Anemia in pregnancy is defined by the World Health Organization as hemoglobin levels of ≤ 11 g/dl. Globally, a prevalence rate of 38% was estimated by the World Health Organization for pregnant women.Treatment of iron deficiency anemia during pregnancy remains a main public health issue. Oral iron salts have been recommended for treatment of iron deficiency anemia e.g. ferrous fumarate. Increasing the dose of ferrous fumarate will subsequently increase the bioavailability of iron preparation, however it also increases the frequency of gastrointestinal tract side effects e.g. nausea, constipation, diarrhea, flatulence, and black stained stools. Besides, the increased bioavailable ferrous fumarate may decrease by many foods and / or chelating drugs in the gastrointestinal tract which interfere with its absorption leading to variability in the hemoglobin correction during the treatment.
Ferrous bisglycinate is an iron amino acid chelate. It is formed by reaction of ferrous iron with two molecules of the amino acid glycine by a covalent bound in a process called chelation. Ferrous bisglycinate is claimed to have better patient compliance because of fewer gastrointestinal tract side effects. It is also claimed that ferrous bisglycinate improves iron absorption, storage and increase hemoglobin level better than the conventionally used iron salts.

开始日期2015-12-31

申办/合作机构

Mansoura University

100 项与甘氨酸亚铁相关的临床结果

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100 项与甘氨酸亚铁相关的转化医学

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100 项与甘氨酸亚铁相关的专利（医药）

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项与甘氨酸亚铁相关的文献（医药）

2024-08-01·Food Research International

Improvement of in vivo iron bioavailability using mung bean peptide-ferrous chelate

Article

作者: Ding, Xiangjun ; Li, Haili ; Xu, Mengdan ; Li, Xueling ; Li, Meiqing

There is an increasing amount of research into the development of a third generation of iron supplementation using peptide-iron chelates. Peptides isolated from mung bean were chelated with ferrous iron (MBP-Fe) and tested as a supplement in mice suffering from iron-deficiency anemia (IDA). Mice were randomly divided into seven groups: a group fed the normal diet, the IDA model group, and IDA groups treated with inorganic iron (FeSO₄), organic iron (ferrous bisglycinate, Gly-Fe), low-dose MBP-Fe(L-MBP-Fe), high-dose MBP-Fe(H-MBP-Fe), and MBP mixed with FeSO₄ (MBP/Fe). The different iron supplements were fed for 28 days via intragastric administration. The results showed that MBP-Fe and MBP/Fe had ameliorative effects, restoring hemoglobin (HGB), red blood cell (RBC), hematocrit (HCT), and serum iron (SI) levels as well as total iron binding capacity (TIBC) and body weight gain of the IDA mice to normal levels. Compared to the inorganic (FeSO₄) and organic (Gly-Fe) iron treatments, the spleen coefficient and damage to liver and spleen tissues were significantly lower in the H-MBP-Fe and MBP/Fe mixture groups, with reparative effects on jejunal tissue. Gene expression analysis of the iron transporters Dmt 1 (Divalent metal transporter 1), Fpn 1 (Ferroportin 1), and Dcytb (Duodenal cytochrome b) indicated that MBP promoted iron uptake. These findings suggest that mung bean peptide-ferrous chelate has potential as a peptide-based dietary supplement for treating iron deficiency.

2024-06-01·Methods

The bioaccessibility and tolerability of marine-derived sources of magnesium and calcium

Article

作者: Nolan, Yvonne ; O'Gorman, Denise M ; Demehin, Olusoji ; O'Connell, Shane ; Dowley, Alison ; Long-Smith, Caitriona M

