Estimation of dietary fatty acid profile and effect of cooking oils high in linoleic acid (n-6 PUFA) compared with traditional MUFA-rich oils on glycemic, lipid and inflammatory markers in overweight and obese adults-A randomized controlled trial

开始日期2020-11-16

申办/合作机构

Indian Council of Medical Research

TCTR20200826001 / Completed临床3期

A CREAM CONTAINING LINOLEIC ACID, 5%DEXPANTHENOL AND CERAMIDE IN THE TREATMENT OF ATOPIC DERMATITIS

开始日期2019-01-23

申办/合作机构-

ChiCTR1800016571 / SuspendedIIT

Clinical Efficacy and Safety of Conjugated Linoleic Acid Capsules for Abdominal Obesity

开始日期2018-07-09

申办/合作机构-

100 项与 Conjugated linoleic acid 相关的临床结果

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100 项与 Conjugated linoleic acid 相关的转化医学

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100 项与 Conjugated linoleic acid 相关的专利（医药）

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13,381

项与 Conjugated linoleic acid 相关的文献（医药）

2024-12-31·Cancer Biology & Therapy

Linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cells and a transgenic model of endometrial cancer

Article

作者: Zhao, Ziyi ; Zhou, Chunxiao ; Zhang, Xin ; Sun, Wenchuan ; Suo, Hongyan ; Hawkins, Gabrielle M ; Paraghamian, Sarah E ; Bae-Jump, Victoria ; Qiu, Jianqing ; Shen, Xiaochang ; Deng, Beor ; Hao, Tianran

Emerging evidence has provided considerable insights into the integral function of reprogramming fatty acid metabolism in the carcinogenesis and progression of endometrial cancer. Linoleic acid, an essential fatty acid with the highest consumption in the Western diet regimen, has shown pro-tumorigenic or anti-tumorigenic effects on tumor cell growth and invasion in multiple types of cancer. However, the biological role of linoleic acid in endometrial cancer remains unclear. In the present study, we aimed to investigate the functional impact of linoleic acid on cell proliferation, invasion, and tumor growth in endometrial cancer cells and in a transgenic mouse model of endometrial cancer. The results showed that Linoleic acid significantly inhibited the proliferation of endometrial cancer cells in a dose-dependent manner. The treatment of HEC-1A and KLE cells with linoleic acid effectively increased intracellular reactive oxygen species (ROS) production, decreased mitochondrial membrane potential, caused cell cycle G1 arrest, and induced intrinsic and extrinsic apoptosis pathways. The anti-invasive ability of linoleic acid was found to be associated with the epithelial-mesenchymal transition process in both cell lines, including the decreased expression of N-cadherin, snail, and vimentin. Furthermore, treatment of Lkb1^fl/flp53^fl/fl transgenic mice with linoleic acid for four weeks significantly reduced the growth of endometrial tumors and decreased the expression of VEGF, vimentin, Ki67, and cyclin D1 in tumor tissues. Our findings demonstrate that linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cell lines and the Lkb1^fl/flp53^fl/fl mouse model of endometrial cancer, thus providing a pre-clinical basis for future dietary interventions with linoleic acid in endometrial cancer.

2024-12-01·Applied Microbiology and Biotechnology

Long chain capsaicin analogues synthetized by CALB-CLEAs show cytotoxicity on glioblastoma cell lines

Article

作者: Diaz-Vidal, Tania ; Rosales-Rivera, Luis Carlos ; Mateos-Díaz, Juan Carlos ; Gutiérrez-Mercado, Yanet K ; Martínez-Pérez, Raúl Balam ; Armenta-Pérez, Vicente Paúl ; Basulto-Padilla, Georgina Cristina ; Rodríguez, Jorge A ; Canales-Aguirre, Alejandro A

