预约演示

更新于：2025-05-07

ADD1

更新于：2025-05-07

基本信息

别名

ADD1、ADDA、adducin 1

+ [2]

简介

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

关联

项与 ADD1 相关的药物

CN114685680

专利挖掘

靶点

ADD1 x ROCK2 x TAT

作用机制-

在研机构

华中科技大学

原研机构

华中科技大学

在研适应症

认知障碍 [+2]

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 ADD1 相关的临床结果

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100 项与 ADD1 相关的转化医学

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0 项与 ADD1 相关的专利（医药）

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571

项与 ADD1 相关的文献（医药）

2025-05-01·Metabolic Engineering

Biosynthesis of 12-aminododecanoic acid from biomass sugars

Article

作者: Hu, Chunyue ; Gao, Haixin ; Bai, Yanfen ; Fang, Qiang ; Chou, Howard H

Biosynthesis of 12-aminododecanoic acid (ADDA) directly from biomass-derived sugars would enable a more sustainable process for manufacturing the engineering polymer Nylon 12. ADDA biosynthesis is currently hindered by the cytotoxicity of dodecanoic acid (DDA) to growing cells, and the accumulation of the overoxidized byproduct dodecanedioic acid (DDDA). In this study, these challenges were addressed by engineering an autoinducible system to better control in vivo DDA synthesis without impacting growth, and deleting aldehyde dehydrogenases and oxidases to reduce DDDA accumulation. As a result, a one-step fermentation process was established to synthesize ADDA from glucose and cellobiose. Finally, batch fermentation achieved 1035 mg/L ADDA and 5% yield, which is the highest titer and yield accomplished directly from sugar to date. This research contributes to the mechanistic understanding of microbial DDA, ADDA, and DDDA synthesis, as well as the goal of developing more sustainable processes for nylon production.

2025-02-21·Environment & Health

Deciphering the Natural Attenuation of Cyanotoxins: Dissipation, Transformation Pathways, and Genotoxicity

Article

作者: Sun, Qian ; Kiki, Claude ; Li, Xi ; Feng, Jinlu ; Zhao, Feng

Microcystin-LR (MC-LR) and cylindrospermopsin (CYN) are toxic cyanotoxins frequently found in drinking water sources, posing significant health risks. This study conducted a microcosm experiment using surface lake water exposed to sunlight to investigate the natural attenuation processes of MC-LR and CYN. Results indicated that photodegradation plays a crucial role in the natural attenuation of cyanotoxins. The half-lives of MC-LR and CYN were 1 and 7 days in summer under a combined effect of direct and indirect photodegradation, respectively. The effectiveness of these natural processes varied seasonally, with faster dissipation rates observed during summer. Bacterial degradation notably affected only MC-LR in summer, with a negligible effect on CYN. The identified transformation products showed that the conversion of MC-LR involved oxidation, hydroxylation, and/or bond cleavage with Adda and Mdha moieties, while it entails the oxidation of the tricyclic guanidine moiety and opening of the uracil ring for CYN. The Ames assay confirmed that these transformation products from the natural attenuation of MC-LR and CYN did not induce genotoxicity or mutagenicity. While these findings enhance our understanding of natural attenuation mechanisms, they also offer valuable insights that could guide artificial control strategies or improve the efficiency of cyanotoxin management. However, natural degradation processes alone, particularly in large water bodies, may be insufficient to fully mitigate cyanotoxin risks, highlighting the continued need for comprehensive management approaches.

2025-02-01·Waste Management

Interactions between fungi and bacteria hosts carrying MGEs is dominant for ARGs fate during manure mesophilic composting

Article

作者: Yuan, Jing ; Jiang, Tao ; Chen, Wenjie ; Wang, Guoying ; Li, Guoxue ; Yin, Jie ; Zhao, Lu ; Yang, Yan

The mycelial networks of fungi promote the interaction between the originally isolated bacteria, thereby potentially enhancing the exchange of nutrients and the horizontal transfer of genetic materials. However, the driving effect of fungi on antibiotic resistance genes (ARGs) during mesophilic facultative composting is still unclear. This study aims to elucidate the changes in ARGs and underlying mechanisms during the mesophilic composting of manure. Results indicated that reduction rates of ARGs in sheep and pig manure over a 90-day composting period were 34.68% and 60.10%, respectively. The sul1, sul2 and tetX were identified as recalcitrant ARGs in both composting treatments, with the additional unique recalcitrant gene addA observed in sheep manure. Fungal communities appeared to have a more significant influence on the cooperation between bacteria and fungi. Massive fungi interacted intensively with bacterial hosts carrying both ARGs and mobile genetic elements (MGEs). In sheep and pig manure, there were 53 and 38 potential bacterial hosts (genus level) carrying both ARGs and MGEs, associated close interactions with fungi. Structural equation modeling revealed that compost properties influence ARGs by affecting the abundance of core fungi and the hosts carrying MGEs, and that core fungi could also impact ARGs by influencing the bacterial hosts carrying MGEs. Core fungi have the potential to facilitate the horizontal transfer of ARGs by enhancing bacterial network interactions.

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