盐酸羟甲唑啉/盐酸丁卡因(Oxymetazoline Hydrochloride/Tetracaine Hydrochloride) - 药物靶点：α1A-AR_在研适应症：麻醉_专利_临床

概要

基本信息

药物类型

小分子化药

别名

KOVANAZE、Kovacaine、Kovacaine Mist

+ [2]

靶点

α1A-AR

作用机制

α1A-AR激动剂(肾上腺素能受体α-1a激动剂)

治疗领域

其他疾病

在研适应症

麻醉

非在研适应症-

原研机构

St. Renatus LLC

在研机构

St. Renatus LLC

非在研机构-

最高研发阶段批准上市

首次获批日期

美国 (2016-06-29),

麻醉

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C16H25ClN2O

InChIKeyBEEDODBODQVSIM-UHFFFAOYSA-N

CAS号2315-02-8

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关联

5

项与盐酸羟甲唑啉/盐酸丁卡因相关的临床试验

NCT04104789

/ Withdrawn临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2020-09-01

申办/合作机构

Virginia Commonwealth University

NCT04105985

/ Withdrawn临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2020-08-01

申办/合作机构

Virginia Commonwealth University

NCT03962634

/ Terminated临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2019-08-28

申办/合作机构

Virginia Commonwealth University

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的临床结果

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100 项与盐酸羟甲唑啉/盐酸丁卡因相关的转化医学

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100 项与盐酸羟甲唑啉/盐酸丁卡因相关的专利（医药）

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2

项与盐酸羟甲唑啉/盐酸丁卡因相关的文献（医药）

2022-04-01·Anesthesia Progress

Kovanaze Intranasal Spray vs Traditional Injected Anesthetics: a Study of Pulpal Blood Flow Utilizing Laser Doppler Flowmetry

Article

作者: Odom, Mark ; Thayer, Scott ; Peters, Mathilde ; Sabey, Kent A. ; Yu, Qingzhao ; Townsend, Janice A.

Objective:An ideal local anesthetic would be effective, minimally reduce pulpal blood flow (PBF), and not require injection. This study compared the effects of 3% tetracaine plus 0.05% oxymetazoline nasal spray (Kovanaze; KNS) and injections using 2% lidocaine with 1:100,000 epinephrine (LE) or 3% mepivacaine plain (MP) on PBF, anesthetic efficacy, and participant preference.Methods:In a double-blind cross-over design, 20 subjects randomly received a test anesthetic and placebo at each of 3 visits (KNS/mock infiltration; mock nasal spray/LE; or mock nasal spray/MP). Nasal sprays and infiltration apical to a maxillary central incisor were delivered ipsilaterally. PBF was evaluated by laser Doppler flowmetry, and local anesthetic success was assessed with electric pulp testing. Postoperative pain levels, participant preference, and adverse events were also assessed.Results:LE injections demonstrated significant reductions in PBF at all time intervals compared with baseline (P < .05), whereas KNS and MP did not. Pulpal anesthesia success rates were higher for LE (85%) compared with MP (35%) and KNS (5%). Participants reported significantly higher postoperative pain levels for KNS compared with LE and MP. Additionally, KNS was the least preferred of the anesthetics administered and resulted in more reported adverse events.Conclusion:Although KNS showed no significant effect on PBF, it was not effective in achieving pulpal anesthesia as used in this study.

2019-03-01·Journal of Endodontics2区 · 医学

Anesthetic Efficacy of Intranasal 3% Tetracaine plus 0.05% Oxymetazoline (Kovanaze) in Maxillary Teeth

2区 · 医学

Article

作者: Drum, Melissa ; Capetillo, Jeremy ; Nusstein, John ; Reader, Al ; Fowler, Sara ; Beck, Mike

