Terpinen-4-ol(Terpinen-4-ol) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用方式-

作用机制-

治疗领域

感染眼部疾病皮肤和肌肉骨骼疾病+ [1]

在研适应症-

非在研适应症

睑缘炎蠕形螨感染未特指的睑结膜炎

原研机构

Tissue Technologies, Inc.

在研机构-

非在研机构

BioTissue Holdings, Inc.

权益机构-

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与 Terpinen-4-ol 相关的临床试验

ChiCTR1900025519

/ SuspendedN/AIIT

The efficacy of Terpinen-4-ol Eyelid Scrub Wipes and Okra Eyelid Patch in treating ocular demodex infestation

开始日期2019-09-16

申办/合作机构-

NCT01647217

/ Completed临床1期

Safety and Efficacy of Single-use Terpinen-4-ol Pads for Treating Ocular Mites A Randomized Clinical Trial

This is a randomized clinical trial to determine the safety and efficacy of terpinen-4-ol (T4O), the most active ingredient of tea tree oil (TTO), in eradicating ocular demodicosis (reducing ocular demodex counts and achieving the clinical improvement with minimal or no irritation).

开始日期2014-02-01

申办/合作机构

BioTissue Holdings, Inc.

[+1]

100 项与 Terpinen-4-ol 相关的临床结果

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100 项与 Terpinen-4-ol 相关的转化医学

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100 项与 Terpinen-4-ol 相关的专利（医药）

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395

项与 Terpinen-4-ol 相关的文献（医药）

2025-06-01·Current Computer-Aided Drug Design

In silico Study on Natural Chemical Compounds from Citric Essential Oils as Potential Inhibitors of an Omicron (BA.1) SARS-CoV-2 Mutants’ Spike Glycoprotein

Article

作者: Booth, Jordhan D. ; Cocroft, Trey M. ; Ovchynnykova, Olha ; Sukhyy, Kostyantyn M. ; Kapusta, Karina

Background:SARS-CoV-2's remarkable capacity for genetic mutation enables it to swiftly adapt to environmental changes, influencing critical attributes, such as antigenicity and transmissibility. Thus, multi-target inhibitors capable of effectively combating various viral mutants concurrently are of great interest.Objective:This study aimed to investigate natural compounds that could unitedly inhibit spike glycoproteins of various Omicron mutants. Implementation of various in silico approaches allows us to scan a library of compounds against a variety of mutants in order to find the ones that would inhibit the viral entry disregard of occurred mutations.Methods:An extensive analysis of relevant literature was conducted to compile a library of chemical compounds sourced from citrus essential oils. Ten homology models representing mutants of the Omicron variant were generated, including the latest 23F clade (EG.5.1), and the compound library was screened against them. Subsequently, employing comprehensive molecular docking and molecular dynamics simulations, we successfully identified promising compounds that exhibited sufficient binding efficacy towards the receptor binding domains (RBDs) of the mutant viral strains. The scoring of ligands was based on their average potency against all models generated herein, in addition to a reference Omicron RBD structure. Furthermore, the toxicity profile of the highest-scoring compounds was predicted.Results:Out of ten built homology models, seven were successfully validated and showed to be reliable for in silico studies. Three models of clades 22C, 22D, and 22E had major deviations in their secondary structure and needed further refinement. Notably, through a 100 nanosecond molecular dynamics simulation, terpinen-4-ol emerged as a potent inhibitor of the Omicron SARS-CoV-2 RBD from the 21K clade (BA.1); however, it did not show high stability in complexes with other mutants. This suggests the need for the utilization of a larger library of chemical compounds as potential inhibitors.Conclusion:The outcomes of this investigation hold significant potential for the utilization of a homology modeling approach for the prediction of RBD’s secondary structure based on its sequence when the 3D structure of a mutated protein is not available. This opens the opportunities for further advancing the drug discovery process, offering novel avenues for the development of multifunctional, non-toxic natural medications.

2025-05-01·Current Microbiology

Synergistic Antimicrobial Effects of Melaleuca alternifolia Essential Oil and Kojic Acid Combinations

