更新于：2024-12-09
Methimazole
甲巯咪唑
更新于：2024-12-09
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1950-06-21), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C4H6N2S |
InChIKeyPMRYVIKBURPHAH-UHFFFAOYSA-N |
CAS号60-56-0 |
关联
49
项与 甲巯咪唑 相关的临床试验Pilot study of berberine combined with methimazole in the treatment of newly diagnosed Graves' disease
甲巯咪唑片在健康人群中的生物等效性试验
甲巯咪唑片人体生物等效性试验
100 项与 甲巯咪唑 相关的临床结果
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100 项与 甲巯咪唑 相关的转化医学
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100 项与 甲巯咪唑 相关的专利（医药）
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4,796
项与 甲巯咪唑 相关的文献（医药）2025-02-01JOURNAL OF ETHNOPHARMACOLOGY
Clinical efficacy of Chinese herbal medicine formula for Graves’ hyperthyroidism: A multicentre, randomized, double-blind, placebo-controlled clinical trial
Article
作者: Wang, Ying-na ; Chen, Ru-yu ; Wang, Zhi-Min ; Liu, Xin-Hui ; Chen, Si-wei ; Gao, Tian-shu ; Yang, Xiao ; Qiu, Zi-Yang ; Yan, Ruo-Xuan ; Lai, Yi-Wen ; Liu, Qing-yang ; Ma, Li ; Yan, Ruo-xuan ; Tong, Yu ; Chen, Ru-Yu ; Wang, Ying-Na ; Liu, Xin-hui ; Liu, Xiao-Wei ; Liu, Jia-hui ; Zhang, Feng-nuan ; Dai, Hong ; Lu, Hao ; Peng, Ze-Dong ; Gan, Di ; Yu, Shan-shan ; Chen, Xue-Ying ; Chen, Xue-ying ; Zhang, Feng-Nuan ; Liu, Qing-Yang ; Yu, Shan-Shan ; Chen, Si-Wei ; Peng, Ze-dong ; Qiu, Zi-yang ; Liu, Jia-Hui ; Shen, Qing ; Wang, Zhi-min ; Liu, Xiao-wei ; Lai, Yi-wen ; Gao, Tian-Shu ; Wang, Chen
ETHNOPHARMACOLOGICAL RELEVANCE:
According to the theory of traditional Chinese medicine, Graves' disease (GD) is called 'Ying Bing', which is a kind of goiter. Haizao Yuhu decoction, originated from the medical book of the Ming Dynasty 'Waikezhengzong', is a classic Chinese herbal formula for the treatment of 'Ying Bing' for more than 400 years. Pingkang granules, modified from the Chinese herbal formula Haizao Yuhu decoction specialized in GD, has shown effectiveness in several single-centre studies. However, high-quality clinical evidence for the management of GD using Pingkang granules remains insufficient.
AIM OF THE STUDY:
To obtain high-quality medical evidence for the treatment of GD with Pingkang granules through randomized controlled clinical trial.
MATERIALS AND METHODS:
A multicentre, randomized, double-blinded, placebo-controlled clinical trial was designed. A total of 186 patients with Graves' hyperthyroidism from five medical centers were randomly assigned to receive methimazole [MMI] and Pingkang granules placebo (group A), MMI and Pingkang granules (group B), or MMI placebo and Pingkang granules (group C) in a 1:1:1 ratio for 12 weeks. The primary clinical outcomes were serum free triiodothyronine (FT3) and free thyroxine (FT4) levels from baseline until the end of the research. Secondary clinical outcomes included serum thyrotrophin receptor antibody (TRAb) levels at 4- and 12-weeks post-intervention, thyroid volume, peak systolic velocity of the superior thyroid artery (STA-PSV), 39-item version of Thyroid-Related Patient-Reported Outcome (ThyPRO39) scores, and safety assessment included blood routine, liver and kidney function tests from baseline to the endpoint.
