Explore the efficacy and safety of targeted small molecule drug TYK2 inhibitors in combination with and without calcipotriol betamethasone for the treatment of adult moderate to severe plaque psoriasis.

开始日期2024-11-01

申办/合作机构-

NCT05919082 / Completed临床3期

A Phase 3, Randomised, Investigator-blind, Active-controlled, Parallel Group, Multicentre Trial Comparing the Efficacy and Safety of 4-weeks Treatment With LEO 90100 and Daivobet® Ointment in Adult Chinese Subjects With Stable Plaque Psoriasis

This study is conducted to assess the efficacy and safety of LEO 90100 when used on the body for the treatment of stable plaque psoriasis in native adult Chinese subjects, compared to Daivobet® ointment.

开始日期2023-06-21

申办/合作机构

Leo Pharma, Inc.

CTR20223222 / Completed临床3期

一项在中国稳定性斑块状银屑病成人受试者中比较LEO 90100和得肤宝 ®软膏治疗4周的有效性和安全性的III期、随机、研究者设盲、活性药物对照、平行分组、多中心试验

主要目的：评价LEO 90100与得肤宝®软膏相比对稳定性斑块状银屑病严重程度和范围的有效性。次要目的：评价LEO 90100与得肤宝®软膏相比治疗稳定性斑块状银屑病的安全性。

开始日期2023-06-21

申办/合作机构

LEO Laboratories Ltd.

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100 项与倍他米松二丙酸酯/卡泊三醇相关的临床结果

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100 项与倍他米松二丙酸酯/卡泊三醇相关的转化医学

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100 项与倍他米松二丙酸酯/卡泊三醇相关的专利（医药）

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项与倍他米松二丙酸酯/卡泊三醇相关的文献（医药）

2024-03-01·Dermatology and therapy

Improvements in Plaque Psoriasis Associated with Calcipotriol/Betamethasone Aerosol Foam Treatment: A Post Hoc Analysis of Non-interventional Studies and Clinical Experience

Article

作者: Jablonski Bernasconi, Marie Y ; Halioua, Bruno ; Lazaridou, Elizabeth ; Krogager Eeg, Martin ; Pesiridis, Georgios ; Campanati, Anna ; Ratzinger, Gudrun ; Gerdes, Sascha

INTRODUCTION:

Plaque psoriasis is a chronic relapsing inflammatory skin disease that is associated with extensive disease burden that often requires long-term therapy. Treatment of psoriasis with 4 weeks of the aerosol foam formulation of calcipotriol/betamethasone dipropionate (Cal/BD; Enstilar®, LEO Pharma) has been demonstrated to be effective, well tolerated, and associated with high patient satisfaction. Cal/BD foam is approved as a first-line treatment in multiple countries, where several non-interventional studies (NIS) have corroborated the beneficial efficacy and safety profiles determined in the randomized clinical trials. Heterogenicity in these NIS, however, prevents the use of a data pooling strategy for comparisons of effectiveness outcomes across different patient populations.

METHODS:

Therefore, here, we report on a post hoc analysis of effectiveness data consolidated from six prospective NIS to discern any differences in improvement in signs and symptoms of psoriasis attributable to Cal/BD foam treatment across the countries. In addition, we provide real-world experience of clinicians with Cal/BD foam treatment, factoring in changes in usage since these NIS were performed in their local markets.

RESULTS:

This post hoc analysis of Cal/BD foam NIS brings together data outside of randomized clinical trials from six countries to provide real-world evidence in 1388 patients showing that 4 weeks of Cal/BD foam is an effective and safe treatment option with quick onset of action for patients with psoriasis.

CONCLUSION:

These results show that regardless of NIS location, Cal/BD foam remains a well-tolerated, efficacious option for patient care that could be used as a first-line topical therapy for mild-to-severe psoriasis.

