更新于：2024-11-01

meteorin

更新于：2024-11-01

基本信息

别名

C16orf23、Meteorin、meteorin, glial cell differentiation regulator

+ [2]

简介

Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).

关联

项与 meteorin 相关的药物

Recombinant human meteorin (Hoba Therapeutics)

靶点

meteorin

作用机制

meteorin调节剂

在研机构

Hoba Therapeutics ApS初创企业

原研机构

Hoba Therapeutics ApS初创企业

在研适应症

三叉神经痛 [+1]

非在研适应症

亨廷顿舞蹈病

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 meteorin 相关的临床结果

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100 项与 meteorin 相关的转化医学

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0 项与 meteorin 相关的专利（医药）

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项与 meteorin 相关的文献（医药）

2024-09-01·Heliyon

A pan-cancer analysis of the association of METRN with prognosis and immune infiltration in human tumors

Article

作者: Wang, Li ; Leng, Xiaoling ; Huang, Guofu ; Xiao, Han

BackgroundMeteorin (METRN) is expressed predominantly in the central nervous system (CNS), where it functions by regulating glial cell differentiation and promoting axonal elongation. Nonetheless, its function within tumors is still not well understood. In this study, we focused on investigating its expression across various cancers and delving deeper into how METRN expression correlates with prognosis and immune infiltration.MethodsWe explored METRN expression patterns in pan-cancers utilizing data obtained from the UCSC Xena and TCGA. In addition, analyses of survival and clinical association were conducted for tumors where METRN could affect the prognosis. Subsequently, nomogram models were constructed for sarcoma (SARC) and prostate adenocarcinoma (PRAD) to verify METRN's prognostic value in tumors. Furthermore, we also discussed the link between METRN and immune infiltration. As far as mechanisms are concerned, functional enrichment analysis was conducted to analyze the functional components and signaling pathways involved in METRN.ResultsThis study found that METRN was abnormally expressed in various tumors, closely connected with the prognosis and clinical characteristics of several tumors, and had good prognostic value. Moreover, analysis of immune infiltration revealed that METRN interacts with multiple immune cells, with alterations in the immune microenvironment potentially influencing tumor prognosis. Enrichment analysis indicates that METRN may influence tumorigenesis and progression through immune-related pathways.ConclusionTo sum up, our study demonstrates that METRN can be a prospective predictive biomarker in diverse cancer types and a promising target for cancer immunotherapy for pan-cancer.

2024-08-08·bioRxiv : the preprint server for biology

Persistent changes in nociceptor translatomes govern hyperalgesic priming in mouse models.

Article

作者: Inturi, Nikhil Nageswar ; Tavares-Ferreira, Diana ; Kume, Moeno ; Mohammed, Ayaan ; Mwirigi, Juliet M ; Munro, Gordon ; Sankaranarayanan, Ishwarya ; Price, Theodore J ; Petersen, Kenneth A

Hyperalgesic priming is a model system that has been widely used to understand plasticity in painful stimulus-detecting sensory neurons, called nociceptors. A key feature of this model system is that following priming, stimuli that do not normally cause hyperalgesia now readily provoke this state. We hypothesized that hyperalgesic priming occurs due to reorganization of translation of mRNA in nociceptors. To test this hypothesis, we used paclitaxel treatment as the priming stimulus and translating ribosome affinity purification (TRAP) to measure persistent changes in mRNA translation in Nav1.8+ nociceptors. TRAP sequencing revealed 161 genes with persistently altered mRNA translation in the primed state. We identified Gpr88 as upregulated and Metrn as downregulated. We confirmed a functional role for these genes, wherein a GPR88 agonist causes pain only in primed mice and established hyperalgesic priming is reversed by Meteorin. Our work demonstrates that altered nociceptor translatomes are causative in producing hyperalgesic priming.

2024-06-12·Journal of Biomolecular Structure and Dynamics

De novo structure prediction of meteorin and meteorin-like protein for identification of domains, functional receptor binding regions, and their high-risk missense variants

Article

作者: Shankar, S Shiva ; Rajesh, S ; Ramasamy, Sureshkumar ; Kulkarni, Mahesh J ; Jathar, Swaraj M ; Banarjee, Reema

Meteorin (Metrn) and Meteorin-like (Metrnl) are homologous secreted proteins involved in neural development and metabolic regulation. In this study, we have performed de novo structure prediction and analysis of both Metrn and Metrnl using Alphafold2 (AF2) and RoseTTAfold (RF). Based on the domain and structural homology analysis of the predicted structures, we have identified that these proteins are composed of two functional domains, a CUB domain and an NTR domain, connected by a hinge/loop region. We have identified the receptor binding regions of Metrn and Metrnl using the machine-learning tools ScanNet and Masif. These were further validated by docking Metrnl with its reported KIT receptor, thus establishing the role of each domain in the receptor interaction. Also, we have studied the effect of non-synonymous SNPs on the structure and function of these proteins using an array of bioinformatics tools and selected 16 missense variants in Metrn and 10 in Metrnl that can affect the protein stability. This is the first study to comprehensively characterize the functional domains of Metrn and Metrnl at their structural level and identify the functional domains, and protein binding regions. This study also highlights the interaction mechanism of the KIT receptor and Metrnl. The predicted deleterious SNPs will allow further understanding of the role of these variants in modulating the plasma levels of these proteins in disease conditions such as diabetes.Communicated by Ramaswamy H. Sarma.