辣椒碱(Capsaicin) - 药物靶点：TRPV1_在研适应症：糖尿病周围神经性疼痛，疱疹后神经痛，神经痛_专利_临床

The objective of this multicentric, randomized controlled double-blind clinical trial is to demonstrate the efficacy of transdermal application of capsaicin in patients with painful digital osteoarthritis with a neuropathic pain component.
Participants will receive either a transdermal patch of capsaicin 179 mg (8%) or the control treatment (capsaicin 0.04%).
Researchers will compare the intensity of pain in the fingers at day 60 in the capsaicin 8% group versus capsaicin 0.04% (control arm)

开始日期2024-09-01

申办/合作机构

Centre Hospitalier Universitaire de Clermont Ferrand

[+1]

NCT06444594 / Not yet recruiting早期临床1期IIT

Transient Receptor Potential Channels in Human Skin

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

开始日期2024-06-15

申办/合作机构

The Pennsylvania State University

CTIS2024-511159-16-00 / Not yet recruitingIIT

Capsaicin in digital osteoarthritis versus control : a randomized study - PHRC IR 2022 MATHIEU

开始日期2024-05-23

申办/合作机构-

100 项与辣椒碱相关的临床结果

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100 项与辣椒碱相关的转化医学

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100 项与辣椒碱相关的专利（医药）

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12,200

项与辣椒碱相关的文献（医药）

2024-12-31·Gut microbes

Pasteurized Akkermansia muciniphila improves irritable bowel syndrome-like symptoms and related behavioral disorders in mice

Article

作者: Ardid, Denis ; Aissouni, Youssef ; Meleine, Mathieu ; Bonnet, Mathilde ; Daugey, Valentine ; Meynier, Maëva ; Barbier, Julie ; Brochot, Amandine ; Carvalho, Frédéric A ; Cani, Patrice D ; Mallaret, Geoffroy ; Suenaert, Peter ; Gervason, Sandie ; Lolignier, Stéphane ; Van Hul, Matthias ; De Vos, Willem M

Gut - brain communications disorders in irritable bowel syndrome (IBS) are associated with intestinal microbiota composition, increased gut permeability, and psychosocial disturbances. Symptoms of IBS are difficult to medicate, and hence much research is being made into alternative approaches. This study assesses the potential of a treatment with pasteurized Akkermansia muciniphila for alleviating IBS-like symptoms in two mouse models of IBS with different etiologies. Two clinically relevant animal models were used to mimic IBS-like symptoms in C57BL6/J mice: the neonatal maternal separation (NMS) paradigm and the Citrobacter rodentium infection model. In both models, gut permeability, colonic sensitivity, fecal microbiota composition and colonic IL-22 expression were evaluated. The cognitive performance and emotional state of the animals were also assessed by several tests in the C. rodentium infection model. The neuromodulation ability of pasteurized A. muciniphila was assessed on primary neuronal cells from mice dorsal root ganglia using a ratiometric calcium imaging approach. The administration of pasteurized A. muciniphila significantly reduced colonic hypersensitivity in both IBS mouse models, accompanied by a reinforcement of the intestinal barrier function. Beneficial effects of pasteurized A. muciniphila treatment have also been observed on anxiety-like behavior and memory defects in the C. rodentium infection model. Finally, a neuroinhibitory effect exerted by pasteurized A. muciniphila was observed on neuronal cells stimulated with two algogenic substances such as capsaicin and inflammatory soup. Our findings demonstrate novel anti-hyperalgesic and neuroinhibitory properties of pasteurized A. muciniphila, which therefore may have beneficial effects in relieving pain and anxiety in subjects with IBS.

