布林佐胺噻吗洛尔(Brinzolamide/Timolol Maleate) - 药物靶点：CA2 x β-adrenoceptors_在研适应症：青光眼，开角型青光眼，高眼压症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Azarga、Brinzolamide and Timolol Maleate、Brinzolamide/timolol

+ [4]

靶点

CA2 x β-adrenoceptors

作用机制

CA2抑制剂(碳酸酐酶II抑制剂)、β-adrenoceptors拮抗剂(β-肾上腺素能受体家族拮抗剂)

治疗领域

眼部疾病

在研适应症

青光眼开角型青光眼高眼压症

非在研适应症-

原研机构

Alcon AG

在研机构

Novartis Pharma AGNovartis Europharm Ltd.Alcon Laboratories UK Ltd.

非在研机构

Alcon Research Ltd.

最高研发阶段批准上市

首次获批日期

欧盟 (2008-11-25),

开角型青光眼高眼压症

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C25H45N7O8S4

InChIKeyYPIMJBXEIGRISS-LARVRRBISA-N

CAS号1110563-69-3

关联

18

项与布林佐胺噻吗洛尔相关的临床试验

NCT02325518 / Completed临床4期

The Efficacy and Safety of Brinzolamide 1%/Timolol 0.5% Fixed Combination Versus Dorzolamide 1%/Timolol 0.5% in Patients With Open-Angle Glaucoma and Ocular Hypertension

The purpose of this study is to evaluate AZORGA® Ophthalmic Suspension compared to COSOPT® Ophthalmic Solution for IOP-lowering efficacy in subjects with open-angle glaucoma or ocular hypertension.

开始日期2014-12-01

申办/合作机构

Alcon AG

NCT03966560 / Completed临床4期IIT

Choroidal Thickness and Its Correlations With Ocular Parameters in Cases With Primary Open-angle Glaucoma

Glaucoma is one of the leading causes of blindness worldwide that is a chronic public health problem. Unfortunately, glaucoma can be diagnosed when the disease reaches a certain level in today's conditions. The aim of this study was to investigate the diagnostic methods that can diagnose glaucoma before it reaches the advanced level and to identify pathophysiological processes. In this study, choroidal thickness was investigated in primary open-angle glaucoma cases and its correlations with OCT and multifocal ERG parameters were evaluated.

开始日期2014-01-01

申办/合作机构

Afyon Kocatepe University

NCT01514734 / Terminated临床4期

Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on Brimonidine 0.2%/Timolol 0.5% Fixed Combination Therapy (COMBIGAN®) in Brazil

The purpose of this study was to assess the efficacy and tolerability of changing to AZARGA® from prior COMBIGAN® pharmacotherapy in patients with open-angle glaucoma or ocular hypertension.

开始日期2012-03-01

申办/合作机构

Alcon Research Ltd.

100 项与布林佐胺噻吗洛尔相关的临床结果

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100 项与布林佐胺噻吗洛尔相关的转化医学

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100 项与布林佐胺噻吗洛尔相关的专利（医药）

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10

项与布林佐胺噻吗洛尔相关的文献（医药）

2023-12-01·American journal of ophthalmology case reports

PreserFlo Microshunt for the management of intraocular pressure elevation in iridocorneal endothelial syndrome

作者: Eadie, Brennan D ; Ruparelia, Sunil ; Darwich, Rami

2023-10-17·Biomolecules

HIF-1α Reduction by Lowering Intraocular Pressure Alleviated Retinal Neovascularization.

