更新于：2024-06-30
Sulpiride
舒必利
更新于：2024-06-30
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C15H23N3O4S |
InChIKeyBGRJTUBHPOOWDU-UHFFFAOYSA-N |
CAS号15676-16-1 |
关联
17
项与 舒必利 相关的临床试验The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement
The role of dopamine: Investigating the impact of Sulpiride exposure on exercise-related enhancement of motor skill learning in healthy volunteers.
The Effect of Antiemetics on Bowel Preparation Before Colonoscopy
100 项与 舒必利 相关的临床结果
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100 项与 舒必利 相关的转化医学
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100 项与 舒必利 相关的专利（医药）
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4,846
项与 舒必利 相关的文献（医药）Journal of biomolecular structure & dynamics
Monophasic coamorphous sulpiride: a leap in physicochemical attributes and dual inhibition of GlyT1 and P-glycoprotein, supported by experimental and computational insights
Article
作者: Singh, Shashi Bala ; Khemchandani, Rahul ; Tomar, Devendra Singh ; Bazaz, Mohd Rabi ; Samanthula, Gananadhamu ; Pardhi, Ekta ; Mehra, Neelesh Kumar ; Dandekar, Manoj P
Study aimed to design and development of a supramolecular formulation of sulpiride (SUL) to enhance its solubility, dissolution and permeability by targeting a novel GlyT1 inhibition mechanism. SUL is commonly used to treat gastric and duodenal ulcers, migraine, anti-emetic, anti-depressive and anti-dyspeptic conditions. Additionally, Naringin (NARI) was incorporated as a co-former to enhance the drug's intestinal permeability by targeting P-glycoprotein (P-gp) efflux inhibition. NARI, a flavonoid has diverse biological activities, including anti-apoptotic, anti-oxidant, and anti-inflammatory properties. This study aims to design and develop a supramolecular formulation of SUL with NARI to enhance its solubility, dissolution, and permeability by targeting a novel GlyT1 inhibition mechanism, extensive experimental characterization was performed using solid-state experimental techniques in conjunction with a computational approach. This approach included quantum mechanics-based molecular dynamics (MD) simulation and density functional theory (DFT) studies to investigate intermolecular interactions, phase transformation and various electronic structure-based properties. The findings of the miscibility study, radial distribution function (RDF) analysis, quantitative simulations of hydrogen/π-π bond interactions and geometry optimization aided in comprehending the coamorphization aspects of SUL-NARI Supramolecular systems. Molecular docking and MD simulation were performed for detailed binding affinity assessment and target validation. The solubility, dissolution and ex-vivo permeability studies demonstrated significant improvements with 31.88-fold, 9.13-fold and 1.83-fold increments, respectively. Furthermore, biological assessments revealed superior neuroprotective effects in the SUL-NARI coamorphous system compared to pure SUL. In conclusion, this study highlights the advantages of a drug-nutraceutical supramolecular formulation for improving the solubility and permeability of SUL, targeting novel schizophrenia treatment approaches through combined computational and experimental analyses.Communicated by Ramaswamy H. Sarma.
2024-01-01Water science and technology : a journal of the International Association on Water Pollution Research
Effective removal of iron, nutrients, micropollutants, and faecal bacteria in constructed wetlands cotreating mine water and sewage treatment plant effluent
Article
作者: Acharya, Kishor ; Plaimart, Jidapa ; Mrozik, Wojciech ; Werner, David ; Davenport, Russell J ; Blackburn, Adrian
Abstract:
Regulators in England and Wales have set new targets under the Environment Act 2021 for freshwater quality by 2038 that include halving the length of rivers polluted by harmful metals from abandoned mines and reducing phosphorus loadings from treated wastewater by 80%. In this context, an intriguing win–win opportunity exists in the removal of iron from abandoned mines and phosphate from small sewage treatment plants by coprecipitation in constructed wetlands (CWs). We investigated such a CW located at Lamesley, Northeast England, which cotreats abandoned coal mine and secondary-treated sewage treatment plant effluents. We assessed the removal of nutrients, heavy metals, organic micropollutants, and faecal coliforms by the CW, and characterized changes in the water bacteriology comprehensively using environmental DNA. The CW effectively removed ammonium-nitrogen, phosphorus, iron, and faecal coliforms by an average of 86, 74, 98, and 75%, respectively, to levels below or insignificantly different from those in the receiving river. The CW also effectively removed micropollutants such as acetaminophen, caffeine, and sulpiride by 70–100%. Molecular microbiology methods showed successful conversion of sewage and mine water microbiomes into a freshwater microbiome. Overall, the CW significantly reduced impacts on the rural water environment with minimal operational requirements.
