 3 study - MO-TRANS (NCT05429632) - evaluating the efficacy and safety of mocravimod as an adjunctive and maintenance therapy to allo-HSCT. The study which is enrolling approximately 250 adult Acute Myeloid Leukemia (AML) patients, is ongoing in the US, Europe, Southeast Asia and Latin America. Mocravimod, which has been previously tested in multiple autoimmune indications, is being developed to enhance the curative potential of allo-HSCT. Moreover, it has shown a clinically meaningful outcome in a Phase 1b/2a study1 in patients with hematologic malignancies undergoing allo-HSCT. Mocravimod (also known as KRP203) is a synthetic, S1P receptor modulator. This novel investigational drug has been assessed in Phase 1 and Phase 2 trials for safety and tolerability, as well as for efficacy in several autoimmune indications. Promising data from a Phase 1b/2a clinical study in patients with hematological malignancies led Priothera to further develop mocravimod for the treatment of blood cancers and the improvement of CAR-T cell therapy. Mocravimod is currently being investigated as an adjunctive and maintenance treatment in a Phase 3 study for patients with AML receiving allogeneic HSCT. Allogeneic HSCT is the only potentially curative approach for AML patients, but current treatments have unacceptably high mortality and morbidity rates. Priothera leverages mocravimod’s dual mode of action to maintain the beneficial graft-versus-leukemia/lymphoma (GvL) activity, while reducing tissue damage resulting from graft-versus-host disease (GvHD), both a consequence of allo-HSCT. This novel treatment approach – mocravimod being the only S1P receptor modulator treating blood cancers – tackles a high unmet medical need and aims to improve patients’ quality of life. Priothera is leading the way in developing orally applied S1P receptor modulators for the treatment of hematological malignancies and for the improvement of CAR-T cell therapies. S1P receptor modulators are known to largely reduce egress of T cells from lymphatic tissues. Unlike immunosuppressive drugs, mocravimod does not suppress the GvL benefits in patients receiving allogeneic HSCT while inhibiting GvHD. Priothera was founded in 2020 by an experienced team of drug development experts and is headquartered in Dublin, Ireland, and with a subsidiary in Saint-Louis, France. The Company is backed by international founding investors Fountain Healthcare Partners (Dublin, Ireland), funds managed by Tekla Capital Management, LLC (Boston, Massachusetts), HealthCap (Stockholm, Sweden), EarlyBird Venture Capital (Berlin, Germany), as well as non-dilutive financing in the form of loans from the European Investment Bank under its Venture Debt Instrument and Bpifrance (Grand Est Bpifrance) in the form of a R&D innovation loan. The content above comes from the network. if any infringement, please contact us to modify.

临床2期孤儿药细胞疗法免疫疗法

2023-01-23

·PRNewswire

Priothera announces first patients enrolled in pivotal MO-TRANS global Phase 2b/3 study with mocravimod as an adjunctive and maintenance therapy for patients with Acute Myeloid Leukemia (AML) undergoing allogeneic Hematopoietic Cell Transplant (HCT)