2024-12-01·Applied microbiology and biotechnology

Article

作者: Rosales-Rivera, Luis Carlos ; Basulto-Padilla, Georgina Cristina ; Mateos-Díaz, Juan Carlos ; Martínez-Pérez, Raúl Balam ; Rodríguez, Jorge A ; Canales-Aguirre, Alejandro A ; Armenta-Pérez, Vicente Paúl ; Diaz-Vidal, Tania ; Gutiérrez-Mercado, Yanet K

Abstract:

Glioblastoma is one of the most lethal tumors, displaying striking cellular heterogeneity and drug resistance. The prognosis of patients suffering from glioblastoma after 5 years is only 5%. In the present work, capsaicin analogues bearing modifications on the acyl chain with long-chain fatty acids showed promising anti-tumoral activity by its cytotoxicity on U-87 and U-138 glioblastoma multiforme cells. The capsaicin analogues were enzymatically synthetized with cross-linked enzyme aggregates of lipase B from Candida antarctica (CALB). The catalytic performance of recombinant CALB-CLEAs was compared to their immobilized form on a hydrophobic support. After 72 h of reaction, the synthesis of capsaicin analogues from linoleic acid, docosahexaenoic acid, and punicic acid achieved a maximum conversion of 69.7, 8.3 and 30.3% with CALB-CLEAs, respectively. Similar values were obtained with commercial CALB, with conversion yields of 58.3, 24.2 and 22% for capsaicin analogues from linoleic acid, DHA and punicic acid, respectively. Olvanil and dohevanil had a significant cytotoxic effect on both U-87 and U-138 glioblastoma cells. Irrespective of the immobilization form, CALB is an efficient biocatalyst for the synthesis of anti-tumoral capsaicin derivatives.

Key points:

• This is the first report concerning the enzymatic synthesis of capsaicin analogues from docosahexaenoic acid and punicic acid with CALB-CLEAs.• The viability U-87 and U-138 glioblastoma cells was significantly affected after incubation with olvanil and dohevanil.• Capsaicin analogues from fatty acids obtained by CALB-CLEAs are promising candidates for therapeutic use as cytotoxic agents in glioblastoma cancer cells.

2024-05-01·The journal of pain

Article

作者: Oh, Seog Bae ; Kim, Hayun ; Roh, Dahee

Lazertinib (JNJ-73841937, YH25448) is a mutant-selective irreversible epidermal growth factor receptor tyrosine kinase inhibitor targeting both the T790M and activating mutation while sparing wild-type epidermal growth factor receptor. Paresthesia is one of the most common adverse events seen with lazertinib treatment, suggesting that lazertinib could affect the sensory nervous system. However, the mechanism of action for this paresthesia remains unclear. In this study, we investigated whether and how lazertinib affects peripheral sensory neurons. Through Fura-2-based calcium imaging and whole-cell patch clamp recording in primary-cultured dorsal root ganglion (DRG) neurons from adult mice, we found that application of lazertinib elicits spontaneous calcium responses in a subset of small-to-medium-sized neurons. Moreover, lazertinib induced spontaneous firings and hyperexcitability in a subset of transient receptor potential vanilloid 1-lineage DRG neurons and sensitized transient receptor potential ankyrin 1 (TRPA1) response, while sparing transient receptor potential vanilloid 1 response. Lazertinib-responsive neurons were also responsive to capsaicin, further supporting that lazertinib selectively activates nociceptive neurons. Lazertinib-induced calcium responses were pharmacologically blocked with HC-030031 (TRPA1 antagonist) and MDL-12330A (adenylyl cyclase inhibitor), suggesting that lazertinib activates sensory neurons through indirect activation of TRPA1. However, unlike vincristine which produces peripheral neuropathy by axonal degeneration, lazertinib did not cause neurite fragmentation in cultured DRG neurons. Finally, intraplantar injection of lazertinib induced TRPA1-dependent pain-like behaviors in vivo. Collectively, our data suggest a direct effect of lazertinib on nociceptive sensory neurons via TRPA1 selective mechanisms, which could be a putative mechanism of lazertinib-induced sensory abnormalities in clinical patients. PERSPECTIVE: This article presents a TRPA1-dependent, lazertinib-induced activation of mouse sensory neurons in vitro and lazertinib-induced pain-like behaviors in vivo. The same mechanisms may underlie the clinical condition, suggesting that TRPA1 could be a potential therapeutic target to manage lazertinib-induced paresthesia.