AbstractGlioblastoma is one of the most lethal tumors, displaying striking cellular heterogeneity and drug resistance. The prognosis of patients suffering from glioblastoma after 5 years is only 5%. In the present work, capsaicin analogues bearing modifications on the acyl chain with long-chain fatty acids showed promising anti-tumoral activity by its cytotoxicity on U-87 and U-138 glioblastoma multiforme cells. The capsaicin analogues were enzymatically synthetized with cross-linked enzyme aggregates of lipase B from Candida antarctica (CALB). The catalytic performance of recombinant CALB-CLEAs was compared to their immobilized form on a hydrophobic support. After 72 h of reaction, the synthesis of capsaicin analogues from linoleic acid, docosahexaenoic acid, and punicic acid achieved a maximum conversion of 69.7, 8.3 and 30.3% with CALB-CLEAs, respectively. Similar values were obtained with commercial CALB, with conversion yields of 58.3, 24.2 and 22% for capsaicin analogues from linoleic acid, DHA and punicic acid, respectively. Olvanil and dohevanil had a significant cytotoxic effect on both U-87 and U-138 glioblastoma cells. Irrespective of the immobilization form, CALB is an efficient biocatalyst for the synthesis of anti-tumoral capsaicin derivatives.Key points• This is the first report concerning the enzymatic synthesis of capsaicin analogues from docosahexaenoic acid and punicic acid with CALB-CLEAs.• The viability U-87 and U-138 glioblastoma cells was significantly affected after incubation with olvanil and dohevanil.• Capsaicin analogues from fatty acids obtained by CALB-CLEAs are promising candidates for therapeutic use as cytotoxic agents in glioblastoma cancer cells.

2024-11-01·Journal of Clinical and Experimental Hepatology

Conjugated Linoleic Acid-induced Hepatotoxicity Requiring Liver Transplant

Article

作者: Gross, Aliza S. ; Saffran, Nathaniel L. ; Yu, Allen T.

Acute liver failure (ALF) typically presents with encephalopathy and impairment in the synthetic function of the liver. Weight loss supplements have been associated with ALF, and their use has only been increasing in the United States. We report a case of a 42-year-old woman with a history of Gilbert's syndrome who presented to the hospital with ALF secondary to weight loss supplements, who ultimately required liver transplantation. This is the first known case of conjugated linoleic acid (CLA) toxicity requiring liver transplantation in the United States.