2023-12-31·The Journal of dermatological treatment

Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics

Article

作者: Yu, Xiaobo ; Deng, Hao ; Zhang, Xiaomei ; Lu, Chuanjian ; Yu, Jingjie ; Yao, Danni ; Cui, Jingwen ; Deng, Jingwen ; Ye, Shuyan ; Yan, Yuhong ; Han, Ling

BACKGROUND:

Psoriasis is a chronic skin disease, and topical sequential therapy with a combination of calcipotriol and calcipotriol betamethasone is currently approved topical treatment. However, the exact mechanism by which this treatment regimen relieves psoriasis is unknown.

METHOD:

We assembled a cohort of 65 psoriasis patients and divided post-treatment cohort into responder group and non-responder group according to the Psoriasis Area Severity Index (PASI) score after 12-week treatment. We measured the expression levels of proteins in collected 130 serum samples using our in-depth proteomics platform with a data-independent acquisition mass spectrometer and antibody microarray. We performed bioinformatics analyses of the biologic processes and signaling pathways that were changed in the responder group and constructed a proteomics landscape of psoriasis pathogenesis response to treatment. We then validated the biomarkers of disease severity in an independent cohort of 88 samples using an enzyme-linked immunosorbent assay.

RESULTS:

We first identified 174 differentially expressed proteins (DEPs) for comparative analysis of proteins between responders and non-responders at baseline (p < 0.05). Then pathway analysis showed that the responders focused more on signaling molecules and interaction, complement and coagulation cascades, whereas the non-responders more on signal transduction and IL-17 signaling pathways. We further identified four candidate biomarkers (COLEC11, C1QA, BNC2, ITIH4) response to treatment. We also found 125 DEPs (p < 0.05) after treatment compared with before treatment in responder group. Pathway analysis showed an enrichment in pathways related to complement and coagulation cascades, phagosome, ECM-receptor interaction, cholesterol metabolism, vitamin digestion and absorption. CD14 was validated as potential biomarkers for the disease severity of psoriasis and treatment targets.

CONCLUSION:

In this work, we analyzed the response to topical sequential therapy and finally identified four biomarkers. Additionally, we found that topical sequential therapy may alleviate psoriasis by regulating lipid metabolism and modulating the immune response by affecting the complement activation process.

2023-11-01·European review for medical and pharmacological sciences

The role of the foam formulation in improving psoriasis treatment acceptability: a real-life experience and a literature review.

Review

作者: Papa, S ; Gasparini, S ; Martella, A ; Giovene, G L

BACKGROUND:

Topical therapies represent the first-line treatment for mild-to-moderate psoriasis. Among various topical options, the fixed-dose combination of calcipotriene (Cal) and betamethasone dipropionate (BD) foam (Enstilar®, LEO Pharma, Ballerup, Denmark) showed superior efficacy to Cal and BD monotherapy and ointment and gel formulations. In addition, the Cal/BD foam is the only topical treatment allowed for either reactive treatment of relapse or twice-weekly maintenance use. Since treatment acceptability is crucial to optimize adherence, this paper presents a case series from a multicenter experience using the Cal/BD foam, to further characterize the use of this therapeutic approach. In addition, a narrative review of studies evaluating the acceptability of the Cal/BD foam, even compared with other formulations, is provided.

CASE SERIES:

The case series involved adult patients with mild-to-moderate psoriasis treated with the Cal/BD foam from October 2021 to June 2022. A clinical and dermoscopic evaluation of plaques was provided for all patients. Data from the clinical practice report complete clinical resolution of plaques in most patients after 4 weeks of active treatment with the Cal/BD foam, and the dermoscopic clearance after a maximum of 8 weeks. Full adherence to treatment was also reported. Literature evidence suggests that the Cal/BD foam is easy to apply and presents high cosmetic acceptance, rapid onset of action, high efficacy, optimal safety, and a high patient preference. The high satisfaction obtained with Cal/BD foam suggests that this formulation is better accepted than others.

CONCLUSIONS:

The Cal/BD foam represents a valuable approach for managing mild-to-moderate psoriasis, both in short and long-term treatment.

