The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2020-09-01

申办/合作机构

Virginia Commonwealth University

NCT04105985 / Withdrawn临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

开始日期2020-08-01

申办/合作机构

Virginia Commonwealth University

NCT03962634 / Terminated临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

开始日期2019-08-28

申办/合作机构

Virginia Commonwealth University

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的临床结果

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100 项与盐酸羟甲唑啉/盐酸丁卡因相关的转化医学

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100 项与盐酸羟甲唑啉/盐酸丁卡因相关的专利（医药）

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项与盐酸羟甲唑啉/盐酸丁卡因相关的文献（医药）

2022-04-01·Anesthesia Progress

Kovanaze Intranasal Spray vs Traditional Injected Anesthetics: a Study of Pulpal Blood Flow Utilizing Laser Doppler Flowmetry

Article

作者: Odom, Mark ; Thayer, Scott ; Peters, Mathilde ; Sabey, Kent A. ; Yu, Qingzhao ; Townsend, Janice A.

Objective:An ideal local anesthetic would be effective, minimally reduce pulpal blood flow (PBF), and not require injection. This study compared the effects of 3% tetracaine plus 0.05% oxymetazoline nasal spray (Kovanaze; KNS) and injections using 2% lidocaine with 1:100,000 epinephrine (LE) or 3% mepivacaine plain (MP) on PBF, anesthetic efficacy, and participant preference.Methods:In a double-blind cross-over design, 20 subjects randomly received a test anesthetic and placebo at each of 3 visits (KNS/mock infiltration; mock nasal spray/LE; or mock nasal spray/MP). Nasal sprays and infiltration apical to a maxillary central incisor were delivered ipsilaterally. PBF was evaluated by laser Doppler flowmetry, and local anesthetic success was assessed with electric pulp testing. Postoperative pain levels, participant preference, and adverse events were also assessed.Results:LE injections demonstrated significant reductions in PBF at all time intervals compared with baseline (P < .05), whereas KNS and MP did not. Pulpal anesthesia success rates were higher for LE (85%) compared with MP (35%) and KNS (5%). Participants reported significantly higher postoperative pain levels for KNS compared with LE and MP. Additionally, KNS was the least preferred of the anesthetics administered and resulted in more reported adverse events.Conclusion:Although KNS showed no significant effect on PBF, it was not effective in achieving pulpal anesthesia as used in this study.

2019-03-01·Journal of Endodontics2区 · 医学

Anesthetic Efficacy of Intranasal 3% Tetracaine plus 0.05% Oxymetazoline (Kovanaze) in Maxillary Teeth

2区 · 医学

Article

作者: Drum, Melissa ; Capetillo, Jeremy ; Nusstein, John ; Reader, Al ; Fowler, Sara ; Beck, Mike

INTRODUCTIONNeedle-free anesthetic delivery is a promising alternative to traditional anesthetic routes of administration. The purpose of this study was to determine the patient preference for and pulpal anesthetic efficacy of a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray in maxillary lateral incisors and first premolars.METHODSFifty adult subjects randomly received a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray and mock infiltration or a mock nasal spray and 2% lidocaine with 1:100,000 epinephrine infiltration at the maxillary lateral incisor or first premolar in 2 appointments spaced at least 1 week apart in a single-blind cross-over design. Pulpal anesthesia was evaluated with an electric pulp tester. Side effects and subject preferences were also recorded.RESULTSAnesthetic success was significantly lower for the Kovanaze nasal spray and mock infiltration (22%-37%) than for the mock nasal spray and lidocaine infiltration (89%-91%). Subjects reported more unwanted effects (nasal drainage and congestion, burning, pressure, and sinus congestion) after the Kovanaze nasal spray and mock infiltration than the mock spray and maxillary infiltration. Before participating in the study, more subjects (56%) preferred the nasal spray route versus a standard infiltration (44%). After experiencing both routes of administration, 100% of subjects preferred the standard infiltration.CONCLUSIONSThe 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray provided significantly less successful pulpal anesthesia than the lidocaine infiltration, was less preferable, and caused more unwanted effects.

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	N01BA53	-

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适应症	国家/地区	公司	日期
麻醉	美国	St. Renatus LLC	2016-06-29

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03962634 (CTgov)	临床2期	根尖周炎 \| 龋齿	3	Kovanaze Nasal Spray (Kovanaze Nasal Spray (Pediatrics))	範網艱鹹鏇衊鹽網襯繭(範鹽膚餘壓艱壓膚齋壓) = 艱積網顧鹹淵齋觸窪淵積簾廠獵築淵廠願鹽鏇 (鹽網鑰淵鏇繭簾糧糧膚, 襯餘遞憲簾餘鹽餘鑰選 ~ 艱醖憲窪範鏇繭淵築糧) 更多	-	2020-11-19
				Articaine Injection (Articaine Injections (Pediatrics))	範網艱鹹鏇衊鹽網襯繭(範鹽膚餘壓艱壓膚齋壓) = 選醖夢顧鹹蓋鑰獵積遞積簾廠獵築淵廠願鹽鏇 (鹽網鑰淵鏇繭簾糧糧膚, 鹹齋鹽膚餘蓋艱簾網齋 ~ 簾網廠艱齋觸鹽鏇夢鬱) 更多
NCT01701505 (CTgov)	临床2期	麻醉	48	400uL of Kovacaine Mist (Kovacaine Mist High Dose)	構簾壓遞遞繭憲蓋鏇糧(觸齋蓋壓膚顧積膚繭廠) = 夢鹹憲鑰範鹹鹽積襯獵醖繭齋構鑰範鏇鹹鹹衊 (壓餘衊糧餘鹹廠願鹹齋, 築遞鹹壓壓獵選蓋網鏇 ~ 蓋糧鹽範鑰遞淵繭積構) 更多	-	2017-08-30
				200uL of Kovacaine Mist (Kovacaine Mist Mid Dose)	膚顧糧艱醖網膚築範襯(網壓製築壓膚顧選窪鹹) = 網鏇構簾鹹構餘繭簾窪壓積鑰襯鏇網觸壓鹽艱 (積糧選選顧糧鹽顧襯衊, 鑰鹹鏇鹽願憲選廠憲鑰 ~ 蓋積齋鑰醖襯鏇齋範觸) 更多
NCT01479517 (CTgov)	临床2期	麻醉	30	Kovacaine Mist 0.1 mL x 4 sprays (Kovacaine Mist 0.1 mL x 4 Sprays)	壓選膚艱製鏇醖遞顧蓋(艱壓蓋夢鏇膚簾廠觸艱) = 窪餘構遞糧夢艱製積窪網廠願醖鹽糧襯鑰鑰醖 (鹹製夢簾鏇鬱構範遞觸, 觸廠壓壓簾艱糧壓餘觸 ~ 構夢遞顧製繭襯廠積願) 更多	-	2016-12-29
				Kovacaine Mist 0.2 mL x 2 sprays (Kovacaine Mist 0.2 mL x 2 Sprays)	壓選膚艱製鏇醖遞顧蓋(艱壓蓋夢鏇膚簾廠觸艱) = 鹹築襯壓蓋廠鹽襯鬱窪網廠願醖鹽糧襯鑰鑰醖 (鹹製夢簾鏇鬱構範遞觸, 築壓鹹鑰糧衊蓋構獵糧 ~ 壓糧簾觸選範願願選網) 更多