预约演示
更新于：2025-03-31
Iopromide
碘普罗胺
更新于：2025-03-31
概要
基本信息
药物类型 造影剂、小分子化药 |
别名 Iopromide (JAN/USP/INN)、N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylisophthalamide、碘普胺 + [7] |
作用方式 拮抗剂、增强剂 |
作用机制 M1 receptor拮抗剂(毒蕈碱型乙酰胆碱受体M1拮抗剂)、M3 receptor拮抗剂(毒蕈碱型乙酰胆碱受体M3拮抗剂)、射线照相增强剂 |
非在研适应症- |
原研机构- |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 澳大利亚 (1991-09-12), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C18H24I3N3O8 |
InChIKeyDGAIEPBNLOQYER-UHFFFAOYSA-N |
CAS号73334-07-3 |
关联
11
项与 碘普罗胺 相关的临床试验NCT03631771
A Multicenter, Prospective Study to Evaluate the Risk of Hypothyroidism in Pediatric Patients Administered Intravascular Iohexol, Iodixanol, Iopromide, or Ioversol. THYROPED.
NCT04605471
Safety Profile of Ultravist in Children and Elderly (UV Age)
NCT03622801
Risk of Anaphylactoid Reactions of Iopromide After Intra-arterial Administration
100 项与 碘普罗胺 相关的临床结果
登录后查看更多信息
100 项与 碘普罗胺 相关的转化医学
登录后查看更多信息
100 项与 碘普罗胺 相关的专利（医药）
登录后查看更多信息
1,629
项与 碘普罗胺 相关的文献（医药）2025-04-01SCIENCE OF THE TOTAL ENVIRONMENT
An integrated analysis of the use and potential risks of pharmaceutical drugs in hospital wastewater: Consumption and occurrence by suspect screening analysis, and antibiotic resistance
Article
作者: Starling, Maria Clara V M ; Becker, Raquel W ; da Silva, Eloísa Stéphanie ; Reis, Ana Paula V ; Mendes, Tiago Antônio de Oliveira ; Aguilar, Ananda Pereira ; Machado, Elayne C ; Sirtori, Carla ; Amorim, Camila C
Hospital wastewater (HWW) contains pharmaceutical drugs, antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARG), and pathogens, posing potential risks to environmental and public health. However, data on the occurrence of these contaminants are scarce, especially in low- and middle-income countries. This study employed LC-QTOF MS for a qualitative suspect screening of 1922 pharmaceutical drugs and metabolites in HWW (n = 8 samples). Results were used in an environmental risk assessment applied with the support of in silico tools, to predict potential risks to aquatic organisms. ARB were analyzed using plate count agar method and ARG by Real-time PCR. 113 drugs were identified in HWW, and antibiotics were the most frequently detected (15 compounds). Environmental risk assessment indicated that 29 compounds have the potential to cause toxic effects to aquatic fauna, among which 4 compounds (ampicillin, escitalopram, iopromide, and topiramate) may pose a very high potential risk (RQ > 2). In addition, ARB resistant to azithromycin and cefazolin (106-107 CFU/mL) were abundant in HWW samples, while low levels of bacteria resistant to meropenem (105 CFU/mL) were detected. The relative number of copies of blaKPC, catA1, sul1, ermB, qnrS, vanB, floR, and aadA were higher in HWW from one of the hospitals. However, there was no significant difference for blaOXA (p value = 0.1271) or mecA genes (p value = 0.6077) in HWW samples. These results call attention to potential risks posed by the discharge of HWW and reveal the need to raise data for improving management practices for environmental protection.
2025-03-01ENVIRONMENTAL RESEARCH
Seasonal variability and risk evaluation of emerging organic contaminants in European river: Linking in silico and in vitro approaches to prioritize hazardous EOCs
Article
作者: Klobučar, Göran ; Hudina, Sandra ; Selak, Ana ; Martinović-Weigelt, Dalma ; Šiljeg, Mario ; Vucić, Matej ; Repec, Siniša ; Bojanić, Krunoslav ; Stipaničev, Draženka
Emerging organic contaminants (EOCs) are a growing concern for aquatic ecosystems, underscoring the need for advanced risk assessment methodologies. This study employed an integrated approach to evaluate the risks associated with 563 EOCs across 13 monitoring sites along the Sava River in Croatia. Sampling was conducted during the winter and spring months, spanning February to May. The detected substances, totaling 551 compounds, included pharmaceuticals, illicit drugs, pesticides, industrial chemicals, hormones, artificial sweetener, and sunscreen chemical. We hypothesized that combining high-resolution chemical monitoring with bio-effect assessment tools could enhance the prioritization of high-risk EOCs and their mixtures. Persistent, bioaccumulative, and toxic (PBT) profiling and risk quotient (RQ) evaluations identified pesticides and industrial chemicals as key contributors to biological impacts, peaking in April due to agricultural activities. In vitro prioritization using exposure-activity ratios (EARs) derived from the ToxCast database revealed exacerbated biological effects during colder months (February and March), driven by elevated levels of pharmaceuticals, particularly synthetic glucocorticoids used for treatments of respiratory infections. By integrating PBT, RQ, and EAR assessments, eight EOCs, including methylprednisolone (a synthetic glucocorticoid), bisphenol A (an industrial chemical), nicotine (a stimulant), and five pesticides (temephos, disulfoton, pyridaben, bifenthrin, and chlorpyrifos-methyl), were prioritized for monitoring and regulatory attention. This multi-method framework advances next-generation risk assessment, offering critical insights for managing EOC pollution and safeguarding aquatic ecosystems and public health.