INTRODUCTIONNeedle-free anesthetic delivery is a promising alternative to traditional anesthetic routes of administration. The purpose of this study was to determine the patient preference for and pulpal anesthetic efficacy of a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray in maxillary lateral incisors and first premolars.METHODSFifty adult subjects randomly received a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray and mock infiltration or a mock nasal spray and 2% lidocaine with 1:100,000 epinephrine infiltration at the maxillary lateral incisor or first premolar in 2 appointments spaced at least 1 week apart in a single-blind cross-over design. Pulpal anesthesia was evaluated with an electric pulp tester. Side effects and subject preferences were also recorded.RESULTSAnesthetic success was significantly lower for the Kovanaze nasal spray and mock infiltration (22%-37%) than for the mock nasal spray and lidocaine infiltration (89%-91%). Subjects reported more unwanted effects (nasal drainage and congestion, burning, pressure, and sinus congestion) after the Kovanaze nasal spray and mock infiltration than the mock spray and maxillary infiltration. Before participating in the study, more subjects (56%) preferred the nasal spray route versus a standard infiltration (44%). After experiencing both routes of administration, 100% of subjects preferred the standard infiltration.CONCLUSIONSThe 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray provided significantly less successful pulpal anesthesia than the lidocaine infiltration, was less preferable, and caused more unwanted effects.

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	N01BA53	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
麻醉	美国	St. Renatus LLC	2016-06-29

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03962634 (CTgov)	临床2期	根尖周炎 \| 龋齿	3	Kovanaze Nasal Spray (Kovanaze Nasal Spray (Pediatrics))	襯製餘夢艱鹽簾顧鬱網(艱廠積艱餘襯壓範襯鑰) = 憲獵鹹繭醖製鬱顧選襯構齋簾鬱選艱構觸獵網 (選簾築選鬱築遞壓觸廠, 遞選觸蓋願觸餘窪鹹選 ~ 鹽膚繭餘鬱願廠鑰簾鹹) 更多	-	2020-11-19
				Articaine Injection (Articaine Injections (Pediatrics))	襯製餘夢艱鹽簾顧鬱網(艱廠積艱餘襯壓範襯鑰) = 觸鹹築顧積繭繭膚糧觸構齋簾鬱選艱構觸獵網 (選簾築選鬱築遞壓觸廠, 襯製齋築憲範顧顧網憲 ~ 淵廠願鹹選醖鹹醖遞鏇) 更多
NCT01701505 (CTgov)	临床2期	麻醉	48	400uL of Kovacaine Mist (Kovacaine Mist High Dose)	壓遞蓋壓遞積積網選選(淵範製蓋範願鹹簾壓鹽) = 鹹憲積選鬱鑰積鏇淵壓鹽遞艱醖鹹選蓋鏇餘蓋 (蓋簾鏇築獵鬱網積壓願, 鏇餘鬱襯顧製獵襯遞膚 ~ 窪網齋餘築膚願齋獵築) 更多	-	2017-08-30
				200uL of Kovacaine Mist (Kovacaine Mist Mid Dose)	選範壓糧衊醖艱鹽衊遞(獵窪憲願壓餘餘獵鑰鏇) = 獵艱願鑰範膚壓製構鏇獵鏇夢鹹鹽積構鹹衊鏇 (選廠壓膚壓網鏇衊齋製, 製顧夢鏇糧選膚憲齋網 ~ 衊鹽獵鑰鑰糧膚夢廠積) 更多
NCT01479517 (CTgov)	临床2期	麻醉	30	Kovacaine Mist 0.1 mL x 4 sprays (Kovacaine Mist 0.1 mL x 4 Sprays)	築醖淵夢鹽鬱餘鏇襯鬱(醖簾遞願膚顧顧糧廠繭) = 憲範鑰簾選簾簾繭襯鑰鹽衊襯糧膚艱廠積蓋淵 (膚遞齋糧鬱艱製餘鬱積, 糧艱顧鏇齋鹹糧願遞膚 ~ 鹽憲餘鑰鹹廠獵顧鏇遞) 更多	-	2016-12-29
				Kovacaine Mist 0.2 mL x 2 sprays (Kovacaine Mist 0.2 mL x 2 Sprays)	築醖淵夢鹽鬱餘鏇襯鬱(醖簾遞願膚顧顧糧廠繭) = 衊製觸艱顧壓糧艱窪糧鹽衊襯糧膚艱廠積蓋淵 (膚遞齋糧鬱艱製餘鬱積, 願淵壓鏇壓鹹構鹽鑰鹹 ~ 餘構繭築憲齋齋襯觸鹽) 更多