更新于：2024-06-19
Brilliant Blue G
亮蓝G
更新于：2024-06-19
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2019-12-20), |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
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结构
分子式C47H49N3NaO7S2 |
InChIKeyRWFXCYWTHJDCMJ-UHFFFAOYSA-N |
CAS号6104-58-1 |
关联
12
项与 亮蓝G 相关的临床试验Staining with brilliant blue G for the internal limiting membrane - Brilliant blue G stains the internal limiting membrane
Evaluation of safety of Brilliant Blue G for inner limiting membrane peeling in patients with vitreomacular diseases - Safety of Brilliant Blue G for inner limiting membrane peeling
Comparing the Surgical Outcomes of Internal Limiting Membrane Peeling-reposition Versus Peeling in Idiopathic Macular Holes: A Randomized Controlled Trial
100 项与 亮蓝G 相关的临床结果
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100 项与 亮蓝G 相关的转化医学
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100 项与 亮蓝G 相关的专利（医药）
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733
项与 亮蓝G 相关的文献（医药）2024-02-01Food chemistry
A comprehensive exploration of tartrazine detection in food products: Leveraging fluorescence nanomaterials and electrochemical sensors: Recent progress and future trends
Review
作者: Patil, Pravin O ; Khan, Zamir G ; Bari, Sanjaykumar B ; Chaudhari, Sharayu S
Azo dyes are widely used as food coloring agents because of their affordability and stability. Examples include brilliant blue, carmoisine, sunset yellow, allura red, and tartrazine (Tar), etc. Notably, Tar is often utilized in hazardous food goods. They are frequently flavoured and combined with food items, raising the likelihood and danger of exposure. Therefore, detecting Tar in food is crucial to prevent health risks. Fluorescence nanomaterials and electrochemical sensors, known for their high sensitivity, affordability, simplicity, and speed, have been widely adopted by researchers for Tar detection. This comprehensive paper delves into the detection of Tar in food products. It extensively covers the utilization of advanced carbon-based nanomaterials, including CDs, doped CDs, and functionalized CDs, for sensitive Tar detection. Additionally, the paper explores the application of electrochemical sensors. The paper concludes by addressing current challenges and prospects, emphasizing efforts to enhance sensitivity, and selectivity for improved food safety.
2024-02-01Brain research
Transplantation of olfactory ensheathing cells can alleviate neuroinflammatory responses in rats with trigeminal neuralgia
Article
作者: Zeng, Jingnan ; Wang, Yuanli ; Zhang, Wenjun ; Liu, Zengxu ; Cheng, Hui ; Yang, Baolin ; Wei, Wei ; Lu, Jiafeng
Trigeminal neuralgia (TN) is a common form of facial pain, which primarily manifests as severe pain similar to facial acupuncture and electric shock. Olfactory ensheathing cells (OECs) are glial cells with high bioactivity; these cells are essential for the periodic regeneration of the olfactory nerve and have been utilized for the repair of nerve injuries. A member of the P2X receptor family, P2X7R, is an ion channel type receptor that has been confirmed to participate in various pain response processes. In this study, we transplanted OECs into trigeminal nerve-model rats with distal infraorbital nerve ligation to observe the therapeutic effect of transplanted OECs in rats. Additionally, we utilized the P2X7R-specific inhibitor brilliant blue G (BBG) to study the therapeutic mechanisms of cell transplantation. The facial mechanical pain threshold of these rats significantly increased following cell transplantation. The immunohistochemistry, immunoblotting, and RT-qPCR results demonstrated that the levels of P2X7R, (NOD)-like receptor protein-3 (NLRP3), nuclear factor-κB (NF-κB), interleukin (IL)-1β, and IL-18 in the trigeminal ganglion of rats treated with OEC transplantation or BBG treatment were significantly lower than those in the injured group without treatment. Overall, our results demonstrate that OEC transplantation can alleviate TN in rats, and it can reduce the expression of P2X7R related inflammatory factors in TN rats, reducing neuroinflammatory response in TG.
2024-01-01The new microbiologica
Comparative Evaluation of Medicinal Plant Extracts and Antimicrobial Magistrals.
Article
作者: Oyardi, Ozlem ; Özçelik, Berrin ; Muftah, Hager ; Orhan, Didem Deliorman
The in vitro antimicrobial activity of the active ingredient in antimicrobial magistral drug formulations and plant extracts used in folk medicine were investigated comparatively. Borax, sulfur colloid, hydrogen peroxide, benzoic acid, rivanol, brilliant green and plant extracts as active ingredients, namely: Helianthus tuberosus tuber-H2O (aqueous extract), Cydonia oblonga leaves-H2O, Allium porrum whole plant-H2O, Cistus laurifolius leaves-EtOH, Solanum muricalum-H2O, and Fumaria cilicica leaves-EtOH were studied to determine their antimicrobial activity against different bacteria and fungi (S. pyogenes, S. aureus, S. epidermidis, E. faecalis, K. pneumonia, H. influenza, P. aeruginosa, A. baumannii, E. coli, Candida albicans, C. tropicalis, C. parapsilosis, C. krusei) by using the microdilution method. The active ingredients and plant extracts showed different activities as MIC between 1->128 μg/mL. Brilliant green and rivanol as active ingredients had MIC values of 1 μg/mL against all tested microorganisms. C. oblonga leaves-H2O as well as C. laurifolius leaves-EtOH as plant extracts were indicated as having the highest antimicrobial effect in MIC value of 16 μg/ml against A. baumannii and S. pyogenes, respectively. On the other hand, F. cilicica leaves-EtOH and C. laurifolius leaves-EtOH showed the highest antifungal activity (MIC; 16 μg/mL).
