预约演示
更新于：2024-12-27
Brilliant Blue G
亮蓝G
更新于：2024-12-27
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2019-12-20), |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C47H49N3NaO7S2 |
InChIKeyRWFXCYWTHJDCMJ-UHFFFAOYSA-N |
CAS号6104-58-1 |
关联
12
项与 亮蓝G 相关的临床试验JPRN-UMIN000031510
Staining with brilliant blue G for the internal limiting membrane - Brilliant blue G stains the internal limiting membrane
JPRN-UMIN000031906
Evaluation of safety of Brilliant Blue G for inner limiting membrane peeling in patients with vitreomacular diseases - Safety of Brilliant Blue G for inner limiting membrane peeling
NCT03020459
Comparing the Surgical Outcomes of Internal Limiting Membrane Peeling-reposition Versus Peeling in Idiopathic Macular Holes: A Randomized Controlled Trial
100 项与 亮蓝G 相关的临床结果
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100 项与 亮蓝G 相关的转化医学
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100 项与 亮蓝G 相关的专利（医药）
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774
项与 亮蓝G 相关的文献（医药）2025-02-01BRAIN BEHAVIOR AND IMMUNITY
Demyelination of the amygdala mediates psychological stress-induced emotional disorders partially contributed by activation of P2X7R/NLRP3 cascade
Article
作者: Lin, Dandan ; Jing, Chenchen ; Fu, Xiaoliang ; Li, Yanning ; Zhang, Yi
Psychological stress can lead to emotional disorders, such as anxiety and depression; however, the underlying mechanisms are complicated and remain unclear. In this study, we established a mouse psychological stress model using an improved communication box, in which the psychologically stressed mice received visual, auditory, and olfactory emotional stimuli from the mice receiving electric foot shock, thus avoiding physical stress interference. After the 14-day psychological stress paradigm, our mice exhibited a significant increase in depressive and anxious behaviors. We then performed proteomic liquid chromatography-tandem mass spectrometry for proteomic data analysis of the amygdala, and the results demonstrated that differentially expressed proteins were more enriched in myelin-related biological processes, cellular components, and molecular functions, indicating a correlation between psychological stress-induced emotional disorders and amygdala myelin damage. Molecular and morphological evidence further confirmed that psychological stress damages myelin ultrastructure, downregulated myelin basic protein and proteolipid protein expression, and reduced oligodendrocyte proliferation in the amygdala. Moreover, clemastine, an antimuscarinic and antihistaminic compound that has been shown to enhance oligodendrocyte differentiation and myelination, rescued depressive behaviors accompanied by increased oligodendrogenesis. In the amygdala, psychological stress was also noted to activate microglia and increase the levels of NOD-like receptor protein 3 (NLRP3) and the proinflammatory cytokines interleukin 1β and tumor necrosis factor α, as indicated by ELISA and Western blot analyses. Moreover, in stressed mice, the administration of Brilliant Blue G, a purinergic ligand-gated ion channel 7 receptor (P2X7R) antagonist, completely reversed the increases in NLRP3 and cleaved caspase-1 levels and partially prevented amygdala myelin damage. In conclusion, amygdala demyelination may mediate psychological stress-induced emotional disorders, and P2X7R/NLRP3 cascade activation partially contributes to amygdala myelin damage after psychological stress.
