更新于：2024-11-01

水解酶 x NAD+

更新于：2024-11-01

基本信息

关联

项与水解酶 x NAD+ 相关的药物

IPG-8294

靶点

水解酶 x NAD+

作用机制

水解酶抑制剂 [+1]

在研机构

安萌得医药科技（上海）有限公司 [+1]

原研机构

南京艾美斐生物医药科技有限公司初创企业

在研适应症

阿尔茨海默症 [+2]

非在研适应症-

最高研发阶段临床申请

首次获批国家/地区-

首次获批日期1800-01-20

100 项与水解酶 x NAD+ 相关的临床结果

登录后查看更多信息

100 项与水解酶 x NAD+ 相关的转化医学

登录后查看更多信息

0 项与水解酶 x NAD+ 相关的专利（医药）

登录后查看更多信息

107

项与水解酶 x NAD+ 相关的文献（医药）

2024-07-01·International Journal of Biological Macromolecules

Comprehensive review on glucose 6 phosphate dehydrogenase: A critical immunometabolic and redox switch in insects

Review

作者: Chen, Junfan ; Feng, Tianxiang ; Ghani, Muhammad Usman ; Wu, Qishu ; Khosravi, Zahra ; Cui, Hongjuan ; Yang, Zihan

Mounting an active immune response is energy intensive and demands the reallocation of nutrients to maintain the body's resistance and tolerance against infections. Central to this metabolic adaptation is Glucose-6-phosphate dehydrogenase (G6PDH), a housekeeping enzyme involve in pentose phosphate pathway (PPP). PPP play an essential role in generating ribose, which is critical for nicotinamide adenine dinucleotide phosphate (NADPH). It is vital for physiological and cellular processes such as generating nucleotides, fatty acids and reducing oxidative stress. The G6PDH is extremely conserved enzyme across species in PP shunt. The deficiency of enzymes leads to serious consequences on organism, particularly on adaptation and development. Acute deficiency can lead to impaired cell development, halted embryonic growth, reduce sensitivity to insulin, hypertension and increase inflammation. Historically, research focusing on G6PDH and PPP have primarily targeted diseases on mammalian. However, our review has investigated the unique functions of the G6PDH enzyme in insects and greatly improved mechanistic understanding of its operations. This review explore how G6PDH in insects plays a crucial role in managing the redox balance and immune related metabolism. This study aims to investigate the enzyme's role in different metabolic adaptations.

2024-07-01·Biomedicine & Pharmacotherapy

Glucose-6-phosphate dehydrogenase and transketolase: Key factors in breast cancer progression and therapy

Review

作者: Zhen, Xin ; Sun, Jing ; Hao, Shiming ; Zhang, Mingyu

Breast cancer is one of the most common malignant tumors in women and is a serious threat to women's health. The pentose phosphate pathway (PPP) is a mode of oxidative breakdown of glucose that can be divided into oxidative (oxPPP) and non-oxidative (non-oxPPP) stages and is necessary for cell and body survival. However, abnormal activation of PPP often leads to proliferation, migration, invasion, and chemotherapy resistance in breast cancer. Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in PPP oxidation. Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) produced by G6PD is the raw material for cholesterol and lipid synthesis and can resist the production of oxygen species (ROS) and reduce oxidative stress damage to tumor cells. Transketolase (TKT) is a key enzyme in non-oxPPP. Ribose 5-phosphate (R5P), produced by TKT, is a raw material for DNA and RNA synthesis, and is essential for tumor cell proliferation and DNA damage repair. In this review, we describe the role and specific mechanism of the PPP and the two most important enzymes of the PPP, G6PD and TKT, in the malignant progression of breast cancer, providing strategies for future clinical treatment of breast cancer and a theoretical basis for breast cancer research.

2024-06-25·Zhen ci yan jiu = Acupuncture research

热补针法对类风湿关节炎寒证家兔膝关节滑膜组织缺氧诱导因子1α和糖酵解活性的影响.

Article

作者: Chen, Ping ; Zhang, Feng-Fan ; Li, Fu-Xin ; Liu, Li-Mei ; Zhang, Xing-Hua ; Jing, Wei-Yao ; DU, Xiao-Zheng ; Li, Xiang-Jun ; Liu, Cui

目的: 观察热补针法对类风湿关节炎（RA）寒证家兔膝关节滑膜炎性反应及滑膜组织、血清中缺氧诱导因子1α（HIF-1α）、糖酵解活性的影响，探讨热补针法治疗RA的机制。方法: 选取32只新西兰兔随机分为正常组、模型组、抑制剂组、热补针法组，每组8只。采用卵蛋白联合弗氏完全佐剂诱导及低温冷冻法复制RA寒证模型。抑制剂组给予2-甲氧基雌二醇腹腔注射，热补针法组给予热补针法针刺“足三里”，留针30 min。各组干预均1次/d，连续14 d。观察家兔膝关节周径及痛阈变化；采用ELISA法检测家兔血清中还原型辅酶Ⅱ（NADPH）、己糖激酶（HK2）、6-磷酸果糖激酶2/2，6-二磷酸果糖激酶3（PFKFB3）含量；HE染色法观察家兔膝关节滑膜组织形态变化；免疫组织化学法检测家兔膝关节滑膜组织中肿瘤坏死因子α（TNF-α）、白细胞介素（IL）-1β、IL-6、IL-17的阳性表达；分光光度法检测家兔膝关节滑膜组织中乳酸含量；Western blot法检测膝关节滑膜组织中HIF-1α、乳酸脱氢酶（LDHA）、丙酮酸激酶2（PKM2）蛋白表达水平。结果: 干预后，与正常组比较，模型组家兔膝关节周径增大（P<0.05），痛阈值降低（P<0.05），可见滑膜细胞中度增生及炎性浸润，滑膜组织病理评分升高（P<0.05），滑膜组织中TNF-α、IL-1β、IL-6、IL-17阳性表达及乳酸含量均升高（P<0.05），血清NADPH、HK2、PFKFB3含量及滑膜组织中HIF-1α、LDHA、PKM2蛋白表达水平均升高（P<0.05）。与模型组比较，抑制剂组及热补针法组家兔膝关节周径缩小（P<0.05），痛阈值升高（P<0.05），滑膜增生、炎性细胞浸润均改善，滑膜组织病理评分降低（P<0.05），滑膜组织中TNF-α、IL-1β、IL-6、IL-17阳性表达及乳酸含量均下降（P<0.05），血清NADPH、HK2、PFKFB3含量及滑膜组织中HIF-1α、LDHA、PKM2蛋白表达水平均下降（P<0.05）。与抑制剂组比较，热补针法组家兔滑膜组织病理评分升高（P<0.05），滑膜组织中TNF-α、IL-1β、IL-6、IL-17阳性表达及乳酸含量均升高（P<0.05），血清NADPH、HK2、PFKFB3含量及滑膜组织中HIF-1α、LDHA、PKM2蛋白表达水平均升高（P<0.05）。结论: 热补针法干预RA寒证家兔可提高痛阈，减小膝关节周径，抑制炎性反应，其作用机制与下调HIF-1α及糖酵解活性相关。.