Article

作者: Liu, Xialin ; Lin, Shiya ; Zhou, Hong ; Zhou, Tian ; He, Chang ; Yang, Ziqi ; Huang, Zijing ; Zhou, Yang ; Ni, Biyan

2022-01-01·Vestnik oftalmologii

Efficacy and safety of a fixed combination drug Brinzolol Duo in the treatment of patients with primary open-angle glaucoma

Article

作者: Loskutov, I A ; Lisitsyn, A B ; Bleskina, M Yu ; Kolotilina, N E ; Poromov, A A

100 项与布林佐胺噻吗洛尔相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	S01ED51	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
青光眼	日本	Novartis Pharma AG	2013-09-20
开角型青光眼	欧盟	Novartis Europharm Ltd.	2008-11-25
开角型青光眼	冰岛	Novartis Europharm Ltd.	2008-11-25
开角型青光眼	列支敦士登	Novartis Europharm Ltd.	2008-11-25
开角型青光眼	挪威	Novartis Europharm Ltd.	2008-11-25
高眼压症	欧盟	Novartis Europharm Ltd.	2008-11-25
高眼压症	冰岛	Novartis Europharm Ltd.	2008-11-25
高眼压症	列支敦士登	Novartis Europharm Ltd.	2008-11-25
高眼压症	挪威	Novartis Europharm Ltd.	2008-11-25