37

项与辣椒碱相关的新闻（医药）

2024-06-11

·Science Daily

Reading pleasure and pain from the brain

Researchers have revealed how the brain processes emotions related to sustained pain and pleasure. A team of researchers led by LEE Soo Ahn and WOO Choong-Wan at the Center for Neuroscience Imaging Research (CNIR) within the Institute for Basic Science (IBS), in collaboration with CHOI Myunghwan at Seoul National University and Tor D. WAGER at Dartmouth College, has revealed how the brain processes emotional information of sustained pain and pleasure. Using functional Magnetic Resonance Imaging (fMRI), the team recorded brain activity while participants experienced sustained pain and pleasure induced by capsaicin and chocolate fluids. Through sophisticated machine learning techniques, they unraveled the brain activity patterns that encode pleasant or unpleasant emotions and the magnitude of sustained pain and pleasure. Although pain and pleasure are opposite experiences, they are intricately connected. Previous studies have suggested a set of brain regions that respond to both pain and pleasure. However, most previous studies have been conducted on animals rather than humans, and studies that directly compared the brain representations of pain and pleasure within the same individuals are still lacking. In this study, the research team conducted an experiment that induced sustained pain and pleasure to participants in the MR scanner, by delivering capsaicin and chocolate fluids. While experiencing sustained pain and pleasure, participants reported moment-by-moment changes in subjective pleasantness and unpleasantness. The participants' subjective reports of pleasantness and unpleasantness gradually increased and persisted during the capsaicin and chocolate fluids deliveries and decreased after the deliveries ended. By inducing dynamic changes in sustained pain and pleasure, the team aimed to identify the brain regions activated by both experiences. The research team collected the brain imaging data and moment-by-moment changes in pleasantness or unpleasantness ratings from 58 participants. The team utilized machine learning techniques to analyze the brain data, and they identified a set of brain regions that responded to both sustained pain and pleasure. Based on the brain activity patterns of these common brain regions, the team developed two predictive models to capture (1) the magnitude of affective experiences regardless of how pleasant or unpleasant they are (i.e., 'affective intensity') and (2) the magnitude of pleasantness or unpleasantness (i.e., 'affective valence'). The researchers found that these models successfully predicted the affective intensity and valence information of sustained pleasure and pain, from both the 58 individuals in the training dataset and 61 new individuals in the independent test dataset. The activity patterns predictive of the affective intensity and valence were spatially distinguishable, and these patterns were connected to distinct functional brain networks. This suggests that the affective intensity and valence information represent multiple aspects of brain mechanisms underlying pain-pleasure interaction. "While there have been separate lines of studies on pain and pleasure, research comparing the experiences of both pain and pleasure within the same individuals has been rarely conducted," stated Dr. WOO Choong-Wan, associate director of IBS, who led the study. "The brain activity patterns for affective valence and intensity can contribute to the understanding of how pain and pleasure interact, as well as the brain mechanisms underlying depression commonly observed in chronic pain patients." LEE Soo Ahn, a doctoral candidate and the first author of this study, emphasized, "These results demonstrate that pain and pleasure share the same underlying emotional information on pleasantness and unpleasantness," adding, "We should focus on the fact that affective valence and intensity information can be represented across multiple brain regions."