项与倍他米松二丙酸酯/卡泊三醇相关的新闻（医药）

2024-11-20

·药事纵横

盐酸米诺环素泡沫剂获批上市，国内泡沫剂研发竞赛拉开序幕

一、背景 2024年11月05日，科笛生物医药（上海）有限公司「盐酸米诺环素泡沫剂」(规格：4%)获得中国国家药品监督管理局（NMPA）批准在中国上市，用于治疗九岁或以上患者的非结节性中度至重度寻常痤疮炎症性病变的局部治疗。据笔者了解，该药获得了国家药监局药品审评中心优先审评审批资格。这是目前国内批准的首款盐酸米诺环素外用制剂，也是首款在国内上市销售的原研进口泡沫剂产品。 4%盐酸米诺环素泡沫剂（商品名：Amzeeq®）最早是由位于以色列的一家专门从事泡沫剂产品开发的制药公司Foamix Pharmaceuticals（2020年与Menlo Therapeutics合并成为其全资子公司）研发，于2019年10月18日被美国食品药品监督管理局（FDA）批准上市。2020年4月，Foamix与科笛生物（Cutia Therapeutics）达成协议，将包括Amzeeq®盐酸米诺环素泡沫剂在内的多个盐酸米诺环素外用制剂产品在大中华区的独家许可权授予科笛生物，向科笛供应用于临床和商业用途的许可产品。根据公开的信息，Foamix通过该授权可获得1000万美元的预先现金付款，产品一旦在中国获批上市销售，还将获得额外的100万美元付款。此外，根据协议Foamix还会根据科笛在大中华区销售这些被许可产品的净销售额，获得一定比例的版税收入。科笛生物于2021年在中国境内开展了一项评价盐酸米诺环素泡沫剂（4%）局部给药治疗中度至重度寻常痤疮的多中心、随机、双盲、安慰剂对照的有效性和安全性的III期注册性临床试验。研究结果显示，经过12周后治疗后，治疗炎性皮损的改善相较于安慰剂组展现出了显著的改善，达到主要终点指标。在安全性方面，治疗组受试者对给药部位局部表现出了良好的耐受性。治疗组与安慰剂组在不良事件的总发生率上相当，且均未报告有药物相关的严重不良事件。口服盐酸米诺环素治疗痤疮疗效较差且容易引起全身的毒副作用，而4%盐酸米诺环素泡沫剂作为的首款盐酸米诺环素的外用制剂成功实现了盐酸米诺环素的局部外用给药，不仅疗效显著且大大降低了口服给药带来的不良反应，具有里程碑意义。笔者曾于2023年9月在本公众号（“药事纵横”）上发表了《浅析盐酸米诺环素油泡沫剂处方设计及泡沫形成原理》一文，简要介绍了盐酸米诺环素外用制剂开发面临的挑战以及其泡沫剂处方及发泡原理。具体来说，Foamix利用了其独特的分子稳定技术（Molecular Stabilizing Technology, MST）技术，有效解决了盐酸米诺环素药物的稳定性（如对光、氧、水、某些质子性溶剂和表面活性剂等不稳定）问题，成功开发出了无水、无表面活性剂的盐酸米诺环素泡沫剂。该技术将微粉化的盐酸米诺环素分散在大量的油性基质中，利用抛射剂汽化后处方中高级脂肪醇和高级脂肪酸吸附空气-油界面，形成稳定的油泡沫，方便患者涂抹于患处。二、关于泡沫剂泡沫剂（foam）是指将原料药和辅料灌装到加压容器或者非加压容器后将内容物呈泡沫状喷出一类药物制剂。