预约演示

更新于：2025-01-23

Carcinoid Heart Disease

类癌心脏病

更新于：2025-01-23

基本信息

别名

Carcinoid Heart Disease、Carcinoid Heart Diseases、Carcinoid heart disease

+ [10]

简介

Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.

关联

项与类癌心脏病相关的药物

Lutetium Dotatate LU-177

(177镥)镥氧奥曲肽

靶点

SSTR2

作用机制

SSTR2拮抗剂 [+1]

在研机构

FUJIFILM Toyama Chemical Co., Ltd. [+11]

原研机构

Advanced Accelerator Applications SA

在研适应症

神经内分泌肿瘤 [+13]

非在研适应症

类癌心脏病 [+2]

最高研发阶段批准上市

首次获批国家/地区

欧盟 [+3]

首次获批日期2017-09-26

Telotristat Etiprate

特罗司他乙酯

靶点

TPH1 x TPH2

作用机制

TPH1抑制剂 [+1]

在研机构

Lexicon Pharmaceuticals, Inc. [+4]

原研机构

Lexicon Pharmaceuticals, Inc.

在研适应症

恶性类癌综合征 [+3]

非在研适应症

晚期胆管癌 [+7]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2017-02-28

项与类癌心脏病相关的临床试验

NCT05064514

/ Active, not recruitingN/A

Single Centre, Prospective, Single Arm Open Label Series of a Transcatheter Tricuspid Valved Stent Graft System for the Reduction of Tricuspid Regurgitation and Improved Patient Reported Outcomes in Patients With Carcinoid Heart Disease

The purpose of this investigation is to see if the TRICENTO Valved Stent Graft implant reduces tricuspid regurgitation (TR) and improves the symptoms and quality of life in 15 participants with carcinoid heart disease, and who are not able to have a new valve via a surgical procedure.

开始日期2022-04-06

申办/合作机构

Queen Mary University of London

[+1]

NCT04810091

/ Active, not recruiting临床3期IIT

TELEHEART: Telotristat Ethyl in a Heart Biomarker Study

This phase III trial compares the effect of telotristat ethyl and the current standard of care somatostatin analog therapy or somatostatin analog therapy alone in treating patients with neuroendocrine tumor that has spread to other places in the body (metastatic). Telotristat ethyl and somatostatin analog therapy may help to control carcinoid syndrome and carcinoid heart disease.

开始日期2021-05-18

申办/合作机构

The University of Texas MD Anderson Cancer Center

NCT04039516

/ Unknown status临床2期IIT

Phase II Randomised Trial to Assess Progression of Carcinoid Heart Disease in Patients Treated With Lutathera Therapy Compared to Best Supportive Care.

Randomised trial to assess progression of carcinoid heart disease in patients treated with Lutathera therapy compared to best supportive care.

开始日期2020-10-01

申办/合作机构

King's College Hospital NHS Foundation Trust

[+1]

100 项与类癌心脏病相关的临床结果

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100 项与类癌心脏病相关的转化医学

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0 项与类癌心脏病相关的专利（医药）

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677

项与类癌心脏病相关的文献（医药）

2025-02-01·Hematology/Oncology Clinics of North America

Surgical Management of Neuroendocrine Tumor Liver Metastases

Review

作者: Chandrasekharan, Chandrikha ; Sherman, Scott K. ; Sherman, Scott K ; Tran, Catherine G ; Tran, Catherine G. ; Howe, James R. ; Howe, James R

Patients with neuroendocrine tumor liver metastases (NETLMs) may develop carcinoid syndrome, carcinoid heart disease, or other symptoms from overproduction of hormones. Hepatic resection and cytoreduction is the most direct treatment of NETLMs in eligible patients, and cytoreduction improves symptoms, may reduce the sequelae of carcinoid syndrome, and extends survival. Parenchymal-sparing procedures, such as ablation and enucleation, should be considered during cytoreduction to maximize treatment of multifocal tumors while preserving healthy liver tissue. For patients with large hepatic tumor burdens, high-grade disease, or comorbidities precluding surgery, liver-directed and systemic therapies can be used to palliate symptoms and improve progression-free survival.

2025-01-01·Catheterization and Cardiovascular Interventions

Percutaneous Pulmonary Valve Implantation With Self‐Expanding Valves for Carcinoid Heart Diseases

Article

作者: Chamuleau, Steven ; Yong, San‐Fui Sophia ; Rosenthal, Eric ; Un, Ka‐Chun ; Beijk, Marcel ; Winter, Robbert de ; Wong, Chun‐Ka ; Qureshi, Shakeel A. ; Straver, Bart ; Jones, Matthew I.

ABSTRACTCarcinoid heart disease is an important complication of neuroendocrine tumors that may lead to significant morbidity and mortality. Right‐sided heart valve involvement with consequent valve dysfunction is one of the common manifestations. Patients often have multiple, significant comorbidities with advanced metastatic disease and, as such, may not be suitable for surgical valve replacement due to excessive risk. Transcatheter valve replacement using balloon‐expandable valves has been the mainstay of management for these patients, particularly with stenotic lesions but there is limited experience in patients with pulmonary regurgitation and dilated pulmonary arteries outside the dimensions that would be suitable for these valves. We report three successful cases of percutaneous pulmonary valve implantation with the VenusP‐valve, a large self‐expanding valve platform, and highlight the technical aspects and challenges specific to treatment of pulmonary regurgitation in patients with carcinoid heart disease. Percutaneous pulmonary valve implantation, using the VenusP‐valve, may be considered an effective treatment in this patient group.

2025-01-01·Giornale italiano di cardiologia (2006)

Un’insolita insufficienza tricuspidale.

Article

作者: Ricci, Alessandra ; Praderio, Angelica

Tricuspid regurgitation can be due to different causes and mechanisms. Among these, cardiac involvement in carcinoid disease is a rare cause of tricuspid valve disease with a peculiar echocardiographic aspect. We report the case of a 59-year-old woman, with no past medical history, who was recently found to have a heart murmur and signs of right heart failure. The echocardiogram showed a remodeling of valvular and subvalvular apparatus, resulting in massive regurgitation. This finding prompted further diagnostic investigations, leading to the diagnosis of carcinoid syndrome with cardiac involvement. This case report therefore provides an opportunity to discuss the pathophysiological aspects and the diagnostic process of carcinoid heart disease, focusing particularly on the echocardiographic features and therapeutic management.

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