2024-01-01Journal of clinical pharmacology
P‐Glycoprotein‐Mediated Interaction Is a Risk Factor for QT Prolongation in Concomitant Use of Antipsychotics and SSRIs as P‐Glycoprotein‐Mediated Inhibitors: Analysis of the Japanese Adverse Drug Event Report Database
Article
作者: Kimura, Satsuki ; Morishita, Hiroki ; Yoshida, Hitoshi ; Ogihara, Takuo ; Sunakawa, Hiroki ; Perera, Liyanage Manosika Buddhini
Abstract:
The inhibition of human ether‐a‐go‐go‐related gene (hERG) channels is a known cause of QT prolongation triggered by antipsychotic drugs. Our previous studies suggest that P‐glycoprotein (P‐gp)‐mediated drug interactions may lead to increased gastrointestinal absorption of pimozide and its accumulation in cardiomyocytes, thereby enhancing the inhibitory effect of hERG channels. There is a paucity of epidemiological studies examining the risk of QT prolongation by antipsychotic drugs in terms of P‐gp‐mediated interactions with concomitant drugs. Therefore, using the Japanese Adverse Event Reporting Database, we investigated whether the risk of QT prolongation triggered by antipsychotic drugs associated with hERG inhibition is affected by the concomitant use of selective serotonin reuptake inhibitors (SSRIs) associated with P‐gp inhibition. The results showed that the frequency of QT prolongation increased when the antipsychotic drugs quetiapine and sulpiride, which are P‐gp substrates, were combined with SSRIs with P‐gp inhibition. In contrast, no association with QT prolongation was observed in patients on non‐P‐gp‐substrate antipsychotics, irrespective of the P‐gp inhibitory effect of the concomitant SSRI. These results suggest that P‐gp‐mediated interactions are a risk factor for antipsychotic‐induced QT prolongation. There is a need for further investigation into the risks of specific drug combinations.
100 项与 舒必利 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 抑郁症 | 日本 | 1979-08-03 | |
| 精神分裂症 | 日本 | 1979-08-03 | |
| 十二指肠溃疡 | 日本 | 1973-01-13 | |
| 胃溃疡 | 日本 | 1973-01-13 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | Sulpiride-treated group | 繭網餘膚積選鹹衊膚醖(艱鹹艱糧齋網築憲鏇選) = 廠壓簾壓糧網鹹繭構構 鹹鹹膚壓繭鹽鏇遞廠構 (構鹽蓋鹽憲餘餘膚艱壓 ) | - | 2020-09-12 | ||
Sulpiride | 繭網餘膚積選鹹衊膚醖(艱鹹艱糧齋網築憲鏇選) = 糧艱選築製夢鹹窪製艱 鹹鹹膚壓繭鹽鏇遞廠構 (構鹽蓋鹽憲餘餘膚艱壓 ) | ||||||
N/A | 糖尿病性视网膜病变 prolactin | - | 窪鬱網糧鑰遞範鏇選構(繭築鹹選積餘繭顧鹹齋) = reduced diabetes-induced retinal vasopermeability 醖齋襯顧窪衊餘願鹹鑰 (築衊築膚襯選夢鹹繭積 ) | - | 2020-06-01 | ||
Sulpiride | |||||||
N/A | - | 16 | Sulpiride 100 mg | 餘繭糧夢壓繭齋膚鹹衊(壓餘觸壓夢夢鏇壓鏇憲) = 醖廠衊鹽衊範構鹽鹽範 夢淵艱顧鹽蓋襯廠襯製 (構鹽餘鹽窪憲繭簾壓繭 ) 更多 | - | 2013-07-01 |
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