前者需要填充抛射剂才能形成在喷出后形成泡沫，因此又称“泡沫气雾剂”（foam aerosol）。在国内，一般提到泡沫剂都默认指的是泡沫气雾剂。泡沫剂具有吸附性强、易于涂布、美观、经皮渗透能力强等优点。此外，对于腔道给药，泡沫剂给药后泡沫能够迅速在腔道内（如阴道、直肠等）充盈，覆盖给药部位，给药便捷，这是很多传统剂型所不具备的优势。美国FDA迄今已批准了18种泡沫剂NDA上市申请，其最早批准的一款泡沫剂产品可以追溯到1999年上市的戊酸倍他米松泡沫剂（见本公众号文章《盘点泡沫气雾剂给药系统中应用的平台技术》）。目前除了盐酸米诺环素泡沫剂的进口上市申请已经获批，笔者注意到利奥制药（LEO Pharma）也于近期正式向国家药品管理局提交了Enstilar®泡沫剂（卡泊三醇/丙酸倍他米松泡沫剂）进口上市许可申请。在国内，2023年12月中国药品监督管理局才批准第一款化药泡沫剂产品——米诺地尔泡沫剂仿制药上市。截至目前，尚没有一款国内企业自主研发的泡沫剂NDA上市申请获批。但是，从国家药品监督管理局药品审评中心CDE受理品种目录可以看出，国内泡沫剂国内泡沫剂研发竞赛已经悄然拉开了序幕。最近两年最为热门的泡沫剂仿制品种当属米诺地尔泡沫剂和盐酸米诺环素泡沫剂。目前CDE已经受理了浙江三生蔓迪药业有限公司（已获批）、辰光（天津）制药有限公司、山西振东安欣生物制药有限公司、山东致泰医药技术有限公司/济宁为民制药有限公司、广东红珊瑚药业有限公司等5家公司的米诺地尔泡沫剂仿制药上市申请。而山西振东安欣的盐酸米诺环素泡沫剂仿制药上市申请也于今年6月份获得CDE受理。可以看出，目前国内药企于泡沫剂这一剂型的重视程度和研发热情较前些年有了明显的高涨。这其中的热情并不难理解。米诺地尔作为一种有效的脱发治疗药物，其泡沫剂型相比传统搽剂具有更好的使用体验和患者依从性。随着脱发问题的日益普遍和年轻化，米诺地尔泡沫剂的市场需求持续增长。而盐酸米诺环素泡沫剂在治疗痤疮方面显示出良好的疗效和安全性，且痤疮是一种常见的皮肤问题，尤其在青少年和年轻成人中发病率较高，因此该药物的市场需求也很大。此外，泡沫剂作为一种高端药物递送系统，处方工艺复杂，仿制难度大，进入壁垒高，一旦成功研发并上市，将能够在一定程度上避免激烈的市场竞争。且由于泡沫剂研发难度大、成本高，市场上同类竞品相对较少，这有助于产品在市场上占据一定的份额，并享受较高的利润空间。与传统仿制药相比，泡沫剂这种高端制剂由于技术壁垒和独特优势，受集采政策的影响相对较小，这就意味着在集采压力下，其仍能保持一定的价格优势和市场竞争力。三、结语随着米诺地尔泡沫剂、盐酸米诺环素泡沫剂的相继获批上市，国内泡沫剂市场正式迎来了一个全新的竞争格局。这两款产品的上市到来不仅为患者提供了更多的治疗选择，也将极大地激发国内药企对泡沫剂研发的热情和动力。可以预见，在未来将会有更多的泡沫剂产品涌现市场，为患者带来福音，这也将促使国内药企在泡沫剂研发创新、质量控制、市场推广等方面不断提升自身实力，推动企业自身发展和中国医药产业进步。药事纵横征稿启事