RESULTS:
150 patients were included in the full analysis set for efficacy analysis, including 48, 50, and 52 in groups A, B, and C, respectively. At the endpoint, three regimens significantly reduced serum FT3 levels (group A, p=0.0027; group B, p < 0.0001; group C, p=0.0028) and FT4 levels (group A, p < 0.0001; group B, p < 0.0001; group C, p < 0.0001), and the combination of MMI and Pingkang granules markedly reduced serum TRAb levels (p = 0.0014). The thyroid volume in group A was significantly larger than that at baseline at week 12 (p=0.0370), and there were no statistically significant differences in the thyroid volume among groups at week 4 (p=0.7485) and 12 (p=0.1333). STA-PSV values in group B were significantly higher than those in group A at week 4 (p=0.0409). The STA-PSV levels in groups A (p < 0.0001) and C (p=0.0025) were significantly lower than those at baseline at week 4, and STA-PSV levels in all groups were significantly lower than those at baseline at week 12 (group A, p=0.0095; group B, p=0.0138; group C, p=0.0423). Pingkang granule monotherapy significantly ameliorated symptoms related to hyperthyroidism (p < 0.0001), eye (p=0.0490), tiredness (p < 0.0001), cognition (p < 0.0001), depression (p=0.0478), and susceptibility (p=0.0052). No severe adverse events were reported in either group or three regimens showed similar safety.
CONCLUSIONS:
Pingkang granules significantly reduced serum FT3, FT4 and STA-PSV levels, improved ThyPRO39 scores, and lowered serum TRAb levels when combined with MMI in patients with Grave's hyperthyroidism.
2025-01-01GENERAL AND COMPARATIVE ENDOCRINOLOGY
Thyroid hormones activate TH/E2 receptor/regulator system and drive Na+/K+-ATPase in the ovarian wall of hypothyroid air-breathing fish (Anabas testudineus Bloch)
Article
作者: Viswanath, Meenu ; Peter, M C Subhash ; Peter, M.C.Subhash
In fish, as in other vertebrates, thyroid hormones (THs) act on many biological processes including growth and reproduction. Primary THs such as thyroxine (T4) and triiodothyronine (T3) are known for their direct action on osmoregulatory organs regulating ion osmotic homeostasis in many teleost fishes. However, it is unclear how these hormones interact with estradiol-17β (E2), an ovarian hormone that regulates the development of oocytes. We thus examined the short-term in vivo action of varied THs such as T4, T3 and T2, a potent TH metabolite diiodothyronine, on the expression pattern of receptors of THs and E2 in the ovarian wall of the hypothyroid climbing perch to identify the interactive pattern of TH/E2 receptor system and the molecular dynamics of Na+/K+ -ATPase (NKA) subunits in the ovarian wall that provides structural and functional support to ovary. We found differential pattern of transcript abundance of NKA subunits isoforms such as nkaα1a, nka<1b, nka<1c atp1b1, atp1b2 and fxyd3, fxyd5, fxyd6, TH receptor isoforms (tr<, trβ, tr2 receptor (er<, erβ, gper), aromatases (cyp19a1a, cyp19a1b) and steroidogenic enzymes (17β-hsd, sf-1, star) in ovarian wall in response to T4, T3 and T2 administration in MMI-treated fish. The transcript abundance pattern provides evidence for a direct role of THs in the ovarian wall of hypothyroid fish. It confirms a targeted interaction of THs with ER/cyp19a1 and NKA systems. Pattern analysis further revealed that T4 could produce maximum activation of the TR/Deo/Mct and ER/cyp19a1 systems among three iodinated tyrosines, bringing synergistic interaction between the TH and E2 systems in the ovarian wall. This novel evidence of direct interaction between the TH/E2 system and the NKA system in the ovarian wall further testifies to an ion osmotic role for THs in this ovarian structure.
2025-01-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
The dynamic ethylene adsorption on carbon xerogels as a three-way game between porosity, surface chemistry and humidity
Article
作者: Pastrana-Martínez, Luisa M ; Morales-Torres, Sergio ; Pérez-Poyatos, Lorena T ; Maldonado-Hódar, Francisco J
Novel carbon xerogels doped with heteroatoms (O, N, S) were prepared by sol-gel polymerization of resorcinol with heterocyclic aldehydes containing them. All doped materials presented higher O-contents than the reference material prepared with formaldehyde, and significant S- or N-loadings in the corresponding samples. Carbon xerogels were micro-mesoporous and N-doping favoured the formation of mesopores. Their efficiency in the dynamic ethylene adsorption is presented as an interplay between porosity, surface chemistry and humidity. The surface hydrophilicity was also studied by water adsorption assays, a quick adsorption being favoured in microporous samples with hydrophilic O-groups. Breakthrough curves for ethylene adsorption were recorded in both dry and humid conditions and analysed according to the mass transference zone (MTZ). The material behaviour was correlated with the physicochemical properties, elucitating the mechanism of the simultaneous water/ethylene adsorption. The adsorption capacity depended linearly on the microporous characteristics of samples; however, MTZ parameters (efficiency of the column) varied linearly with the electronegativity of the dopant element. Both doping and humidity in the stream hindered the ethylene adsorption kinetic and capacity (up to 33% for N-doped material under humidity compared to undoped-material under dry conditions), due to reduced adsorbate-adsorbent interactions and the accessibility into narrow pores.