2024-05-30

·生物谷

天津大学康君副教授团队在eLife发文揭示辣椒碱预防酒精所致急性胃粘膜损伤的新机制

“钟鼓馔玉不足贵，但愿长醉不复醒”，李白斗酒诗百篇，留下无数佳作。酒，作为一种古老而神秘的饮品，承载着人类的情感与文化。但是，过量饮酒可能会造成机体损伤。酒精的主要成分是乙醇，在大量饮酒时，乙醇在胃内快速吸收，直接损伤胃粘膜上皮细胞，破坏胃黏膜的屏障作用，导致胃黏膜充血、水肿、糜烂，甚至胃出血，即所谓“酒精性急性胃炎”，该过程与氧化损伤密切相关。KEAP1-NRF2-ARE轴是最重要的抗氧化系统。在过去的几十年里，研究者们一直在努力寻找能够激活NRF2的分子，一系列NRF2激动剂被报道。但在实际应用中面临两个挑战：1）亲电性小分子共价修饰KEAP1存在“脱靶”效应；2）人工合成小分子诱导的NRF2过度激活可能促进癌症进展。开发非共价调节KEAP1-NRF2相互作用的小分子抑制剂，具有较好的应用前景。近日，天津大学生命科学学院康君副教授研究团队在eLife期刊在线发表了题为“Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction”的研究论文，在体外使用多种技术(Co-IP, Pull-down, SPR, BLI, HDX-MS, CETSA和MD）证明辣椒碱可以直接结合并变构调节KEAP1的Kelch结构域，抑制NRF2和KEAP1的相互作用，促进NRF2的稳定和核易位。此外，IR-Dye800修饰白蛋白包被辣椒碱纳米颗粒的设计提高了药物溶解度和递送效率，在大鼠体内急性乙醇所致胃粘膜损伤模型中具有出色的抗氧化和抗炎效果，证明了研究结果的实际应用价值。该研究阐明辣椒碱促进NRF2表达和下游抗氧化靶基因激活的机制，进一步为辣椒碱的作用模式提供了新的见解。在KEAP1敲除的293T 细胞中，辣椒碱未能激活NRF2表达。辣椒碱通过与Keap1蛋白的Kelch结构域非共价结合，并变构调节KEAP1的三个潜在区域：L342-L355、D394-G423和N482-N495。目前尚未有天然小分子化合物非共价结合KEAP1的报道，本研究表明辣椒碱可能是一种安全且新颖的NRF2激动剂，这将有助于开发用于氧化应激相关疾病（例如衰老，癌症，神经退行性和心血管疾病）的先导药物。天津大学生命科学学院康君副教授、王涛教授、祝诚副教授和和清华大学张博副研究员为本文的共同通讯作者。天津大学生命科学学院博士生高小宁、天津捷昂康科技发展有限公司研发总监郭武艳和生命科学学院刘培源老师为本文的共同第一作者。生命科学学院首届强基计划本科生（已转段至本院直博生）巴君丽、生命科学学院研究生宇文铭玥、刘子翔、谭汝阳、刘凯瑞、杨智茹、白雪、沙马石体和汤聪等同学也为该研究做出了贡献。天津大学生命科学学院为本论文第一完成单位，该研究获得国家自然科学基金等经费资助。原文链接：https://elifesciences.org/reviewed-preprints/97632本文仅用于学术分享，转载请注明出处。若有侵权，请联系微信：bioonSir 删除或修改！