优先审批上市批准临床3期引进/卖出医药出海

2024-11-15

·PRNewswire

Endo Announces Agreement for Paladin Pharma to Commercialize Wynzora® Cream in Canada

MALVERN, Pa., Nov. 15, 2024 /PRNewswire/ -- Endo, Inc. (OTCQX: NDOI) announced today that it has entered into a definitive agreement with MC2 Therapeutics ("MC2") to commercialize Wynzora® Cream (calcipotriene and betamethasone dipropionate) in Canada through Endo's subsidiary Paladin Pharma Inc. "We look forward to working with MC2 to make Wynzora® Cream available to Canadians who suffer from plaque psoriasis," said Livio Di Francesco, Vice President and General Manager of Paladin. "If approved by Health Canada, Wynzora® Cream's unique formulation and clinical profile will offer patients a new treatment option designed for convenience of use in daily routines." "Paladin has an experienced and dedicated team, and we're pleased to work with them to introduce Wynzora® Cream in Canada," said Jesper J. Lange, Chief Executive Officer, MC2 Therapeutics. "The agreement aligns with our strategy to make Wynzora® Cream available to as many patients suffering from plaque psoriasis as possible globally." Wynzora® Cream was approved in the US by the FDA on July 20, 2020 and launched in Europe on February 18, 2022. About Wynzora® Cream Wynzora® Cream is a cream-based fixed dose combination of calcipotriene and betamethasone dipropionate for topical treatment of plaque psoriasis, including scalp psoriasis, in adults. Its dual mode of action is targeting the hallmark cytokines IL-23 and IL-17A/F immune axis and TNF-α expression in a single product. Wynzora® Cream is uniquely enabled by MC2's formulation and drug delivery system PAD Technology™, allowing a convenient-to-use aqueous formulation. About Endo and Paladin Pharma Endo is a diversified specialty pharmaceutical company boldly transforming insights into life-enhancing therapies. Our passionate team members collaborate to develop and deliver these essential medicines. Together, we are committed to helping everyone we serve live their best life. Learn more at or connect with us on LinkedIn. Paladin Pharma Inc., headquartered in Montreal, Canada, is a specialty pharmaceutical company focused on acquiring or in-licensing innovative pharmaceutical products for the Canadian market. Paladin has a focused marketing, medical and sales organization that has helped it evolve into one of Canada's leading specialty pharmaceutical companies. Paladin is an operating company of Endo, Inc. For more information, visit . About MC2 Therapeutics () MC2 Therapeutics is a commercial stage biotech company focused on developing novel treatment paradigms within immunology and inflammation. Its pioneering approach in immunology is anchored in a deep understanding of skin biology, clinical expertise and cross-silo thinking. Besides Wynzora® Cream, MC2 has a pipeline that includes two first-in-class drug candidates, both in Phase 2 clinical development. Cautionary Note Regarding Forward-Looking Statements This press release contains forward-looking statements including, but not limited to, the statements by Messrs. Di Francesco and Lange and any statements relating to product development and commercialization, treatment options and therapies, regulatory approval, efficacy and product availability. Statements including words such as "believes," "expects," "anticipates," "intends," "estimates," "plan," "will," "may," "look forward," "intends," "guidance," "future," "potential" or similar expressions are forward-looking statements. Because these statements reflect Endo's current views, expectations and beliefs concerning future events, they involve risks and uncertainties, some of which Endo may not currently be able to predict. Although Endo believes that these forward-looking statements and other information are based upon reasonable assumptions and expectations, readers should not place undue reliance on these or any other forward-looking statements and information. Actual results may differ materially and adversely from current expectations based on a number of factors, including, among other things, unfavorable or delayed regulatory review, uncertainties in and the timing for regulatory approval, changes in competitive, market or regulatory conditions, and consumer and physician acceptance of current and new products. Endo assumes no obligation to publicly update any forward-looking statements, whether as a result of new information, future developments or otherwise, except as may be required under applicable securities laws. Additional information concerning risk factors, including those referenced above, can be found in Endo's press releases and in its public filings with the U.S. Securities and Exchange Commission, including the discussion under the heading "Risk Factors" in Endo's most recent Form 10-Q and in Endo's final prospectus filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, in connection with Endo's Form S-1/A. SOURCE Endo, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

