盐酸莫沙维林(Moxaverine Hydrochloride) - 药物靶点：PDEs_在研适应症：心血管疾病，肌肉痉挛_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Certonal、Kollateral、Sorbosan

靶点

PDEs

作用方式

抑制剂

作用机制

Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) inhibitors

治疗领域

神经系统疾病心血管疾病皮肤和肌肉骨骼疾病+ [1]

在研适应症

心血管疾病肌肉痉挛

非在研适应症-

原研机构-

在研机构-

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C20H22ClNO2

InChIKeyDULZSDGCXSLVAQ-UHFFFAOYSA-N

CAS号1163-37-7

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关联

8

项与盐酸莫沙维林相关的临床试验

NCT02977286

/ Terminated临床4期IIT

Impact of Naloxegol on Prevention of Lower GI Tract Paralysis in Critically Ill Adults Initiated on Scheduled Intravenous Opioid Therapy: A Randomized, Double-Blind, Placebo-Controlled, Phase II, Single-Center, Proof of Concept Study

This study evaluates the addition of naloxegol (Movantik) to a laxative protocol in critically ill adults requiring scheduled opioid (e.g. fentanyl) therapy. Half of the participants will receive naloxegol and a laxative protocol and half the participants will receive a placebo and a laxative protocol.

开始日期2017-01-01

申办/合作机构

Tufts Medical Center, Inc.

NCT01629680

/ Completed临床2期IIT

A Randomized, Placebo-controlled Study Investigating the Effects of Moxaverine on Ocular Blood Flow After Oral Administration in Healthy Subjects

A number of common eye diseases such as age-related macular degeneration and glaucoma are associated with ocular perfusion abnormalities. Although this is well recognized there is not much possibility to improve blood flow to the posterior pole of the eye in these diseases.
For many years, moxaverine has been used in the therapy of perfusion abnormalities in the brain, the heart and the extremities. This is based on a direct vasodilatatory effect of the drug, but also on the rheological properties of red blood cells. In two recent studies the investigators have shown that intravenous moxaverine increases choroidal and retrobulbar blood flow in healthy young subjects, in elderly people with healthy eyes and in patients with eye diseases associated with hypoperfusion. The present study aims to investigate, whether ocular blood flow is also improved after oral administration of moxaverine.

开始日期2010-10-01

申办/合作机构

Medical University of Vienna

EUCTR2009-017789-22-AT

/ Not yet recruitingN/A

A randomized, placebo-controlled study investigating the effects of moxaverine on ocular blood flow after oral administration in healthy subjects - MOXOPH3

开始日期2010-05-19

申办/合作机构

URSAPHARM Arzneimittel GmbH & Co. KG

100 项与盐酸莫沙维林相关的临床结果

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100 项与盐酸莫沙维林相关的转化医学

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100 项与盐酸莫沙维林相关的专利（医药）

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134

项与盐酸莫沙维林相关的文献（医药）

2022-02-01·Fuel

Examination of characteristics of anti-oxidation compound inhibitor for preventing the spontaneous combustion of coal

作者: Cheng, Weimin ; Dong, Hao ; Xue, Di ; Liang, Yuntao ; Hu, Xiangming ; Wang, Wei

To improve the efficiency of inhibitors in preventing the spontaneous combustion of coal, an antioxidant-type high-efficiency composite inhibitor (SAP + MLT + Ben) was synthesized by solution polymerizationSEM, Fourier transform IR spectra, ESR, and programmed temperature experiment were employed to clarify the inhibition mechanism of SAP + MLT + Ben on coal oxidationResults revealed that (1) The combined effect of Ben and acrylic acid/sodium acrylate leads to the improvement in the water absorption properties of the hydrogel; (2) Melatonin captures hydroxyl radicals, lipoxy radicals, and lipoperoxy radicals in coal by providing lone pairs of electrons, thereby reducing the concentration of easily oxidizable hydroxyl, Me, and methylene groups and increasing the number of stable ether bonds; (3) The concentration of free radicals in the coal sample treated with SAP + MLT + Ben is 6.00% less than that of the original coal sample, the temperature to reach the maximum weight loss rate is delayed by 24.53°C, and the retention rate of heated water gets increased by 13.93%.This study provides a scientific basis for the prevention of spontaneous combustion of coal and development of novel composite inhibitors.

