别名 Long transient receptor potential channel 6、LTrpC-6、LTrpC-6LTrpC6 + [7] |
简介 Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures (PubMed:15306801, PubMed:15852009, PubMed:16174775, PubMed:25559186, PubMed:37857704). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (PubMed:15306801). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May plays a role in prostate cancer cell migration (PubMed:16174775, PubMed:25559186).
Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel. |
作用机制 自由基抑制剂 [+4] |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 韩国 |
首次获批日期2025-04-24 |
作用机制 TRPA1激动剂 [+1] |
在研适应症 |
非在研适应症- |
最高研发阶段批准上市 |
首次获批国家/地区 美国 |
首次获批日期2008-02-20 |
开始日期2025-05-01 |
申办/合作机构 ![]() [+1] |
开始日期2025-03-05 |
申办/合作机构 |
开始日期2025-01-15 |
申办/合作机构 |