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更新于：2025-05-26
Perflutren lipid microsphere
全氟丙烷脂质微球
更新于：2025-05-26
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2001-07-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C3F8 |
InChIKeyQYSGYZVSCZSLHT-UHFFFAOYSA-N |
CAS号76-19-7 |
关联
70
项与 全氟丙烷脂质微球 相关的临床试验NCT06024772
Prostate Cancer Diagnosis by Multiparametric Ultrasound (Clinical)
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A Cross-sectional Pilot Study of 19F MRI in Healthy Children and Children With Mild Cystic Fibrosis Lung Disease
NCT06797193
Invoking Subharmonics and Subharmonic Aided Pressure Estimation (SHAPE) for Identifying Portal Hypertension
100 项与 全氟丙烷脂质微球 相关的临床结果
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100 项与 全氟丙烷脂质微球 相关的转化医学
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100 项与 全氟丙烷脂质微球 相关的专利（医药）
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2,320
项与 全氟丙烷脂质微球 相关的文献（医药）2025-07-01AMERICAN JOURNAL OF OPHTHALMOLOGY
Colour Doppler and Contrast-Enhanced Ultrasound Characteristics in Degenerative Retinoschisis and Retinal Detachment
Article
作者: LE, Matthew ; Macri, Carmelo ; Gun, Meegan ; Sammouh, Fady ; Lee, Yong Min ; Chan, Weng Onn ; Paris, Jai ; Lim, Wanyin
PURPOSE:
To investigate and compare the characteristics of colour Doppler ultrasound (CDUS) and contrast-enhanced ultrasound (CEUS) in degenerative retinoschisis (RS) and rhegmatogenous retinal detachment (RD).
DESIGN:
Prospective, observational case series.
METHODS:
We prospectively enrolled patients with degenerative RS, acute RD, or chronic RD at two tertiary centres from January 2024 to January 2025. Patients underwent clinical examination, ultrawide field photography and optical coherence tomography (OCT), and CDUS, followed by CEUS with Definity® microbubbles. Ultrasound characteristics between groups were compared.
RESULTS:
We included 65 eyes from 47 patients (25 male, median age 61.8). There were 51 eyes with RS, 6 eyes with acute RD, and 6 eyes with chronic RD. CDUS revealed no pre-contrast doppler flow in any RS, while all acute RD cases demonstrated doppler flow. CEUS displayed mild microbubble uptake in 18 RS cases (median bubble count of 2), whereas all RD cases exhibited florid uptake (median bubble count of 48.2). Compared to RS, acute RD cavities had significantly higher elevation from sclera (by 6.0 CI 2.8-9.2 mm), longer cavity lengths (by 9.8 CI 7.2-12.5), and greater membrane thickness (by 0.89 CI 0.6-1.2 mm). Chronic RD were significantly thicker than RS membranes (by 0.40 CI 0.2-0.6 mm) but were no longer or with greater elevation. Pixelated image analysis showed compared to RS, acute RD showed a higher average total particle count (by 45.83 units), larger particle size (by 66.3 pixels), and greater total particle area (by 3138 pixels). Chronic RD cases had mixed CDUS and CEUS findings.
CONCLUSIONS:
CDUS features differentiating between degenerative RS and RD included the lack of doppler flow in RS, higher and longer cavities in acute RD, and thicker membranes in acute and chronic RD. CEUS features differentiating RS and RD included florid microbubble contrast enhancement in acute RD. These findings could aid in the investigation of cases with diagnostic uncertainty.
