Double-blind, placebo-controlled clinical study to analyze the efficacy of an organic pomegranate polyphenol complex supplementation on bone mineral density, bone turnover markers, inflammatory status, and antioxidant status in post-menopausal women

开始日期2022-09-02

申办/合作机构-

NCT03772418 / Unknown status临床1期IIT

Formulation and Evaluation of Topical Preparation Containing Pomegranate and Ginkgo Biloba for Anti-aging Activities

As the quality of life improves, people are seeking to look as young as they feel. Ginkgo biloba (GB) and Pomegranate (PG) extract can be used to create efficacious topical anti-aging products. GB & PG are now widely used in research and clinical trials on age-associated diseases, for example, skin aging, brain dysfunction, cardiovascular system diseases, carcinogen metabolism. The investigator's aim is to formulate a topical cream in the form (O/W or W/O emulsion) formulation, containing GB as an anti-aging formulation for the public.

开始日期2018-05-18

申办/合作机构-

NCT02095145 / Completed临床2期IIT

A Phase IIA Exploratory, Randomized, Placebo-Controlled Trial of Pomegranate Fruit Extract/Pomx™ in Subjects With Clinically Localized Prostate Cancer Undergoing Active Surveillance

This randomized phase II trial studies pomegranate-extract pill in preventing tumor growth in patients with prostate cancer that is limited to a certain part of the body (localized), who have chosen observation as their treatment plan. The use of pomegranate-extract pill may slow disease progression in patients with localized prostate cancer.

开始日期2014-05-08

申办/合作机构

National Cancer Institute

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项与石榴提取物相关的文献（医药）

2024-03-01·Complementary therapies in medicine

The effects of pomegranate consumption on liver function enzymes in adults: A systematic review and meta-analysis

Review

作者: Asbaghi, Omid ; Goudarzi, Kian ; Kolbadi, Kosar Sadat Hosseini ; Hosseini, Ali ; Naderian, Moslem ; Rafiei, Hossein ; Bahari, Hossein ; Omidian, Kosar

BACKGROUND:

We performed a systematic review and meta-analysis of all published clinical trial studies to provide a more accurate estimation of pomegranate effects on liver enzymes in different clinical conditions.

METHODS:

A systematic literature search was carried out using electronic databases, including PubMed, Web of Science, and Scopus, up to March 2023 to identify eligible randomized clinical trials (RCTs) evaluating the effect of pomegranate consumption on liver function enzymes. Heterogeneity tests of the selected trials were performed using the I² statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval.

RESULTS:

Out of 3811 records, 9 eligible RCTs were included in the current study. However, there are limitations in the included studies, which can be mentioned in the dose, duration, and type of interventions that are different among the studies, as well as the small number of included studies. All this causes heterogeneity among studies and this heterogeneity limits the consistency of the results. Our meta-analysis showed that pomegranate intake had a significant effect on lowering aspartate aminotransferase (AST) levels in long-term intervention (> 8 weeks), obese (BMI≥30) individuals, or patients with metabolic disorders. Furthermore, results showed a significant decrease in alanine aminotransferase (ALT) levels in the long-term intervention (> 8 weeks) or in patients with metabolic disorders following the pomegranate intake. Combined results from the random-effects model indicated a significant reduction in gamma-glutamyl transferase (GGT) levels (WMD: -5.43 IU/L 95% CI: -7.78 to -3.08; p < 0.001;) following the pomegranate intake. The results of Egger's test mentioned a significant publication bias for the trials examining the effect of pomegranate intake on AST (p = 0.007) and ALT (p = 0.036).

CONCLUSION:

Our results suggest that long-term pomegranate intake may be effective in ameliorating liver enzymes in adults with obesity and metabolic disorders who are more likely to have elevated baseline liver enzymes due to some degree of liver injury or tissue damage. However, some studies failed to conduct independent biochemical characterization of the product used, including the presence and quantity of polyphenols, antioxidants, and proanthocyanidins.

