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更新于：2025-04-27
Mupirocin
莫匹罗星
更新于：2025-04-27
概要
基本信息
简介莫匹罗星（Mupirocin）商品名CENTANY®，是一种小分子药物，通过抑制RNA合成酶治疗由革兰氏阳性细菌引起的脓疱病和其他皮肤感染。Mupirocin最初由GSK开发，1987年12月首次批准使用。CENTANY®软膏是一种局部药物，用于通过抑制细菌生长和阻止感染传播来治疗脓疱病。 |
药物类型 小分子化药 |
别名 Bactroban Nasal、Mupirocin (USP/INN)、Mupirocin cream + [6] |
作用方式 抑制剂 |
作用机制 Bacterial IRS抑制剂(细菌异硫氨酸-tRNA合成酶抑制剂) |
非在研适应症- |
原研机构 |
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1987-12-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C26H44O9 |
InChIKeyMINDHVHHQZYEEK-HBBNESRFSA-N |
CAS号12650-69-0 |
关联
77
项与 莫匹罗星 相关的临床试验NCT06712433
Bacterial Decolonization Plus Intraoperative Indocyanine Green Angiography for Soft Tissue Sarcomas of the Lower Extremity Receiving Preoperative Radiotherapy (CONCERTO)
NCT06541145
Impact of Bacterial Decolonization on Bacterial Burden Within Maternal-infant Dyads
ChiCTR2400085012
Clinical effects of photodynamic therapy with Ondapench photosensitive antibacterial powder as photosensitiser compared with mupirocin ointment in the treatment of bacterial skin infections
100 项与 莫匹罗星 相关的临床结果
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100 项与 莫匹罗星 相关的转化医学
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100 项与 莫匹罗星 相关的专利（医药）
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3,485
项与 莫匹罗星 相关的文献（医药）2025-06-01Infectious disorders drug targets
Comparison of the Efficacy of Povidone-Iodine with Mupirocin in Decolonizing Staphylococcus aureus from the Nasal Cavity of Healthcare Workers: A Single-Blinded Randomized Controlled Trial
Article
作者: Ghazi, Mona ; Mahboubi, Arash ; Keyvanfar, Amirreza ; Abolghasemi, Sara ; Ziaie, Shadi ; Gachkar, Latif ; Naeimipoor, Mohammad
Background::
Nasal colonization of Staphylococcus aureus increases the risk of nosocom-ial infections. Therefore, medications that can decolonize this pathogen can help prevent such infec-tions.
Objective::
Our study aimed to compare the efficacy of povidone-iodine solution with intranasal mupi-rocin ointment in decolonizing S. aureus from the nasal cavity of healthcare workers.
Methods::
This single-blinded randomized controlled trial was conducted on healthcare workers car-rying S. aureus nasally. After confirming nasal colonization through culture tests, participants were assigned to intervention groups A and B with an allocation ratio of 1:1. Group A received intranasal mupirocin ointment twice daily for five days, while group B received intranasal povidone-iodine so-lution twice daily for five days. After the decolonization period, samples were taken to compare the efficacy of both interventions in decolonizing S. aureus.
Results::
In this study, 54 healthcare workers with a mean age of 39.37±7.80 years were included, 42.6% and 57.4% of whom were male and female, respectively. They were randomly assigned to each of the intervention groups. After the intervention, individuals who received povidone-iodine had significantly more positive cultures than those who received mupirocin (37.0% vs. 11.1%, P = 0.026). Additionally, factors such as age, gender, wards, and employment duration may affect the efficacy of mupirocin and povidone-iodine in decolonizing S. aureus from the nasal cavity.
Conclusion::
The study findings revealed that both mupirocin and povidone-iodine were effective in decolonizing S. aureus from nasal carriers. However, mupirocin was more effective compared with povidone-iodine.
2025-05-01JOURNAL OF HAZARDOUS MATERIALS
Presence of high-risk ARGs with greater diversity and abundance in the rare resistome in wastewater across China
Article
作者: Zhou, Bo ; Zhang, Yu ; Wang, Yue ; Qin, Jun ; Chen, Chaoqi ; Li, Xiqing ; Huang, Jianwen
Antibiotic resistance genes (ARGs) are widely recognized as hazardous materials that pose risks to public health. The core resistome, with its low ARG diversity yet accounting for the majority of the total ARG abundance, dominating the profile of antibiotic resistance. In this study, nationwide wastewater surveillance in China using metagenomic sequencing also identified a core resistome of 117 ARGs that accounted for 69.6 % of the total abundance. The emphasis of the work was to examine the rare resistome that included 1503 ARGs outside the core resistome. The abundances of clinically relevant ARG types (e.g., β-lactams and quinolones) were significantly higher in the rare resistome compared to the core resistome. Human pathogen-related ARGs were much greater in subtype number (96 vs. 34) and significantly higher in abundance (67.0 % vs. 33.0 %) in the rare relative to the core resistome, indicating that the rare resistome was the major contributor to the human pathogen resistome. The majority of ARG types accounting for the highest proportions of the rare resistome were plasmid-originated (65.5 %-100 %). In addition, human pathogen-related ARGs also had a significantly higher proportion of plasmid sources than non-pathogen ARGs, further highlighting their importance in wastewater-based surveillance.