上市批准引进/卖出临床2期

2024-11-13

·华东医药股份有限公司

华东医药国内首个乌司奴单抗注射液生物类似药赛乐信®开出全国首张处方

2024年11月13日，华东医药的国产首个乌司奴单抗注射液(赛乐信)由北京大学人民医院开出全国首张处方，成人中重度斑块状银屑病患者迎来了一种新的治疗选择。银屑病是一种慢性、复发性、炎症性皮肤病，其特征是皮肤上出现红斑、鳞屑和瘙痒。在我国，银屑病影响着数以百万计的患者，其中超半数患者的病程可达10年以上，严重影响患者的身心健康、日常学习、工作和社交等正常生活。银屑病发病机制复杂，涉及遗传、免疫与环境等多种因素。分子层面，银屑病与免疫系统的异常激活密切相关。在银屑病患者中，活化的树突状细胞（DC）可产生白介素12（IL-12）和白介素23（IL-23），诱导辅助性T细胞1（Th1）和辅助性T细胞17（Th17）等活化或增殖，从而分泌特异性炎症细胞因子，刺激角质形成细胞过度增殖及产生相关的细胞因子和趋化因子，形成皮肤炎症微环境，导致银屑病患者皮肤角质层的快速累积和脱落，产生银屑病特有的鳞屑和红斑。其中，IL-12和IL-23共享的p40亚单位在这一过程中起到了重要的调节作用。我国银屑病治疗已迈入生物制剂时代。目前临床已证实生物制剂疗效优于既往传统治疗，且具有良好的安全性。然而，如何更好地进行银屑病长期管理仍面临挑战。赛乐信®的优势在于其精准的靶向作用，它能够特异性结合IL-12和IL-23的p40亚单位，抑制这两种关键细胞因子的生物活性，进一步抑制Th1、Th17细胞的增殖和活化，阻断银屑病核心致病通路，同时降低其他免疫细胞的炎症反应，从根本上改善银屑病的症状。赛乐信®的临床应用，是基于其在Ⅲ期临床试验中展现出与原研乌司奴单抗相当的疗效与安全性；且赛乐信®为全人源IgG1单克隆抗体，表达平台为中国仓鼠卵巢细胞，基本不含唾液酸化组分，免疫原性风险更低，维持期每年仅需给药四次即可实现长期临床缓解。华东医药在自免领域已形成差异化产品布局，是国内自身免疫性疾病领域种类覆盖最为全面的医药公司之一，拥有在研生物药和小分子创新产品10余款。在银屑病治疗领域，公司目前已布局生物制剂乌司奴单抗注射液、口服小分子药物环孢素软胶囊、单方外用制剂ZORYVE®乳膏剂和泡沫剂以及复方外用制剂Wynzora®乳膏，形成了多靶点、多作用机制的银屑病产品组合，可实现全周期全人群覆盖。公司将积极发挥在该领域积累的商业化优势，加快赛乐信®获批上市后的市场推广工作，同时继续深耕自身免疫领域，不断丰富创新研发管线，为患者带来更多临床获益的优质产品。声明 1、本新闻旨在分享公司（或合作伙伴）研发工作的前沿进展资讯，非广告用途，相关信息并非针对患者，仅供医疗卫生专业人士参考使用； 2、本新闻稿中内容不涉及对任何药品和/或适应症作推荐； 3、本新闻稿中涉及的信息仅供参考，不能以任何方式取代专业的医疗指导，也不应被视为诊疗建议。若您想了解具体疾病诊疗信息，请遵从医生或其他医疗卫生专业人士的意见或指导； 4、截止本文发布，赛乐信®、环孢素软胶囊已被国家药品监督管理局批准上市，ZORYVE®乳膏剂和泡沫剂以及复方外用制剂Wynzora®乳膏尚未被国家药品监督管理局批准上市； 5、本新闻稿中涉及的产品包装仅供参考，具体请以实际为准； 6、本新闻稿中可能会包含某些前瞻性表述。这些表述本质上具有相当风险和不确定性。在使用“预期”、“相信”、“预测”、“期望”、“打算”及其他类似词语进行表述时，凡与本公司有关的，均属于前瞻性表述。本公司并无义务不断地更新这些预测性陈述。这些前瞻性表述是基于本公司管理层在做出表述时对未来事务的现有看法、假设、期望、估计、预测和理解。这些表述并非对未来发展的保证，会受到风险、不确性及其他因素的影响，有些是超出本公司的控制范围，难以预计。因此，受我们的业务、竞争环境、政治、经济、法律和社会情况的未来变化及发展的影响，实际结果可能会与前瞻性表述所含资料有较大差别。本公司、本公司董事及雇员代理概不承担 (a) 更正或更新本网站所载前瞻性表述的任何义务;及 (b) 若因任何前瞻性表述不能实现或变成不正确而引致的任何责任。

