更新于：2024-12-17
Brilliant Blue G
亮蓝G
更新于：2024-12-17
概要
基本信息
药物类型 小分子化药 |
别名 Acid Blue 90、BRILLIANT BLUE G、Brilliant blue G (JAN) + [3] |
作用机制 P2X7 receptor拮抗剂(嘌呤P2X7受体拮抗剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2019-12-20), |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
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结构
分子式C47H49N3NaO7S2 |
InChIKeyRWFXCYWTHJDCMJ-UHFFFAOYSA-N |
CAS号6104-58-1 |
关联
12
项与 亮蓝G 相关的临床试验Staining with brilliant blue G for the internal limiting membrane - Brilliant blue G stains the internal limiting membrane
Evaluation of safety of Brilliant Blue G for inner limiting membrane peeling in patients with vitreomacular diseases - Safety of Brilliant Blue G for inner limiting membrane peeling
Comparing the Surgical Outcomes of Internal Limiting Membrane Peeling-reposition Versus Peeling in Idiopathic Macular Holes: A Randomized Controlled Trial
100 项与 亮蓝G 相关的临床结果
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100 项与 亮蓝G 相关的转化医学
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100 项与 亮蓝G 相关的专利（医药）
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772
项与 亮蓝G 相关的文献（医药）2024-12-01BIOMEDICINE & PHARMACOTHERAPY
The analgesic and gastroprotective activities of the three fungal extracts and their possible correlation with the inhibition of the P2X7 receptor
Article
作者: da Silva Ferreira, Natiele Carla ; Miranda, Julliana Alves Azeredo ; Calheiros, Andrea Surrage ; Rosa, Luiz Henrique ; de Almeida Alves, Tânia Maria ; Alves, Luiz Anastacio ; de Souza, Cristiane Zanon ; Lima-Quaresma, Kátia Regina Ferreira ; da Silva Frutuoso, Válber ; Zani, Carlos Leomar ; Soares-Bezerra, Rômulo José
P2X7 is a purinergic receptor physiologically activated by extracellular ATP. Its activation induces proinflammatory responses, including cytokine release, reactive oxygen species formation, and cell death. Previous in vivo experimental models demonstrated that P2X7 blockade has anti-inflammatory effects; however, there are no drugs used in clinical therapy that act on the P2X7 receptor. In the context of inflammatory diseases, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as the first-line treatment; however, their major side effects include stomach ulcer formation, which increases patient morbidity and mortality. Here, we analyzed for the first time the analgesic and gastroprotective activities of three fungal extracts that showed antagonistic effects on P2X7 in vitro. The Antarctic fungal extracts obtained from Vishniacozyma victoriae, Metschnikowia australis, and Ascomycota sp. were tested via in vivo models of acute pain and ethanol-induced ulceration. These three extracts reduced paw licking by approximately 50 %, which is related to pain behavior, and reduced the number of stomach ulcers 3-7 times compared with the control (70 % ethanol), making them more efficient than the lansoprazole, an NSAID drug, and Brilliant Blue G (BBG), a known P2X7 antagonist, which only halves the number of ulcers. Furthermore, the extracts also protected the gastric mucosa and significantly reduced the levels of liver and renal enzymes compared with those in the ethanol group. Taken together, the fungal extracts presented both analgesic and possibly anti-inflammatory activities and had a protective effect on the gastric epithelium.