2024-05-24

·生物谷

关于热搜「原来吃辣是有好处的」是真的吗？研究表明：吃辣竟可以增强免疫力、抑制幽门螺杆菌，甚至可以长寿

吃辣究竟好不好？许多人无辣不欢，不管吃什么都要加一些辣椒才觉得过瘾，网友热评“就喜欢吃辣那种嘶哈~嘶哈~魂飞魄散的感觉”。但医生们也经常会告诫人们要尽量少吃辣，因为会刺激消化系统，还会引发炎症反应等等。这是因为辣椒素可以通过激活人体伤害性感受器的TRPV1受体（也就是辣椒素受体），引发兴奋，产生辣辣的灼痛感。不过让人意想不到的是，这样的刺激还有意想不到的好处。1. 吃辣可以刺激免疫反应近日，军事科学院的研究团队在《细胞》上发表了一篇题为“Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity”的研究，他们发现伤害感觉神经纤维广泛分布并沿着血管伸展，它们不仅支配脾脏，还深入到B细胞区，因此这些脾脏伤害感受器能够促进抗原诱导的GC反应和体液免疫。人体的健康防御体系构建在免疫系统与周围神经系统（PNS）的协同合作之上，这一联合是维持日常生理平衡及应对疾病挑战的核心机制。其中，中枢神经系统扮演着调控免疫反应的远程指挥官角色，而周围神经系统则更专注于通过局部的神经-免疫直接对话来微调免疫功能，这一机制全面涉及了PNS的两大功能性分支：自主神经系统，负责无意识的身体机能调节；感觉神经系统，负责感知外部及内部环境变化。先前研究已证实，自主神经系统可以直接介入并调节脾脏的工作状态，而脾脏作为免疫系统的关键成员，其健康状态对全身免疫至关重要。与此同时，作为外周环境的哨兵，感觉神经元，特别是痛觉感受器，利用它们独特的离子通道设备（如Nav1.8和TRPV1），能够迅速捕捉到多种有害刺激，及时触发保护机制，帮助身体避免伤害。当前科研前沿正聚焦于痛觉感受器在先天免疫和组织炎症条件下的免疫调节潜能，它们通过释放诸如降钙素基因相关肽（CGRP）之类的信号分子，直接与免疫细胞和血管细胞进行信息交换，精准指导炎症的发展与消退过程。此外，痛觉感受器在指导T细胞对抗皮肤感染和黑色素瘤方面的作用已有所发现，但在促进B细胞活化和体液免疫应答的具体机制上，仍是一片等待探索的未知领域。图1：脾脏内伤害性感受神经元的神经支配促进生发中心反应和体液免疫而这正是该研究希望解开的谜团。他们发现，脾神经支配的伤害感受器主要源自左侧T8至T13背根神经节（DRGs），这些感受器不仅调控脾生发中心（GC）的反应，还积极促进体液免疫的激活。当抗原诱导脾内前列腺素E2 (PGE2) 积聚时，伤害感受器会被激活，随后释放降钙素基因相关肽（CGRP）。CGRP的释放进一步推动了早期脾GC反应的增强。在分子机制层面，CGRP通过其特异性受体CALCRL-RAMP1，以及环AMP (cAMP) 信号通路，直接作用于B细胞，从而影响免疫反应。此外，研究还发现，通过摄取辣椒素来激活伤害感受器，可以显著增强脾GC反应，并提升抗流感免疫能力。所以以后感冒了不光是可以喝热开水，可能还可以来一顿火锅？2. 辣椒素可以对抗幽门螺杆菌辣椒素的好处还不只这些，它甚至还能对付难缠的幽门螺旋杆菌。之前有一项题为"Anti-inflammatory Effect of Capsaicin in Helicobacter pylori-Infected Gastric Epithelial Cells"的研究发现，辣椒素能够通过核因子卡巴（NF-kappaB）信号来抑制被幽门螺杆菌感染的胃上皮细胞释放促炎症细胞因子——白介素-8（IL-8）（竟是真的！研究表明，吃辣不仅可以抗癌、长寿，还能抑制幽门螺杆菌生长）。该研究采用了AGS或MKN45细胞作为胃上皮细胞，并使用了Vac A+, CagA+野生型H. pylori菌株ATCC 49503进行研究。结果显示，当辣椒素随着浓度与时间递增，其能显著减少幽门螺杆菌诱发的IL-8。在辣椒素浓度为100 µmol/L时，24小时后，KN4细胞的IL-8产出降至对照组的43.2%，而AGS细胞也被抑制至对照组的70%。此外，辣椒素在感染幽门螺杆菌6小时后抑制了胃上皮细胞的IL-8 mRNA表达。具体来说，添加100 µmol/L的辣椒素，即抑制了在感染1小时幽门螺杆菌后引起的NF-κB在胃上皮细胞中的激活。同时，辣椒素还抑制了IκB的降解和IKK的激活。可见无毒剂量的辣椒素通过调节IκB-、NF-κB-和IL-8途径，有效抑制了幽门螺杆菌引起的胃上皮细胞IL-8的产生。这一发现表明，辣椒素可能作为一种潜在的抗炎药，用于抑制幽门螺杆菌感染胃上皮后产生的IL-8。3. 定期摄入辣椒的人更长寿？除了这些之外，其实吃辣的好处还有很多，比如还能长寿。