别名 Epididymis tissue protein Li 131P、netrin 1、Netrin-1 + [2] |
简介 Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335). |
靶点 |
作用机制 netrin-1调节剂 |
最高研发阶段临床1期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2024-07-01 |
申办/合作机构 |
开始日期2023-12-04 |
申办/合作机构 |
开始日期2023-03-28 |
申办/合作机构 |