2025-03-01International Journal of Environmental Science and Technology
Multivariate analysis of ozonation as a control for the formation of iodinated disinfection by-products from iopamidol oxidation
作者: J. Lopez-Prieto, Israel ; Nunez-Correa, S. ; C. Cuevas-Diaz, M. ; Rodriguez-Ramirez, T. E. ; Perez-Pastenes, H. ; Guzman-Lopez, O.
There is a global concern about iodinated contrast media because they may be an anthropogenic source of iodine, and thereby precursors of iodinated disinfection byproducts during chlorine disinfection.These byproduct compounds may exert higher toxicity than regulated-disinfection byproducts (i.e., trihalomethanes and haloacetic acids).This represents a challenge for water utilities due to the unknown formation of these iodinated disinfection byproducts.This work is two folded: on one hand, it researches the effects of ozone as pretreatment for iopamidol oxidation through a sequential treatment of low-pressure UV light followed by free chlorine, and in the other hand, it applies an algorithm of principal component anal. to obtain the multivariable of these sequential treatments.In this context, a formation iodinated disinfection byproducts to iodide correlation models were developed under each treatment condition (i.e., UV-Cl2, and O3-UV-Cl2).Addnl., five iodinated disinfection byproducts were detected: dichloroidomethane, chlorodiiodomethane, iodoform, iodoacetonitrile and chloroiodoacetamide, corresponding to trihalomethanes, haloacetonitriles and haloacetamides resp.Showed that ozonation as a pre-treatment step (O3-UV-Cl2) reduced up to 53% byproducts formation than UV-Cl2.Using principal component anal., it was found that iodinated disinfection byproducts to iodide correlation models showed a better correlation for the ozonation pretreatment with a R2 = 0.9122 along with a Pearson coefficient of r = 0.9551.Ozonation should be considered as a strategy to control the formation of these iodinated byproducts for water reuse from waters enriched with anthropogenic iodine.Future experiments with different source waters should be addressed to explore the formation and control of unregulated iodinated disinfection byproducts.
100 项与 碘普罗胺 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 乳腺疾病 | 美国 | 2023-05-25 | |
| 主动脉疾病 | 美国 | 1995-05-10 | |
| 心血管疾病 | 美国 | 1995-05-10 | |
| 脑血管疾病 | 美国 | 1995-05-10 | |
| 冠状动脉疾病 | 美国 | 1995-05-10 | |
| 外周动脉疾病 | 美国 | 1995-05-10 | |
| 尿道疾病 | 美国 | 1995-05-10 | |
| 造影剂 | 澳大利亚 | 1991-09-12 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | 132,850 | (Children (<18 years)) | 繭願襯夢襯艱構襯蓋憲(繭淵觸蓋繭衊範餘願衊) = 窪觸餘積獵糧夢顧構餘 鑰艱齋築鬱淵窪糧壓壓 (鬱衊艱餘鏇醖鏇壓獵網 ) | - | 2021-12-01 | |
(Elderly (≥65 years)) | 繭願襯夢襯艱構襯蓋憲(繭淵觸蓋繭衊範餘願衊) = 憲醖獵獵齋衊鑰膚鑰膚 鑰艱齋築鬱淵窪糧壓壓 (鬱衊艱餘鏇醖鏇壓獵網 ) | ||||||
临床3期 | 435 | (Iopromide 370 mg I/mL) | 壓顧窪網獵選獵淵鹽鹹 = 觸觸齋鑰餘鹹糧餘製膚 鹹獵衊鬱鑰廠廠簾壓鬱 (製廠遞襯鑰淵襯艱夢願, 襯鏇蓋醖選膚鹹選鹹製 ~ 構顧廠衊窪遞糧鏇選醖) 更多 | - | 2009-07-20 | ||
(Iopromide 300 mg I/mL) | 壓顧窪網獵選獵淵鹽鹹 = 製網構夢鹽獵鏇夢鬱餘 鹹獵衊鬱鑰廠廠簾壓鬱 (製廠遞襯鑰淵襯艱夢願, 繭築鬱製鏇製簾鹹築選 ~ 餘選遞膚顧淵醖繭獵願) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用