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更新于：2025-01-23

STARD5

更新于：2025-01-23

基本信息

别名

MGC10327、StAR related lipid transfer domain containing 5、StAR-related lipid transfer protein 5

+ [2]

简介

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

关联

STARD5抑制剂(Virginia Commonwealth University)

靶点

STARD5

作用机制

STARD5抑制剂

在研机构

Virginia Commonwealth University

原研机构

Virginia Commonwealth University

在研适应症

结直肠癌

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 STARD5 相关的临床结果

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100 项与 STARD5 相关的转化医学

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0 项与 STARD5 相关的专利（医药）

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项与 STARD5 相关的文献（医药）

2024-12-01·Biochemistry and Biophysics Reports

StarD5 modulates B cell cholesterol synthesis and IgG1 plasma cell differentiation

Article

作者: Kakiyama, Genta ; Tharakan, Anuj ; Damle, Sheela ; Pandak, William M ; Gil, Gregorio ; Martin, Rebecca K ; Rodriguez-Agudo, Daniel

StarD5 is an ER stress protein that binds cholesterol and transfers it to the plasma membrane. It additionally binds and regulates 25-hydroxycholesterol (25-HC) levels. However the full function of the StarD5-25-HC axis is unknown. 25-HC has been recently described as an important suppressor of IgA + plasma cell differentiation in the Peyer's patches, and regulates the switch between germinal center and plasma cells. Since StarD5 regulates 25-HC, we examined the role of StarD5 in B cells using StarD5^-/- mice. We found that StarD5^-/- mice have normal B cell development and antibody production at baseline, but after T-dependent immunization a reduction in class-switched IgG1 germinal center B cells and plasma cells was observed. T-independent immune responses additionally result in a reduction in IgG1 responses and this likely B cell intrinsic. In addition, there was impairment at the T1 to T2 transitional B cell stage after T-independent immunization. In conclusion, StarD5 appears important for IgG1 responses in B cells and may regulate B cell development under stress conditions. Our findings suggest a role for StarD5 as a key regulator of B cell function and activation following immunization.

2024-08-02·Journal of Asthma

Decoding the genetic landscape of allergic rhinitis: a comprehensive network analysis revealing key genes and potential therapeutic targets

Article

作者: Lin, Xiaohong ; Liao, Ruosha ; Yuan, Chile

BACKGROUNDAllergic Rhinitis (AR), an inflammatory affliction impacting the upper respiratory tract, has been registering a substantial surge in incidence across the globe.METHODSWe embarked on examination of differentially expressed genes (DEGs) and the Weighted Gene Co-Expression Network Analysis (WGCNA). With this armory of genes identified, we engaged the tools of Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Our study continued with the establishment of a protein-protein interaction (PPI) network and the application of LASSO regression. Finally, we leveraged a docking model to elucidate potential drug-gene interactions involving these key genes.RESULTSThrough WGCNA and different express genes screening, PPI network was performed, identifying top 20 key genes, including CD44, CD69, CD274. LASSO regression identified three independent factors, STARD5, CST1, and CHAC1, that were significantly associated with AR. A predictive model was developed with an AUC value over 0.75. Also, 105 potential therapeutic agents were discovered, including Fluorouracil, Cyclophosphamide, Doxorubicin, and Hydrocortisone, offering promising therapeutic strategies for AR.CONCLUSIONBy fuzing DEGs with key genes derived from WGCNA, this study has illuminated a comprehensive network of gene interactions involved in the pathogenesis of AR, paving the way for future biomarker and therapeutic target discovery in AR.

2024-06-01·American Journal of Physiology-Gastrointestinal and Liver Physiology

StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis

Article

作者: Pandak, William M. ; Kakiyama, Genta ; Bai-Kamara, Nanah ; Rodriguez-Agudo, Daniel ; Minoiwa, Kei ; Hashiguchi, Taishi

We have found that deletion of the cholesterol transport protein StarD5 in mice leads to an increase in insulin resistance and lipid accumulation due to the upregulation of lipid synthesis and decrease VLDL secretion from the liver. In addition, deletion of StarD5 increased fibrosis when mice were fed a Western diet. This represents a novel pathway of fibrosis development in the liver.

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