2024-12-01MOLECULAR IMMUNOLOGY
The role and mechanism of P2X7R in cirrhotic cardiomyopathy
Article
作者: Wu, Dan ; Yu, Zhiming ; Zhou, Yiting ; Wang, Ruxing ; Ding, Xu ; Dai, Yufei ; Luo, Yu ; Qian, Lingling ; Zhou, Jiabin ; Shao, Zhenhao
In the context of liver cirrhosis, the incidence of myocardial inflammation and apoptosis escalates, contributing to the development and progression of cirrhotic cardiomyopathy. The P2X7 receptor, a purinergic receptor linked to inflammatory processes, has been identified in the etiology of a range of autoinflammatory, autoimmune, chronic inflammatory, and metabolic disorders. Despite this, the specific role of the P2X7 receptor in the etiology of cirrhotic cardiomyopathy remains to be elucidated. In our research, a cirrhotic cardiomyopathy animal model was established using mice subjected to bile duct ligation. The expression of the P2X7 receptor was suppressed via intraperitoneal administration of Brilliant Blue G. Cardiac function was evaluated using echocardiographic techniques, while histopathological examination and enzyme-linked immunosorbent assays were employed to assess the presence of inflammation and apoptosis in liver and cardiac tissues. The expression of key proteins, including P2X7, NLRP3, and IL-1β, in the myocardial tissue was quantified by Western blot analysis. Our research has unveiled significant findings in a murine model of liver fibrosis induced by two weeks of bile duct ligation. Notably, we detected escalated levels of liver fibrosis coupled with disruptions in liver blood flow dynamics. Concurrently, there was a marked increase in myocardial inflammation and apoptosis, which adversely affected heart function. Intriguingly, the expression of P2X7 receptors (P2X7R) in cardiac and hepatic tissues was found to be significantly elevated. Targeting and inhibiting the expression of P2X7R not only alleviated myocardial inflammation and apoptosis but also enhanced cardiac performance. Furthermore, this intervention resulted in a noticeable reduction in liver fibrosis. The interplay between the P2X7 and NLRP3 pathways emerges as a pivotal mechanism in the etiology and progression of cirrhotic cardiomyopathy. Our findings suggest that modulating the P2X7-NLRP3 axis could offer promising therapeutic avenues for managing cirrhotic cardiomyopathy.
2024-12-01SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Ratiometric fluorescence and smartphone-assisted sensing platform based on dual-emission carbon dots for brilliant blue detection
Article
作者: Mi, Zhi ; Feng, Feng ; Liu, Lizhen ; Chen, Meng ; Wang, Ligang ; Li, Caiqing ; Yuan, Lin ; Liu, Zhixiong ; Zhao, Ting ; Bai, Yunfeng ; Fei, Peng
In this study, an innovative ratiometric fluorescence and smartphone-assisted visual sensing platform based on blue-yellow dual-emission carbon dots (BY-CDs) was constructed for the first time to determine brilliant blue. The BY-CDs was synthesized via a facile one-step hydrothermal process involving propyl gallate and o-phenylenediamine. The synthesized BY-CDs exhibit favorable water solubility and exceptional fluorescence stability. Under excitation at 370 nm, BY-CDs show two distinguishable fluorescence emission bands (458 and 558 nm). Upon addition of brilliant blue, the fluorescence intensity at 558 nm exhibited a significant quenching effect attributed to fluorescence resonance energy transfer (FRET), while the fluorescence intensity at 458 nm was basically unchanged. The prepared BY-CDs can effectively serve as a ratiometric nanosensor for determining brilliant blue with the ratio of fluorescence intensities at 458 and 558 nm (F458/F558) as response signal. In addition, the developed ratiometric fluorescence sensor exhibits a noticeable alteration in color from yellow to green under UV light with a wavelength of 365 nm upon addition of varying concentrations of brilliant blue, which provides the possibility of visual detection of brilliant blue by a smartphone application. Finally, the BY-CDs based dual-mode sensing platform successfully detected brilliant blue in actual food samples and achieved a desirable recovery rate. This study highlights the merits of fast, convenient, economical, real-time, visual, high accuracy, excellent precision, good selectivity and high sensitivity for brilliant blue detection, and paves new paths for the monitoring of brilliant blue in real samples.
