预约演示
更新于：2025-01-08
Sulpiride
舒必利
更新于：2025-01-08
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C15H23N3O4S |
InChIKeyBGRJTUBHPOOWDU-UHFFFAOYSA-N |
CAS号15676-16-1 |
关联
17
项与 舒必利 相关的临床试验NCT05208294
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement
ACTRN12620000075987
The role of dopamine: Investigating the impact of Sulpiride exposure on exercise-related enhancement of motor skill learning in healthy volunteers.
NCT04583111
The Effect of Antiemetics on Bowel Preparation Before Colonoscopy
100 项与 舒必利 相关的临床结果
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100 项与 舒必利 相关的转化医学
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100 项与 舒必利 相关的专利（医药）
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4,906
项与 舒必利 相关的文献（医药）2025-03-01BEHAVIOURAL BRAIN RESEARCH
Exploring the contribution of the dopaminergic and noradrenergic systems in the antidepressant-like action of 1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone in mice
Article
作者: Goulart, Taís Barcelos ; Zuge, Narryman Pinto ; da Rocha, Marcia Juciele ; Presa, Marcelo Heinemann ; Bortolatto, Cristiani Folharini ; Brüning, César Augusto ; Ledebuhr, Kauane Nayara Bahr ; Alves, Diego
1-(2-(4-(4-ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethanone (ETAP) is a novel hybrid compound containing 1,2,3-triazole and acetophenone. It exhibits antidepressant-like effects in male mice, linked to modulation of serotonergic receptors and monoamine oxidase A (MAO-A) inhibition. This study aimed to evaluate the involvement of the dopaminergic and noradrenergic systems, as well as MAO-B activity inhibition, in the antidepressant-like effect of ETAP in male mice, and to evaluate the antidepressant-like effect of ETAP in female mice. Male mice were treated with different dopaminergic and noradrenergic receptors antagonists 15 min before administering ETAP (1 mg/kg, intragastrically, i.g.). The tail suspension test (TST) was performed 30 minutes later. Different male mice were treated with ETAP (1 mg/kg, i.g.), and 30 minutes later, were euthanized to assess MAO-B activity in the prefrontal cortex and hippocampus. To evaluate the antidepressant-like of ETAP in female mice, ETAP (1 mg/kg, i.g.) was administered, followed by the TST and the forced swimming test (FST) 30 minutes later. The dopaminergic antagonists haloperidol (0.05 mg/kg, intraperitoneally, i.p.), SCH23390 (0.01 mg/kg, subcutaneously, s.c.), and sulpiride (50 mg/kg, i.p.), as well the noradrenergic antagonists prazosin (1 mg/kg, i.p.), yohimbine (1 mg/kg, i.p.), and propranolol (2 mg/kg, i.p.), prevented the antidepressant-like effect of ETAP in the TST. MAO-B activity was unaffected by ETAP in both the prefrontal cortex and hippocampus. ETAP (1 mg/kg, i.g.) induced a significant antidepressant-like effect in female mice in the TST and FST. These findings provide valuable insights into the antidepressant-like effect of ETAP, highlighting its potential for developing more effective depression treatments.
2025-02-01NEUROCHEMICAL RESEARCH
Cannabidiol Plays a Modulatory Function on the Methamphetamine-Induced Reward Through Hippocampal D2-Like Dopamine Receptors
Article
作者: Azizbeigi, Ronak ; Haghparast, Abbas ; Omidiani, Seyed Erfan ; Mohammadi, Mahsa
Methamphetamine (METH), a stimulant that is extremely addictive, directly affects the central nervous system. METH's abuse and consumption are directly linked to mental illnesses, psychosis, and behavioral and cognitive impairments. It may disrupt the reward system and dopaminergic transmission. METH's rewarding qualities are associated with a rise in dopamine. Additionally, cannabidiol (CBD), one of the primary cannabinoid components of the cannabis plant, significantly affects dopaminergic transmission and may aid in reward- and addiction-related behaviors. To shed light on the role of the D2-like dopamine receptor (D2R) in the hippocampal dentate gyrus (DG), the present study examined the effects of CBD on the acquisition and expression of the conditioned place preference (CPP) induced by METH. The function of D2R was ascertained by delivering Sulpiride microinjections, as a D2R antagonist Sulpiride (0.25, 1, and 4 μg/0.5 μL DMSO12%) into the DG. Moreover, an intracerebroventricular injection of CBD at a dose of 10 μg/5 μL for CPP acquisition and 50 μg/5 μL for CPP expression was given to rats. According to the current research, CBD dramatically reduced the acquisition and expression of CPP resulting from METH. However, Sulpiride suppressed the effect of CBD on METH-induced CPP acquisition and expression, with a greater impact on expression experiments. Ultimately, this study proposed that the expression experiment of METH-induced CPP appears to be heavily dependent on D2R in the DG.
