Arginine Butyrate(Arginine Butyrate) - 药物靶点：thymidine kinase_在研适应症：短肠综合征_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

thymidine kinase

作用方式

刺激剂

作用机制

thymidine kinase刺激剂(胸苷激酶刺激剂)

治疗领域

消化系统疾病内分泌与代谢疾病其他疾病

在研适应症

短肠综合征

非在研适应症

镰状细胞血症β地中海贫血爱泼斯坦-巴尔病毒阳性淋巴瘤+ [2]

原研机构

Boston University

在研机构

Baxter Healthcare Corp.

非在研机构

Boston UniversityHemaQuest Pharmaceuticals, Inc.

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评孤儿药 (美国)

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结构/序列

分子式C10H22N4O4

InChIKeyHTWPXGKLFMPZHG-WCCKRBBISA-N

CAS号80407-72-3

关联

5

项与 Arginine Butyrate 相关的临床试验

NCT00992732

/ Terminated临床2期

A Phase 2a Open-Label Multi-Center Study Evaluating HQK-1004 Administered With Valganciclovir in Patients With Relapsed or Refractory Epstein-Barr Virus-Positive Lymphoid Malignancies or Lymphoproliferative Disorders

The purpose of this study is to determine if treatment with HQK-1004 and valganciclovir will result in complete or partial responses in patients with EBV-positive lymphoid malignancies or lymphoproliferative disorders.

开始日期2010-05-01

申办/合作机构

HemaQuest Pharmaceuticals, Inc.

NCT00917826

/ Terminated临床2期

A Phase II Trial of Low-Dose Arginine Butyrate and Ganciclovir/Valganciclovir in EBV(+)Lymphoid Malignancies

The purpose of this study is to assess whether administration of Arginine Butyrate + ganciclovir/valganciclovir for up to three 21-day cycles is tolerable, and results in partial or complete responses in patients with EBV(+) lymphoid malignancies.

开始日期2008-09-01

申办/合作机构

HemaQuest Pharmaceuticals, Inc.

[+1]

NCT00006136

/ Completed临床2期IIT

Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia Intermedia

OBJECTIVES: I. Determine whether arginine butyrate with or without epoetin alfa can stimulate gamma-globin chain production to a degree that decreases anemia and results in hematologic improvement in patients with thalassemia intermedia.
II. Determine whether a proportional increase in gamma-globin synthesis and mRNA and an improvement in nonalfa and alfaglobin chain imbalance by at least 10% over baseline correlate with improved hematologic response in these patients when treated with this regimen.
III. Determine whether a decrease in hemolysis, as assayed by a decrease in LDH, compared to baseline levels correlates with improved hematologic response in these patients when treated with this regimen.
IV. Determine whether any particular genotypes are more responsive than others to this therapy in these patients.
V. Determine whether baseline epoetin alfa levels, gender, and/or baseline reticulocyte counts (or percent circulating nucleated erythroblasts) correlate with improved hematologic response in these patients when treated with this regimen.

开始日期1999-03-01

申办/合作机构

Boston University

100 项与 Arginine Butyrate 相关的临床结果

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100 项与 Arginine Butyrate 相关的转化医学

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100 项与 Arginine Butyrate 相关的专利（医药）

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111,412

项与 Arginine Butyrate 相关的文献（医药）

2025-12-31·International Journal of Food Properties

FTIR characteristics of sweet flour as affected by particle size distribution and in vitro digestibility of gluten-free sweet potato noodles

作者: Mohamed Ahmed, Isam A. ; Qureshi, Tahir Mahmood ; Wadood, Syed Abdul ; Azeem, Muhammad ; Ali, Asmahan A. ; Anees Ur Rehman, Muhammad ; Aljobair, Moneera O.

There is a need to explore the influence of particle size of sweet potato flour on physicochem. properties and in vitro starch digestibility of gluten free sweet potato noodles.The aim of this work was to examine the influence of purple-fleshed sweet potato flour (PFSPF) having different particle size distribution (355 μm to 75μ m) on physicochem. properties and in vitro starch digestibility of gluten-free purple sweet potato noodles.Pasting properties and sugar contents were pos. correlated toward the finest particle fraction.The hardness of noodles was pos. and significantly correlated to the finest particle size fraction.Sweet potato flour (SPF) noodles prepared with particle size of 75 μm retained lower hardness 5.74 N.An abrupt increase in yellowness was observed with decreasing particle size that might be attributed to the reduction of protein.The results of FTIR suggested that with the reduction of particle size, protein and carbohydrates decreased that much associated with crystallization and retrogradation of starch.Among all the amino acids, aspartic acid and glutamic acid were observed to be more abundant, i.e. approx. 13.33 and 29.05‰, resp.In this way, PFSPF with particle size 75 μm exhibited significant application potential for producing gluten free noodles due to high resistant starch and lower hardness.It may be concluded that particle sizes of sweet potato flour influenced pasting properties, textural characteristics, sugar contents, protein contents, amino acid contents, carbohydrate contents of prepared noodles.

