别名 Kisspeptin-1受体、AXOR12、G protein-coupled receptor 54 + [11] |
简介 Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
靶点 |
作用机制 GPR54激动剂 |
在研适应症 |
非在研适应症- |
最高研发阶段临床前 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 GPR54激动剂 |
在研机构- |
在研适应症- |
最高研发阶段终止 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
靶点 |
作用机制 GPR54激动剂 |
在研机构- |
在研适应症- |
非在研适应症 |
最高研发阶段终止 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2018-05-23 |
申办/合作机构 |
开始日期2017-10-30 |
申办/合作机构 |
开始日期2015-09-10 |