更新于：2024-06-24
Calcium Chloride Hydrate
氯化钙
更新于：2024-06-24
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式CaCl2 |
InChIKeyUXVMQQNJUSDDNG-UHFFFAOYSA-L |
CAS号10043-52-4 |
关联
14
项与 氯化钙 相关的临床试验Post Operative Atrial Fibrillation: Alleviation by Calcium Chloride Injection Into Cardiac Ganglionic Plexus During Coronary Artery Bypass Grafting.
Effect of intravenous calcium chloride injection on the amplitude of transcranial motor evoked potential in spine surgery: a pilot study
Efficacy of intravenous calcium chloride plus oxytocin vs oxytocin alone for the prevention of blood loss during caesarean delivery: A randomized controlled trial. - NIL
100 项与 氯化钙 相关的临床结果
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100 项与 氯化钙 相关的转化医学
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100 项与 氯化钙 相关的专利（医药）
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1,881
项与 氯化钙 相关的文献（医药）2024-05-01Food chemistry
Effects of calcium chloride on the gelling and digestive characteristics of myofibrillar protein in Litopenaeus vannamei
Article
作者: Liu, Huilin ; Li, Na ; Li, Deyang ; Wang, Yefan ; Zhang, Kexin ; Fan, Xin ; Liu, Xiaoyang ; Tan, Zhifeng ; Zhou, Dayong
In this study, the effects of CaCl2 (0, 25, 50, 75, and 100 mM) on the gelling and digestive properties of the myofibrillar protein (MP) in Litopenaeus vannamei were investigated. The results showed that increasing CaCl2 concentration led to changes in the tertiary structure of MP. Specifically, compared with the control group, a 64.31 % increase in surface hydrophobicity and a 45.90 % decrease in the sulfhydryl group were observed after 100 mM CaCl2 treatment. Correspondingly, the water holding capacity and strength of the MP gel increased by 24.46 % and 55.99 %, respectively. These changes were positively correlated with the rheological properties, microstructure pore size, and content of non-flowable water. The mechanical properties of MP gel were improved, and the microstructure became more compact with the increase in CaCl2 concentration. Furthermore, the particle size of the digested MP gels decreased in the presence of CaCl2, which improved the digestion characteristics of MP gels.
Cell biochemistry and biophysics
Mitigation of the Deleterious Effect of Heavy Metals on the Conformational Stability of Ubiquitin through Osmoprotectants
Article
作者: Sharma, Pradakshina ; Farooqi, Humaira ; Alazoumi, Khadega Khamis Moh ; Islam, Asimul
The Ubiquitin-Proteasome System (UPS) is important in protein homeostasis and is involved in many cell processes. UPS's wide range of regulatory activities is based on the unique and diverse signals transmitted through all-encompassing processes. Cells need a fully functional UPP to cope with oxidative stress, so cellular redox status modulates ubiquitin activity. However, these protein quality control systems are compromised under adverse conditions such as heavy metal stress, resulting in pathological conditions. Heavy metals disrupt the physiological action of sensitive proteins by forming complexes with side-chain functional groups or by dislocating critical metal ions in metalloproteins. In addition, perturbation in the structure of Ubiquitin may affect the ubiquitin-proteasome pathway. In this study, it has been investigated the effects of heavy metals likewise chromium (Cr), cadmium (Cd), and mercury chloride (HgCl2) on the conformational stability of Ubiquitin as well as overcome their hazardous effect, the interaction of osmo-protectants such as Sesamol, gallic acid, Glycine, and ascorbic acid have also been explored in the study. The near and far UV-circular dichroism measurements deduced the secondary and tertiary structural changes. The size of the Ubiquitin before and after exposure to heavy metals was measured by DLS (dynamic light scattering). Docking research was also used to investigate the interaction of Ubiquitin with various heavy metals. Near and far UV-circular dichroism (CD) measurements revealed that mercury, chromium, and cadmium disrupt Ubiquitin's secondary and tertiary structure. The effect of chromium, even at low concentrations, was significantly deleterious compared to cadmium and mercury chloride. Ubiquitin's far-UV circular dichroism spectra subjected to heavy metals were recorded in several osmo-protectants, such as ascorbic acid, Glycine, gallic acid, and Sesamol, which offset the adverse effects of heavy metals. DLS studies revealed a noteworthy change in the hydrodynamic radius of Ubiquitin in the presence of heavy metals. Docking analysis revealed a significant binding affinity of mercury and cadmium ions with Ubiquitin. This study can infer the heavy metals' disruption of Ubiquitin's secondary and tertiary structure. Osmo-protectants produced by animal cells are more effective against heavy metals than plant antioxidants.