2025-02-01BEHAVIOURAL PHARMACOLOGY
Role of D1- and D2-like dopamine receptors within the CA1 hippocampal region in the stress-induced antinociceptive response in the exposure to acute pain
Article
作者: Haghparast, Abbas ; Golmohammadi, Homayoon ; Seyedaghamiri, Fatemehsadat ; Shirmohammadi, Diba
Exposure to stressful conditions such as forced swim stress (FSS) induces antinociception. Previous reports determined that dopamine receptors in the CA1 hippocampal area are important in chronic pain processing. Considering that neural mechanisms behind acute and chronic pain differ significantly, in this study, we have investigated the role of dopamine receptors within the CA1 region in the FSS-induced antinociceptive response in the acute pain induced by the tail-flick test in the rat. The cannula was implanted unilaterally in the CA1 region of the animal brain. Animals received drugs or vehicles 5 min before FSS exposure. SCH23390 as the D1-like dopamine receptor (D1R) antagonist and Sulpiride as the D2-like dopamine receptor (D2R) antagonist were microinjected into the CA1 area at three doses (0.25, 1, and 4 μg/0.5 μl vehicle); the vehicle groups received saline instead of SCH23390 and dimethyl sulfoxide instead of Sulpiride. After exposure to FSS, the tail-flick test was done. The findings of this study revealed that FSS significantly attenuates nociceptive response during the tail-flick test (P < 0.0001). Moreover, intra-CA1 microinjection of SCH23390 and Sulpiride significantly reduces the FSS-induced antinociception in the inducing acute pain (P < 0.0001). The comparison of effective dose of 50% for D1R and D2R antagonists showed that both receptors in the CA1 almost equally reduce the FSS-induced antinociception in the tail-flick test. The result of this study supports the hypothesis, that the dopaminergic system in CA1 is involved in triggering a stress-induced antinociceptive response in acute pain conditions.
100 项与 舒必利 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 抑郁症 | 日本 | 1979-08-03 | |
| 精神分裂症 | 日本 | 1979-08-03 | |
| 十二指肠溃疡 | 日本 | 1973-01-13 | |
| 胃溃疡 | 日本 | 1973-01-13 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | Sulpiride-treated group | 鹽獵築選餘鏇繭憲壓齋(衊夢積淵廠繭蓋壓襯顧) = 醖構網餘窪餘鑰襯構衊 壓襯餘餘淵醖獵窪窪構 (製範簾醖壓餘顧鏇繭襯 ) | - | 2020-09-12 | ||
鹽獵築選餘鏇繭憲壓齋(衊夢積淵廠繭蓋壓襯顧) = 艱選艱顧憲獵齋繭網獵 壓襯餘餘淵醖獵窪窪構 (製範簾醖壓餘顧鏇繭襯 ) | |||||||
N/A | 糖尿病性视网膜病变 prolactin | - | 繭齋鑰觸願鏇網夢網糧(淵糧膚顧襯積遞鏇廠願) = reduced diabetes-induced retinal vasopermeability 衊醖構廠淵遞築壓餘顧 (鹹齋獵鑰範衊醖衊鏇獵 ) | - | 2020-06-01 | ||
(Control (non-diabetic)) | |||||||
N/A | - | 16 | 鬱鹽窪齋鏇醖鏇襯鏇製(襯齋襯鬱簾簾觸遞齋衊) = 範襯觸艱積構觸願鏇夢 鬱襯鹹襯鑰夢鏇簾憲遞 (顧膚鑰構糧簾壓艱衊簾 ) 更多 | - | 2013-07-01 |
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