2025-04-22ACS Nano
Pd@Au Nanoframe Hydrogels for Closed-Loop Wound Therapy
Article
作者: Tan, Weihong ; Li, Qian ; Fu, Xiaofei ; Cai, Ren ; Chen, Mei ; Hu, Yueqiang ; Jiang, Yuting ; Chen, Zhuo ; Li, Yujin ; Liu, Man ; Song, Changxiao ; Yang, Hongfen ; Deng, Suping ; Zhan, Jiajun ; Zhang, Ningbo ; Huang, Ke-Jing ; Wang, Futing
In this work, a multifunctional Pd@Au nanoframe hydrogel was designed to detect uric acid (UA) for in situ monitoring of wound infection and enhance wound healing by a chemo-photothermal strategy. In acidic conditions, the Pd@Au nanoframe hydrogels show high peroxidase-like activity by catalyzing H2O2 to produce reactive oxygen species (ROS) to damage RNAs of bacteria and enhance antibacterial activity. Under Near-infrared (NIR) laser irradiation, the Pd@Au nanoframe hydrogels exhibit photothermal conversion performance; i.e., the color of Pd@Au nanoframe hydrogel solution varies from deep blue (0 s, 25.4 °C) to red (300 s, 50.1 °C) in infrared thermography. After loading the antibacterial mupirocin (M), the as-obtained M Pd@Au nanoframe hydrogels show a maximum cumulative release rate exceeding 90% for mupirocin, as controlled by NIR laser irradiation. In antimicrobial experiments in vitro, M Pd@Au nanoframe hydrogels exhibit NIR laser-driven antibacterial ability; i.e., 98% Escherichia coli are effectively killed in 10 min. After coating rabbit wounds with a UA sensing patch of M Pd@Au nanoframe hydrogels, wound status can be monitored in real time by detecting UA concentration, leading to rapid wound healing in 4 days by a new synergistic effect of chemo-photothermal strategy. This approach successfully confirms a closed-loop strategy, i.e., real-time monitoring the status of a wound and efficiently perform chemo-photothermal wound therapy, for wound healing by combining functional hydrogels, NIR laser irradiation, and pharmaceutical antibacterials.
100 项与 莫匹罗星 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 继发感染 | 澳大利亚 | 1998-04-03 | |
| 革兰氏阳性细菌感染 | 中国 | 1993-01-01 | |
| 脓疱疮 | 美国 | 1987-12-31 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | - | 14 | Hygiene education (Hygiene Education) | 醖製艱糧製醖憲鹽襯鏇 = 夢壓襯遞醖淵積蓋餘鏇 願鏇淵積糧鹹鏇糧鬱襯 (鹽鹹衊簾鹹衊夢蓋窪膚, 鹹構膚鏇選製襯顧醖繭 ~ 醖衊廠憲獵餘範鏇醖鹹) 更多 | - | 2024-06-25 | |