2024-02-01·Food science & nutrition

The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

Review

作者: Asbaghi, Omid ; Goudarzi, Kian ; Kolbadi, Kosar Sadat Hosseini ; Hosseini, Ali ; Mirmohammadali, Seyedeh Nooshan ; Pourreza, Sanaz ; Naderian, Moslem ; Bahari, Hossein

Abstract:

Evidence supports the potential application of polyphenols as agents against obesity. Pomegranate is one of the fruits that possess a high content of polyphenols. This systematic review and meta‐analysis of randomized controlled trials (RCTs) sought to evaluate the effects of pomegranate consumption on obesity indices, including body mass index (BMI), body weight, waist circumference (WC), fat mass (FM), body fat percentage (BFP), and fat‐free mass (FFM) in adults. Relevant RCTs were obtained by searching databases, including PubMed, SCOPUS, and Web of Science, up to May 2023. Heterogeneity tests of the included trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval. Pooled analysis of 28 trials revealed that pomegranate consumption led to a significant reduction in body weight (WMD: −1.97, 95% CI: −2.91, −1.03, p < .05), and a significant decrease in BMI (WMD: −0.48, 95% CI: −0.76, −0.20, p < .05) in comparison with the control group. However, there were no significant effects on WC, FM, FFM, and BFP in comparison with the control group. Pomegranate consumption may yield a beneficial effect on body weight and BMI in adults. However, there were no significant effects on WC, FM, FFM, and BFP, by pomegranate consumption. Also, pomegranate consumption can reduce body weight, BMI, WC, and BFP in obese adults. Long‐term trials with different doses of pomegranate are needed.

2024-01-01·Diabetes & metabolic syndrome

The effects of pomegranate consumption on glycemic indices in adults: A systematic review and meta-analysis

Review

作者: Goudarzi, Kian ; Asbaghi, Omid ; Ashtary-Larky, Damoon ; Hosseini, Ali ; Mirmohammadali, Seyedeh Nooshan ; Naderian, Moslem ; Bahari, Hossein ; Hosseini Kolbadi, Kosar Sadat

BACKGROUND AND AIM:

Epidemiologic studies have shown that type 2 diabetes (T2D) is more prevalent worldwide; therefore, improving glycemic indices to prevent or control T2D is vital. Randomized controlled trials (RCTs) on the effects of pomegranate consumption on glycemic indices have shown inconsistent results. Therefore, we aim to evaluate the impact of pomegranate consumption on fasting blood glucose (FBG), fasting insulin, hemoglobin A1c (HbA1c), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) in adults.

METHODS:

A systematic literature search was performed using electronic databases, including PubMed, Web of Science, and Scopus, up to May 2023 to identify eligible RCTs evaluating the effect of pomegranate consumption on glycemic indices. Heterogeneity tests of the included trials were performed using the I² statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95 % confidence interval.

RESULTS:

Of 1999 records, 32 eligible RCTs were included in the current study. Our meta-analysis of the pooled findings showed that pomegranate consumption significantly reduced FBG (WMD: -2.22 mg/dL; 95 % CI: -3.95 to -0.50; p = 0.012), fasting insulin (WMD: -1.06 μU/ml; 95%CI: -1.79 to -0.33; p = 0.004), HbA1c (WMD: -0.22 %; 95% CI: -0.43 to -0.01; p = 0.037), and HOMA-IR (WMD: -0.30; 95%CI: -0.61 to -0.00; p = 0.046).

CONCLUSION:

Overall, the results demonstrated that pomegranate consumption benefits glycemic indices in adults. However, further research with long-term interventions is required.

PROSPERO REGISTRATION CODE:

CRD42023422780.

项与石榴提取物相关的新闻（医药）

2024-05-22

·Science Daily

Naturally occurring substance in pomegranates can improve treatment of Alzheimer's disease