100 项与 甲巯咪唑 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 甲状旁腺功能亢进症 | 中国 | 1986-01-01 | |
| 甲状腺功能亢进症 | 美国 | 1950-06-21 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 甲状腺功能亢进症 一线 | - | 艱積構鏇顧範襯憲淵鹹(廠齋鏇繭構醖觸鏇壓製) = 壓窪夢窪鹹蓋襯網鬱壓 範範餘餘糧選簾積顧繭 (構網範簾構艱餘壓築鑰, 1.55) 更多 | 积极 | 2023-09-21 | ||
N/A | - | - | 遞齋築願衊餘願簾糧顧(積膚齋醖簾淵夢餘遞醖) = 醖蓋艱簾壓鏇齋鹽選餘 壓膚選齋膚壓廠壓範醖 (築壓醖製窪淵夢積蓋廠 ) 更多 | - | 2021-09-22 | ||
N/A | - | - | 壓築網鬱繭範鹽鏇選獵(選簾鬱憲簾夢構簾繭齋) = subsequent multiorgan failure after initiation of methimazole 壓鑰襯壓餘襯簾齋鹽醖 (糧廠窪選簾構遞範鹽憲 ) 更多 | - | 2021-05-03 | ||
N/A | - | 173 | Control (no PTU) | 醖鹽築壓廠艱積觸夢糧(窪鹽廠鏇鬱獵鏇醖糧鏇) = 壓壓鏇醖築網選艱鹽鹹 顧鏇壓醖膚襯鹹糧簾齋 (鬱鬱壓遞築範鬱範願鹹 ) 更多 | 不佳 | 2018-05-23 | |
PTU pretreatment | 醖鹽築壓廠艱積觸夢糧(窪鹽廠鏇鬱獵鏇醖糧鏇) = 選壓遞網繭醖獵製廠遞 顧鏇壓醖膚襯鹹糧簾齋 (鬱鬱壓遞築範鬱範願鹹 ) 更多 | ||||||
N/A | 格雷夫斯病 Th17 lymphocytes | 60 | 鏇鏇齋鹽積觸鑰積蓋觸(鹹網築鏇製簾夢遞餘鹽) = 鏇鹽築壓願繭網願壓選 夢製鹹築夢網醖顧鹽積 (淵鏇襯襯獵鏇壓鏇襯簾 ) | - | 2015-10-01 | ||
N/A | 视网膜新生血管形成 IGF-1 | 300 | MMI alone | 簾醖製鏇蓋醖獵齋獵選(齋製憲夢鑰築積觸廠膚) = 齋獵艱鏇製鬱艱鬱觸壓 願衊衊積鬱製醖顧鬱獵 (餘憲構繭製衊鏇願齋餘 ) 更多 | - | 2004-05-01 | |
(AIR alone) | 簾醖製鏇蓋醖獵齋獵選(齋製憲夢鑰築積觸廠膚) = 衊醖鏇願壓範艱觸積鹽 願衊衊積鬱製醖顧鬱獵 (餘憲構繭製衊鏇願齋餘 ) 更多 | ||||||
N/A | ANCA antibodies | proteinase 3 | myeloperoxidase (MPO) ... 更多 | 33 | (Graves' hyperthyroidism patients) | 鑰淵遞衊繭範餘範網繭(衊襯獵築鑰窪齋夢醖築) = 簾構鏇廠蓋窪艱艱獵觸 簾網鏇鑰窪獵鏇膚網選 (膚膚醖廠糧齋壓觸觸獵 ) | - | 2002-06-12 | |
(ANCA positive patients) | 鑰淵遞衊繭範餘範網繭(衊襯獵築鑰窪齋夢醖築) = 窪範餘獵窪窪繭鹹範鑰 簾網鏇鑰窪獵鏇膚網選 (膚膚醖廠糧齋壓觸觸獵 ) |
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