Multicentric Randomized Double Blind Double Dummy Placebo Controlled Clinical Trial for Assessment of Safety and Efficacy of a Echinacea/Sage Spray in Comparison to a Chlorhexidine/Lidocaine Spray in the Treatment of Acute Sore Throats

The aim of the study is to show non-inferiority of an echinacea/sage spray compared to a chlorhexidine/lidocaine-spray in the treatment of acute sore throat during five days of treatment.
Main outcome parameter is the non-inferiority in number of responders between the two treatment groups. A responder is defined as a reduction by 50% of the total baseline score taken prior to treatment start. The symptoms are assessed with a symptom score.

开始日期2006-02-01

申办/合作机构

A. Vogel AG

100 项与紫锥花提取物/丹参提取物相关的临床结果

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100 项与紫锥花提取物/丹参提取物相关的转化医学

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100 项与紫锥花提取物/丹参提取物相关的专利（医药）

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项与紫锥花提取物/丹参提取物相关的文献（医药）

2016-01-01·Central European Journal of Immunology4区 · 医学

The modulatory influence of some Echinacea -based remedies on antibody production and cellular immunity in mice

4区 · 医学

ArticleOA

作者: Bałan, Barbara Joanna ; Skopiński, Piotr ; Sokolnicka, Irena ; Skopińska-Różewska, Ewa

Echinacea purpurea-containing remedies are herbal medicines used in respiratory tract infections and several inflammatory conditions as enhancers of non-specific and modulators of specific cellular immunity. They also exert anti-inflammatory, anti-viral, and anti-microbial activity. The aim of the present study was to compare the in vivo influence of orally administered three Echinacea purpurea-based remedies (IMMUNAL drops, ECHINACEA FORTE drops, IMMUNAL FORTE tablets) on some parameters of cellular and humoral immunity in mice.RESULTSFeeding mice for seven days with IMMUNAL drops resulted in enhanced anti-SRBC antibody production and modulatory effect on proliferative response to PHA of their splenic lymphocytes. No stimulatory effect was observed on splenocytes chemokinesis. Mice fed with ECHINACEA FORTE drops presented enhanced response to PHA of their splenocytes. However, contrary to the previous group, no enhancement of antibody production was observed. In this group, lymphocyte-induced immunological angiogenesis (LIA) and chemokinesis (spontaneous migration - SM) of spleen lymphocytes was diminished after feeding mice with both doses (LIA) or with a higher dose (SM) of remedy. Lymphocyte-induced immunological angiogenesis activity of splenocytes collected from animals fed with prophylactic and therapeutic IMMUNAL FORTE tablet doses did not differ from the controls.

African Health Sciences

Identification of HPV16’s E6 gene in suspected cases of cervical lesions and docking study of its L1 protein with active components of Echinacea purpurae

Article

作者: Saidu, Abdulkadir ; Lukman, Yusuf ; Abubakar, Aliyu I ; Abubakar, Bala J ; Saleh, Kumurya A ; Bala, Doro A ; Malik, Kabir I

Background: HPV 16 is the primary etiologic agent of cervical cancer and the presence of L1 and E6 oncoproteins are largely responsible for its virulence. It was the objective of this study to identify HPV16 isolates from suspected cases of cervical cancer at Specialist Hospital Sokoto and Sir Yahaya Memorail Hospiatal Birnin Kebbi, Nigeria and also to identifypotent HPV16’s L1 protein inhibitor using in silico analysis. Methods: A total of 144 cervical samples consisting of 21 low grade squamous intraepithelial lesion, 6 high grade lesion and 117 negative pap smears were collected. The samples were subjected for molecular detection using PCR targeting E6 gene of the virus. Data generated for the molecular prevalence was statistically analyzed using Chi-square method. AutoDock Vina was used to carry out the molecular docking between 2hr5 and Chicoric acid, curcumin and Echinacoside. Results: Out of the 144 samples, 24 samples were positive for the PCR representing 16.9% molecular prevalence rate. There is statistically significant association between cyto-diagnoses and presence of HPV16 (P < 0.05). Docking analysis showed that the Chicoric acid components of Echinacea purpurae have strong binding affinity (-8.7 kcal/mol) to the L1 protein of the HPV. Conclusion: This study provides data on HPV 16 epidemiology in northern Nigeria, and also provides novel evidence for consideration on certain interacting residues, when synthesizing Anti-HPV compounds in the wet lab. Keywords: HPV; Echinacea purpurae; chicoric acid; echinacoside; curcumin.

100 项与紫锥花提取物/丹参提取物相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
咽炎	临床2期	瑞士	A. Vogel AG	2006-02-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00707902 (Pubmed \| Eur J Med Res)	临床3期	慢性咽炎	154	Echinacea/sage spray	膚艱選鏇齋鬱繭製積鬱(選憲遞鹹製憲選夢鬱鏇) = 鬱鬱鏇醖遞膚壓積廠積構網糧顧蓋鏇廠膚願夢 (壓範鬱衊顧鹹鏇鏇廠繭 )	积极	2009-09-01
				Chlorhexidine/lidocaine spray	膚艱選鏇齋鬱繭製積鬱(選憲遞鹹製憲選夢鬱鏇) = 鹽艱構積憲積觸簾鑰夢構網糧顧蓋鏇廠膚願夢 (壓範鬱衊顧鹹鏇鏇廠繭 )