2024-03-01International journal of biological macromolecules
Fabrication of maleic anhydride-acrylamide copolymer based sodium alginate hydrogel for elimination of metals ions and dyes contaminants from polluted water
Article
作者: Ali, Tariq ; Cheng, Ye ; Orooji, Yasin ; Claudine, Umuhoza ; Raza, Saleem ; Zhang, Pengfei ; Bashir, Tariq ; Hayat, Asif ; Ghasali, Ehsan
The study explores the synergy of biobased polymers and hydrogels for water purification. Polymer nanomaterial's, synthesized by combining acrylamide copolymer with maleic anhydride, were integrated into sodium alginate biopolymer using an eco-friendly approach. Crosslinking agents, calcium chloride and glutaraladehyde, facilitated seamless integration, ensuring non-toxicity, high adsorption performance, and controlled capacity. This innovative combination presents a promising solution for clean and healthy water supplies, addressing the critical need for sustainable environmental practices in water purification. In addition, the polymer sodium alginate hydrogel (MAH@AA-P/SA/H) underwent characterization via the use of several analytical procedures, such as FTIR, XPS, SEM, EDX and XRD. Adsorption studies were conducted on metals and dyes in water, and pollutant removal methods were explored. We investigated several variables (such as pH, starting concentration, duration, and absorbent quantity) affect a material's capacity to be adsorbed. Moreover, the maximum adsorption towards Cu2+ is 754 mg/g while for Cr6+ metal ions are 738 mg/g, while the adsorption towards Congo Red and Methylene Blue dye are 685 mg/g and 653 mg/g correspondingly, within 240 min. Adsorption results were further analyzed using kinetic and isothermal models, which showed that MAH@AA-P/SA/H adsorption is governed by a chemisorption process. Hence, the polymer prepared from sodium alginate hydrogel (MAH@AA-P/SA/H) has remarkable properties as a versatile material for the significantly elimination of harmful contaminants from dirty water.
100 项与 氯化钙 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 低钙血症 | 日本 | 1991-07-31 | |
| 铅中毒 | 日本 | 1991-07-31 | |
| 骨软化 | 日本 | 1991-07-31 |
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临床结果
临床结果
适应症
分期
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临床3期 | 120 | (Calcium Chloride) | 簾廠顧範觸鏇網選構顧(網鏇鏇醖構蓋繭淵鏇壓) = 醖願淵構構餘鬱蓋積範 積積衊鑰範構願鬱製鑰 (鏇構衊願廠範糧鬱襯繭, 築鏇餘鹹鹹憲觸鏇蓋遞 ~ 鹹簾觸鬱繭遞艱窪築鬱) 更多 | - | 2024-06-11 | ||
Saline placebo (Saline Placebo) | 簾廠顧範觸鏇網選構顧(網鏇鏇醖構蓋繭淵鏇壓) = 獵襯蓋鬱窪製齋製鏇壓 積積衊鑰範構願鬱製鑰 (鏇構衊願廠範糧鬱襯繭, 醖餘衊築鏇遞鏇選糧選 ~ 餘築鏇糧鬱鏇鏇窪憲選) 更多 | ||||||
临床1/2期 | 40 | 廠廠獵範遞顧鬱顧齋蓋(鬱築繭膚齋糧築鑰襯遞) = Calcium recipients tolerated the drug infusion well, with no adverse events and an equal incidence of potential side effects in the calcium and placebo groups. 襯積鬱窪顧遞艱鑰餘範 (簾顧選淵蓋鏇醖憲繭衊 ) 更多 | 积极 | 2022-04-18 | |||
Saline placebo control | |||||||
临床2期 | 397 | (Calcium) | 積構繭鹽網蓋糧糧壓廠(艱膚鑰鑰鬱構蓋憲簾鬱) = 顧鏇衊觸窪衊簾淵製繭 網積襯齋憲觸艱窪願壓 (鬱壓觸淵顧願夢鏇選衊, 遞蓋鑰糧願鑰鹹醖憲淵 ~ 鏇遞糧獵窪夢餘鬱衊網) 更多 | - | 2022-02-25 | ||
(Placebo) | 積構繭鹽網蓋糧糧壓廠(艱膚鑰鑰鬱構蓋憲簾鬱) = 壓網蓋顧築鬱繭繭窪廠 網積襯齋憲觸艱窪願壓 (鬱壓觸淵顧願夢鏇選衊, 願廠襯鹹顧觸選獵夢製 ~ 選齋顧壓鑰顧鏇壓願獵) 更多 |
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