A substance naturally occurring in i.a. pomegranates, strawberries and walnuts can improve memory and treatment of Alzheimer's disease, a new study concludes. A substance naturally occurring in i.a. pomegranates, strawberries and walnuts can improve memory and treatment of Alzheimer's disease, a new study conducted at the University of Copenhagen concludes. Forgetfulness, difficulty finding words and confusion about time and place. These are some of the most common symptoms of Alzheimer's disease. Now researchers at the University of Copenhagen have discovered that an ordinary fruit can help. "Our study on mouse models with AD shows that urolithin A, which is a naturally occurring substance in i.a. pomegranates, can alleviate memory problems and other consequences of dementia," says Vilhelm Bohr, who is Affiliate Professor at the Department of Cellular and Molecular Medicine at the University of Copenhagen and prevoiusly Department Chair at the US National Institute on Aging. This is good news for patients with dementia -- a disease that is difficult to treat. "Even though the study was conducted on mouse models, the prospects are positive. So far, research has shown promising results for the substance in the muscles, and clinical trials on humans are being planned." Substance improves brain function The researchers previously discovered that a specific molecule, nicotinamide riboside (NAD supplement), plays a key role in neurodegenerative diseases such as Alzheimer's and Parkinson's, as it actively helps remove damaged mitochondria from the brain. "Many patients with neurodegenerative diseases experience mitochondrial dysfunction, also known as mitophagy. This means that the brain has difficulties removing weak mitochondria, which thus accumulate and affect brain function. If you are able to stimulate the mitophagy process, removing weak mitochondria, you will see some very positive results," Vilhelm Bohr explains. The results of the new study show that a substance found in pomegranates, urolithin A, removes weak mitochondria from the brain just as effectively as NAD supplement. Possible preventive effect The researchers still don't know how much urolithin A is needed to improve memory and alleviate symptoms of i.a. Alzheimer's. "We still cannot say anything conclusive about the dosage. But I imagine that it is more than a pomegranate a day. However, the substance is already available in pill form, and we are currently trying to find the right dosage," Vilhelm Bohr says. He also hopes the substance can be used for preventive purposes with no significant side effects. "The advantage of working with a natural substance is the reduced risk of side effects. Several studies so far show that there are no serious side effects of NAD supplementation. Our knowledge of urolithin A is more limited, but as I mentioned, clinical trials with Urolithin A have been effective in muscular disease, and now we need to look at Alzheimers disease. ," he says and adds: "If we are going to eat something in the future to reduce the risk of Alzheimer's, which we talk a lot about, we have to make sure there are no significant side effects."

2023-12-28

·PRNewswire

3 Tips to Combat Dry Skin in Winter, including Essential Skin Food From ActivatedYou By Maggie Q

A Skin Nourishing Collagen Support Complex For a Clear, Hydrated, and Healthy-looking Complexion LOS ANGELES, Dec. 28, 2023 /PRNewswire/ -- With winter here, the drop in temperature often brings along a common problem: dry, dehydrated skin. The cold air outside, combined with the warm, dry air indoors, can strip the skin of its natural moisture, leaving it feeling dry, itchy, and patchy. Actor and wellness advocate Maggie Q recognizes the challenges that winter poses to our skin and shares these tips to help combat this seasonal skin struggle. Continue Reading ActivatedYou Essential Skin Food is a skin-nourishing collagen support complex designed to deliver smooth, tight, and youthful-looking skin regardless of age or season, making it particularly beneficial during winter. This dietary supplement operates internally, promoting healthy collagen production—the essential foundation of your skin. Hydrate from Within: As soon as you wake up, drink at least a full glass of water to start your day off hydrated. Hydration comes from the inside, and maintaining a good water intake helps your