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更新于：2025-05-16
Mupirocin
莫匹罗星
更新于：2025-05-16
概要
基本信息
简介莫匹罗星（Mupirocin）商品名CENTANY®，是一种小分子药物，通过抑制RNA合成酶治疗由革兰氏阳性细菌引起的脓疱病和其他皮肤感染。Mupirocin最初由GSK开发，1987年12月首次批准使用。CENTANY®软膏是一种局部药物，用于通过抑制细菌生长和阻止感染传播来治疗脓疱病。 |
药物类型 小分子化药 |
别名 Bactroban Nasal、Mupirocin (USP/INN)、Mupirocin cream + [6] |
作用方式 抑制剂 |
作用机制 Bacterial IRS抑制剂(细菌异硫氨酸-tRNA合成酶抑制剂) |
非在研适应症- |
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1987-12-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C26H44O9 |
InChIKeyMINDHVHHQZYEEK-HBBNESRFSA-N |
CAS号12650-69-0 |
关联
81
项与 莫匹罗星 相关的临床试验NCT06712433
Bacterial Decolonization Plus Intraoperative Indocyanine Green Angiography for Soft Tissue Sarcomas of the Lower Extremity Receiving Preoperative Radiotherapy (CONCERTO)
NCT06541145
Impact of Bacterial Decolonization on Bacterial Burden Within Maternal-infant Dyads
ChiCTR2400085012
Clinical effects of photodynamic therapy with Ondapench photosensitive antibacterial powder as photosensitiser compared with mupirocin ointment in the treatment of bacterial skin infections
100 项与 莫匹罗星 相关的临床结果
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100 项与 莫匹罗星 相关的转化医学
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100 项与 莫匹罗星 相关的专利（医药）
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3,521
项与 莫匹罗星 相关的文献（医药）2025-06-01JOURNAL OF HAZARDOUS MATERIALS
Removal of antibiotic resistance from wastewater in aquatic ecosystems dominated by submerged macrophytes
Article
作者: Huang, Xian-Hui ; Li, Xin-Ting ; Li, Ling-Lin ; Zhang, Rong-Min ; Tan, Hui-Zhen ; Li, Ya-Fei ; Huang, Wen-Qing ; Chen, Xiao-Jie ; Xie, Jie ; Chong, Yun-Xiao ; Lian, Xin-Lei
Submerged macrophytes in constructed wetlands (CWs) can effectively improve wastewater quality. However, the effectiveness of different submerged macrophytes in removing antibiotic-resistant genes (ARGs) from wastewater remains unexplored. Additionally, wastewater loading in wetlands can fluctuate due to climate change, potentially affecting ARG removal efficiency. In this study, we systematically constructed microscale wetlands using three submerged plants: Vallisneria natans (VN), Sagittaria pygmaea (SP), and Myriophyllum spicatum (MS). Their effectiveness in ARGs removal was analyzed at hydraulic retention times (HRTs) of 0, 3, 6, and 9 days under high (HWL) and low (LWL) wastewater loading. The results indicated that under LWL conditions, all ecosystems exhibited a higher reduction rate of ARG diversity and relative abundance (RS) compared to HWL conditions. The efficiency of all ecosystems in reducing ARG diversity and abundance followed the order: MS > VN > SP. The sul resistance gene exhibited the highest RS and was degraded most rapidly in all samples. Additionally, sulfadimidine concentrations significantly decreased under LWL conditions, which was significantly correlated with sul reduction. Chemical oxygen demand, total phosphorus, total nitrogen, ammonium nitrogen, and nitrate nitrogen were identified as key factors influencing bacterial and ARG profiles. The increase in rhizobial bacteria and decrease in aerobic denitrifying bacteria likely contributed significantly to ARGs removal. This study offers new insights into ARG removal by submerged macrophytes in CWs, emphasizing the role of wastewater loading and the potential of MS in enhancing ARG degradation. These findings enhance CW design and management to mitigate ARG contamination in wastewater.
2025-06-01JOURNAL OF HAZARDOUS MATERIALS
Metagenomic insights into the inhibitory effect of phytochemical supplementation on antibiotic resistance genes and virulence factors in the rumen of transition dairy cows
Article
作者: Zhao, Huiying ; Zhang, Ao ; Wang, Ying ; Jiang, Linshu ; Tan, Jian ; Zhao, Yuchao ; Li, Liuxue
Antimicrobial resistance (AMR) is a major global health concern, with the rumen microbiota of dairy cows serving as an important reservoir for antibiotic resistance genes (ARGs) and virulence factors (VFs). This study explores the impact of dietary phytochemical supplementation on the rumen resistome and virulome of transition dairy cows using metagenomic sequencing. Naringin supplementation reduced the abundance of ARGs by up to 9.0 % and VFs by up to 7.2 % during the transition period, as indicated by metagenomic analysis (P < 0.05). Clinically high-risk ARGs, including those conferring resistance to beta-lactams (mecA), tetracyclines (tetM, tetO), and aminoglycosides (rmtF), were notably downregulated (P < 0.05). Virulence factors associated with adherence, secretion systems, and toxins were also significantly decreased (P < 0.05). Naringin altered the microbial community structure, particularly reducing the abundance of Proteobacteria, a key phylum harboring ARGs and VFs. Despite inducing increased ARG-VF network complexity, naringin supplementation promoted a less pathogenic microbiome with reduced resistance potential. These findings demonstrate the potential of naringin as a natural dietary strategy to mitigate AMR by reducing the risk of ARG and VF dissemination into the environment, while supporting rumen microbiota stability in transition dairy cows.
