更新于：2024-11-01

细胞黏附分子

更新于：2024-11-01

基本信息

别名-

简介-

关联

项与细胞黏附分子相关的药物

TBC-2019

靶点

细胞黏附分子

作用机制

细胞黏附分子调节剂

在研机构-

原研机构

Encysive Pharmaceuticals, Inc.

在研适应症-

非在研适应症

哮喘

最高研发阶段终止

首次获批国家/地区-

首次获批日期1800-01-20

ABS-205R

靶点

细胞黏附分子

作用机制

细胞黏附分子调节剂

在研机构-

原研机构

QHSLab, Inc.

在研适应症-

非在研适应症

认知障碍 [+1]

最高研发阶段终止

首次获批国家/地区-

首次获批日期1800-01-20

P-1025

靶点

细胞黏附分子

作用机制

细胞黏附分子调节剂

在研机构-

原研机构

King's College London

在研适应症-

非在研适应症

龋齿

最高研发阶段终止

首次获批国家/地区-

首次获批日期1800-01-20

100 项与细胞黏附分子相关的临床结果

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100 项与细胞黏附分子相关的转化医学

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0 项与细胞黏附分子相关的专利（医药）

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310

项与细胞黏附分子相关的文献（医药）

2024-08-24·British Journal of Cancer

Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation

Article

作者: Richtig, Erika ; Gschwendtner, Anna ; Hengstschläger, Markus ; Eckel, Oliver ; Mirea, Madalina A ; Vock, Laurenz ; Schörghofer, David ; Neesen, Jürgen ; Mikula, Mario

AbstractBackgroundDespite ongoing research and recent advances in therapy, metastatic melanoma remains one of the cancers with the worst prognosis. Here we studied the postsynaptic cell adhesion molecule Neuroligin 4X (NLGN4X) and investigated its role in melanoma progression.MethodsWe analysed histologic samples to assess the expression and predictive value of NLGN4X in human melanoma. The oncogenic role of NLGN4X was determined by loss or gain-of-function experiments in vitro as well as by analysis of tumorspheres, which were grafted to human skin organoids derived from pluripotent stem cells. Whole genome expression analysis and validation experiments were performed to clarify the molecular mechanism.ResultsWe identified that suppression of NLGN4X down regulated the prefoldin member Von Hippel-Lindau binding protein 1 (VBP1). Moreover, loss of VBP1 was sufficient for accumulation of HIF1A and HIF1A signalling was further shown to be essential for the acquisition of migratory properties in melanoma. We re-established NLGN4X expression in late stage melanoma lines and observed decreased tumour growth after transplantation to human skin organoids generated from pluripotent stem cells. In line, we showed that high amounts of NLGN4X and its target VBP1 in human patient samples had a beneficial prognostic effect on patient survival.ConclusionIn view of these findings, we propose that decreased amounts of NLGN4X are indicative of a metastatic melanoma phenotype and that loss of NLGN4X provides a novel mechanism for HIF induction.

2024-06-01·Journal of Assisted Reproduction and Genetics

Bioinformatic analysis of the role of immune checkpoint genes and immune infiltration in the pathogenesis and development of premature ovarian insufficiency

Article

作者: Yang, Tongkun ; Kong, Li ; Wang, Ling ; Du, Jing ; Zhang, Xiyan ; Wei, Luxiao

AbstractPurposeWith advances in immunology, increasing evidence suggests that immunity is involved in premature ovarian insufficiency (POI) pathogenesis. This study investigated the roles of immune checkpoint genes and immune cell infiltration in POI pathogenesis and development.MethodsThe GSE39501 dataset and immune checkpoint genes were obtained from the Gene Expression Omnibus database and related literature. The two datasets were intersected to obtain immune checkpoint-related differentially expressed genes (ICRDEGs), which were analyzed using Gene Ontology and Kyoto Encyclopedia of Gene and Genomes enrichment analysis, weighted correlation network analysis, protein–protein interaction and related microRNAs, transcription factors, and RNA binding proteins. The immune cell infiltration of ICRDEGs was explored, and receiver operating characteristic curves were used to validate the diagnostic value of ICRDEGs in POI.ResultsWe performed ICRDEG functional enrichment analysis and found that these genes were closely related to immune processes, such as T cell activation. Specifically, they are enriched in various biological processes and pathways, such as cell adhesion molecule and T cell receptor signaling pathways. Weighted correlation network analysis identified seven hub genes: Cd200, Cd274, Cd28, neurociliary protein-1, Cd276, Cd40lg, and Cd47. Furthermore, we identified 112 microRNAs, 17 RNA-binding proteins, and 101 transcription factors. Finally, immune infiltration analysis showed a clear positive correlation between hub genes and multiple immune cell types.ConclusionBioinformatic analysis identified seven potential ICRDEGs associated with POI, among which the immune checkpoint molecules CD200 and neurociliary protein-1 may be involved in the pathogenesis of POI.

2024-06-01·Skin Research and Technology

Human dermal fibroblast‐derived secretory proteins for regulating nerve restoration: A bioinformatic approach

Article

作者: Suh, Sang Bum ; Cho, Sung Bin ; Lee, Hyeri ; Suh, Ji Youn

AbstractBackgroundHuman dermal fibroblasts secrete diverse proteins that regulate wound repair and tissue regeneration.MethodsIn this study, dermal fibroblast‐conditioned medium (DFCM) proteins potentially regulating nerve restoration were bioinformatically selected among the 337 protein lists identified by quantitative liquid chromatography‐tandem mass spectrometry. Using these proteins, protein–protein interaction network analysis was conducted. In addition, the roles of DFCM proteins were reviewed according to their protein classifications.ResultsGene Ontology protein classification categorized these 57 DFCM proteins into various classes, including protein‐binding activity modulator (N = 11), cytoskeletal protein (N = 8), extracellular matrix protein (N = 6), metabolite interconversion enzyme (N = 5), chaperone (N = 4), scaffold/adapter protein (N = 4), calcium‐binding protein (N = 3), cell adhesion molecule (N = 2), intercellular signal molecule (N = 2), protein modifying enzyme (N = 2), transfer/carrier protein (N = 2), membrane traffic protein (N = 1), translational protein (N = 1), and unclassified proteins (N = 6). Further protein–protein interaction network analysis of 57 proteins revealed significant interactions among the proteins that varied according to the settings of confidence score.ConclusionsOur bioinformatic analysis demonstrated that DFCM contains many secretory proteins that form significant protein–protein interaction networks crucial for regulating nerve restoration. These findings underscore DFCM proteins’ critical roles in various nerve restoration stages during the wound repair process.