skin stay moisturized. Herbal teas and water-rich foods, like fruits and vegetables, can also contribute to your overall hydration. Use a Humidifier: Combat the dry indoor air by incorporating a humidifier into your living or working space. Central heating systems tend to sap the moisture from the air, leading to drier skin. A humidifier helps maintain the humidity levels, preventing your skin from becoming excessively dry. Take a Daily Skin Health Supplement: Skin health supplements such as ActivatedYou Essential Skin Food® are designed to support healthy collagen production, the key to firmer and plumper-looking skin. This formulation is crafted with six plant-based skin-nourishing compounds that work synergistically to support the production of collagen – the fundamental building blocks of the skin. These compounds not only aid in collagen synthesis but also combat skin-damaging free radicals, helping to promote a clear, hydrated, and healthy-looking complexion.†* What is ActivatedYou Essential Skin Food?†* ActivatedYou Essential Skin Food is a skin-nourishing collagen support complex designed to deliver smooth, tight, and youthful-looking skin regardless of age or season, making it particularly beneficial during winter. This dietary supplement operates internally, promoting healthy collagen production—the essential foundation of your skin. Crafted with six plant-based skin-nourishing compounds, each ingredient helps facilitate healthy cell turnover, combat elastin breakdown that causes the appearance of sagging skin, and fight skin-damaging free radicals. The result is a clear, hydrated, and healthy complexion, ideal for combating the harsh effects of winter weather. Unlike conventional collagen supplements, ActivatedYou Essential Skin Food distinguishes itself as a natural collagen builder without any animal-based collagen. Completely derived from plant-based ingredients, it actively supports the natural growth of collagen within your body. This winter, fortify your skin from head to toe with an innovative approach to skincare that enhances your skin's resilience and radiance. ActivatedYou Essential Skin Food Key Ingredients† Vitamin C: a natural antioxidant that promotes a more radiant and bright complexion, contributing to healthier-looking skin by fending off free radicals that can harm the skin.* Amino Acid Complex: a combination of Lysine and L-Proline, essential building blocks of collagen. These components work in harmony to help tighten and enhance the look of skin's plumpness over time.* Dermaval™: a natural collagen booster that harnesses the power of phytonutrient compounds like pomegranate extract, camu camu, coffeeberry, and quercetin to combat the breakdown of elastin in the body, supporting skin elasticity and firmness.* Cosmythic™: an elixir infused with polyphenols that help support collagen production for more youthful-looking skin.* Where to Purchase ActivatedYou Essential Skin Food ActivatedYou Essential Skin Food can be purchased on the ActivatedYou website for $69.95 with a 90-day money-back guarantee. About Maggie Q As a health advocate, animal rights activist, founder of fitness apparel brand Qeep Up, ActivatedYou founder, and actor—best known for her roles in Nikita, Designated Survivor, and Mission: Impossible III, Maggie Q uses her name to advocate for those in need. Maggie's personal health struggles led her to do extensive research in the world of nutrition and inspired her to create her own line of wellness supplements, ActivatedYou. Follow @maggieq on Instagram. About ActivatedYou ActivatedYou was founded by health advocate, animal rights activist, and actor Maggie Q, with Dr. Frank Lipman, a renowned gut-health expert and a pioneer of integrative medicine. ActivatedYou's unique formulas blend the latest in cutting-edge health and nutrition with age-old Eastern traditions and healthy ingredients for unique, effective formulas designed to help revolutionize health and improve lives. ActivatedYou's best-selling products include Advanced Restorative Probiotic, AdrenaLife, and Active Enzyme. To learn more about Maggie Q's ActivatedYou line, visit and follow @activatedyou on Instagram, @ActivatedYou on Twitter, and ActivatedYou on YouTube. *All individuals are unique. Your results can and will vary. Press Contact: Laura Baumgartner - Asylum PR [email protected] SOURCE ActivatedYou

