奥谷胱甘肽(Oxiglutatione) - 在研适应症：缺氧，肝病，中毒_专利_临床

概要

基本信息

药物类型

小分子化药

别名

GSSG、Glutathione disulphide、Oxidized glutathione

+ [6]

靶点-

作用方式-

作用机制-

治疗领域

消化系统疾病其他疾病

在研适应症

缺氧肝病中毒+ [1]

非在研适应症-

原研机构

Takeda Pharmaceutical Co., Ltd.

在研机构

重庆药友制药有限责任公司Alcon Laboratories, Inc.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1991-10-04),

眼科外科手术

最高研发阶段(中国)批准上市

特殊审评-

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结构/序列

分子式C20H32N6O12S2

InChIKeyYPZRWBKMTBYPTK-BJDJZHNGSA-N

CAS号27025-41-8

关联

3

项与奥谷胱甘肽相关的临床试验

JPRN-UMIN000015962

/ CompletedN/AIIT

A study of the effectiveness and safety of pars plana vitrecotmy with subretinal oxiglutatione injection for the treatment of refractory macular edema - Subretinal oxiglutatione injection for the treatment of macular edema

开始日期2015-01-05

申办/合作机构-

JPRN-UMIN000016712

/ RecruitingN/AIIT

Evaluation of the efficacy of vitrectomy with Subretinal oxiglutatione intraocular irrigating solution injection for macula edema - Evaluation of the efficacy of vitrectomy with Subretinal oxiglutatione intraocular irrigating solution injection for macula edema

开始日期2014-03-01

申办/合作机构-

JPRN-UMIN000015296

/ RecruitingN/AIIT

Evaluation of the efficacy of vitrectomy with Subretinal oxiglutatione intraocular irrigating solution injection for subretinal hemorrhages - Vitrectomy with Subretinal oxiglutatione intraocular irrigating solution injection for subretinal hemorrhages

开始日期2014-03-01

申办/合作机构-

100 项与奥谷胱甘肽相关的临床结果

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100 项与奥谷胱甘肽相关的转化医学

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100 项与奥谷胱甘肽相关的专利（医药）

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17,603

项与奥谷胱甘肽相关的文献（医药）

2025-06-01·International Journal of Environmental Research

Screening for Heavy Metal-Resistant Clones in the Xero-Halophyte Atriplex halimus L.: A Prerequisite for Phytoremediation of Polymetallic Mining Pollution in Arid Areas

作者: Debez, Ahmed ; Dekaezmaeker, Paul ; Abdelly, Chedly ; Zaghdoudi, Rania ; Necib, Maher ; Zorrig, Walid ; Dailly, Helene ; Lutts, Stanley ; Sghayar, Souhir

Abstract: Atriplex halimus L. is a promising xero-halophyte species for phytoremediation purposes but displays high levels of genetic variability.As an attempt to select uniform material suitable for phytomanagement, five clones were established by cuttings from three non-polluted sites (Tunis, Nabeul and Sfax), one moderately Pb-polluted site (Sousse) and a highly polymetallic polluted mining site (Gafsa).Cuttings were cultivated during 90 days under controlled conditions on soil issued from the most polluted area.The clone from Gafsa accumulated higher concentrations of metals in roots (Cr) and leaves (Cd, Sr, Zn and Cu) than other clones.Gafsa showed the highest absorption efficiency, translocation factor, bioconcentration factor and bioaccumulation coefficient compared to other clones but displayed the lowest relative growth rate (RGR) value while the highest RGR was found in the clone from Sousse.Heavy metal tolerance in Gafsa was not related to a more efficient management of oxidative stress or higher concentration of phytochelatins.Total amount of Sr and Zn removed from the substrate was the highest for Sousse while removal of Cd, Cu, Cr and Ni was the highest for Gafsa.It is concluded that cuttings allow to obtain uniform material for phytoremediation by Atriplex halimus and that combining different clones with complementary properties is an attractive option for phytomanagement of polymetallic polluted soils by this species.

2025-06-01·Journal of Photochemistry and Photobiology A: Chemistry

Silver ions and bacteria as promoters of UV-A photocatalysis

作者: Tenkumo, Taichi ; Sasaki, Keiichi ; Ogawa, Toru ; Mokudai, Takayuki ; Yoda, Nobuhiro ; Iwabuchi, Taito

This study aimed to identify the ions used in disinfection treatments involving UV-A irradiation and to clarify the mechanism of free radical generation in three combinations of silver ions, Staphylococcus aureus, and UV-A irradiation, for applications in dental implants.Free radicals were analyzed 1 or 4 min after combining various ions (Na, Mg, Al, Ca, Fe, Cu, Zn, Ag, Pt, or Au) with S. aureus, followed by UV-A irradiationThe mechanism of free radical generation from the UV-A irradiation of a mixture of Ag and S. aureus was examined using ESR (ESR), NMR (NMR), X-ray diffraction, and GSH/GSSG ELISA assays.Free radicals were generated from combinations of Na, Mg, Al, Ca, Zn, and Ag ions under UV-A irradiation in bacterial suspensions, with Ag producing the highest yield among all ions.Addnl., the mixture of Fe ions and bacterial suspension generated DMPO-SG.The combination of Ag ions and UV-A irradiation in bacterial suspensions resulted in the production of hydroxyl radicals.Free radicals were also generated from all cellular fractions upon UV-A irradiation in the presence of silver, with a higher yield observed in lipopolysaccharide and peptidoglycan.The combination of silver ions and UV-A irradiation oxidized GSH to GSSG, producing thiol radicals.Silver ions in bacteria act as promoters of UV-A photocatalysis.

