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更新于：2025-05-07

Cfr

更新于：2025-05-07

基本信息

别名-

简介-

关联

项与 Cfr 相关的药物

8-O-methyltetrangulol (MTL)

靶点

Cfr

作用机制

Cfr inhibitors

在研机构

McMaster University

原研机构

McMaster University

在研适应症

细菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

8-O-methyltetrangomycin (MTN)

靶点

Cfr

作用机制

Cfr inhibitors

在研机构

McMaster University

原研机构

McMaster University

在研适应症

细菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 Cfr 相关的临床结果

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100 项与 Cfr 相关的转化医学

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0 项与 Cfr 相关的专利（医药）

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621

项与 Cfr 相关的文献（医药）

2025-12-01·Molecular Biology Reports

The molecular basis of Staphylococcus aureus resistance to linezolid and the role of silver nanoparticles in attenuating linezolid resistance

Article

作者: Alalawy, Adel I ; El Rabey, Haddad A ; Salah, Nouran M

BACKGROUNDSeveral linezolid resistance mechanisms have been reported in human pathogen methicillin-resistant Staphylococcus aureus (MRSA). This study investigated the molecular basis of methicillin resistance in S. aureus with increased linezolid minimum inhibitory concentrations (MICs).METHODS AND RESULTSThe antimicrobial efficacy of silver nanoparticles (AgNPs) derived from S. aureus and rosemary leaves (Rosmarinus officinalis) was evaluated against linezolid-resistant S. aureus strains. 81% of the isolates were MRSA, and 20% were linezolid resistant. Twelve isolates were linezolid-resistant S. aureus (LRSA) via the agar dilution. Molecular confirmation of linezolid-resistant S. aureus was performed by detecting the nuc gene and sequencing the 16 S rRNA gene. Molecular analysis of the resistant isolates revealed that mutations in domain V of the 23 S rRNA, rplC and rplV genes were detected in all the isolates, whereas the cfr gene was not assigned. DNA sequencing revealed that the major mutation in our isolates was a G to A mutation at different positions despite the presence of the T2500A mutation.CONCLUSIONSAgNPs synthesized from rosemary leaves and S. aureus had a significant antimicrobial effect on LRSA isolates. In addition, the LRSA isolates became sensitive to linezolid after mixing linezolid with the synthesized AgNPs.

2025-07-01·Journal of Hazardous Materials

Removal efficiency and adaptive response mechanisms of microalgal-bacterial granular sludge in treating chloramphenicol-laden wastewater

Article

作者: Chen, Bingheng ; Liu, Yu ; Liang, Hua ; Li, Anjie ; Ji, Bin ; Bai, Yang ; Zhang, Xiaoyuan

Efficient and eco-friendly technologies for removing antibiotic pollutants like chloramphenicol (CAP) from wastewater are becoming increasingly important. Among these, microalgal-bacterial granular sludge (MBGS) represents a promising green biotechnology capable of tackling such contaminants. However, the interactions between CAP and MBGS, as well as how CAP influences the community structure and function of MBGS, have not yet been fully understood. This study investigated the effectiveness of the MBGS system in CAP removal and examined microbial responses to CAP exposure. Our findings indicate that MBGS exhibits remarkable adaptability to CAP, altering its microbial characteristics to mitigate CAP toxicity while maintaining the efficacy of pollutant removal. Notably, there was a significant increase in key microorganisms such as Hydrogenophaga, Polaromonas, and Acidovorax. Additionally, the prevalence of resistance genes cmlA8, floR, catB and cfr under CAP exposure suggests adaptive mechanisms likely involving efflux pumps, CAP acetyltransferase B and ribosomal RNA methyltransferase. CAP degradation appears to proceed via the amide bond hydrolase EstDL136, thereby reducing its toxicity and producing less harmful byproducts such as 2,2-dichloroacetic acid. This study provides new insights into how CAP affects MBGS communities and identifies the mechanisms for CAP degradation, offering valuable insights that MBGS could serve as an effective and environmentally sustainable technology for the treatment of wastewater containing antibiotic pollutants.

2025-06-01·Poultry Science

Genetic characterization and transmission of the multidrug resistance gene cfr in fecal and environmental pathways on a chicken farm in China

Article

作者: Yuan, Li ; He, Dandan ; Pan, Yushan ; Hu, Gongzheng ; Liu, Jianhua ; Li, Tiantian ; Li, Xuexue ; Zhao, Shiyun ; Feng, Yiming ; Zhai, Yajun

The emergence and spread of the multidrug-resistant gene cfr have raised significant public health concerns worldwide. To investigate its prevalence and dissemination dynamics, 18 cfr-positive strains were isolated in 2021 from fecal and environmental samples. Antimicrobial susceptibility testing showed that all strains were 100 % multidrug-resistant. Conjugation experiments demonstrated that a cfr- carrying IncFII(K)-IncR-IncFIB multi-replicon plasmid could transfer to E. coli J53. S1-nuclease digestion and Southern blotting identified cfr on plasmids of varying sizes, while whole-genome sequencing confirmed its presence on multiple plasmid types: IncX4, IncN, IncFII(K)-IncR-IncFIB, IncFIB-IncFII-IncR-IncHI2-IncHI2A multi-replicon plasmids, and two plasmids of unknown types. Genetic environment analysis revealed that cfr is categorized into five distinct structures (Types I-V). Reverse PCR results showed that Types I, II, and IV can form three circular intermediates of varying lengths (cfr-IS26). Network analysis further indicated strong association between cfr, tet(M), and dfrA14 mediated by IS26. Phylogenetic analysis revealed that the four ST1140 E. coli strains and all nine K. pneumoniae strains showed minimal genetic divergence. These findings suggest both clonal and horizontal transmission of cfr within the poultry farm. Continuous monitoring of cfr in animal-related environments is essential to mitigate its potential transfer to humans.

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