2025-12-31·Journal of the International Society of Sports Nutrition

Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes

Article

作者: Buzdağlı, Yusuf ; Savaş, Adem ; Kavcı, Zafer ; Uçar, Halil ; Ozan, Murat

BACKGROUNDTaekwondo is a complex martial art that requires speed, balance, agility, and endurance. This study aims to examine the effects of nitrate and L-arginine supplementation on acute aerobic and anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.METHODThis study was conducted as a double-blind, randomized, crossover study with the participation of 15 experienced taekwondo athletes aged 19.06 ± 0.96 years and 8.93 ± 1.27 years of training experience. Participants visited the laboratory a total of nine times, including a practice session and anthropometric measurements. These visits consisted of eight experimental sessions conducted at 72-hour intervals. The experimental sessions were conducted with nitrate, L-arginine, and a combination of both supplements (NIT*L-ARG) and placebo. Nitrate supplementation was provided by homogenizing fresh spinach (837.40 mg/kg), while L-ARG was given as a single dose of 6 g in powder form three hours before exercise.RESULTSNIT*L-ARG supplementation significantly improved the anaerobic performance of athletes in Wingate peak power and peak power (w/kg) compared to placebo and in mean power compared to NIT, L-ARG, and PLA. In addition, NIT*L-ARG supplementation significantly improved blood lactate levels and agility performance immediately after Wingate and Shuttle run tests.CONCLUSIONThe combined intake of NIT*L-ARG was found to be effective in improving aerobic, anaerobic, and agility performances as well as fatigue levels of athletes. It was determined that taking NIT and L-ARG supplements alone contributed to the improvement of improving athletes' performance in Wingate mean power values and subsequent fatigue level compared to PLA.

2025-12-01·Nano-Micro Letters

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Article

作者: Shi, Jue ; He, Jing ; Hong, Gaoying ; Liu, Nian ; Xie, Zhijian ; Yuan, Ximin ; Xia, Pengcheng ; Hu, Zihe ; Yao, Ke ; Li, Yuanrong ; He, Yong ; Chen, Yuewei ; Zhou, Yanyan ; Kong, Weicheng

AbstractHydrogel scaffolds have numerous potential applications in the tissue engineering field. However, tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical properties. Inspired by Chinese ramen, we propose a universal fabricating method (printing-P, training-T, cross-linking-C, PTC & PCT) for tough hydrogel scaffolds to fill this gap. First, 3D printing fabricates a hydrogel scaffold with desired structures (P). Then, the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance (T). Finally, the training results are fixed by photo-cross-linking processing (C). The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa (622-fold untreated) and have excellent biocompatibility. Furthermore, this scaffold possesses functional surface structures from nanometer to micron to millimeter, which can efficiently induce directional cell growth. Interestingly, this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt, and many hydrogels, such as gelatin and silk, could be improved with PTC or PCT strategies. Animal experiments show that this scaffold can effectively promote the new generation of muscle fibers, blood vessels, and nerves within 4 weeks, prompting the rapid regeneration of large-volume muscle loss injuries.

100 项与 Arginine Butyrate 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
镰状细胞血症	临床1期	美国	Boston University	1997-09-01
β地中海贫血	临床1期	美国	Boston University	1997-09-01
下肢溃疡	临床1期	美国	Boston University	1997-09-01
短肠综合征	临床前	美国	Baxter Healthcare Corp.	2023-03-09
爱泼斯坦-巴尔病毒阳性淋巴瘤	临床前	美国	HemaQuest Pharmaceuticals, Inc.	2010-05-01
EBV相关淋巴瘤	临床前	美国	HemaQuest Pharmaceuticals, Inc.	2008-09-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00004412 (CTgov)	临床2期	β地中海贫血 \| 下肢溃疡 \| 镰状细胞血症	23	Standard local care dressing (Standard Local Care Dressing)	鑰築蓋蓋獵醖選鏇膚鬱(製範齋憲遞衊顧願鬱觸) = 糧觸鑰鏇遞蓋衊鬱壓衊鹹選夢艱淵鹽鹹遞築淵 (憲膚淵鹽鑰壓蓋膚廠鏇, 齋淵鏇鹹淵選遞夢鬱顧 ~ 構鬱醖獵齋醖壓獵鹽遞) 更多	-	2015-03-31
NCT00004412 (CTgov)	临床2期	β地中海贫血 \| 下肢溃疡 \| 镰状细胞血症	23	Standard local care dressing+Arginine Butyrate (Arginine Butyrate)	鑰築蓋蓋獵醖選鏇膚鬱(製範齋憲遞衊顧願鬱觸) = 齋鑰膚鬱範鏇壓醖獵憲鹹選夢艱淵鹽鹹遞築淵 (憲膚淵鹽鑰壓蓋膚廠鏇, 憲餘鏇膚衊顧選顧顧繭 ~ 蓋壓衊鬱鑰獵築構淵廠) 更多	-	2015-03-31
Pubmed \| Br J Haematol	临床2期	下肢溃疡	-	Arginine Butyrate (Standard local care)	醖簾鬱選醖鹽製顧獵艱(繭餘網範膚壓憲網網鹽) = 衊餘遞繭鬱鏇網齋範夢遞鬱製製壓憲衊願淵願 (繭衊衊網蓋鑰鬱築積製 )	-	2010-12-01
Pubmed \| Br J Haematol	临床2期	下肢溃疡	-	Standard care with Arginine Butyrate	醖簾鬱選醖鹽製顧獵艱(繭餘網範膚壓憲網網鹽) = 蓋蓋製鹽鏇鏇觸繭憲膚遞鬱製製壓憲衊願淵願 (繭衊衊網蓋鑰鬱築積製 )	-	2010-12-01
Pubmed \| Blood	临床1/2期	爱泼斯坦-巴尔病毒相关肿瘤	15	Arginine butyrate	(齋鹽鏇餘繭獵願衊憲糧) = 壓網製艱觸膚鑰夢蓋網構鹽願繭遞遞餘齋願網 (衊糧網築鏇鹹糧襯網遞 )	-	2007-03-15
ASCO2006	临床1/2期	爱泼斯坦-巴尔病毒相关肿瘤	-	Arginine Butyrate	(鏇網淵範醖積鏇鬱窪夢) = 顧繭廠廠鹽網膚鹹積糧積衊膚鏇鏇簾糧網襯鹹 (選鹹鏇繭遞遞繭淵製齋 )	-	2006-06-20