Mocravimod is the only S1PR modulator being developed to treat blood cancers and improve CAR-T therapy Phase 1b/2a data has shown mocravimod is safe and well tolerated DUBLIN, Jan. 23, 2023 /PRNewswire/ -- Priothera, a late-clinical stage biotechnology company pioneering the development of its S1P receptor modulator compound mocravimod today announced that the first patients have been enrolled in the pivotal MO-TRANS global Phase 2b/3 study evaluating mocravimod in AML patients undergoing allogeneic hematopoietic cell transplant (HCT). Mocravimod, a sphingosine 1 phosphate (S1P) receptor modulator which has been previously tested in multiple autoimmune indications, is being developed to enhance the curative potential of allogeneic HCT. Mocravimod has shown a clinically relevant benefit in an early clinical study in patients with hematologic malignancies undergoing allogeneic HCT. Priothera is initiating the pivotal MO-TRANS global Phase 2b/3 study in Europe, Israel, the US and in additional Asian and Latin American countries, to assess the efficacy and safety of mocravimod as an adjunctive and maintenance therapy in AML patients undergoing allogeneic HCT. The double-blind, placebo-controlled study assesses relapse-free and overall survival of two dose levels of mocravimod in comparison to placebo. Topline data from this study are expected in 2025. Marcos de Lima, M.D., is the Principal Investigator for the MO-TRANS global Phase 2b/3 trial. Dr. de Lima is professor of medicine at The Ohio State University College of Medicine and a hematologist-oncologist at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Prof de Lima said : "We are excited to be part of the important MO-TRANS global Phase 2b/3 study to investigate mocravimod, a potential new adjunctive and maintenance therapy for patients with Acute Myeloid Leukemia undergoing allogeneic Hematopoietic Cell Transplant. Maintenance therapy is fast becoming the new frontier in the treatment of AML and we are committed to bringing forth new innovative therapies to AML patients." Elisabeth Kueenburg, M.D., Chief Medical Officer at Priothera, commented: "This MO-TRANS global Phase 2b/3 study builds on pre-clinical and clinical proof of concept studies which demonstrated mocravimod's ability to improve survival outcomes for patients with hematological malignancies requiring allogeneic HCT. The mode of action has been well-established in autoimmune indications, but never in hematology. Mocravimod has the potential to be a first-in-class therapy in maintaining the graft-versus-leukemia effect, while preventing graft-versus-host disease, one of the most serious complications of allogeneic HCT. We expect this trial to deliver important clinical data supporting the registration of mocravimod in this indication." Florent Gros, Co-Founder and CEO of Priothera, said: "Having successfully enrolled the first AML patients undergoing allogeneic HCT in our MO-TRANS global study represents a significant milestone for Priothera as we believe mocravimod has the potential to address a significant unmet need. Furthermore, we anticipate a strong uptake in patient enrollment with a significant number of patients currently being identified. We look forward to seeing topline results in 2025." About mocravimod Mocravimod (also known as KRP203) is a synthetic, sphingosine 1-phosphate receptor (S1PR) modulator. This novel investigational drug has been assessed in Phase 1 and Phase 2 trials for safety and tolerability, as well as for efficacy in several autoimmune indications. Promising data from a Phase 1b/2a clinical study in patients with hematological malignancies led Priothera to further develop mocravimod for the treatment of blood cancers and the improvement of CAR-T cell therapy. Mocravimod is currently being investigated as an adjunctive and maintenance treatment in a Phase 2b/3 study for patients with Acute Myeloid Leukemia (AML) receiving allogeneic hematopoietic cell transplantation (HCT). Allogeneic HCT is the only potentially curative approach for AML patients, but current treatments have unacceptably high mortality and morbidity rates. Priothera leverages mocravimod's unique mode of action to maintain the beneficial graft-versus leukemia (GVL) activity, while reducing tissue damage resulting from graft-versus-host disease (GVHD), both a consequence of allogeneic HCT. This novel treatment approach – mocravimod being the only S1PR modulator treating blood cancers – tackles a high unmet medical need and aims to improve patients' quality of life. About Priothera Priothera is leading the way in developing orally applied sphingosine-1-phosphate (S1P) receptor modulators for the treatment of hematological malignancies and for the improvement of CAR-T cell therapies. S1P receptor modulators are known to largely reduce egress of T cells from lymphatic tissues. Unlike immunosuppressive drugs, mocravimod does not suppress the graft-versus-leukemia (GVL) benefits in patients receiving HCT while inhibiting graft-versus-host-disease (GVHD). Priothera was founded in 2020 by an experienced team of drug development experts and is headquartered in Dublin, Ireland, and with a subsidiary in Saint-Louis, France. The Company is backed by international founding investors Fountain Healthcare Partners (Dublin, Ireland), funds managed by Tekla Capital Management, LLC (Boston, Massachusetts), HealthCap (Stockholm, Sweden), EarlyBird Venture Capital (Berlin, Germany), as well as non-dilutive financing in the form of loans from the European Investment Bank under its Venture Debt Instrument and Bpifrance (Grand Est Bpifrance) in the form of a R&D innovation loan. For more information please visit: or follow Priothera on LinkedIn Contacts Priothera Florent Gros, CEO E: [email protected] MEDiSTRAVA Consulting Sylvie Berrebi, Sandi Greenwood, Frazer Hall E: [email protected] T: +44 (0) 203 928 6900 SOURCE Priothera

细胞疗法免疫疗法临床研究

2022-11-14

·PRNewswire

Priothera - Positive mocravimod Phase 1b clinical data published in Transplantation and Cellular Therapy