2024-12-01MOLECULAR IMMUNOLOGY
The role and mechanism of P2X7R in cirrhotic cardiomyopathy
Article
作者: Wu, Dan ; Yu, Zhiming ; Zhou, Yiting ; Wang, Ruxing ; Ding, Xu ; Dai, Yufei ; Luo, Yu ; Qian, Lingling ; Zhou, Jiabin ; Shao, Zhenhao
In the context of liver cirrhosis, the incidence of myocardial inflammation and apoptosis escalates, contributing to the development and progression of cirrhotic cardiomyopathy. The P2X7 receptor, a purinergic receptor linked to inflammatory processes, has been identified in the etiology of a range of autoinflammatory, autoimmune, chronic inflammatory, and metabolic disorders. Despite this, the specific role of the P2X7 receptor in the etiology of cirrhotic cardiomyopathy remains to be elucidated. In our research, a cirrhotic cardiomyopathy animal model was established using mice subjected to bile duct ligation. The expression of the P2X7 receptor was suppressed via intraperitoneal administration of Brilliant Blue G. Cardiac function was evaluated using echocardiographic techniques, while histopathological examination and enzyme-linked immunosorbent assays were employed to assess the presence of inflammation and apoptosis in liver and cardiac tissues. The expression of key proteins, including P2X7, NLRP3, and IL-1β, in the myocardial tissue was quantified by Western blot analysis. Our research has unveiled significant findings in a murine model of liver fibrosis induced by two weeks of bile duct ligation. Notably, we detected escalated levels of liver fibrosis coupled with disruptions in liver blood flow dynamics. Concurrently, there was a marked increase in myocardial inflammation and apoptosis, which adversely affected heart function. Intriguingly, the expression of P2X7 receptors (P2X7R) in cardiac and hepatic tissues was found to be significantly elevated. Targeting and inhibiting the expression of P2X7R not only alleviated myocardial inflammation and apoptosis but also enhanced cardiac performance. Furthermore, this intervention resulted in a noticeable reduction in liver fibrosis. The interplay between the P2X7 and NLRP3 pathways emerges as a pivotal mechanism in the etiology and progression of cirrhotic cardiomyopathy. Our findings suggest that modulating the P2X7-NLRP3 axis could offer promising therapeutic avenues for managing cirrhotic cardiomyopathy.
2024-12-01BIOMEDICINE & PHARMACOTHERAPY
The analgesic and gastroprotective activities of the three fungal extracts and their possible correlation with the inhibition of the P2X7 receptor
Article
作者: da Silva Ferreira, Natiele Carla ; Miranda, Julliana Alves Azeredo ; Calheiros, Andrea Surrage ; Rosa, Luiz Henrique ; de Almeida Alves, Tânia Maria ; Alves, Luiz Anastacio ; de Souza, Cristiane Zanon ; da Silva Frutuoso, Válber ; Lima-Quaresma, Kátia Regina Ferreira ; Zani, Carlos Leomar ; Soares-Bezerra, Rômulo José
P2X7 is a purinergic receptor physiologically activated by extracellular ATP. Its activation induces proinflammatory responses, including cytokine release, reactive oxygen species formation, and cell death. Previous in vivo experimental models demonstrated that P2X7 blockade has anti-inflammatory effects; however, there are no drugs used in clinical therapy that act on the P2X7 receptor. In the context of inflammatory diseases, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as the first-line treatment; however, their major side effects include stomach ulcer formation, which increases patient morbidity and mortality. Here, we analyzed for the first time the analgesic and gastroprotective activities of three fungal extracts that showed antagonistic effects on P2X7 in vitro. The Antarctic fungal extracts obtained from Vishniacozyma victoriae, Metschnikowia australis, and Ascomycota sp. were tested in animal models of acute pain and ethanol-induced ulceration. These three extracts reduced paw licking by approximately 50 %, which is related to pain behavior, and reduced the number of stomach ulcers 3-7 times compared with the control (70 % ethanol), making them more efficient than the lansoprazole, an NSAID drug, and Brilliant Blue G (BBG), a known P2X7 antagonist, which only halves the number of ulcers. Furthermore, the extracts also protected the gastric mucosa and significantly reduced the levels of liver and renal enzymes compared with those in the ethanol group. Taken together, the fungal extracts presented both analgesic and possibly anti-inflammatory activities and had a protective effect on the gastric epithelium.