2020-05-01·Materials Science and Engineering: C2区 · 工程技术

Carboxymethyl fenugreek galactomannan-g-poly(N-isopropylacrylamide-co-N,N′-methylene-bis-acrylamide)-clay based pH/temperature-responsive nanocomposites as drug-carriers

2区 · 工程技术

Article

作者: Gajbhiye, Virendra ; Yang, Mingshi ; Tambe, Prajakta ; Liew, Kok Fui ; Kumar, Pramod ; Azad, A K ; Abbasi, Yasir Faraz ; Bera, Hriday ; Cun, Dongmei

The current study dealt with the synthesis and characterization of carboxymethyl fenugreek galactomannang-g-poly(N-isopropylacrylamide-co-N,N'-methylene-bis-acrylamide)-bentonite [CFG-g-P(NIPA-co-MBA)-BEN] based nanocomposites (NCs) as erlotinib (ERL)-delivery devices for lung cancer cells to suppress excessive cell proliferation. The blank NCs exhibited outstanding biodegradability and pH/temperature-dependent swelling profiles, which were significantly influenced by their BEN contents (0-20%). The molar mass (M¯c) between the crosslinks of these NCs was declined with temperature. The composite architecture of these scaffolds was confirmed by XRD, FTIR, TGA, DSC and SEM analyses. The corresponding ERL-loaded matrices (F-1-F-3) portrayed outstanding drug encapsulation efficiency (DEE, 93-100%) with zeta potential between -8 and -16 mV and diameter between 615 and 1258 nm. These formulations demonstrated sustained ERL elution profiles (Q_8h, 62-98%) with an initial burst release of drug. The drug dissolution pattern of the optimized matrices (F-3) obeyed first-order kinetic model and was driven by Fickian diffusion. The mucin adsorption behavior of F-3 was best fitted to Freudlich isotherms. The ERL-loaded formulation suppressed A549 cell proliferation and promoted apoptosis to a greater extent than the pristine drug, as detected by cellular uptake analysis, MTT cytotoxicity test and AO/EB staining assay.

2017-10-02·Angewandte Chemie International Edition1区 · 化学

Redox‐Neutral Manganese(I)‐Catalyzed C−H Activation: Traceless Directing Group Enabled Regioselective Annulation

1区 · 化学

Article

作者: Greßies, Steffen ; Cembellín, Sara ; Glorius, Frank ; Klauck, Felix J. R. ; Lu, Qingquan ; Daniliuc, Constantin G.

AbstractA strategy is reported in which traceless directing groups (TDGs) are used to promote the redox‐neutral MnI‐catalyzed regioselective synthesis of N‐heterocycles. Alkyne coupling partners bearing a traceless directing group, which serves as both the chelator and internal oxidant, were used to control the regioselectivity of the annulation reactions. This operationally simple approach is highly effective with previously challenging unsymmetrical alkyne systems, including unbiased dialkyl alkynes, with perfect regioselectivity. The simple conditions and the ability to carry out synthesis on a gram scale underscore the usefulness of this method. The application of this strategy in the concise synthesis of the bioactive compound PK11209 and the pharmaceutical moxaverine is also described.

100 项与盐酸莫沙维林相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D08238	盐酸莫沙维林	A03AD30	DB12251

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
心血管疾病	-	-	-
肌肉痉挛	-	-	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02977286 (CTgov)	临床4期	便秘	12	Polyethylene Glycols+Magnesium Citrate Oral Liquid Product+Bisacodyl 10 mg Suppository+Docusate Sodium 100 Mg oral capsule [Colace]+Senna 217 Mg Oral Tablet+Naloxegol Oral Tablet+Methylnaltrexone (Naloxegol Oral Tablet)	範窪鬱壓獵齋艱簾襯蓋(遞積構築網網憲鹹齋簾) = 鬱鬱窪範淵膚餘醖鹹網鑰襯網積襯鏇壓餘獵觸 (窪淵衊鏇鏇窪鹽夢獵壓, 淵築醖鹹齋獵齋齋衊糧 ~ 夢範遞窪窪鹹製夢繭壓) 更多	-	2023-02-16
NCT02977286 (CTgov)	临床4期	便秘	12	Placebo Oral Tablet+Magnesium Citrate Oral Liquid Product+Bisacodyl 10 mg Suppository+Docusate Sodium 100 Mg oral capsule [Colace]+Senna 217 Mg Oral Tablet+Methylnaltrexone (Placebo Oral Tablet)	範窪鬱壓獵齋艱簾襯蓋(遞積構築網網憲鹹齋簾) = 廠廠淵鹽築衊鬱夢齋憲鑰襯網積襯鏇壓餘獵觸 (窪淵衊鏇鏇窪鹽夢獵壓, 顧鑰糧遞顧觸艱壓製齋 ~ 網簾廠觸築壓鹽醖積獵) 更多	-	2023-02-16
NCT00569621 (ARVO2008)	临床2期	缺血	16	Moxaverine	鑰膚願繭範艱遞願鑰遞(遞蓋製遞壓襯鏇夢網憲) = 醖蓋廠築憲製繭蓋製艱鑰繭窪網衊繭膚憲醖膚 (簾網壓選構齋廠鏇淵憲 ) 更多	积极	2008-05-01