Mocravimod is safe and well-tolerated in allogeneic hematopoietic cell transplantation (HCT) patients Mocravimod significantly reduced circulating lymphocyte numbers and did not affect engraftment DUBLIN, Nov. 14, 2022 /PRNewswire/ -- Priothera, a late-clinical stage biotechnology company pioneering the development of its S1P receptor modulator compound mocravimod, announces that positive data from the Phase 1b clinical trial evaluating mocravimod in allogeneic hematopoietic cell transplantation patients has been published in Transplantation and Cellular Therapy. The study assessed the safety and tolerability of mocravimod in patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) for hematological malignancies. The secondary objectives were to determine the pharmacokinetic profile of mocravimod in this patient group as well as to assess GvHD-free, relapse-free survival at 6 months after last treatment. The study found that mocravimod can safely be added to standard treatment regimens in patients with hematological malignancies requiring allo-HCT. CD4+ T cells were more sensitive to mocravimod treatment than CD8+ T cells. Mocravimod resulted in a significant reduction of circulating lymphocyte numbers and had no negative impact on engraftment and transplant outcomes. Mocravimod, a sphingosine 1 phosphate (S1P) receptor modulator which has been previously tested in multiple autoimmune indications, is being developed to enhance the curative potential of HCT. A global Phase 2b/3 study assessing the efficacy and safety of mocravimod as an adjunctive and maintenance therapy in acute myeloid leukemia (AML) patients undergoing allo-HCT is planned to start in the coming months. The trial design for this study will be published as an online abstract as part of the 2022 American Society of Hematology (ASH) conference (December 10-13th). Florent Gros, Co-Founder and CEO of Priothera, said: "The positive Phase 1b data reinforce the potential for mocravimod to improve survival outcomes for patients with hematological malignancies requiring HCT. We're looking forward to building upon this foundation with our upcoming pivotal Phase 2b/3 trial and advancing our lead asset towards its next significant milestones." Elisabeth Kueenburg, M.D., Chief Medical Officer at Priothera, commented: "Mocravimod's mode of action has already been well established in autoimmune indications, and the Phase 1b trial shows that its potential also extends to hematology. We believe mocravimod has the potential to be a first-in-class therapy in maintaining graft-versus-leukemia responses, one of the most serious complications of allogeneic HCT, while preventing graft-versus-host disease." References S. Dertschnig et al. Mocravimod, a selective S1PR modulator in allogeneic hematopoietic stem cell transplantation for malignancy, Transplantation and Cellular Therapy. Online publication: About mocravimod Mocravimod (also known as KRP203) is a synthetic, sphingosine 1-phosphate receptor (S1PR) modulator. This novel investigational drug has been assessed in Phase 1 and Phase 2 trials for safety and tolerability, as well as for efficacy in several autoimmune indications. Promising data from a Phase 1b/2a clinical study in patients with hematological malignancies - commonly known as leukemias and lymphomas - led Priothera to further develop mocravimod for the treatment of blood cancers and the improvement of CAR-T cell therapy. Mocravimod is being investigated as an adjunctive and maintenance treatment in a Phase 2b/3 study for patients with Acute Myeloid Leukemia (AML) receiving allogeneic hematopoietic cell transplantation (HCT). Allogeneic HCT is the only potentially curative approach for AML patients, but current treatments have unacceptably high mortality and morbidity rates. Priothera leverages mocravimod's unique mode of action to maintain the beneficial graft-versus leukemia (GVL) activity, while reducing tissue damage resulting from graft-versus-host disease (GVHD), both a consequence of allogeneic HCT. This novel treatment approach – mocravimod being the only S1PR modulator treating blood cancers – tackles a high unmet medical need and intends to add quality life to patients. About Priothera Priothera is leading the way in developing orally applied sphingosine-1-phosphate (S1P) receptor modulators for the treatment of hematological malignancies and for the improvement of CAR-T cell therapies. S1P receptor modulators are known to largely reduce egress of T cells from lymphatic tissues. Unlike immunosuppressive drugs, mocravimod does not suppress the graft-versus-leukemia (GVL) benefits in patients receiving HCT while inhibiting graft-versus-host-disease (GVHD). Priothera was founded in 2020 by an experienced team of drug development experts and is headquartered in Dublin, Ireland, and with a subsidiary in Saint-Louis, France. The Company is backed by international founding investors Fountain Healthcare Partners (Dublin, Ireland), funds managed by Tekla Capital Management, LLC (Boston, Massachusetts), HealthCap (Stockholm, Sweden), EarlyBird Venture Capital (Berlin, Germany), as well as non-dilutive financing in the form of loans from the European Investment Bank under its Venture Debt Instrument and Bpifrance (Grand Est Bpifrance) in the form of a R&D innovation loan. For more information please visit: or follow Priothera on LinkedIn Contacts Priothera Florent Gros, CEO E: [email protected] MEDiSTRAVA Consulting Sylvie Berrebi, Sandi Greenwood, Frazer Hall E: [email protected] T: +44 (0) 203 928 6900 SOURCE Priothera

