预约演示

更新于：2025-05-07

Pyuria

脓尿

更新于：2025-05-07

基本信息

别名

High urine neutrophil count、PYURIA、Pus cells in urine

+ [27]

简介

The presence of white blood cells (LEUKOCYTES) in the urine. It is often associated with bacterial infections of the urinary tract. Pyuria without BACTERIURIA can be caused by TUBERCULOSIS, stones, or cancer.

关联

项与脓尿相关的药物

Gepotidacin

靶点

Bacterial DNA gyrase x Bacterial top IV x Top II

作用机制

Bacterial DNA gyrase 抑制剂 [+2]

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2025-03-25

Tebipenem Pivoxil

替比培南酯

靶点

PBPs

作用机制

PBPs抑制剂

在研机构

GSK Plc [+5]

原研机构

Meiji Seika Pharma Co., Ltd.

在研适应症

中耳炎 [+6]

非在研适应症

复杂的尿路感染 [+3]

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期2009-04-22

项与脓尿相关的临床试验

NCT06597344

/ Completed临床3期

A Phase 3b, Open-label, Single-arm Study in Adolescent and Adult Female Participants to Evaluate Clinical Symptom Improvement and the Safety of Gepotidacin During Treatment of Uncomplicated Urinary Tract Infections (Acute Cystitis)

The study will be conducted to evaluate the clinical symptom improvement and safety of oral gepotidacin for treatment of uncomplicated UTI (acute cystitis) in adolescent and adult female participants.

开始日期2024-10-02

申办/合作机构

GSK Plc

CTRI/2024/04/066014

/ Not yet recruiting临床2/3期

A Phase II/III, Randomized, Double-blind, Multicenter, Comparative Study to Determine the Efficacy and Safety of Cefepime- Tazobactam (WCK 4282) vs. Meropenem in the Treatment of Complicated Urinary Tract Infection or Acute Pyelonephritis in Adults - NIL

开始日期2024-04-25

申办/合作机构-

NCT06059846

/ Recruiting临床3期

A Phase 3, Randomized, Double-blind, Double-dummy, Multicenter, Multinational Study to Assess the Efficacy and Safety of Orally Administered Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenously Administered Imipenem-cilastatin in Patients With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)

The primary purpose of this study is to assess the efficacy of oral TBP-PI-HBr as compared with intravenous (IV) imipenem-cilastatin with respect to the overall response (combined clinical cure plus microbiological eradication) at the Test-of-Cure (TOC) visit in hospitalized adult participants (≥18 years of age) with cUTI or AP.

开始日期2023-12-21

申办/合作机构

Spero Therapeutics, Inc.

[+1]

100 项与脓尿相关的临床结果

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100 项与脓尿相关的转化医学

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0 项与脓尿相关的专利（医药）

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2,580

项与脓尿相关的文献（医药）

2025-05-01·Acta Paediatrica

Clinical outcomes in febrile children with a positive urine culture without pyuria: Implications for antibiotics

Article

作者: Miyake, Rei ; Hataya, Hiroshi

AbstractAimThis study aimed to investigate whether antibiotics should be administered to patients aged <2 years with a positive urine culture without pyuria by identifying their clinical characteristics and outcomes in the absence of antibiotic treatment.MethodsThis retrospective, observational study included children aged <2 years with positive findings on a culture of urine obtained using a catheter in the paediatric emergency department between 2016 and 2021. The primary outcome was the spontaneous resolution of fever without antibiotics in patients with a positive urine culture without pyuria. The clinical characteristics of the patients with and without pyuria were also compared.ResultsOf 391 patients, 86 (22%) were negative for pyuria. Of these, 63 (73%) received no antibiotics, and 56 (89%) had spontaneous defervescence and no symptom recurrence. The patients without pyuria had a higher proportion of other possible causes of fever, lower inflammatory markers, fewer cultured bacteria, and a higher proportion of multiple, bacterial species in their culture than the patients with pyuria.ConclusionsMost of the patients with a positive urine culture without pyuria may not require antibiotics if their fever resolves spontaneously.

2025-04-16·Zhonghua er ke za zhi = Chinese journal of pediatrics

[Clinical analysis of pediatric renal abscess].