2025-05-01JOURNAL OF HAZARDOUS MATERIALS
Presence of high-risk ARGs with greater diversity and abundance in the rare resistome in wastewater across China
Article
作者: Zhou, Bo ; Zhang, Yu ; Wang, Yue ; Qin, Jun ; Chen, Chaoqi ; Li, Xiqing ; Huang, Jianwen
Antibiotic resistance genes (ARGs) are widely recognized as hazardous materials that pose risks to public health. The core resistome, with its low ARG diversity yet accounting for the majority of the total ARG abundance, dominating the profile of antibiotic resistance. In this study, nationwide wastewater surveillance in China using metagenomic sequencing also identified a core resistome of 117 ARGs that accounted for 69.6 % of the total abundance. The emphasis of the work was to examine the rare resistome that included 1503 ARGs outside the core resistome. The abundances of clinically relevant ARG types (e.g., β-lactams and quinolones) were significantly higher in the rare resistome compared to the core resistome. Human pathogen-related ARGs were much greater in subtype number (96 vs. 34) and significantly higher in abundance (67.0 % vs. 33.0 %) in the rare relative to the core resistome, indicating that the rare resistome was the major contributor to the human pathogen resistome. The majority of ARG types accounting for the highest proportions of the rare resistome were plasmid-originated (65.5 %-100 %). In addition, human pathogen-related ARGs also had a significantly higher proportion of plasmid sources than non-pathogen ARGs, further highlighting their importance in wastewater-based surveillance.
100 项与 莫匹罗星 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 继发感染 | 澳大利亚 | 1998-04-03 | |
| 革兰氏阳性细菌感染 | 中国 | 1993-01-01 | |
| 脓疱疮 | 美国 | 1987-12-31 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | - | 14 | Hygiene education (Hygiene Education) | 衊顧鏇憲鬱糧鬱壓憲壓 = 糧餘顧選鹽觸蓋顧簾製 簾淵鹹範獵構鹽鑰構築 (繭築壓製繭製艱範築鏇, 窪網壓網鏇鑰鏇淵鬱鑰 ~ 觸憲獵鹽襯網壓遞積觸) 更多 | - | 2024-06-25 | |
Sodium Hypochlorite+Mupirocin ointment (Hygiene Education and Decolonization) | 衊顧鏇憲鬱糧鬱壓憲壓 = 廠遞壓築構選膚範繭鏇 簾淵鹹範獵構鹽鑰構築 (繭築壓製繭製艱範築鏇, 網襯壓繭願觸鹹觸製鏇 ~ 衊襯鹽憲鏇膚觸夢糧觸) 更多 | ||||||
临床4期 | 353,323 | (Arm 1: Routine Care (Mupirocin/CHG)) | 簾窪製觸築構構築獵窪 = 顧壓繭壓壓餘艱艱積鏇 餘夢蓋築艱鏇蓋築膚餘 (製壓淵願網餘觸築鹽鏇, 鬱鑰鏇壓鏇築齋膚構糧 ~ 齋鑰糧餘鏇餘窪遞築鹽) 更多 | - | 2024-02-07 | ||