2025-05-01·Journal of Colloid and Interface Science

Hypoxia-Targeted-Therapy: Mussel-inspired hollow polydopamine nanocarrier containing MoS2 nanozyme and tirapazamine with anti-angiogenesis property for synergistic tumor therapy

Article

作者: Huang, Chih-Ching ; Wang, Chen-Yow ; Chang, Huan-Tsung ; Hsu, Shih-Hao ; Ciou, Sin-Yi ; Chang, Jia-Yaw ; Lee, Yu-Cheng ; Chen, Yi-Chia ; Demissie, Girum Getachew

Photothermal therapy (PTT) using thermal and tumor microenvironment-responsive reagents is promising for cancer treatment. This study demonstrates an effective PTT nanodrug consisting of hollow-structured, thermally sensitive polydopamine nanobowls (HPDA NB), molybdenum sulfide (MoS₂) nanozyme, and tirapazamine (TPZ; a hypoxia-responsive drug), with a structure of HPDA@TPZ/MoS NBs_, which is hereafter denoted as HPTZMoS NBs. With the Fenton-like activity, the HPTZMoS NBs in the presence of H₂O₂ catalyze the formation of hydroxyl radicals, providing chemodynamic therapy (CDT) effect and deactivating glutathione. Under acidic conditions, HPTZMoS NBs facilitate the release of sulfide ions (S^2-) and TPZ, providing a combination of chemotherapy (CT) and hydrogen sulfide (H₂S) gas therapy (GT). Under an 808-nm NIR laser irradiation, the HPTZMoS NBs efficiently convert photo energy to thermal energy, providing PTT and improved CDT, CT, and GT effects. Upon treatment with an NIR laser and H₂O₂, a synergistic effect leads to substantial tumor cell eradication. Additionally, HPTZMoS NBs disrupt vascular endothelial growth factor (VEGF-A₁₆₅)-induced cell migration in human umbilical vein endothelial cells through its strong interaction with VEGF-A₁₆₅. In vivo studies in 4T1-tumor-bearing mice confirm that HPTZMoS NBs induces significant tumor destruction through a combination of PTT, hyperthermia-induced CDT, GT, and CT pathways. This study presents a multifaceted, highly selective nanotherapy platform with potent anti-angiogenesis properties, holding significant promise for future clinical applications.

1

项与奥谷胱甘肽相关的新闻（医药）

2022-08-23

·药研

为药企的多肽药物立项作参考

作者｜大小姐整理｜药研鉴于多肽类药物的品种特性，引起越来越多的药企关注，本文检索、搜集了国内外的信息，汇总如下。且根据目前市场情况，笔者推荐品种是，阿托西班、布舍瑞林、西曲瑞克、利拉鲁肽、奥谷胱甘肽。备注：仅供参考，项目品种的立项涉及多方面的考虑。------------THE END------------点击查看：投稿获丰厚稿费关注药研一路同行药研论坛：始终以为药品研发一线人员提供高质量、高性价比培训为第一宗旨。自成立以来，累计举办近50期药品研发类、注册类研讨班。据统计，中国医药工业百强企业中超过85%参加过药研收费类培训。截至2021年底，包括上海强生、辉瑞、阿斯利康、山德士、日本大冢、大鹏、卫材、小林制药、扬子江、恒瑞、正大天晴、东阳光、科伦、中科院等在内的2000余家企事业单位参加过药研线下论坛，得到业界普遍认可与好评，已成为制药领域知名高端培训品牌！药研公众号：自2016年成立以来持续为业内提供药物研发、生产和注册相关信息，目前药品研发领域关注用户约10万人！制药企业和研发机构关注量4000家。药研学院：截至2021年底，已同众多企业合作近60期直播课，观看量突破40万+，药研直播课聚焦药品研发相关主题，平均观看人数行业领先。商务合作：15911172616

100 项与奥谷胱甘肽相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D00031	奥谷胱甘肽	V03AB	DB03310

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
缺氧	中国	重庆药友制药有限责任公司	1999-01-01
肝病	中国	重庆药友制药有限责任公司	1999-01-01
中毒	中国	重庆药友制药有限责任公司	1999-01-01
眼科外科手术	日本	Alcon Laboratories, Inc.	1991-10-04

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ARVO2023	N/A	-	-	Glutathione oxidized	顧艱醖製顧簾蓋夢積鹽(蓋繭積艱餘獵鹽製艱醖) = 觸簾壓夢憲襯繭艱淵鹽襯廠積鹽艱衊淵襯襯膚 (醖製鹽艱齋鏇襯廠構鏇 )	-	2023-06-01
				Raddeanin A	顧艱醖製顧簾蓋夢積鹽(蓋繭積艱餘獵鹽製艱醖) = 顧夢觸糧鏇廠鏇鬱願鹽襯廠積鹽艱衊淵襯襯膚 (醖製鹽艱齋鏇襯廠構鏇 )
ARVO2006	N/A	-	-	Ascorbic Acid (BSS Plus)	艱廠範鹽壓範觸觸襯艱(選衊構構憲壓壓艱鬱製) = 膚簾壓積淵齋壓鏇簾鑰膚憲淵壓餘築糧窪壓憲 (夢窪糧積選觸製憲憲鬱 )	-	2006-05-01
				BSS Plus and ascorbic acid solution	艱廠範鹽壓範觸觸襯艱(選衊構構憲壓壓艱鬱製) = 獵網選積襯願窪夢壓鹽膚憲淵壓餘築糧窪壓憲 (夢窪糧積選觸製憲憲鬱 )