2023-12-11

·PRNewswire

A Delicious Way to Support Your Immune System

MISSION, Kan., Dec. 11, 2023 /PRNewswire/ -- (Family Features) Bolstering your immune system during winter, when coughs and colds seem to take control, is a must for the entire family. Supporting your wellness can start in a simple place – with the foods you eat and drink. Continue Reading Orange Juice and Coconut Chickpea Soup Superfruit Breakfast Smoothie Consider an easy choice for any season like Florida Orange Juice, which can help you and your loved ones get the vitamins and minerals you need all winter long. With 100% of the daily recommended value of vitamin C in every 8-ounce serving along with key nutrients like potassium and magnesium, there's a reason it's referred to as the "Original Wellness Drink." With no added sugar or artificial flavor, it provides the benefits you need without the additives you don't. It contains natural sugar from the whole fruit for a delicious solution that's one of nature's nutrient-rich foods with vitamins, minerals and phytonutrients. Plus, it's easy to use as a nutritional ingredient in wintertime favorites like this comforting Orange Juice and Coconut Chickpea Soup or to start your day strong with a Superfruit Breakfast Smoothie. Paired with a healthy lifestyle, 8 ounces of 100% orange juice may help support a healthy immune system as an excellent source of vitamin C and a good source of vitamin D in fortified juices. Vitamin C is commonly associated with helping maintain and strengthen healthy immune systems by protecting cells and promoting the production and function of immune cells. Meanwhile, vitamin D also plays an important role in regulating immune response by helping immune cells fight off bacteria and viruses. "Safeguarding your health against the spread of illness is important year-round, especially during colder months when reports of cold and flu increase," said Dr. Rosa Walsh, director of scientific research at the Florida Department of Citrus. "A key step in supporting your immune system is maintaining a well-balanced diet that is high in essential nutrients. Incorporating an 8-ounce glass of 100% orange juice can help you meet the recommended daily value of vitamin C and support your hydration." Beneficial plant compounds, like those in Florida Orange Juice, along with flavonoids and colorful carotenoids work to support the immune system by fighting inflammation and helping cells communicate, which can help strengthen immune responses when encountering infections. Additionally, 100% orange juice is a source of phytonutrients like hesperidin, which has been shown in clinical studies to have antioxidant-like properties, heart health benefits and may help reduce inflammation. Hesperidin has also been linked with benefits related to cognitive function, immune system function and bone health. To find more information and immunity-boosting winter recipes, visit FloridaJuice.com. Orange Juice and Coconut Chickpea Soup Servings: 8 1 tablespoon olive oil 1 cup diced yellow onion 1 red bell pepper, diced 1 1/2 cups diced carrots 1 1/2 teaspoons kosher salt 3 cloves garlic, finely grated 1/2 teaspoon ground cardamom 1 quart vegetable broth 1 can (14 ounces) light coconut milk 1 can (14 ounces) chickpeas, drained and rinsed 1/2 cup Florida Orange juice chopped cilantro (optional) In medium saucepan over medium high, heat olive oil until it shimmers. Add onions, bell pepper, carrots and salt; cook until onions are translucent, 5-7 minutes. Add garlic and cardamom; cook 1-2 minutes, or until garlic is fragrant. Do not brown. Add vegetable broth, coconut milk and chickpeas; bring to simmer. Decrease heat to low and cook until carrots are tender, about 10 minutes. Add orange juice, remove from heat and stir. Taste and adjust seasoning as desired. Serve garnished with cilantro, if desired. Superfruit Breakfast Smoothie Servings: 2 8 ounces Florida Orange Juice 4 ounces dark sweet cherries 2 ounces pomegranate juice In blender, puree orange juice, cherries and pomegranate juice then serve. Michael French [email protected] 1-888-824-3337 editors.familyfeatures.com About Family Features Editorial Syndicate A leading source for high-quality food, lifestyle and home and garden content, Family Features provides readers with topically and seasonally relevant tips, takeaways, information, recipes, videos, infographics and more. Find additional articles and information at Culinary.net and eLivingToday.com. SOURCE Family Features Editorial Syndicate

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02095145 (CTgov)	临床2期	涎腺多形性腺瘤 \| 局限性前列腺癌	38	Pharmacological Study+Pomegranate-Extract Pill (Group I (Pomegranate-extract Pill))	積鹽壓積襯築餘膚製衊(製夢鑰夢壓範鹽顧積遞) = 淵廠範憲齋鹽繭襯憲蓋選夢窪齋願願選繭蓋觸 (願齋襯積鹽築願積廠夢, 淵鹽範憲鑰糧窪淵繭齋 ~ 鹽願餘膚鏇餘簾鹽鹹網) 更多	-	2020-02-05
				Placebo (Group II (Placebo))	積鹽壓積襯築餘膚製衊(製夢鑰夢壓範鹽顧積遞) = 網蓋網簾顧廠獵遞襯夢選夢窪齋願願選繭蓋觸 (願齋襯積鹽築願積廠夢, 構獵顧壓醖鑰蓋齋襯簾 ~ 鑰鑰蓋鬱衊壓製鏇積構) 更多
NCT01102140 (CTgov)	临床2期	肾功能不全 \| 应激氧化 \| 心脏衰竭 ... 更多	20	POMx, pomegranate polyphenol extract (POMx)	選艱積淵窪淵選鹹鏇鹽(膚簾網艱窪壓憲窪艱鹽) = 壓鹹鹽積顧齋蓋網餘觸鬱蓋選淵壓壓窪夢範壓 (網積鏇鹽蓋製鬱鏇衊夢, 鹹簾醖蓋鏇築餘艱製衊 ~ 襯壓夢鏇簾範蓋製淵壓) 更多	-	2017-07-14
				sugar pill (Control- Sugar Pill)	選艱積淵窪淵選鹹鏇鹽(膚簾網艱窪壓憲窪艱鹽) = 鑰獵憲獵鹽積淵膚膚膚鬱蓋選淵壓壓窪夢範壓 (網積鏇鹽蓋製鬱鏇衊夢, 獵窪餘願餘蓋繭繭蓋醖 ~ 餘鬱鹽顧窪糧繭製觸窪) 更多