项与 Conjugated linoleic acid 相关的新闻（医药）

2023-06-28

·PRNewswire

NUTRITION 2023 FEATURES LEADING NUTRITION EXPERTS AND GROUNDBREAKING RESEARCH

Get your press pass now to hear nutrition news from top experts in the field BETHESDA, Md., June 27, 2023 /PRNewswire/ -- Join us at NUTRITION 2023 for an exciting lineup of scientific symposia, educational sessions, hot-topic discussions, and award lectures covering the latest developments in nutrition science. NUTRITION 2023, the annual flagship meeting of the American Society for Nutrition (ASN), will be held July 22-25 at the Sheraton Boston. Explore the meeting schedule and register for a press pass to attend. The meeting will feature distinguished leaders in the field and important discussions that are helping to move nutrition science forward. Highlights include: Ultra-processed foods - Observational studies have linked consumption of ultra-processed foods (UPFs) with an increased risk of obesity and chronic diseases, yet the mechanisms behind these associations are unknown and there is little evidence from clinical trials. Nevertheless, the World Health Organization and multiple countries discourage consumption of UPFs. Limiting UPFs runs the risk of not meeting intake needs of key nutrients and, thus, reducing diet quality as well as an increased risk of food poisoning and food waste. In the U.S., a review of the evidence has been recommended for the 2025 Dietary Guidelines Advisory Committee. This session will review research from a food science perspective and examine the potential mechanisms of action of UPFs. A research roadmap will be presented to establish a stronger, more balanced evidence base to advance the understanding of if and how UPFs impact the risk of obesity and cardiometabolic diseases. (10-11:30 a.m. ET, Sunday, July 23, more information) Heart health - Linoleic acid is a polyunsaturated omega-6 fatty acid found in vegetable oils, nuts, seeds, meats, and eggs. There is confusion among the public concerning the effects of linoleic acid on health and recommendations on whether and how to include it in a healthful diet. During the NUTRITION 2023 opening session and presidential symposium "Food as Medicine: New Findings to Explain Reduced Risk of Cardiovascular Disease by Dietary Linoleic Acid," top researchers will present and discuss the latest clinical findings and new basic biology insights into how this dietary oil benefits the heart. (4:30-6 p.m. ET, Saturday, July 22, more information) Weight loss - Can scientists with opposing views work together to figure out why lost pounds are often gained back? The existence and clinical relevance of metabolic adaptation -- a physiological phenomenon that might make it hard to keep weight off -- remains one of the most controversial issues in nutrition science. The session "Metabolic Adaptation and Increased Drive to Eat as Drivers of Weight Regain in Individuals with Obesity. Myth or Reality? An Exercise in Adversarial Collaboration" will introduce collaborators with differing views who have agreed to work together to untangle the controversy. Catia Martins, PhD, RD, from The University of Alabama at Birmingham, and Jonathan Krakoff, MD, from NIDDK-Phoenix, Arizona, will present what is known about metabolic adaptation, their opposing views, and a research plan to advance the science. (10-11:30 a.m. ET, Tuesday, July 25, more information) Food and society - Patrick Stover, PhD, will give the 2023 W.O. Atwater Memorial Lecture "Enhancing the Purpose of Food," which will focus on agriculture, food, and nutrition as a solution to challenges facing society. Stoveris vice chancellor and dean of agriculture and life science and director of the Institute for Advancing Health through Agriculture at Texas A&M College Station. He is an international leader in biochemistry, agriculture, and nutrition. (2-3 p.m. ET, Sunday, July 23, more information) To apply for a press pass to attend NUTRITION 2023 in Boston, check our Media Policies and submit a Press Registration Form. Qualifying journalists will receive: A press badge granting entry to all in-person meeting sessions in Boston Early access to embargoed materials featuring high-impact research Personal introductions for one-on-one interviews with featured scientists Can't join us in person? With a press pass, you can still be part of the action with access to embargoed press materials before the meeting. Stay in the know by joining the discussion and getting the latest nutrition news: Subscribe to email updates geared for journalists Visit the NUTRITION 2023 Virtual Newsroom Follow #Nutrition2023on Facebook, Twitter, and Instagram About the American Society for Nutrition (ASN) ASN is the preeminent professional organization for nutrition scientists and clinicians around the world. Founded in 1928, the society brings together the top nutrition researchers, medical practitioners, policy makers and industry leaders to advance our knowledge and application of nutrition. ASN publishes four peer-reviewed journals and provides education and professional development opportunities to advance nutrition research, practice, and education. Since 2018, the American Society of Nutrition has presented NUTRITION, the leading global annual meeting for nutrition professionals. Provided by Newswise, online resource for knowledge-based news at Media Contacts: Nancy Lamontagne Media Liaison (919) 617-1330 (mobile) [email protected] SOURCE American Society for Nutrition (ASN)