It is generally accepted that mineral deficiencies, including magnesium and calcium, are widespread globally. Dietary supplementation may be an effective approach to combat such deficiencies. However, challenges associated with limited mineral solubility in the digestive system can impede effective dissolution and hinder absorption, leading to deficiency, and undesirable gastrointestinal disturbances including diarrhoea. Seawater is considered to be a rich source of bioactive magnesium, calcium, and 72 other trace minerals. In this study, we examine two different marine-derived multimineral products as potential dietary supplements. Aquamin-Mg, sourced from seawater is rich in magnesium (12%), and Aquamin F, a seaweed-derived multimineral is rich in calcium (32%). Both products also contain a diverse array of over 72 minerals, characteristic of their oceanic origin. Our study comprises two experiments. The first experiment evaluates and compares the solubility of Aquamin-Mg, commercially available magnesium bisglycinate, and Pure Magnesium Bisglycinate (PrizMAG) during in vitro digestion using the INFOGEST method. Results demonstrate that Aquamin-Mg exhibits superior solubility than the other magnesium sources during the gastric and intestinal phases, particularly when administered alongside food materials. The second experiment is a randomized, double-blind, placebo-controlled study in a small cohort of healthy older aged adults to assess the tolerability of a combined Aquamin-Mg/Aquamin-F supplement over a 12-week period. The findings indicate that this combination supplement is well-tolerated, with no significant adverse events reported, emphasizing its potential as a means of addressing mineral deficiencies.

2024-05-01·Neurochemistry International

Potential of the Blue Calm® food supplement in the treatment of alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio)

Article

作者: Sousa, Kalina Kelma O de ; Nascimento, Gabriela A do ; Marques, Luzia Débora S ; Alves, Daniela R ; Rocha, Yatagan M da ; Silva, Wildson Max B da ; Vieira, Natália Chaves G ; Magalhães, Francisco Ernani Alves ; de Morais, Selene Maia ; Campos, Adriana Rolim ; Coutinho, Henrique Douglas Melo ; de Oliveira, Keciany A ; Santos, Sacha Aubrey A R ; Moura, Luiz Francisco Wemmenson G ; Vieira-Neto, Antonio Eufrásio ; da Silva, Larissa Morais R

Alcohol use disorder (AUD) is characterized by a set of behavioral, cognitive, nutritional, and physiological phenomena derived from the uncontrolled use of alcoholic beverages. There are cases in which AUD is associated with anxiety disorder, and when untreated, it requires careful pharmacotherapy. Blue Calm® (BC) is a food supplement indicated to aid restorative sleep, which has traces of medicinal plant extracts, as well as myo-inositol, magnesium bisglycinate, taurine, and L-tryptophan as its main chemical constituents. In this context, this study aimed to evaluate the potential of the BC in the treatment alcohol withdrawal-induced anxiety in adult zebrafish (aZF). Initially, BC was submitted to antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl radical. Subsequently, the aZF (n = 6/group) were treated with BC (0.1 or 1 or 10 mg/mL; 20 μL; p.o.), and the sedative effect and acute toxicity (96 h) were evaluated. Then, the anxiolytic-like effect and the possible GABAergic mechanism were analyzed through the Light & Dark Test. Finally, BC action was evaluated for treating alcohol withdrawal-induced anxiety in aZF. Molecular docking was performed to evaluate the interaction of the major chemical constituents of BC with the GABA_A receptor. BC showed antioxidant potential, a sedative effect, was not toxic, and all doses of BC had an anxiolytic-like effect and showed potential for the treatment of alcohol withdrawal-induced anxiety in aZF. In addition to the anxiolytic action, the main chemical constituents of BC were confirmed in the molecular docking, thus suggesting that BC is an anxiolytic that modulates the GABAergic system and has pharmacological potential for the treatment of alcohol withdrawal-induced anxiety.