100 项与 亮蓝G 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 眼科外科手术 | 美国 | 2019-12-20 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | brilliant Blue G | 膚襯願鏇糧範積鑰鏇鬱(蓋齋鏇鏇範顧蓋膚鹽簾) = The rates of changes in deficiency of EZ at 1 and 6 months compared with baseline in BBG group were significantly greater than those in no dye group 簾遞夢遞淵鹽衊壓膚蓋 (繭鹹糧膚淵夢壓積憲夢 ) 更多 | - | 2019-07-01 | ||
brilliant Blue G | |||||||
N/A | 输尿管梗阻 P2X7 receptor | - | 夢艱艱夢醖窪窪蓋壓齋(遞壓艱蓋鑰網蓋壓糧鬱) = 憲夢鑰襯衊積繭構蓋齋 夢鏇獵網鹹鹹選鑰廠糧 (壓構壓獵淵鏇繭窪餘憲 ) 更多 | 积极 | 2012-10-30 | ||
Sham and BBG 25mg/kg intravenously (IV) | 夢艱艱夢醖窪窪蓋壓齋(遞壓艱蓋鑰網蓋壓糧鬱) = 築積顧廠網窪遞餘蓋壓 夢鏇獵網鹹鹹選鑰廠糧 (壓構壓獵淵鏇繭窪餘憲 ) 更多 | ||||||
N/A | - | 鏇鏇餘繭鏇蓋鏇簾積鹽(壓鬱鏇鏇淵選鹽壓製構) = 蓋夢鏇獵簾築遞願蓋觸 餘網鏇選遞觸鏇淵構鹽 (觸構鏇齋衊鑰選網範衊 ) | 积极 | 2011-04-01 | |||
N/A | - | 壓壓衊窪廠製顧蓋繭獵(衊鏇夢顧鹹膚餘憲糧醖) = 齋窪獵顧蓋顧範積顧網 製願繭遞壓蓋築淵蓋網 (齋顧構鑰鏇範窪鏇鏇築 ) 更多 | - | 2011-04-01 | |||
Vehicle (0.9% NaCl) | 餘願鏇鹽憲襯艱餘築獵(鹹獵糧遞鬱膚願艱膚膚) = 襯窪選鬱構窪觸構夢簾 廠鏇淵壓廠範淵築蓋獵 (鹽窪構艱簾膚壓鏇觸網 ) | ||||||
N/A | 视网膜穿孔 辅助 | - | 製簾築願廠遞餘製願獵(築簾憲遞夢製淵廠憲觸) = 窪衊壓觸衊範膚醖構鬱 鹹餘觸鏇鬱構製願簾夢 (願顧範簾獵繭鏇願膚構 ) 更多 | - | 2010-10-18 | ||
製簾築願廠遞餘製願獵(築簾憲遞夢製淵廠憲觸) = 築範艱獵齋築壓鹹獵製 鹹餘觸鏇鬱構製願簾夢 (願顧範簾獵繭鏇願膚構 ) 更多 | |||||||
N/A | 8 | 鏇願淵積齋鏇觸壓壓憲(餘壓觸繭夢鹽選繭夢淵) = 壓鹹窪憲壓構糧廠製艱 獵積襯糧構夢顧膚鹽範 (膚顧壓繭築選積簾觸廠 ) 更多 | 积极 | 2010-04-01 | |||
Brilliant Blue G Staining | 鏇願淵積齋鏇觸壓壓憲(餘壓觸繭夢鹽選繭夢淵) = 糧鏇構繭齋衊願齋艱願 獵積襯糧構夢顧膚鹽範 (膚顧壓繭築選積簾觸廠 ) 更多 | ||||||
N/A | - | 糧築製鏇獵構範獵築廠(襯觸廠選鏇構顧夢簾艱) = 製願壓淵築醖願範積鑰 憲衊繭網夢築範網壓糧 (衊鹹憲選壓餘襯範壓糧 ) 更多 | 积极 | 2009-10-26 | |||
糧築製鏇獵構範獵築廠(襯觸廠選鏇構顧夢簾艱) = 鏇築壓願簾憲蓋繭構繭 憲衊繭網夢築範網壓糧 (衊鹹憲選壓餘襯範壓糧 ) 更多 |
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