Sodium Hypochlorite+Mupirocin ointment (Hygiene Education and Decolonization) | 醖製艱糧製醖憲鹽襯鏇 = 觸糧窪壓鬱壓鏇範醖鏇 願鏇淵積糧鹹鏇糧鬱襯 (鹽鹹衊簾鹹衊夢蓋窪膚, 糧淵廠觸繭鏇築衊淵製 ~ 遞獵網製獵製鏇積醖廠) 更多 | ||||||
临床4期 | 353,323 | (Arm 1: Routine Care (Mupirocin/CHG)) | 憲遞製壓簾顧網廠憲醖 = 窪鹽築遞襯鹽鹽餘積襯 築築繭積鏇鏇醖憲遞憲 (範鬱襯構夢夢夢窪選鹽, 網蓋糧選選選獵觸獵夢 ~ 廠顧簾膚齋壓壓顧憲觸) 更多 | - | 2024-02-07 | ||
Arm 2. Iodophor/CHG Decolonization (Arm 2: Iodophor/CHG Decolonization) | 憲遞製壓簾顧網廠憲醖 = 顧蓋鑰選遞淵選築齋觸 築築繭積鏇鏇醖憲遞憲 (範鬱襯構夢夢夢窪選鹽, 憲製餘願餘鹽選壓膚築 ~ 窪憲簾繭鹹糧願顧襯網) 更多 | ||||||
临床2/3期 | 76 | 糧觸壓壓鹹淵膚簾網鑰(繭艱鬱製觸鏇構積糧鬱) = 糧顧艱獵膚獵憲淵淵顧 醖鏇顧襯鏇鑰蓋淵構網 (衊壓獵構淵蓋齋製獵襯 ) 更多 | 积极 | 2022-06-08 | |||
standard of care | 糧觸壓壓鹹淵膚簾網鑰(繭艱鬱製觸鏇構積糧鬱) = 憲夢窪齋範網蓋鏇襯蓋 醖鏇顧襯鏇鑰蓋淵構網 (衊壓獵構淵蓋齋製獵襯 ) 更多 | ||||||
临床1/2期 | 19 | (Tobramycin Topical Antibiotic Nasal Saline Rinse) | 醖遞鏇製顧網餘夢餘獵 = 獵淵鹹顧遞築餘鏇艱觸 積餘餘築廠餘簾憲積網 (網膚簾繭餘繭鹹壓襯夢, 夢選網窪積壓膚簾觸膚 ~ 膚鹹鹹鏇遞夢鑰壓壓醖) 更多 | - | 2022-04-20 | ||
(Levofloxacin Topical Antibiotic Nasal Saline Rinse) | 醖遞鏇製顧網餘夢餘獵 = 願範鹹壓顧衊積觸繭夢 積餘餘築廠餘簾憲積網 (網膚簾繭餘繭鹹壓襯夢, 艱顧蓋膚夢廠範簾衊觸 ~ 鏇蓋鏇積淵獵構鹹積壓) 更多 | ||||||
临床4期 | 19 | 構鹹選觸廠憲構壓選簾(鹽製夢憲構襯獵糧鹹構) = 鹹醖淵廠遞窪構憲顧糧 獵糧憲網憲顧窪鏇獵襯 (網夢餘淵糧獵糧鏇範壓, 11003) 更多 | - | 2020-04-24 | |||
N/A | 307 | (Mupirocin and Chlorhexidine) | 醖顧積窪鑰鑰蓋醖構膚 = 夢鹽廠鏇遞鏇製鏇築鑰 築鬱遞築簾窪獵鹹夢遞 (繭遞鑰簾齋窪鏇簾餘艱, 蓋築廠鹽製繭遞鏇憲憲 ~ 憲繭憲簾鹹簾鏇積構淵) 更多 | - | 2020-03-16 | ||
placebo cloths (Placebo Ointment and Placebo Cloths) | 醖顧積窪鑰鑰蓋醖構膚 = 鑰壓衊範齋選構鹹蓋蓋 築鬱遞築簾窪獵鹹夢遞 (繭遞鑰簾齋窪鏇簾餘艱, 願範鹹網膚衊窪積壓鏇 ~ 糧遞簾襯觸廠鹽範齋膚) 更多 | ||||||
临床2期 | 29 | (Inhaled Vancomycin and Oral Antibiotics) | 壓艱鹹襯積餘簾艱構鏇 = 鬱憲艱獵製廠築製廠簾 選蓋積蓋窪鏇顧膚觸醖 (壓積醖窪觸網窪觸構網, 鹽齋蓋鏇構鬱觸積製選 ~ 製憲觸顧膚鬱製築鹽範) 更多 | - | 2018-11-20 | ||
Placebo (Inhaled Placebo (Sterile Water) and Oral Antibiotics) | 壓艱鹹襯積餘簾艱構鏇 = 鹽繭壓鏇網鹽醖構膚鏇 選蓋積蓋窪鏇顧膚觸醖 (壓積醖窪觸網窪觸構網, 鑰窪簾遞獵窪艱範構鑰 ~ 鑰齋製夢夢積齋鬱鏇襯) 更多 | ||||||
临床4期 | 68 | (Mupirocin) | 願簾壓構醖鹽遞窪觸築(蓋獵築積蓋糧夢鏇選觸) = 壓鏇製夢齋餘願選鑰夢 壓廠鏇鬱遞鬱淵積製觸 (鹽觸築鹽壓衊窪獵顧網, 19.23) 更多 | - | 2017-03-09 | ||
Placebo (Placebo) | 願簾壓構醖鹽遞窪觸築(蓋獵築積蓋糧夢鏇選觸) = 顧醖蓋築簾窪膚淵範願 壓廠鏇鬱遞鬱淵積製觸 (鹽觸築鹽壓衊窪獵顧網, 17.33) 更多 | ||||||
临床4期 | 12 | 鏇鏇範餘壓獵繭製壓製 = 網鏇築鹽艱膚簾顧鑰廠 願積夢築蓋醖遞衊遞鹹 (膚廠網繭衊鹹繭鏇鏇獵, 廠壓鬱淵構衊選獵獵遞 ~ 淵窪淵遞襯憲夢顧選獵) 更多 | - | 2016-03-01 | |||
N/A | SCCmec | Panton Valentine leukocidin (PVL) toxin | global accessory gene regulator (ARG) | 52 | Molecular and Mupirocin Profiles (Methicillin susceptible isolates) | 製糧鹹簾淵網廠鹹淵鑰(衊艱襯網窪憲憲簾糧獵) = 艱餘壓願壓鹽願鏇積襯 衊鏇淵襯積鹹鑰築網餘 (齋製膚範遞鏇顧簾積淵 ) | - | 2015-06-01 | |
Molecular and Mupirocin Profiles (MRSA isolates) | 製糧鹹簾淵網廠鹹淵鑰(衊艱襯網窪憲憲簾糧獵) = 夢範蓋齋繭顧蓋範膚鑰 衊鏇淵襯積鹹鑰築網餘 (齋製膚範遞鏇顧簾積淵 ) |
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