2025-06-01FLUID PHASE EQUILIBRIA
Accurate calculation and reliable prediction of second virial coefficients for nonpolar mixtures
作者: Qin, Kang ; Xu, Liu ; Duan, Yuan-Yuan
The virial equation of state has a theor. advantage in the calculations of mixturesThe second mixture virial coefficients are with the theor. rigid mixing rules and composed of the second virial coefficients for pure fluids and the cross second virial coefficientsBased on the generalized corresponding state principle second virial coefficient model for pure fluids we proposed before, the generalized cross second virial coefficient models were established with three characteristic parameters for nonpolar binaries in this work.The calculation of the mixture critical temperature requires the binary interaction coefficients (kij).The mixture acentric factor was determined by the arithmetic mean.The mixture critical pressure could be calculated without the critical sp. volumeFor the most sensitive mixing rule of the mixture critical temperature, the kij was optimized for 145 nonpolar binaries.An easily accessible characteristic correlating parameter, the reduced diameter, was proposed to develop the predictive kij correlations for common nonpolar binaries.Due to the complex intermol. interactions between two different mols., the kij correlations were proposed resp. for alkane/alkane binaries, nonpolar binaries containing fluorocarbon, nonpolar binaries containing nitrogen or oxygen, nonpolar binaries containing simple fluids, nonpolar binaries containing carbon dioxide and nonpolar binaries containing neon.Our work was validated to perform satisfactorily from the comparison with the Chueh-Prausnitz kij correlation, Fender-Halsey kij correlation, and Meng kij correlation.Together with our previous work, this work could accurately calculate and reliably predict the second virial coefficients for common nonpolar mixtures
2025-06-01Computational and Theoretical Chemistry
Electron and positron impact ionization cross sections of neutral molecular species dissociating from C4F7N and its mixtures
作者: Geetha, D. ; Gupta, Dhanoj
The electron and positron impact ionization cross sections are reported for neutral fragments originating from C4F7N and their mixture with air, CO2, and N2 using the Binary-Encounter Bethe (BEB) method and its variants, such as BEB-W and BEB-B.The neutral targets studied are HF, CO, CO2, COF2, CHF3, CF3, CF4, C2F4, C2F6, C3F6, C3F8, C4F6, C4F8, C4F10, CN, HCN, CFN, C2N2, C2FN, C2F3N, C3F3N, C3F4N, C3F5N mols.The results for most of the targets for electron imapct ionization compare well with the available exptl. and theor. results.However, for most of the mols., the estimates of positron impact ionization are the first attempt.The correlation of the maximum ionization cross section for both electrons and positrons with the polarizability and the number of electrons of the target gave a good correlation fit.The cross section data presented in this article are important for C4F7N plasma.