细胞疗法临床1期ASH会议临床2期免疫疗法

100 项与 Mocravimod hydrochloride 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
成人急性髓性白血病	临床3期	美国	Priothera SAS	2022-06-16
成人急性髓性白血病	临床3期	日本	Priothera SAS	2022-06-16
成人急性髓性白血病	临床3期	阿根廷	Priothera SAS	2022-06-16
成人急性髓性白血病	临床3期	巴西	Priothera SAS	2022-06-16
成人急性髓性白血病	临床3期	法国	Priothera SAS	2022-06-16
成人急性髓性白血病	临床3期	德国	Priothera SAS	2022-06-16
成人急性髓性白血病	临床3期	以色列	Priothera SAS	2022-06-16
成人急性髓性白血病	临床3期	意大利	Priothera SAS	2022-06-16
成人急性髓性白血病	临床3期	波兰	Priothera SAS	2022-06-16
成人急性髓性白血病	临床3期	罗马尼亚	Priothera SAS	2022-06-16

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01830010 (PRNewswire) 人工标引	临床1期	造血干细胞移植	-	mocravimod	製繭觸積顧憲觸餘壓艱(襯鑰衊築網鏇願壓獵鏇) = Mocravimod is safe and well-tolerated in allogeneic hematopoietic cell transplantation (HCT) patients 襯壓繭醖選製範齋齋選 (壓積選醖範鹽築壓積築 )	积极	2022-11-14
EHA2022 人工标引	临床1期	血液肿瘤	-	CsA+KRP203 3mg	範願製遞鹽選製積觸獵(網襯衊繭憲襯獵鏇夢衊) = 製鑰淵糧夢衊構獵鏇獵鹽淵膚膚衊願選淵觸觸 (淵獵願艱獵齋醖襯網鬱 ) 更多	积极	2022-05-12
				CsA+KRP203 1mg	範願製遞鹽選製積觸獵(網襯衊繭憲襯獵鏇夢衊) = 遞廠窪獵餘憲膚鬱製願鹽淵膚膚衊願選淵觸觸 (淵獵願艱獵齋醖襯網鬱 ) 更多
Tandem Meetings ASTCT and CIBMTR2022	临床1期	血液肿瘤	-	3mg KRP203+CsA/MTX	鬱製艱艱觸蓋衊壓選糧(餘窪簾範夢繭齋鹽鏇淵) = 衊積齋獵醖選餘艱鏇製齋襯鹽夢鑰淵蓋簾窪觸 (遞廠網鹽積構淵齋醖淵 ) 更多	积极	2022-03-01
				1mg KRP203+CsA/MTX	鬱製艱艱觸蓋衊壓選糧(餘窪簾範夢繭齋鹽鏇淵) = 鹹夢窪積鬱顧鹽選糧醖齋襯鹽夢鑰淵蓋簾窪觸 (遞廠網鹽積構淵齋醖淵 ) 更多
NCT01830010 (P229, EBMT2019)	临床1期	移植物抗宿主病	23	KRP203 3 mg/day + tacrolimus/MTX	窪範壓獵鹽蓋獵齋淵廠(餘積憲構膚顧鏇遞遞憲) = 襯壓鏇鏇壓鏇鹽艱衊顧獵醖築鑰餘顧簾鑰鹹淵 (鏇襯艱遞窪廠製觸製醖 ) 更多	积极	2019-03-24
				KRP203 1 mg/day + CsA/MTX	窪範壓獵鹽蓋獵齋淵廠(餘積憲構膚顧鏇遞遞憲) = 蓋襯鑰觸餘鏇糧壓壓遞獵醖築鑰餘顧簾鑰鹹淵 (鏇襯艱遞窪廠製觸製醖 ) 更多
ECCO2016	临床2期	溃疡性结肠炎	30	KRP203 1.2 mg	淵鏇鹹醖築遞網膚鬱窪(觸簾鏇顧窪簾繭淵鑰夢) = 鏇窪鹽築醖窪夢製艱願襯繭蓋網選窪鏇鑰廠獵 (襯鹹膚獵夢獵衊餘夢糧 ) 更多	积极	2016-02-12
				Placebo	壓鏇範積遞蓋鬱鹹齋願(壓淵鏇遞憲製蓋淵選衊) = 獵顧觸網憲築鑰遞鬱顧糧遞築繭壓鑰遞獵襯觸 (淵網夢築鹽蓋醖窪鬱淵 )