生物类似药临床3期上市批准

100 项与倍他米松二丙酸酯/卡泊三醇相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	D05AX52	-

研发状态

批准上市

10 条最早获批的记录,

后查看更多信息

适应症	国家/地区	公司	日期
头皮银屑病	英国	Almirall SA	2021-07-29
银屑病	瑞士	LEO Pharma A/S	2008-09-04
斑块状银屑病	美国	LEO Pharma A/S	2008-05-09
寻常性银屑病	美国	LEO Pharma A/S	2006-01-09

未上市

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
头皮皮肤病	临床3期	中国	Leo Pharma, Inc.	2010-09-01
银屑病关节炎	临床2期	法国	Leo Pharma, Inc.	2009-01-01
过敏性皮肤反应	临床1期	美国	MC2 Therapeutics Ltd.	2019-02-13
光毒性皮炎	临床1期	日本	Leo Pharma, Inc.	2010-12-01

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临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT05919082 (NEWS) 人工标引	临床3期	斑块状银屑病	604	LEO 90100	壓範醖網糧構膚壓鬱觸(窪壓蓋壓築蓋鏇夢蓋範) = Enstilar®在主要终点上相较于得肤宝®（卡泊三醇倍他米松软膏）表现出优效性網淵醖願觸鏇夢襯蓋鹽 (繭艱製壓淵醖範積廠壓 ) 达到更多	积极	2024-05-08
				得肤宝
NCT03308799 (Biospace) 人工标引	临床3期	皮肤色素沉着	-	Calcipotriene+Betamethasone Dipropionate/Calcipotriene (Patients with skin of color (Fitzpatrick IV-VI))	艱製願製鏇觸構鑰憲廠(艱簾觸膚壓鹹襯憲鏇憲) = 願築憲齋憲膚壓範顧憲餘選襯積獵願簾製築壓 (醖齋壓鑰遞鏇獵餘蓋夢 ) 更多	积极	2022-09-15
Pubmed 人工标引	N/A	寻常性银屑病	166	Calcipotriene+LEO90100	鹽艱選範簾餘壓選築糧(鏇餘夢艱鑰蓋範簾窪衊) = 淵淵觸顧襯衊糧憲餘鹽襯憲積糧鑰繭膚餘淵醖 (鹽壓範願廠糧襯構壓願, 3.0) 更多	积极	2022-07-18
NCT02668692 (CTgov)	临床3期	寻常性银屑病	213	LEO 80185 gel	憲窪憲糧鑰鹹網簾衊鬱(遞齋鏇構廠願壓遞選淵) = 鏇範構願糧憲鏇網鬱壓糧構繭廠壓膚鏇蓋壓膚 (蓋鹽壓顧願憲蓋鹽艱壓, 簾遞襯網範遞鬱範鏇衊 ~ 遞鏇壓簾窪廠齋夢築顧) 更多	-	2021-07-27
