盐酸羟甲唑啉/盐酸丁卡因(Oxymetazoline Hydrochloride/Tetracaine Hydrochloride) - 药物靶点：α1A-AR_在研适应症：麻醉_专利_临床

概要

基本信息

药物类型

小分子化药

别名

KOVANAZE、Kovacaine、Kovacaine Mist

+ [2]

靶点

α1A-AR

作用方式

激动剂

作用机制

α1A-AR激动剂(肾上腺素能受体α-1a激动剂)

治疗领域

其他疾病

在研适应症

麻醉

非在研适应症-

原研机构

St. Renatus LLC

在研机构

St. Renatus LLC

非在研机构-

最高研发阶段批准上市

首次获批日期

美国 (2016-06-29),

麻醉

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构/序列

分子式C16H25ClN2O

InChIKeyBEEDODBODQVSIM-UHFFFAOYSA-N

CAS号2315-02-8

查看全部结构式(2)

关联

5

项与盐酸羟甲唑啉/盐酸丁卡因相关的临床试验

NCT04104789

/ Withdrawn临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2020-09-01

申办/合作机构

Virginia Commonwealth University

NCT04105985

/ Withdrawn临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2020-08-01

申办/合作机构

Virginia Commonwealth University

NCT03962634

/ Terminated临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2019-08-28

申办/合作机构

Virginia Commonwealth University

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的临床结果

登录后查看更多信息

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的转化医学

登录后查看更多信息

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的专利（医药）

登录后查看更多信息

2

项与盐酸羟甲唑啉/盐酸丁卡因相关的文献（医药）

2022-04-01·Anesthesia Progress

Kovanaze Intranasal Spray vs Traditional Injected Anesthetics: a Study of Pulpal Blood Flow Utilizing Laser Doppler Flowmetry

Article

作者: Odom, Mark ; Thayer, Scott ; Peters, Mathilde ; Sabey, Kent A. ; Yu, Qingzhao ; Townsend, Janice A.

Objective:An ideal local anesthetic would be effective, minimally reduce pulpal blood flow (PBF), and not require injection. This study compared the effects of 3% tetracaine plus 0.05% oxymetazoline nasal spray (Kovanaze; KNS) and injections using 2% lidocaine with 1:100,000 epinephrine (LE) or 3% mepivacaine plain (MP) on PBF, anesthetic efficacy, and participant preference.Methods:In a double-blind cross-over design, 20 subjects randomly received a test anesthetic and placebo at each of 3 visits (KNS/mock infiltration; mock nasal spray/LE; or mock nasal spray/MP). Nasal sprays and infiltration apical to a maxillary central incisor were delivered ipsilaterally. PBF was evaluated by laser Doppler flowmetry, and local anesthetic success was assessed with electric pulp testing. Postoperative pain levels, participant preference, and adverse events were also assessed.Results:LE injections demonstrated significant reductions in PBF at all time intervals compared with baseline (P < .05), whereas KNS and MP did not. Pulpal anesthesia success rates were higher for LE (85%) compared with MP (35%) and KNS (5%). Participants reported significantly higher postoperative pain levels for KNS compared with LE and MP. Additionally, KNS was the least preferred of the anesthetics administered and resulted in more reported adverse events.Conclusion:Although KNS showed no significant effect on PBF, it was not effective in achieving pulpal anesthesia as used in this study.

2019-03-01·Journal of Endodontics2区 · 医学

Anesthetic Efficacy of Intranasal 3% Tetracaine plus 0.05% Oxymetazoline (Kovanaze) in Maxillary Teeth

2区 · 医学

Article

作者: Drum, Melissa ; Capetillo, Jeremy ; Nusstein, John ; Reader, Al ; Fowler, Sara ; Beck, Mike