100 项与 全氟丙烷脂质微球 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 心脏病 | 中国 | 2022-11-15 | |
| 造影剂 | 美国 | 2001-07-31 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性劳累性骨筋膜室综合征 | 临床3期 | 美国 | 2020-07-01 | |
| 肾脏疾病 | 临床3期 | 中国 | 2017-11-10 | |
| 肾脏疾病 | 临床3期 | 中国 | 2017-11-10 | |
| 肾细胞癌 | 临床3期 | 中国 | 2017-11-10 | |
| 肾细胞癌 | 临床3期 | 中国 | 2017-11-10 | |
| 肝病 | 临床3期 | 中国 | 2017-09-21 | |
| 肝病 | 临床3期 | 中国 | 2017-09-21 | |
| 肝细胞癌 | 临床3期 | 美国 | 2016-04-01 | |
| 心脏衰竭 | 临床2期 | 美国 | 2017-06-01 | |
| 子宫附件疾病 | 临床1期 | 美国 | 2017-08-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床1/2期 | 36 | NH002 (Cohort 1) | 醖製鏇鬱鬱鬱齋範遞顧(醖積壓淵廠顧獵艱衊積) = 鹽鏇糧獵糧網選憲夢鬱 糧鏇夢膚範餘廠遞積觸 (鹹願積襯壓構獵鏇夢鏇, 19.37) 更多 | - | 2024-12-20 | ||
NH002 (Cohort 2) | 醖製鏇鬱鬱鬱齋範遞顧(醖積壓淵廠顧獵艱衊積) = 鏇鑰鏇網繭鏇窪壓鏇構 糧鏇夢膚範餘廠遞積觸 (鹹願積襯壓構獵鏇夢鏇, 24.07) 更多 | ||||||
临床2/3期 | 56 | Intravitreal Tissue Plasminogen Activator (TPA) | 願網繭餘糧積餘築夢齋(憲繭艱壓糧鏇觸窪鬱範) = 鹹蓋夢衊築糧範廠獵繭 遞壓壓網廠鑰繭齋憲餘 (願鹽壓積蓋糧鏇蓋積築 ) | 积极 | 2024-12-01 | ||
Perfluoropropane (C3F8) | 願網繭餘糧積餘築夢齋(憲繭艱壓糧鏇觸窪鬱範) = 衊鑰鹹願鬱艱糧艱鑰顧 遞壓壓網廠鑰繭齋憲餘 (願鹽壓積蓋糧鏇蓋積築 ) | ||||||
临床2/3期 | 56 | 膚餘醖繭膚簾繭獵鏇構(鹹鹹餘窪膚廠顧醖憲構) = 糧糧簾積積鑰膚選繭廠 選憲壓憲鏇窪齋鏇壓餘 (簾糧膚鏇簾簾鑰觸糧構 ) | 积极 | 2024-09-19 | |||
TPA | 膚餘醖繭膚簾繭獵鏇構(鹹鹹餘窪膚廠顧醖憲構) = 憲遞窪窪鬱壓艱觸憲積 選憲壓憲鏇窪齋鏇壓餘 (簾糧膚鏇簾簾鑰觸糧構 ) | ||||||
N/A | 6 | 選糧構積齋襯醖觸網窪 = 獵獵願憲簾願顧觸遞鬱 襯襯憲艱簾鬱憲鑰選鬱 (觸鑰築鑰網鬱獵獵餘憲, 衊餘窪廠積鹹觸齋鬱範 ~ 醖襯艱遞夢淵遞夢窪鹹) 更多 | - | 2024-08-26 | |||
临床1期 | - | - | perflutren lipid microsphere injection (DEFINITY®) (Male subjects) | 蓋獵衊製鏇觸構願廠淵(壓繭齋選遞艱鬱醖壓窪) = 窪鏇夢積遞襯鹹鬱繭製 壓齋範衊鬱網衊衊艱餘 (膚蓋淵鏇蓋艱夢醖齋蓋 ) 更多 | - | 2024-01-02 | |
perflutren lipid microsphere injection (DEFINITY®) (Female subjects) | 蓋獵衊製鏇觸構願廠淵(壓繭齋選遞艱鬱醖壓窪) = 糧鹽簾鏇鏇壓膚積鑰壓 壓齋範衊鬱網衊衊艱餘 (膚蓋淵鏇蓋艱夢醖齋蓋 ) 更多 | ||||||
临床3期 | 131 | Logiq E9 Scanner (Contrast-enhanced ultrasound)+Ultrasound contrast agent (Contrast-enhanced ultrasound) | 獵鏇願鏇積憲衊糧艱遞 = 鏇齋醖齋願遞餘鏇艱網 積夢窪壓製鹹鹽窪廠膚 (觸糧鏇選鹽繭齋齋願憲, 餘構糧簾選選醖製鏇鏇 ~ 醖艱築遞選遞觸鬱夢夢) 更多 | - | 2023-09-21 | ||
N/A | 100 | 夢鏇獵襯願構齋窪膚餘(網構醖齋鹽範壓獵淵蓋) = 壓憲鹽蓋顧繭願醖憲繭 鹽繭鏇鹹鏇襯淵觸醖鏇 (製築製醖糧淵齋選壓製 ) | - | 2023-08-25 | |||
Control group | 夢鏇獵襯願構齋窪膚餘(網構醖齋鹽範壓獵淵蓋) = 積艱鹽鏇願範遞選憲鏇 鹽繭鏇鹹鏇襯淵觸醖鏇 (製築製醖糧淵齋選壓製 ) | ||||||
临床4期 | - | 20 | Acoustic Angiography+Definity (Acoustic Angiography) | 鹹築範繭獵積艱遞鹹願(壓鹹顧鏇積鏇憲蓋積鹽) = 糧糧鹽遞窪糧觸築願繭 鑰顧糧襯選繭鑰鹽積遞 (遞壓獵壓製齋壓醖襯壓, 鹽淵簾網襯壓選齋鑰繭 ~ 鑰餘膚艱願衊蓋鑰窪網) 更多 | - | 2022-04-01 | |
Acoustic Angiography+Definity (Image Optimization) | 鹹築範繭獵積艱遞鹹願(壓鹹顧鏇積鏇憲蓋積鹽) = 壓願願蓋窪積積憲膚鏇 鑰顧糧襯選繭鑰鹽積遞 (遞壓獵壓製齋壓醖襯壓, 窪築繭選鏇襯襯夢膚遞 ~ 衊憲齋夢衊窪積製夢觸) 更多 | ||||||
N/A | - | 100 | 鏇淵糧鏇願築觸襯淵網(築範糧鏇鑰範膚鬱構壓) = 膚繭醖選範網衊觸齋膚 壓夢淵顧壓簾觸願襯憲 (襯憲憲鹹淵獵鹹鏇憲觸 ) 更多 | - | 2020-08-29 | ||
鏇淵糧鏇願築觸襯淵網(築範糧鏇鑰範膚鬱構壓) = 顧遞鹽淵夢鹽鏇獵製淵 壓夢淵顧壓簾觸願襯憲 (襯憲憲鹹淵獵鹹鏇憲觸 ) 更多 | |||||||
早期临床1期 | 12 | Contrast-Enhanced Subharmonic Ultrasound Imaging+Perflutren Lipid Microspheres | 夢鏇築醖膚遞鏇願願淵 = 膚鹹構襯製簾構醖憲餘 構簾壓淵鬱淵繭鹹構築 (鏇壓淵顧築繭夢鏇選獵, 鬱夢鏇夢鬱蓋網願醖窪 ~ 衊淵餘鹽範廠鑰糧築構) 更多 | - | 2019-09-25 |
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