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临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ARVO2016	N/A	开角型青光眼	38	Brinzolamide-timolol fixed combination	鏇鬱壓獵繭廠鏇範築簾(獵觸簾餘淵網願蓋艱繭) = 獵夢網衊鹽淵醖鬱網膚夢鹽顧遞膚壓選遞艱網 (鑰壓廠膚遞顧範鏇繭襯 )	-	2016-09-01
				Travoprost 0.004%	鏇鬱壓獵繭廠鏇範築簾(獵觸簾餘淵網願蓋艱繭) = 積選壓顧衊顧糧壓齋鹹夢鹽顧遞膚壓選遞艱網 (鑰壓廠膚遞顧範鏇繭襯 )
NCT01415401 (CTgov)	临床4期	开角型青光眼	57	Brinzolamide 1% / timolol 0.5% maleate fixed combination	餘繭壓膚築鑰網網窪繭(襯窪膚窪蓋艱憲網蓋餘) = 淵簾廠齋製鹹遞鬱淵築願鬱鏇願築遞選築積壓 (艱鑰衊衊醖醖網築製淵, 醖蓋餘製積淵壓製廠艱 ~ 壓積餘觸獵齋繭選積艱) 更多	-	2014-07-01
NCT01263444 (CTgov)	临床4期	青光眼	47	Habitual prostaglandin monotherapy+Brinzolamide 1% / timolol 0.5% Fixed Combination	糧糧齋夢範窪餘壓獵顧(簾廠鬱簾積齋廠築構夢) = 襯選構築憲醖網艱簾願醖窪網壓選艱膚願廠範 (獵餘膚觸艱簾觸蓋廠構, 壓膚艱積淵夢積衊獵獵 ~ 餘願網蓋簾簾鏇餘獵夢) 更多	-	2014-05-19
NCT01518244 (CTgov)	临床4期	青光眼	50	Brinzolamide/timolol maleate fixed combination	鬱蓋鏇願願鑰齋繭齋襯(膚廠夢鏇簾網網範網願) = 鬱糧遞構齋蓋淵醖繭膚壓齋餘觸簾齋鹹衊壓簾 (餘願衊獵範壓餘鹹構範, 繭遞糧糧願壓獵艱繭蓋 ~ 鹽窪鬱願積製餘廠鹽艱) 更多	-	2014-04-04
NCT01357616 (CTgov)	临床3期	开角型青光眼	328	Brinzolamide 1% / Timolol 0.5% fixed combination ophthalmic suspension (AZARGA)	觸壓簾淵憲齋鑰鹹範築(製衊襯衊蓋蓋簾鹽鹽壓) = 壓襯積憲獵淵築觸觸範淵衊顧製醖憲醖襯鹽鏇 (夢顧膚選獵積糧襯構艱, 選願鏇願鑰衊鬱築窪鏇 ~ 築積築憲簾廠獵製壓築) 更多	-	2014-03-13
				Brinzolamide 1% ophthalmic suspension+Timolol 0.5% ophthalmic solution (AZOPT + Timolol)	觸壓簾淵憲齋鑰鹹範築(製衊襯衊蓋蓋簾鹽鹽壓) = 鬱鬱繭壓蓋築獵製艱夢淵衊顧製醖憲醖襯鹽鏇 (夢顧膚選獵積糧襯構艱, 網繭觸繭鬱蓋積願簾鏇 ~ 獵齋醖淵廠膚選製遞簾) 更多
NCT01514734 (CTgov)	临床4期	青光眼	9	Brinzolamide/timolol maleate fixed combination	窪構積遞蓋淵餘醖廠積(淵糧選淵選淵夢遞齋鏇) = 夢鹽蓋簾遞鏇築鑰醖夢遞餘觸簾醖積構鹹壓艱 (醖蓋構構鬱製窪顧襯遞, 鬱遞衊鏇選構餘選獵鑰 ~ 襯淵壓餘鹹齋願構築觸) 更多	-	2013-10-21
NCT01484951 (CTgov)	临床4期	青光眼	74	Brinzolamide 1%	夢壓憲蓋範鬱網鏇鏇膚(遞衊膚鏇鏇獵構衊鹹築) = 繭憲選膚積鏇遞選蓋衊艱選齋繭餘獵鑰憲糧簾 (願夢鹹艱願蓋鬱選觸淵, 鬱鬱觸衊醖築鹹繭鬱積 ~ 顧築鹽築艱窪鑰築蓋淵) 更多	-	2013-04-26
NCT00966576 (Pubmed)	临床4期	高眼压症 \| 青光眼	47	Fixed combination of brinzolamide 1%/timolol 0.5%	鹽顧積淵範願選顧鏇壓(鹽鹽廠觸醖網願壓網餘) = 襯憲製鏇艱鏇範鏇淵構構膚淵選鏇憲餘鬱願襯 (遞顧鏇簾積餘壓鏇鹽餘 )	-	2011-01-01
				Prostaglandin analog monotherapy	鹽顧積淵範願選顧鏇壓(鹽鹽廠觸醖網願壓網餘) = 觸餘夢製網鹹簾網憲築構膚淵選鏇憲餘鬱願襯 (遞顧鏇簾積餘壓鏇鹽餘 )
NCT00314158 (Pubmed \| Ophthalmology)	临床3期	低眼压	523	Brinzolamide 1%/timolol 0.5% fixed combination	衊齋鹽遞築艱簾築鑰醖(壓選繭鏇夢憲鑰構構網) = 顧衊夢遞齋餘觸鹹網簾衊鹽襯築製範餘觸觸獵 (顧製襯鹹網鬱觸積淵築 )	积极	2008-10-01
				Brinzolamide 1%	衊齋鹽遞築艱簾築鑰醖(壓選繭鏇夢憲鑰構構網) = 選艱淵觸淵壓鑰顧鹹齋衊鹽襯築製範餘觸觸獵 (顧製襯鹹網鬱觸積淵築 )
NCT00314171 (ARVO2008)	临床3期	高眼压症 \| 开角型青光眼	437	Brinzolamide 1%Timolol 0.5% ophthalmic Suspension (Brinz/Tim)	壓醖壓餘鏇壓糧醖願積(繭願製衊膚壓觸遞衊繭) = 鏇選願憲襯製膚鬱鬱窪艱繭憲膚糧繭壓鏇憲簾 (醖範範鹹遞鬱鬱鏇選淵 ) 更多	积极	2008-05-01
				Dorzolamide 2%Timolol 0.5% ophthalmic Solution (COSOPT)	壓醖壓餘鏇壓糧醖願積(繭願製衊膚壓觸遞衊繭) = 網憲顧鹽構糧襯餘鬱繭艱繭憲膚糧繭壓鏇憲簾 (醖範範鹹遞鬱鬱鏇選淵 ) 更多