2023-06-21

·Science Daily

Omega-3 fatty acids linked to slower decline in ALS

People with amyotrophic lateral sclerosis (ALS) who eat more foods high in certain omega-3 fatty acids like flaxseed oil, walnuts, canola oil and pumpkin seeds may have a slower physical decline from the disease and may have a slightly extended survival. Researchers also found an omega-6 fatty acid may be beneficial. The study does not prove that these omega fatty acids slow decline of ALS or extend survival; it only shows an association. People with amyotrophic lateral sclerosis (ALS) who eat more foods high in certain omega-3 fatty acids like flaxseed oil, walnuts, canola oil and pumpkin seeds may have a slower physical decline from the disease and may have a slightly extended survival. The study, which looked at the survival of people with ALS over the course of 18 months, was published in the June 21, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. Researchers also found an omega-6 fatty acid may be beneficial. The study does not prove that these omega fatty acids slow decline of ALS or extend survival; it only shows an association. ALS is a rare, progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. People with ALS lose the ability to initiate and control muscle movement, which often leads to total paralysis and death. The average life span after diagnosis is two to five years. "The link our study found between diet and ALS is intriguing and suggests, but does not prove, that people with ALS may benefit from incorporating more omega-3 fatty acids into their diet," said Kjetil Bjornevik, MD, PhD, of Harvard University in Boston, Massachusetts, and member of the American Academy of Neurology. "It will now be important to conduct additional research looking specifically at the plant-based omega-3 fatty acid alpha-linolenic acid in people with ALS to further explore this possibility." The study involved 449 people who had ALS with an average age of 58, who were followed over 18 months. Of the total participants, 126 or 28%, died by the end of the study. Researchers looked at levels of omega-3 fatty acids in participants' blood. They divided them into four groups based on lowest to highest amounts. Participants took a test to assess their disease progression and severity of symptoms. The test measured 12 aspects of physical function including swallowing, speaking, chewing, and the ability to use muscles in the hands, arms, legs and torso, as well as respiratory function. Each category was scored from zero, meaning no ability, to four, meaning normal ability. Total scores ranged between zero to 48, with higher scores indicating better function and less severe symptoms. Researchers found an omega-3 fatty acid called alpha-linolenic acid was the most beneficial. This acid is found in many seeds and oils, including flaxseed, walnuts, chia, hemp, and many common vegetable oils. The people with the highest amount of alpha-linolenic acid had an average score of 38.3 at the start of the study, while the people with the lowest amount had an average score of 37.6. A lower number of people from the group with the most alpha-linolenic acid died during the study, with 21 deaths, or 19%, compared to people in the lowest group, with 37 deaths or 33%. After adjusting for age, sex and ethnicity, people with the highest amounts of alpha-linolenic acid had a 50% lower risk of death during the study compared to people with the lowest amount. Higher levels of a specific omega-3 fatty acid called eicosapentaenoic acid that is found in fatty fish and fish oil supplements was also associated with a lower risk of death during the study. In addition, researchers found an omega-6 fatty acid called linoleic acid that is found in vegetable oils, nuts, meats, seeds and eggs was associated with a lower risk of death during the study. A limitation of the study is the lack of access to data on the overall diet of the participants, including other nutrients and supplements as well as total caloric intake, which could all be associated with survival time in ALS. The study was supported by the ALS Association.

临床结果

2022-11-23

·World Pharma News

Pocket feature shared by deadly coronaviruses could lead to pan-coronavirus antiviral treatment

Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery, until now. Researchers of the University of Bristol-led study, published in Science Advances today, say their findings could lead to the development of a pan-coronavirus treatment to defeat all coronaviruses - from the 2002 SARS-CoV outbreak to Omicron, the current variant of SARS-CoV-2, as well as dangerous variants that may emerge in future. In this new study, an international team, led by Bristols Professor Christiane Schaffitzel, scrutinised the spike glycoproteins decorating all coronaviruses. They reveal that a tailor-made pocket feature in the SARS-CoV-2 spike protein, first discovered in 2020, is present in all deadly coronaviruses, including MERS and Omicron. In striking contrast, the pocket feature is not present in coronaviruses which cause mild infection with cold-like symptoms. The team say their findings suggest that the pocket, which binds a small molecule, linoleic acid - an essential fatty acid indispensable for many cellular functions including inflammation and maintaining cell membranes in the lungs so that we can breathe properly - could now be exploited to treat all deadly coronaviruses, at the same time rendering them vulnerable to a linoleic acid-based treatment targeting this pocket. COVID-19, caused by SARS-CoV-2, is the third deadliest coronavirus outbreak following SARS-CoV in 2002 and MERS-CoV in 2012. The much more infectious SARS-CoV-2 continues to infect people and damage communities and economies worldwide, with new variants of concern emerging successively, and Omicron evading vaccination and immune response. Professor Schaffitzel from Bristols School of Biochemistry, explained: In our earlier work we identified the presence of a small molecule, linoleic acid, buried in a tailor-made pocket within the SARS-Cov-2 glycoprotein, known as the Spike protein, which binds to the human cell surface, allowing the virus to penetrate the cells and start replicating, causing widespread damage. "We showed that binding linoleic acid in the pocket could stop virus infectivity, suggesting an anti-viral treatment. This was in the original Wuhan strain that started the pandemic. Since then, a whole range of dangerous SARS-CoV-2 variants have emerged, including Omicron, the currently dominating variant of concern. We scrutinised every new variant of concern and asked whether the pocket function is still present." Omicron has undergone many mutations, enabling it to escape immune protection offered by vaccination or antibody treatments that lag behind this rapidly evolving virus. Intriguingly, while everything else may have changed, the researchers found that the pocket remained virtually unaltered, also in Omicron. Christine Toelzer, Research Associate in the School of Biochemistry and lead author of the study, added: "When we realised that the pocket we had discovered remained unchanged, we looked back and asked whether SARS-CoV and MERS-CoV, two other deadly coronaviruses causing previous outbreaks years ago, also contained this linoleic acid binding pocket feature." The team applied high-resolution electron cryo-microscopy, cutting-edge computational approaches and cloud computing. Their results showed that SARS-CoV and MERS-CoV also had the pocket, and could bind the ligand, linoleic acid, by a virtually identical mechanism. Professor Schaffitzel concluded: "In our current study, we provide evidence that the pocket remained the same in all deadly coronaviruses, from the first SARS-CoV outbreak 20 years ago to Omicron today. We have shown previously that linoleic acid binding to this pocket induces a locked spike, abrogating viral infectivity. We also show now that linoleic acid supplementation suppresses virus replication inside cells. We anticipate that future variants will also contain the pocket, which we can exploit to defeat the virus." Halo Therapeutics, a recent University of Bristol spin-out Professor Schaffitzel co-founded, is using these findings to develop pocket-binding pan-coronavirus antivirals. The team included experts from the Bristol UNCOVER Group, Max Planck Bristol Centre for Minimal Biology, Bristol University spin-out Halo Therapeutics Ltd, and collaborators in Sweden and France. The studies have been supported by funds from Max Planck Gesellschaft, Wellcome Trust and European Research Council, with additional support from Oracle for Research for high-performance cloud computing resources. Christine Toelzer, Kapil Gupta, Sathish KN Yadav, Lorna Hodgson, Maia Kavanagh Williamson, Dora Buzas, Ufuk Borucu, Kyle Powers, Richard Stenner, Kate Vasileiou, Frederic Garzoni, Daniel Fitzgerald, Christine Payr, Gunjan Gautam, Grard Lambeau, Andrew D Davidson, Paul Verkade, Martin Frank, Imre Berger, Christiane Schaffitzel. The free fatty acid-binding pocket is a conserved hallmark in pathogenic -coronavirus spike proteins from SARS-CoV to Omicron. Science Advances, 2022. doi: 10.1126/sciadv.adc9179

100 项与 Conjugated linoleic acid 相关的药物交易

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


Pubmed \| Eur J Nutr	N/A	营养和代谢疾病	-	Conjugated linoleic acid (CLA)	餘遞獵選鏇淵簾觸獵齋(構夢構糧獵鹹鹹憲範觸) = 鏇鬱築淵齋蓋醖獵襯鏇膚憲艱艱醖顧獵衊鹽範 (鏇壓製廠糧範醖糧願艱, -1.79 ~ -0.86) 更多	不佳	2012-03-01
NCT00204932 (Pubmed \| Am J Clin Nutr)	临床2期	肥胖	23	CLA supplementation	網淵鬱鬱鹹齋艱壓蓋簾(艱繭獵願餘顧構築選獵) = 獵糧醖築餘觸憲網願製餘夢壓齋餘齋簾範鹹齋 (範遞糧憲齋壓鏇鏇獵夢 ) 更多	-	2007-09-01
				Conjugated linoleic acid (Placebo)	製窪襯鹹糧製壓選醖選(鹹鹽願鹹艱艱艱糧襯窪) = 網選廠範鑰鏇窪襯鏇願艱範憲蓋顧顧鏇膚壓齋 (築鬱鏇淵網構構繭醖夢 ) 更多
Pubmed \| J Nutr	N/A	肥胖	-	Conjugated Linoleic Acid	(鏇膚積遞窪窪衊選壓積) = 鹹繭築憲窪繭艱膚鑰鹹鹽觸積範窪醖糧膚糧艱 (製齋廠艱願構衊鬱製觸 )	-	2007-05-01
Pubmed \| Int J Obes (Lond)	N/A	-	-	Conjugated linoleic acid (CLA)	鬱製夢築衊糧網積鬱獵(簾製鹽鏇廠鑰糧衊製範): P-Value = 0.04	积极	2001-08-01
				Conjugated linoleic acid (CLA) (Placebo)