项与甘氨酸亚铁相关的新闻（医药）

2024-02-01

·PRNewswire

Designs for Health Launches ElectroPure Hydration™ to Redefine Hydration

Leading supplement brand delivers another high-quality, convenient product for smarter hydration that supports everyday life and performance goals of athletes and non-athletes alike PALM COAST, Fla., Feb. 1, 2024 /PRNewswire/ -- Designs for Health, the expert-recommended and preferred brand for high-quality, professional strength, research-backed supplements, today announced the launch of ElectroPure Hydration™, a great-tasting, clementine-flavored electrolyte drink mix in a convenient stick pack that supports recommendations for optimal hydration and peak athletic performance*. ElectroPure Hydration™ delivers two times the electrolytes of the leading electrolyte powder brand and nine times the electrolytes of the leading sports drink†, allowing consumers to refuel with advanced cellular hydration*. This zero-sugar hydration formula is sweetened with stevia and monk fruit and is made with a full spectrum of balanced ingredients that replenish the electrolytes lost due to sweating.* It uniquely features sodium and potassium in a 1:1 ratio for more optimal, balanced electrolyte replacement.* It also features D-ribose, a key component in ATP synthesis to promote cellular energy production and muscle recovery*; vitamin C for antioxidant support during and post-exercise*; and magnesium bisglycinate chelate and zinc for increased cellular bioavailability*. "While physical activity and exposure to hot weather are the biggest sources of electrolyte and water loss, our bodies can also suffer water loss from everyday activity and bodily functions. This product is made for the athlete and non-athlete alike as it is imperative to maintain cellular hydration and replenish fluids or we risk a potential decrease in not only athletic performance and muscle, but also cognitive function, and even mental health*," said Dr. David M. Brady, Chief Medical Officer at Designs for Health. "Water alone is not effective in replenishing the electrolytes our bodies need. With the launch of ElectroPure Hydration™, we are providing a solution that supports functioning at our best, no matter what our daily regimen looks like. Our consumers deserve that and we're excited to deliver it." The recommended use for the gluten-free, dairy-free, soy-free, and non-GMO ElectroPure Hydration™ product is to mix 1 stick pack (8 grams) in 16 ounces of water per day or as directed by your health care provider. The product is available to purchase at: . Designs for Health began in 1989 as a small educational services company with deep roots in natural medicine and big ambitions to revolutionize the industry. More than 30 years later, the company is pioneering new approaches to nutritional science, breaking barriers in quality standards, and ultimately transforming the healthcare ecosystem. Through a robust product pipeline and a diverse portfolio of more than 300 nutritional products, Designs for Health is leading the charge in the natural and integrative medicine movement to design a well world for all. To learn more about Designs for Health and its comprehensive portfolio of products, including its line of oral health products, visit . You can also tune in to Designs for Health's podcast, Conversations for Health, to immerse yourself in the current landscape of Functional Medicine and further empower you to design a well world with us. About Designs for Health, Inc. Family-owned Designs for Health, Inc. offers high-quality dietary supplements and functional foods to health care professionals and their patients. Guided by its founding philosophy of "Science-First™," the company holds an unwavering commitment to creating research-driven formulations with meaningful quantities of functional ingredients that maximize the potential for successful health outcomes. For over 30 years, Designs for Health has been many healthcare professionals' trusted source for not only product innovation but also leadership in clinical education and practice development solutions. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. † 1. 2X the total electrolytes per serving vs. Liquid I.V. Hydration Multiplier Powder Packets, the leading brand per Stackline sales data as of September 2023. 2. 9X the total electrolytes per serving vs. Gatorade Classic 12 fl oz as of September 2023. Contact: 5WPR 212-999-5585 [email protected] SOURCE Designs for Health

100 项与甘氨酸亚铁相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
缺铁性贫血	临床3期	印度	GSK Plc	2010-10-13
便秘	临床3期	印度	GSK Plc	2010-10-13
疲劳	临床3期	印度	GSK Plc	2010-10-13
头痛	临床3期	印度	GSK Plc	2010-10-13
营养不良	临床3期	印度	GSK Plc	2010-10-13
月经过多	临床3期	印度	GSK Plc	2010-10-13
恶心	临床3期	印度	GSK Plc	2010-10-13
感觉异常	临床3期	印度	GSK Plc	2010-10-13
铁缺乏	药物发现	印度	GSK Plc	2010-10-13
呕吐	药物发现	印度	GSK Plc	2010-10-13