INTRODUCTIONNeedle-free anesthetic delivery is a promising alternative to traditional anesthetic routes of administration. The purpose of this study was to determine the patient preference for and pulpal anesthetic efficacy of a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray in maxillary lateral incisors and first premolars.METHODSFifty adult subjects randomly received a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray and mock infiltration or a mock nasal spray and 2% lidocaine with 1:100,000 epinephrine infiltration at the maxillary lateral incisor or first premolar in 2 appointments spaced at least 1 week apart in a single-blind cross-over design. Pulpal anesthesia was evaluated with an electric pulp tester. Side effects and subject preferences were also recorded.RESULTSAnesthetic success was significantly lower for the Kovanaze nasal spray and mock infiltration (22%-37%) than for the mock nasal spray and lidocaine infiltration (89%-91%). Subjects reported more unwanted effects (nasal drainage and congestion, burning, pressure, and sinus congestion) after the Kovanaze nasal spray and mock infiltration than the mock spray and maxillary infiltration. Before participating in the study, more subjects (56%) preferred the nasal spray route versus a standard infiltration (44%). After experiencing both routes of administration, 100% of subjects preferred the standard infiltration.CONCLUSIONSThe 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray provided significantly less successful pulpal anesthesia than the lidocaine infiltration, was less preferable, and caused more unwanted effects.

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
-	-	N01BA53	-

研发状态

10 条最早获批的记录,

登录

后查看更多信息

适应症	国家/地区	公司	日期
麻醉	美国	St. Renatus LLC	2016-06-29

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03962634 (CTgov)	临床2期	根尖周炎 \| 龋齿	3	Kovanaze Nasal Spray (Kovanaze Nasal Spray (Pediatrics))	淵膚廠齋窪鑰衊淵願積(選獵糧遞願壓鬱淵衊網) = 餘窪蓋醖積醖鏇膚遞衊繭憲獵憲衊膚鑰構範遞 (餘獵壓鏇網網鹹糧製簾, 膚積鹽網衊製壓選獵廠 ~ 夢鑰遞淵鑰糧顧觸艱鏇) 更多	-	2020-11-19
				Articaine Injection (Articaine Injections (Pediatrics))	淵膚廠齋窪鑰衊淵願積(選獵糧遞願壓鬱淵衊網) = 艱構獵醖網鬱簾膚網鑰繭憲獵憲衊膚鑰構範遞 (餘獵壓鏇網網鹹糧製簾, 顧遞憲廠鹽製襯願齋壓 ~ 構網顧衊鏇積繭構選願) 更多
NCT01701505 (CTgov)	临床2期	麻醉	48	400uL of Kovacaine Mist (Kovacaine Mist High Dose)	築艱淵廠廠鹹觸繭壓鹽(鏇繭壓窪鑰糧範廠醖鑰) = 憲遞糧繭願艱夢憲鏇積繭衊艱糧願鹽築獵鏇壓 (壓構簾蓋壓窪獵膚襯範, 鹽獵顧夢淵願夢願選齋 ~ 製獵淵鬱夢齋獵糧築糧) 更多	-	2017-08-30
				200uL of Kovacaine Mist (Kovacaine Mist Mid Dose)	壓壓鑰壓鬱廠淵壓壓夢(顧願淵繭壓顧鹹鑰簾餘) = 齋膚糧網廠淵廠鹽鏇艱餘繭蓋艱窪網積積襯獵 (選觸廠蓋願鏇餘膚壓醖, 繭選製餘餘餘壓範築醖 ~ 蓋糧壓築膚鏇齋鹹醖糧) 更多
NCT01479517 (CTgov)	临床2期	麻醉	30	Kovacaine Mist 0.1 mL x 4 sprays (Kovacaine Mist 0.1 mL x 4 Sprays)	鑰構製鑰鏇淵蓋壓糧艱(鑰範艱築廠壓壓積壓鹽) = 觸製製簾範鹽襯廠蓋築範簾鑰襯糧選醖鑰鹹遞 (夢遞簾範選窪衊願蓋築, 繭艱窪餘蓋餘鑰網廠醖 ~ 齋網醖壓製築築艱築糧) 更多	-	2016-12-29
				Kovacaine Mist 0.2 mL x 2 sprays (Kovacaine Mist 0.2 mL x 2 Sprays)	鑰構製鑰鏇淵蓋壓糧艱(鑰範艱築廠壓壓積壓鹽) = 簾鏇糧廠蓋積壓窪鑰膚範簾鑰襯糧選醖鑰鹹遞 (夢遞簾範選窪衊願蓋築, 遞蓋糧膚遞製淵鹽齋選 ~ 醖築積鏇繭願齋齋襯鹽) 更多