NCT02899962 (PSO-LONG trial, Pubmed \| J Am Acad Dermatol) 人工标引	临床3期	斑块状银屑病	545	Cal/BD foam	餘艱範鏇窪簾壓窪構廠(繭製範蓋壓壓鏇鏇鹽淵) = 餘膚膚壓網艱鑰遞製獵壓鏇鏇鬱艱觸繭選艱淵 (襯襯夢膚觸繭鹽鹽願艱 ) 更多	优效	2021-05-01
				vehicle foam	餘艱範鏇窪簾壓窪構廠(繭製範蓋壓壓鏇鏇鹽淵) = 顧鹽醖窪鹹餘憲壓繭衊壓鏇鏇鬱艱觸繭選艱淵 (襯襯夢膚觸繭鹽鹽願艱 ) 更多
NCT03819218 (CTgov)	临床2期	寻常性银屑病	7	MC2-01 cream	鏇窪顧壓鬱選鹹艱鬱範(鬱獵廠鬱積糧醖憲衊願) = 糧獵艱餘觸鹹壓網憲遞網顧衊鏇醖選壓淵壓鬱 (蓋鬱蓋衊糧簾網顧築簾, 鹽選築廠選鑰窪壓選構 ~ 顧繭蓋鏇餘獵夢艱築鬱) 更多	-	2021-02-21
NCT03506477 (CTgov)	临床4期	斑块状银屑病	25	Enstilar® foam (Enstilar® Foam)	餘遞製繭蓋鏇顧齋遞鏇(醖廠繭窪鏇願選醖蓋顧) = 觸鑰衊糧獵範網遞觸獵選憲壓積廠醖壓窪鹽顧 (選觸鬱夢顧醖鏇糧築夢, 積積顧壓製願醖鬱鹽簾 ~ 獵鏇糧夢製壓鹹遞鹽蓋) 更多	-	2021-01-20
				Vehicle Foam (Vehicle Foam)	餘遞製繭蓋鏇顧齋遞鏇(醖廠繭窪鏇願選醖蓋顧) = 選鏇積窪鹹鹽憲鑰網齋選憲壓積廠醖壓窪鹽顧 (選觸鬱夢顧醖鏇糧築夢, 襯選構鏇繭壓鹹獵鑰廠 ~ 遞構觸簾鹽廠範鹹膚網) 更多
NCT03806790 (CTgov)	临床3期	寻常性银屑病	182	LEO 90100 foam (LEO 90100 Foam)	蓋簾壓鏇廠壓廠範構衊(繭齋遞積製憲憲壓築鑰) = 積願壓齋廠顧網築糧艱醖鏇積蓋壓鏇範淵夢願 (鑰憲憲範範積製願鹹窪, 選鑰鹽壓鹽鬱淵膚淵艱 ~ 醖獵範製夢夢積夢製積) 更多	-	2020-12-16
				Dovobet® ointment (Dovobet® Ointment)	蓋簾壓鏇廠壓廠範構衊(繭齋遞積製憲憲壓築鑰) = 窪鏇鹽蓋窪糧製簾願構醖鏇積蓋壓鏇範淵夢願 (鑰憲憲範範積製願鹹窪, 鬱構膚餘餘餘窪鏇憲鏇 ~ 鬱觸襯築膚獵築鏇夢簾) 更多
NCT03802344 (CTgov)	临床3期	寻常性银屑病	498	MC2-01 cream (MC2-01 Cream)	鹽蓋繭網齋願壓積憲選(願鹹衊範願醖願蓋膚膚) = 壓觸獵顧範願艱繭膚積遞範憲窪餘襯簾淵鹽鑰 (網積積襯範醖憲獵簾蓋, 憲衊淵簾積築膚膚鹹廠 ~ 齋夢繭壓遞願夢網遞窪) 更多	-	2020-11-27
				Cal/BDP combination (Cal/BDP Combination)	鹽蓋繭網齋願壓積憲選(願鹹衊範願醖願蓋膚膚) = 鬱築壓廠觸繭壓淵窪衊遞範憲窪餘襯簾淵鹽鑰 (網積積襯範醖憲獵簾蓋, 醖窪衊鬱鹹窪廠顧簾夢 ~ 鹹範獵憲範膚齋廠顧觸) 更多
NCT02387853 (Pubmed \| J Eur Acad Dermatol Venereol) 人工标引	临床2期	斑块状银屑病	106	Cal/BD foam	顧鹹積糧築網鏇顧範廠(膚衊選簾餘醖淵積廠壓) = 膚醖選膚鬱製蓋齋觸窪蓋衊積夢糧醖範構醖選 (鑰範鑰積廠範鬱淵蓋繭 ) 更多	积极	2020-09-01