100 项与 亮蓝G 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 眼科外科手术 | 美国 | 2019-12-20 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 纤维化 | 临床前 | - | - | 2013-04-01 |
| 肾炎 | 临床前 | - | - | 2013-04-01 |
| 视网膜变性 | 临床前 | 日本 | 2011-04-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | (No-dye group) | 壓鬱餘齋鑰繭鹽獵繭遞(網廠範製醖淵壓齋願蓋) = The rates of changes in deficiency of EZ at 1 and 6 months compared with baseline in BBG group were significantly greater than those in no dye group 餘鑰構醖糧製顧衊築築 (艱選簾願網鹹繭積網鹽 ) 更多 | - | 2019-07-01 | ||
(BBG group) | |||||||
N/A | 输尿管梗阻 P2X7 receptor | - | (Sham operated and saline infusion) | 鏇選膚廠構壓衊衊鏇觸(醖憲糧膚醖糧艱構齋廠) = 鏇願衊衊觸簾遞夢襯製 齋鏇糧淵衊壓顧範鑰築 (廠願製選製獵鬱願築顧 ) 更多 | 积极 | 2012-10-30 | |
Sham and BBG 25mg/kg intravenously (IV) | 鏇選膚廠構壓衊衊鏇觸(醖憲糧膚醖糧艱構齋廠) = 襯範艱築艱築觸鬱鬱簾 齋鏇糧淵衊壓顧範鑰築 (廠願製選製獵鬱願築顧 ) 更多 | ||||||
N/A | - | 網蓋獵築願鬱願蓋鑰窪(糧選鏇醖憲觸衊繭醖鹽) = 糧窪簾鬱築衊製鬱鏇衊 餘築築網鹽糧積構網糧 (憲蓋襯窪獵顧製願壓遞 ) | 积极 | 2011-04-01 | |||
N/A | - | 顧顧鑰鏇遞膚壓鏇顧淵(簾構鏇觸積鏇襯選淵獵) = 鑰網獵廠願鹽積製壓願 廠鹽鑰餘醖觸構鬱膚艱 (壓淵顧範齋窪鏇顧鹹鹽 ) 更多 | - | 2011-04-01 | |||
Vehicle (0.9% NaCl) | 觸範構選淵範鹽築窪蓋(艱獵範簾窪繭艱鹹衊積) = 夢蓋憲艱顧艱簾顧鹹衊 憲窪簾夢觸艱衊餘簾壓 (襯淵淵憲願齋膚獵築鑰 ) | ||||||
N/A | 视网膜穿孔 辅助 | - | 顧構醖廠淵製繭鬱鹽憲(夢膚鹽壓顧醖獵衊鬱餘) = 遞憲膚壓憲衊壓蓋鬱觸 鹹製願鑰鹽繭淵積範鑰 (醖齋鬱顧遞餘選襯壓觸 ) 更多 | - | 2010-10-18 | ||
顧構醖廠淵製繭鬱鹽憲(夢膚鹽壓顧醖獵衊鬱餘) = 遞網夢選獵餘觸憲廠艱 鹹製願鑰鹽繭淵積範鑰 (醖齋鬱顧遞餘選襯壓觸 ) 更多 | |||||||
N/A | 8 | 淵選壓願齋繭積壓築鬱(鹽鏇壓鹽鬱鹽願糧蓋糧) = 範鏇餘壓願築鹹觸壓顧 廠簾構淵範築積製簾蓋 (鑰鹹鬱範衊鬱餘餘憲顧 ) 更多 | 积极 | 2010-04-01 | |||
(SF6 gas tamponade) | 淵選壓願齋繭積壓築鬱(鹽鏇壓鹽鬱鹽願糧蓋糧) = 淵壓壓艱構鹹鹽鬱窪構 廠簾構淵範築積製簾蓋 (鑰鹹鬱範衊鬱餘餘憲顧 ) 更多 | ||||||
N/A | - | 顧襯網艱衊憲鏇憲糧網(艱襯網觸襯繭獵醖簾淵) = 鬱壓鑰艱遞獵製衊鑰願 積選選廠遞製鹽窪鏇憲 (齋願製壓鬱製簾觸艱遞 ) 更多 | 积极 | 2009-10-26 | |||
顧襯網艱衊憲鏇憲糧網(艱襯網觸襯繭獵醖簾淵) = 範簾蓋蓋鏇鏇憲夢顧鹹 積選選廠遞製鹽窪鏇憲 (齋願製壓鬱製簾觸艱遞 ) 更多 |
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