Article

作者: Kırcı, Damla ; Demirci, Betül ; Demirci, Fatih ; Batur, Özge Özşen

Melaleuca alternifolia (tea tree) essential oil (TTO) is widely recognized for its anti-inflammatory and antimicrobial properties, attributed primarily to its major constituent, terpinen-4-ol. Kojic acid, a well-established compound used mainly in cosmetic formulations, exhibits potent antioxidant and broad-spectrum antimicrobial activities. In this study, the antimicrobial potential of commercial Pharmacopoeia-grade TTO was evaluated with kojic acid and terpinen-4-ol combinations. The quality of TTO was confirmed through GC-FID and GC/MS analyses, where terpinen-4-ol was the major component (44.4%). In vitro antimicrobial assays were performed against human pathogens including Candida utilis, Candida albicans, Candida krusei, Candida tropicalis, Candida parapsilosis, Escherichia coli, and Salmonella Typhimurium. Notably, all tested samples demonstrated activity against S. Typhimurium. Kojic acid combined with TTO showed a synergistic effect, with a fractional inhibitory concentration index (FICI) of 0.266, while the combination of kojic acid and terpinen-4-ol showed an even stronger synergistic effect (FICI: 0.039). The combination of TTO and terpinen-4-ol produced an additive effect (FICI: 0.508). To the best of our knowledge, this study is the first to demonstrate the combined effectiveness of TTO and kojic acid against S. Typhimurium. The synergistic activity observed with the combination of terpinen-4-ol and kojic acid highlights its potential as an antimicrobial for a therapeutic strategy, after safety evaluations.

2025-03-12·Journal of Agricultural and Food Chemistry

Functional Characterization of an Antenna-Biased Odorant Receptor AaOr96 Involved in Tea Tree Oil Repellency Against Aedes aegypti

Article

作者: Chen, Mengli ; Chen, Guoxing ; Chen, Peitong ; Yan, Ru ; Song, Tiefeng ; Tian, Chunxia ; Xu, Zhanyi ; Zhu, Guonian ; Qian, Jiali ; Jin, Yongfeng

Numerous essential oils have been well acknowledged as eco-friendly alternatives to combat insect pests due to synthetic insecticide-induced pest resistance and environment pollution. As a highly commercial essential oil, tea tree oil exhibits excellent insecticidal and repellent activities. However, the molecular mechanism of the olfactory system mediating the tea tree oil-induced repellency against insect pests remains unknown. In our study, mosquito was used as a suitable model to examine the molecular mechanism of tea tree oil-induced repellency against insect pests. The results showed that tea tree oil exhibited excellent spatial and oviposition repellency against Aedes aegypti adults and outstanding repellency against larvae, which were conferred by the main constituent terpinen-4-ol. The reduced repellency in the Orco^-/- mutant strain revealed that tea tree oil-induced repellency against mosquitoes was dependent on odorant receptor(s). Moreover, we identified one antenna-biased odorant receptor, AaOr96, that was involved in detecting constituents of tea tree oil to elicit repellency, and the predicted protein-ligand complex indicated that AaOr96 interacted with terpinen-4-ol via van der Waals forces from five key residues. Finally, knocking out AaOr96 resulted in a reduced spatial repellency against A. aegypti by tea tree oil and terpinen-4-ol, and a reduced oviposition repellency by terpinen-4-ol, but not by tea tree oil. Our study not only reveals that tea tree oil has great potential in pest management but also provides more insights into the molecular basis of repellency of essential oils.

100 项与 Terpinen-4-ol 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
未特指的睑结膜炎	临床1期	美国	BioTissue Holdings, Inc.	2014-02-28
睑缘炎	临床1期	美国	BioTissue Holdings, Inc.	2014-02-01
蠕形螨感染	临床1期	美国	BioTissue Holdings, Inc.	2014-02-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01647217 (DBTS, CTgov)	临床1期	蠕形螨感染 \| 睑缘炎	17	Terpinen-4-ol (Terpinen-4-ol Treatment Arm)	獵網襯鑰製襯憲衊鏇積(糧鏇積蓋廠獵網鑰糧夢) = 醖製蓋鬱遞觸醖夢壓廠壓願醖獵膚網蓋鏇選網 (夢襯齋壓鹽憲繭鏇艱齋, 鏇壓窪遞衊築選蓋願蓋 ~ 願願鹹壓築糧構鑰積鏇) 更多	-	2017-07-26
NCT01647217 (DBTS, CTgov)	临床1期	蠕形螨感染 \| 睑缘炎	17	Placebo (Placepo Pads Contol Arm)	獵網襯鑰製襯憲衊鏇積(糧鏇積蓋廠獵網鑰糧夢) = 鏇淵膚窪夢齋鬱顧糧壓壓願醖獵膚網蓋鏇選網 (夢襯齋壓鹽憲繭鏇艱齋, 遞鏇糧鹽鹽構襯窪網糧 ~ 衊壓製蓋願積艱壓鏇鏇) 更多	-	2017-07-26
UEGW2015	N/A	结直肠癌	-	Terpinen-4-ol	衊構夢簾蓋夢鹽願獵簾(鹹衊鏇鹽獵夢襯醖鬱膚) = 鹽襯繭網襯廠艱鹹夢選淵醖築襯夢顧簾鹽餘襯 (膚願選繭襯夢願製窪蓋 )	积极	2015-10-01