在2020年，发表在《血液循环》期刊上的一篇题为“Impact of Chilli-pepper Intake on All-cause and Cardiovascular Mortality - A Systematic Review and Meta-analysis”的研究发现，与那些少吃或不吃辣椒的人相比，定期摄入辣椒的人展现出显著的健康益处。具体来说，他们的全因死亡率相对风险降低了25%，这一数据以相对风险（RR）0.75表示，95%的置信区间（CI）为0.64-0.88，且p值为0.0004，显示出强烈的统计显著性。通过进一步的观察发现，心血管病死亡率也相对降低了26%，其RR值为0.74，95% CI为0.62-0.88，p值为0.0006，同样显示了显著的统计差异。同样令人鼓舞的是，癌症死亡率也降低了23%，其RR值为0.77，95% CI为0.71-0.84，p值为0.0001。然而，辣椒摄入对脑血管意外的影响并未显示出统计学上的显著差异，其RR值为0.76，95% CI为0.36-1.60，p值为0.47。这些发现为辣椒的健康益处提供了新的见解，但关于其潜在机制仍需要进一步的研究。4. 吃辣有助于调节造血干细胞的功能而在另一项发表在《自然》上的题为“Nociceptive nerves regulate haematopoietic stem cell mobilization”的研究中，研究人员发现吃辣还有助于调节造血干细胞的功能。该研究表明，高达77%的造血干细胞受到痛感神经的调控。这些痛感神经通过分泌降钙素基因相关肽（CGRP）的神经递质，促进造血干细胞从骨髓中进入血管。有趣的是，摄入辣椒中的辣素（如辣椒素）可以触发痛觉神经元的激活，从而显著增强小鼠造血干细胞的活跃程度。为了刺激造血干细胞的动员，可能需要每天摄入相当于10个墨西哥红辣椒的辣度，并持续4天。这对于那些造血干细胞异常的白血病、淋巴瘤患者来说，可能是一个新的治疗策略，有助于延长他们的生存期。因此，针对痛觉神经系统进行调控，或许能成为提高造血干细胞产量和治疗效果的新方向。不过说了这么多吃辣的好处，最后还是要强调一下，吃辣也要适度，否则对身体的坏处也是显而易见的，比如造成皮肤病、口腔溃疡、肠胃不适、便秘等等。我们需要的是：辣得刚刚好！参考文献：1. Min Wu, Guangping Song, et al., Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity, Cell, May 20, 2024. DOI:https://doi-org.libproxy1.nus.edu.sg/10.1016/j.cell.2024.04.0272. Anti-inflammatory effect of capsaicin in Helicobacter pylori-infected gastric epithelial cells.2007 Oct;12(5):510-7.doi: 10.1111/j.1523-5378.2007.00521.x.3. Abstract 12729：Impact ofChilli-pepper Intake on All-cause and Cardiovascular Mortality - A SystematicReview and Meta-analysis. Circulation. 2020;142：A12729. https：//www.ahajournals.org/doi/abs/10.1161/circ.142.suppl_3.127294. Nociceptive nerves regulate haematopoietic stem cellmobilization. Nature (2020). https：//doi.org/10.1038/s41586-020-03057-y.撰文 | linwen编辑 | lcc部分文字来源于网络，本文仅用于分享，转载请注明出处。若有侵权，请联系微信：bioonSir 删除或修改！精彩推荐：1、一日三餐中，早饭可有可无吗？超24万人的荟萃研究证明：不吃早饭心血管疾病和癌症死亡风险飙升，定期早餐习惯对健康和长寿至关重要！2、原来一天一杯也是多！研究表明：每天喝≥500ml含糖饮料，脱发、多种慢性疾病风险增加，但天然果汁有降低患痴呆症奇效3、你是否“中午不睡，魂归床畔”？多项研究表明：经常午睡会导致高血压风险升高12%，中风风险升高24%，且午睡不宜超过60分钟4、完胜司美格鲁肽？Nature最新研究：带“馅儿”的Plus减肥药，GLP-1类减肥药包裹药物MK-801，有更强更持久的减肥效果5、25岁是体重的分水岭，极易绷不住！研究表明：肥胖率具有年龄差异性，控制新陈代谢和食欲的神经元形状会随年龄发生变化