Article

作者: Tu, J ; Sun, J S ; Chen, C Y ; Geng, H Y ; Li, H R ; Yan, Y C ; Wan, L

目的： 分析儿童肾脓肿临床资料，提高对儿童肾脓肿的认识，为尽早诊断和治疗提供参考。 方法： 回顾性分析2019年1月至2024年6月首都医科大学附属首都儿童医学中心肾脏内科收治的20例肾脓肿患儿的一般情况、实验室检查和影像学结果，以及治疗和预后情况。 结果： 20例患儿中男8例、女12例，发病年龄3.0（0.8，9.0）岁。所有患儿均存在发热，6例患儿伴腹痛，6例伴食欲下降，5例伴呕吐，5例伴尿路刺激症状，20例患儿外周血白细胞计数20.4（17.4，26.3）×10⁹/L，C反应蛋白126（77，154）mg/L，红细胞沉降率60（41，73）mm/1 h，10例患儿伴有降钙素原升高4.7（1.2，33.5）μg/L。有18例患儿存在不同程度脓尿。尿培养阳性患儿8例，其中屎肠球菌和铜绿假单胞菌各2例，血培养仅1例患儿检出肺炎克雷伯菌。所有患儿肾脏CT增强扫描检查均可见肾脓肿形成，肾脏超声检查仅9例可见肾脓肿，有14例患儿在病初行肾脏磁共振成像检查均可见肾脓肿形成。9例患儿存在先天性肾脏和尿路畸形。所有患儿均仅应用内科保守治疗，病初以广谱抗生素类药物静脉注射抗感染治疗23（14，39）d，有11例升级为美罗培南或亚胺培南，口服抗生素23（14，28）d。随访1年内，除了1例患儿出现复发，余预后良好。 结论： 对于不明原因发热、同时伴有呕吐、腹痛，白细胞计数、C反应蛋白、红细胞沉降率升高、伴有脓尿的患儿需要警惕是否存在肾脓肿。超声作为筛查和随访检查方式，CT或磁共振成像可用于确认诊断。广谱抗生素保守治疗效果值得肯定，可作为儿童肾脓肿治疗的首选治疗方案。.

2025-04-01·Microbiology Spectrum

Exploring the association between the degree of pyuria and urinary tract infections

Article

作者: Cronin, Katie ; Bond, Katherine ; Chan, Eddie ; Tien, Hsin ; Hong, Wei

ABSTRACT We aim to define the optimal white cell count threshold that correlates with a clinically significant urinary tract infection, as there is insufficient data exploring this in the adult population. We conducted a retrospective cohort study at the Royal Melbourne Hospital analyzing urine samples collected over 6 months in 2022. Urinary tract infection (UTI) was defined as the presence of symptoms (dysuria, urgency, frequency, flank pain, or loin to groin pain) and isolation of a uropathogen with colony counts greater than 10 7 CFU/L. The relationship between urinary white cell count, growth of uropathogen, and likelihood of UTI was estimated using locally weighted scatterplot smoothing. Of the 6,328 samples included, at a urinary white cell count of less than 10 per microliter, 38% grew a microorganism, while 7% of the total grew a uropathogen. For our sub-analysis part C, at the same WBC count, 2% of samples fulfilled our criteria for UTI. The optimal WBC range for identifying a UTI was 30–50 WBC/µL, demonstrating the most pragmatic balance of sensitivity (92.3%–94.9%, 95% CI 85.9–98.1) and specificity (41.6–47.2, 95% CI 38.6%–50.3%) for a UTI. A lower-than-expected number of UTIs were confirmed in our study, likely due to inappropriate indications for culture collection and the types of urine specimens collected. However, the optimal white cell cutoff for identifying a UTI was higher than the defined pyuria cutoff of 10 WBC/µL. Utilizing a higher urinary WBC cutoff could improve urine culture processing protocols. IMPORTANCEThe importance of this study is that it explores the optimal range of white cell count that defines a clinically significant urinary tract infection. The traditional cutoff of more than 10 white blood cells per microliter is often used; however, we now recognize that using this cutoff may not accurately represent true urinary infections, especially in certain populations such as young women. The uncertainty in the optimal white cell count cutoff has widespread implications. For the clinician, it may lead to unnecessary prescribing of antibiotics for patients who do not have a Urinary tract infection, such as asymptomatic bacteriuria. For the microbiology laboratory, it may lead to unnecessary workup and culture of urine samples that are not clinically relevant. Many studies to date have attempted to define an optimal value for urinary white cell count; however, not many have incorporated relevant clinical data, which this study has.

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