更新于：2024-06-19
Meglumine Antimoniate
锑酸葡甲胺
更新于：2024-06-19
概要
基本信息
结构
分子式C7H18NO8Sb |
InChIKeyJLGCKKAHTCRITP-SESJOKTNSA-O |
CAS号133-51-7 |
关联
42
项与 锑酸葡甲胺 相关的临床试验Comparison of efficacy of infrared heat therapy with cryotherapy as an adjunct to meglumine antimoniate in treatment of cutaneous leishmaniasis
Comparison of Efficacy of Intravenous Versus Intramuscular Injection Meglumine Antimoniate in patients of Cutaneous Leishmaniasis
Evaluating the effectiveness of intralesional injection of Glucantime® plus cotton boll extract compared to intralesional injection of Glucantime® plus cryotherapy in patients infected with Leishmania tropica
100 项与 锑酸葡甲胺 相关的临床结果
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100 项与 锑酸葡甲胺 相关的转化医学
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100 项与 锑酸葡甲胺 相关的专利（医药）
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1,300
项与 锑酸葡甲胺 相关的文献（医药）2024-03-01Travel medicine and infectious disease
Hypersensitivity eosinophilic myocarditis possibly triggered by meglumine antimoniate
Letter
作者: Medina-Lozano, Leidy J ; Herrera, Ana Catalina ; Galves, Oscar ; Vega Báez, Merardo Andrés ; Bolivar-Lozano, Sergio A ; Vargas-Hernández, Diego A ; Faccini-Martínez, Álvaro A
2024-01-10Antimicrobial agents and chemotherapy
Anti-
Leishmania
compounds can be screened using
Leishmania
spp. expressing red fluorescence (
tdTomato
)
Article
作者: Murta, Silvane Maria Fonseca ; Siqueira, Ezequias Pessoa de ; Oliveira, Edward ; Santi, Ana Maria Murta ; Morais-Teixeira, Eliane de ; Caldeira, Alisson Samuel Portes ; Cruz, Mariza Gabriela Faleiro de Moura Lodi ; Alves, Tânia Maria de Almeida
ABSTRACT:
The main challenges associated with leishmaniasis chemotherapy are drug toxicity, the possible emergence of resistant parasites, and a limited choice of therapeutic agents. Therefore, new drugs and assays to screen and detect novel active compounds against leishmaniasis are urgently needed. We thus validated
Leishmania braziliensis
(Lb) and
Leishmania infantum
(Li) that constitutively express the tandem tomato red fluorescent protein (
tdTomato
) as a model for large-scale screens of anti-
Leishmania
compounds. Confocal microscopy of
Lb
and
Li::tdTomato
revealed red fluorescence distributed throughout the entire parasite, including the flagellum, and flow cytometry confirmed that the parasites emitted intense fluorescence. We evaluated the infectivity of cloned promastigotes and amastigotes constitutively expressing
tdTomato
, their growth profiles in THP-1 macrophages, and susceptibility to trivalent antimony, amphotericin, and miltefosine
in vitro
. The phenotypes of mutant and wild-type parasites were similar, indicating that the constitutive expression of
tdTomato
did not interfere with the evaluated parameters. We applied our validated model to a repositioning strategy and assessed the susceptibility of the parasites to eight commercially available drugs. We also screened 32 natural plant and fungal extracts and 10 pure substances to reveal new active compounds. The infectivity and Glucantime treatment efficacy of BALB/c mice and golden hamsters infected with
Lb
and
Li::tdTomato
mutant lines, respectively, were very similar compared to animals infected with wild-type parasites. Standardizing our methodology would offer more rapid, less expensive, and easier assays to screen of compounds against
L. braziliensis
and
L. infantum in vitro
and
in vivo
. Our method could also enhance the discovery of active compounds for treating leishmaniasis.
2024-01-02Natural product research
Phytochemical study of
Seriphidium khorassanicum (
syn.
Artemisia khorassanica)
aerial parts: sesquiterpene lactones with anti-protozoal activity
Article
作者: Zolfaghari, Behzad ; Zulfiqar, Fazila ; Khan, Ikhlas A. ; Saberi, Sedigheh ; Abdeyazdan, Sara ; Fattahian, Maryam ; Ali, Zulfiqar ; Ghanadian, Mustafa
Two new eudesmane-type sesquiterpene lactones, 1β,3α,8α-trihydroxy-11β,13-dihydroeudesma-4(15)-en-12,6α-olide (1) and 1β,4α,8α-trihydroxy-11β,13-dihydroeudesma-12,6α-olide (2), and an unprecedented elemane-type sesquiterpene lactone, 1β,2β,8α-trihydroxy-11β,13-dihydroelema-12,6α-olide (3) along with a known eudesmanolide artapshin (4) were isolated from Seriphidium khorassanicum. Structures were elucidated by NMR, HR-ESI-MS, and ECD spectral data analysis. The anti-protozoal activity was evaluated against Leishmania major promastigotes and amastigote-infected macrophages. They showed dose- and time-dependent activity against L. major amastigotes with IC50 values in the range of 4.9 to 25.3 μM being favourably far below their toxicity against normal murine macrophages with CC50 values ranging from 432.5 to 620.7 μM after 48 h of treatment. Compound 3 exhibited the strongest activity and the highest selectivity index (SI) with IC50 of 4.9 ± 0.6 μM and SI of 88.2 comparable with the standard drug, meglumine antimoniate (Glucantime), with IC50 and SI values of 15.5 ± 2.1 μM and 40.0, respectively.
100 项与 锑酸葡甲胺 相关的药物交易
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 利什曼病 | - | - |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 6 | 襯願膚醖醖鏇遞齋積壓(鬱夢壓選壓夢積鑰積糧) = 積獵網鏇鹽網鏇衊鬱壓 網鬱餘製簾憲淵觸餘觸 (積醖壓獵窪獵鏇淵鹽艱 ) 更多 | 积极 | 2023-07-03 | |||
临床3期 | 180 | 醖積鑰觸衊選網網製淵(顧壓範蓋鑰餘繭壓顧鹹) = 遞艱膚鹹廠顧鹹簾糧廠 鏇淵築構壓蓋壓簾鑰選 (糧齋窪衊淵構繭壓網顧 ) | - | 2022-07-08 | |||
醖積鑰觸衊選網網製淵(顧壓範蓋鑰餘繭壓顧鹹) = 獵簾壓糧壓艱鬱廠憲壓 鏇淵築構壓蓋壓簾鑰選 (糧齋窪衊淵構繭壓網顧 ) | |||||||
N/A | - | 鬱齋廠鹹廠願鬱網範觸(獵鏇築繭範製範築遞膚) = 範選糧襯蓋襯鏇選製鹹 鑰積餘網製齋鏇鏇憲襯 (鏇齋製餘蓋築願選鬱願, 3.59 ~ 14.26) | - | 2017-04-01 | |||
鬱齋廠鹹廠願鬱網範觸(獵鏇築繭範製範築遞膚) = 醖願築醖膚簾鹽顧襯繭 鑰積餘網製齋鏇鏇憲襯 (鏇齋製餘蓋築願選鬱願, 14.48 ~ 29.58) |
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