100 项与辣椒碱相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00250	-	M02AB01 N01BX04	DB06774

研发状态

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适应症	国家/地区	公司	日期
糖尿病周围神经性疼痛	美国	Averitas Pharma, Inc.初创企业	2020-07-17
疱疹后神经痛	美国	Averitas Pharma, Inc.初创企业	2009-11-16
神经痛	中国	长春普华制药股份有限公司	2003-01-24
疼痛	中国	长春普华制药股份有限公司	2003-01-24

未上市

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适应症	最高研发状态	国家/地区	公司	日期
拇外翻	临床3期	美国	Anesiva, Inc.	2008-03-01
HIV感染	临床3期	美国	NeurogesX, Inc.	2003-08-01
痛性神经病变	临床3期	美国	NeurogesX, Inc.	2003-08-01
带状疱疹	临床3期	美国	NeurogesX, Inc.	2003-06-03
周围神经系统疾病	临床3期	美国	NeurogesX, Inc.	2003-06-03
膝关节炎	临床2期	美国	Propella Therapeutics, Inc.	2018-05-14
周围神经损伤	临床2期	韩国	Samyang Biopharmaceuticals Corp.	2009-02-01
疝	临床2期	丹麦	AlgoRx Pharmaceuticals, Inc.	2005-09-01
腹股沟疝	临床2期	丹麦	AlgoRx Pharmaceuticals, Inc.	2005-09-01
膝盖受伤	临床2期	美国	AlgoRx Pharmaceuticals, Inc.	2005-07-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04256733 (CTgov)	早期临床1期	咳嗽	19	Supra-threshold (Supra-threshold Capsaicin)	醖顧製積範遞顧範衊繭(糧構壓蓋鹽廠獵選齋憲) = 糧繭廠夢遞壓遞顧鏇襯觸憲蓋願膚觸鹹醖壓製 (築鬱壓鹹遞憲願餘範鹹, 鏇鬱醖積鹹鑰遞廠鏇憲 ~ 壓鹹窪艱衊鬱築簾鹽壓) 更多	-	2024-03-04
				Sub-threshold doses of diluted capsiacin via a KoKo Digidoser nebulizer (Sub-threshold Capsaicin)	醖顧製積範遞顧範衊繭(糧構壓蓋鹽廠獵選齋憲) = 夢窪簾鑰鹹醖鏇鏇網構觸憲蓋願膚觸鹹醖壓製 (築鬱壓鹹遞憲願餘範鹹, 簾範獵顧鏇齋範獵鹹糧 ~ 鑰繭淵構獵遞齋鏇顧夢) 更多
EBCC2022	N/A	辅助	35	Capsaicin patch 179 mg	構範餘憲築餘襯糧艱選(遞鬱窪憲齋願構築夢簾) = 夢鏇夢鑰艱繭蓋艱顧鬱壓願醖構繭鏇遞廠餘窪 (鑰窪鑰積鏇網醖醖鹹膚 ) 更多	-	2022-11-17
NCT02441660 (CTgov)	N/A	神经痛 \| 脊髓损伤	11	Capsaicin (Experimental Group)	醖簾襯醖範網製廠簾構(壓網簾獵醖繭憲齋構鬱) = 醖鬱蓋遞積餘餘選壓餘窪遞網鹽網壓淵醖顧襯 (願製繭蓋製糧壓築廠襯, 襯窪窪願餘夢餘顧齋齋 ~ 窪壓觸醖顧鹹觸壓夢構) 更多	-	2022-10-06
				capsaicin (Control Group)	醖簾襯醖範網製廠簾構(壓網簾獵醖繭憲齋構鬱) = 構構網獵鏇遞艱獵糧築窪遞網鹽網壓淵醖顧襯 (願製繭蓋製糧壓築廠襯, 簾鹹齋襯餘鬱簾襯夢遞 ~ 窪淵憲醖獵鬱淵鹽網願) 更多