Arm 2. Iodophor/CHG Decolonization (Arm 2: Iodophor/CHG Decolonization) | 簾窪製觸築構構築獵窪 = 蓋醖願製餘糧鹹艱鹹獵 餘夢蓋築艱鏇蓋築膚餘 (製壓淵願網餘觸築鹽鏇, 壓顧糧鹽鬱淵膚蓋選餘 ~ 選艱遞繭製蓋繭醖醖窪) 更多 | ||||||
临床2/3期 | 76 | 醖糧衊壓鹽壓窪築積糧(醖壓淵壓齋構窪繭鹽網) = 築構壓壓醖鬱製鏇糧壓 鏇夢鹽獵餘鹽觸鏇窪繭 (壓齋鏇糧淵衊襯選窪選 ) 更多 | 积极 | 2022-06-08 | |||
standard of care | 醖糧衊壓鹽壓窪築積糧(醖壓淵壓齋構窪繭鹽網) = 鑰窪餘糧繭願選鬱醖膚 鏇夢鹽獵餘鹽觸鏇窪繭 (壓齋鏇糧淵衊襯選窪選 ) 更多 | ||||||
临床1/2期 | 19 | (Tobramycin Topical Antibiotic Nasal Saline Rinse) | 夢襯糧鹽壓膚廠鏇襯餘 = 壓鹹糧廠鬱鬱餘齋餘選 衊鑰繭構繭膚廠鬱獵鑰 (鹽廠鹽範衊衊鏇鬱遞廠, 網鬱積憲積廠顧鬱鑰簾 ~ 構遞鑰壓構艱餘鹽窪願) 更多 | - | 2022-04-20 | ||
(Levofloxacin Topical Antibiotic Nasal Saline Rinse) | 夢襯糧鹽壓膚廠鏇襯餘 = 遞鬱簾蓋範齋蓋廠衊鬱 衊鑰繭構繭膚廠鬱獵鑰 (鹽廠鹽範衊衊鏇鬱遞廠, 蓋構積醖襯製繭簾淵廠 ~ 網淵壓範觸顧衊衊構蓋) 更多 | ||||||
临床4期 | 19 | 範廠築醖艱餘糧觸繭繭(範遞鑰製鏇艱簾築鏇窪) = 艱衊範願壓襯醖顧艱遞 艱鑰壓膚觸鏇夢壓鏇網 (衊網餘鬱獵構夢願網窪, 11003) 更多 | - | 2020-04-24 | |||
N/A | 307 | (Mupirocin and Chlorhexidine) | 獵衊遞淵襯鏇遞齋觸網 = 淵艱糧繭夢範餘遞餘築 鑰範鹹簾醖觸網蓋廠夢 (壓壓鑰膚鹹衊餘願蓋鹽, 鏇窪顧膚鑰積齋醖衊製 ~ 艱憲窪築壓衊壓遞夢簾) 更多 | - | 2020-03-16 | ||
placebo cloths (Placebo Ointment and Placebo Cloths) | 獵衊遞淵襯鏇遞齋觸網 = 餘鏇夢遞選鬱蓋簾餘糧 鑰範鹹簾醖觸網蓋廠夢 (壓壓鑰膚鹹衊餘願蓋鹽, 積壓膚鑰觸遞範積築餘 ~ 鏇窪鹽衊蓋醖憲鏇憲醖) 更多 | ||||||
临床2期 | 29 | (Inhaled Vancomycin and Oral Antibiotics) | 範製膚鹽襯糧鑰鏇膚顧 = 壓糧艱壓遞膚鑰鹽夢壓 築齋範鹹繭遞醖製選壓 (網夢簾網簾艱鹽積壓獵, 鹹蓋艱願膚鏇艱鑰壓衊 ~ 願願選廠壓鹹網齋淵蓋) 更多 | - | 2018-11-20 | ||
Placebo (Inhaled Placebo (Sterile Water) and Oral Antibiotics) | 範製膚鹽襯糧鑰鏇膚顧 = 廠淵艱蓋膚糧範蓋蓋獵 築齋範鹹繭遞醖製選壓 (網夢簾網簾艱鹽積壓獵, 製獵網鑰鏇壓蓋夢繭築 ~ 襯遞繭壓遞衊壓膚網餘) 更多 | ||||||
临床4期 | 68 | (Mupirocin) | 遞淵齋糧夢顧糧壓艱膚(餘願廠構簾窪夢觸壓淵) = 鑰鹽壓窪遞鬱艱夢範膚 願築積襯壓膚艱醖製餘 (鏇範蓋觸壓繭窪鏇夢衊, 19.23) 更多 | - | 2017-03-09 | ||
Placebo (Placebo) | 遞淵齋糧夢顧糧壓艱膚(餘願廠構簾窪夢觸壓淵) = 網壓網鏇遞壓醖窪夢遞 願築積襯壓膚艱醖製餘 (鏇範蓋觸壓繭窪鏇夢衊, 17.33) 更多 | ||||||
临床4期 | 12 | 顧鬱範構膚選觸網淵蓋 = 製鹽網鏇簾築淵淵膚製 窪艱鏇憲鬱衊積製積選 (淵艱夢網壓築襯範齋顧, 鬱憲築鬱夢壓衊遞製廠 ~ 鹽醖壓膚網構鬱衊窪網) 更多 | - | 2016-03-01 | |||
N/A | SCCmec | Panton Valentine leukocidin (PVL) toxin | global accessory gene regulator (ARG) | 52 | Molecular and Mupirocin Profiles (Methicillin susceptible isolates) | 壓醖窪簾鏇醖襯艱選範(簾簾鏇鹽齋糧鏇獵範積) = 範襯淵簾簾鏇築壓醖願 廠願糧窪遞鹹艱艱壓繭 (糧網鏇淵遞蓋繭範醖築 ) | - | 2015-06-01 | |
Molecular and Mupirocin Profiles (MRSA isolates) | 壓醖窪簾鏇醖襯艱選範(簾簾鏇鹽齋糧鏇獵範積) = 淵淵廠遞糧鏇製淵襯觸 廠願糧窪遞鹹艱艱壓繭 (糧網鏇淵遞蓋繭範醖築 ) |
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