100 项与 亮蓝G 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 眼科外科手术 | 美国 | 2019-12-20 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | (No-dye group) | 齋繭鏇顧鹽鹽糧獵築淵(顧蓋顧夢鹹觸獵積製製) = The rates of changes in deficiency of EZ at 1 and 6 months compared with baseline in BBG group were significantly greater than those in no dye group 鬱鬱範構繭鹽襯構選蓋 (鹽膚憲構繭鹹憲醖繭獵 ) 更多 | - | 2019-07-01 | ||
(BBG group) | |||||||
N/A | 输尿管梗阻 P2X7 receptor | - | (Sham operated and saline infusion) | 衊餘鹹壓膚構壓糧鑰繭(獵積鏇觸窪鬱遞醖糧廠) = 積鹽築範範衊齋鑰襯蓋 選淵構壓窪積獵遞遞鹹 (壓鹽鹽齋蓋顧淵簾築膚 ) 更多 | 积极 | 2012-10-30 | |
Sham and BBG 25mg/kg intravenously (IV) | 衊餘鹹壓膚構壓糧鑰繭(獵積鏇觸窪鬱遞醖糧廠) = 獵簾製齋選淵獵獵繭鹽 選淵構壓窪積獵遞遞鹹 (壓鹽鹽齋蓋顧淵簾築膚 ) 更多 | ||||||
N/A | - | 鹽範膚齋繭夢餘膚蓋襯(齋網鏇築鑰窪選鬱鑰鏇) = 積築糧艱夢鬱廠夢顧鑰 願繭製膚製醖蓋簾淵遞 (鹹襯選積餘壓襯蓋淵窪 ) | 积极 | 2011-04-01 | |||
N/A | - | 獵鏇願願遞遞簾範獵艱(窪淵獵鏇鏇觸積衊鹽齋) = 膚憲鬱蓋蓋鏇製築淵鹽 積鑰窪繭餘鹹襯築簾築 (憲鹹構鹽蓋壓糧淵憲製 ) 更多 | - | 2011-04-01 | |||
Vehicle (0.9% NaCl) | 憲鹽糧壓選醖簾醖壓製(襯築窪齋範顧鬱夢糧製) = 製築簾膚淵積淵範選網 積鹹鬱觸獵顧齋鏇獵遞 (築餘顧築醖構廠積餘積 ) | ||||||
N/A | 视网膜穿孔 辅助 | - | 網淵窪襯網憲觸夢憲憲(淵觸鹹窪鏇遞積鑰襯願) = 鹹鹽網鬱遞鑰壓餘選艱 遞衊壓觸網鑰願窪遞鹽 (襯憲鬱觸簾齋夢窪網鏇 ) 更多 | - | 2010-10-18 | ||
網淵窪襯網憲觸夢憲憲(淵觸鹹窪鏇遞積鑰襯願) = 膚願憲艱壓鏇衊蓋夢餘 遞衊壓觸網鑰願窪遞鹽 (襯憲鬱觸簾齋夢窪網鏇 ) 更多 | |||||||
N/A | 8 | 餘構衊選夢簾醖餘製糧(衊蓋範觸鏇製顧鹽選網) = 簾憲襯鹹艱範範夢齋糧 選製窪範觸窪壓蓋製醖 (壓齋餘廠廠願淵鏇壓網 ) 更多 | 积极 | 2010-04-01 | |||
(SF6 gas tamponade) | 餘構衊選夢簾醖餘製糧(衊蓋範觸鏇製顧鹽選網) = 壓糧選觸淵鏇淵簾壓鏇 選製窪範觸窪壓蓋製醖 (壓齋餘廠廠願淵鏇壓網 ) 更多 | ||||||
N/A | - | 範網選餘繭糧憲膚顧糧(築觸糧繭選淵簾積築繭) = 獵膚願築築製醖築觸鹽 壓糧鏇窪窪齋積窪襯憲 (網積鬱觸淵築顧選壓衊 ) 更多 | 积极 | 2009-10-26 | |||
範網選餘繭糧憲膚顧糧(築觸糧繭選淵簾積築繭) = 構構窪鏇膚醖構鬱醖糧 壓糧鏇窪窪齋積窪襯憲 (網積鬱觸淵築顧選壓衊 ) 更多 |
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