NCT03429049 (CTgov)	临床3期	膝关节炎	332	Placebo (Placebo)	夢選鬱糧願網壓艱鑰壓(範窪襯網淵鏇膚淵顧鹹) = 構襯鬱遞遞糧鏇艱窪鬱鬱構夢醖網鹹齋齋膚壓 (願淵繭鹽鬱膚餘襯鏇鑰, 艱夢蓋遞構願積積餘鹽 ~ 衊淵簾鬱鹽襯糧醖鏇艱) 更多	-	2022-04-08
				CNTX-4975-05 (CNTX-4975-05)	夢選鬱糧願網壓艱鑰壓(範窪襯網淵鏇膚淵顧鹹) = 齋襯艱夢構構遞膚糧構鬱構夢醖網鹹齋齋膚壓 (願淵繭鹽鬱膚餘襯鏇鑰, 艱襯蓋遞壓觸鏇鹹齋襯 ~ 糧選壓蓋積艱網衊製齋) 更多
NCT03223350 (CTgov)	临床2期	家族性周期性呕吐综合征	30	Capsaicin 0.1% Cream (Capsaicin)	淵願窪鏇廠願遞齋餘壓(願衊鹹願積獵蓋壓壓淵) = 壓壓鏇淵願襯鏇蓋衊糧遞製餘淵獵願襯衊製積 (鏇顧獵鹹糧獵壓構鬱膚, 構構鬱願膚獵襯壓齋願 ~ 選網齋餘網蓋廠鏇鬱網) 更多	-	2021-12-15
				Placebos (Placebo)	淵願窪鏇廠願遞齋餘壓(願衊鹹願積獵蓋壓壓淵) = 糧獵遞願觸壓積範簾遞遞製餘淵獵願襯衊製積 (鏇顧獵鹹糧獵壓構鬱膚, 淵壓艱鑰壓鹽窪艱鏇簾 ~ 顧築壓簾製廠夢鑰築鏇) 更多
NCT02346903 (CTgov)	N/A	胸痛	99	Capsaicin	願鹽糧鑰艱獵淵膚衊簾(齋製糧範窪網鏇壓窪築) = 憲觸窪艱簾遞鹹衊網獵憲獵鏇積糧簾鏇簾網糧 (遞鬱願糧網構憲淵壓廠, 簾築網蓋鏇願淵蓋糧糧 ~ 餘製醖窪艱蓋壓鏇獵壓) 更多	-	2021-03-04
NCT02346916 (CTgov)	N/A	胸痛 \| 心肌缺血	22	Capsaicin	壓願獵遞鏇製鏇糧遞鑰(糧遞製鹹範鬱廠餘醖廠) = 衊齋餘淵鬱鹹淵願鹽構製膚顧憲網鹽衊選夢鏇 (繭願獵廠醖憲糧夢願廠, 積鬱衊醖餘獵衊範膚醖 ~ 憲簾網鬱願鬱鏇簾糧淵) 更多	-	2021-03-04
NCT02493257 (CTgov)	临床2期	常年性变应性鼻炎 \| 急性刺激性鼻炎	22	Capsaicin (Intranasal Capsaicin)	齋積壓蓋憲築膚觸願鑰(憲製壓艱夢夢淵積蓋觸) = 廠範製積獵窪壓獵製網憲觸襯糧艱願鑰簾遞襯 (蓋醖膚選壓夢衊範築積, 廠顧艱壓築夢獵製獵選 ~ 壓獵壓壓鬱積顧糧膚顧) 更多	-	2020-08-17
				Placebo (Vehicle Solution)	齋積壓蓋憲築膚觸願鑰(憲製壓艱夢夢淵積蓋觸) = 齋觸製齋廠衊鏇築遞醖憲觸襯糧艱願鑰簾遞襯 (蓋醖膚選壓夢衊範築積, 糧遞憲顧網窪製鏇繭網 ~ 淵製選鏇憲淵網積製齋) 更多
NCT03528369 (CTgov)	临床2期	疼痛 \| 膝关节炎	122	CGS-200-1 (CGS-200-1)	積壓壓壓糧齋窪遞餘獵(選憲齋艱膚鹹遞窪衊艱) = 願夢繭蓋淵夢積窪糧蓋範鏇衊鹹糧壓願餘網遞 (襯選蓋獵構鑰鏇簾顧願, 淵憲積憲遞淵醖鹽餘簾 ~ 構積網膚窪衊憲簾艱蓋) 更多	-	2019-12-17
				CGS-200-5 (CGS-200-5)	積壓壓壓糧齋窪遞餘獵(選憲齋艱膚鹹遞窪衊艱) = 壓壓齋鏇製廠構顧膚選範鏇衊鹹糧壓願餘網遞 (襯選蓋獵構鑰鏇簾顧願, 鏇鹹網餘築壓鹽積鬱衊 ~ 廠鹽艱窪糧願製構鑰醖) 更多
CNTX-4975 (EULAR2019)	临床3期	膝关节炎	5	CNTX-4975	蓋獵鑰衊醖選鹹願顧糧(製製鹹壓鹽艱繭獵廠鹽) = 窪獵蓋鑰選鏇壓網蓋遞鬱憲糧糧鬱築艱網顧鏇 (鑰鹽獵築獵繭選構構鹽 ) 更多	积极	2019-06-12
				CNTX-4975	蓋獵鑰衊醖選鹹願顧糧(製製鹹壓鹽艱繭獵廠鹽) = 製獵淵夢艱糧鏇鏇齋醖鬱憲糧糧鬱築艱網顧鏇 (鑰鹽獵築獵繭選構構鹽 ) 更多