Benefits of Insoles With Real-Time Alert and Foot Self-Care Education in Improving Adherence for Prescribed Footwear in Patients With Diabetes Mellitus

Novel approaches to promote adherence to diabetic footwear and prevent high incidence of diabetes foot ulcers are urgently needed. Investigators propose to translate an innovative and practical technology to supplement clinical and risk evaluation for patients with diabetes through wearable insoles and smart watch, along with foot self-care education, to improve adherence to prescribed footwear and reduce incidence of foot ulcers in those with diabetes and at risk for foot ulcers.

开始日期2026-10-20

申办/合作机构

Texas Woman's University

NCT06940063

/ Not yet recruitingN/AIIT

Does Active Music-Based Intervention Alter Cognitive Function, Sensitivity to Stimuli, Pain Catastrophizing and Quality of Life in Patients With Chronic Low Back Pain?

The goal of this clinical trial is to learn if active music-based intervention works to treat patients with chronic low back pain. The main questions it aims to answer are:
1. Does active music-based intervention improve cognitive function?
2. Does active music -based intervention improve sensitivity to stimuli?
3. Does active music-based intervention improve pain catastrophizing behavior?
4. Does active music-based intervention improve quality of life?
Participant will visit the clinic for 5 sessions of assessments and active music-based intervention over 2 weeks. On the first visit, it will take each participant 45 minutes to complete the pre-intervention assessments followed by a 45-minute active music-based intervention. The active music-based intervention will last about an hour for the remaining 4 visits. On the 5th or last visit, after the one-hour intervention, it will take another 30 minutes for each participant to complete the post-intervention assessments.

开始日期2025-06-01

申办/合作机构

Texas Woman's University

[+1]

NCT06705634

/ RecruitingN/AIIT

Effects of Dry Needling of C5-C6 on Shoulder Range of Motion, Strength, Tender Points, and Blood Flow

Segmental facilitation, originally proposed by Korr in the 1950s, suggests that certain spinal segments can become hyperexcitable, leading to chronic pain development. In a facilitated segment, neurons governing sensory, motor, and autonomic functions are in a state of heightened sensitivity, making them responsive to normally weak stimuli. Clinical signs include non-fatigable muscle weakness, brisk reflexes, muscle hypertonicity, tenderness upon palpation, and trophic changes like an orange-peel appearance in the affected segment's innervated areas. It's hypothesized that increased synaptic excitability in facilitated segments could cause vasoconstriction and reduced blood flow, contributing to trophic changes and muscle hypertonicity.
Manual therapies like dry needling have been shown to alleviate muscle inhibition in the extremities. Previous studies have demonstrated that mobilization of the C5-6 joint can reduce non-fatigable weakness in shoulder external rotators primarily innervated by these segments. However, the neurophysiological effects of dry needling (DN) on muscle inhibition due to a facilitated segment remain unclear. While DN has been observed to increase local tissue blood flow, its potential to mitigate the clinical signs of segmental facilitation is uncertain. While DN has been observed to increase local tissue blood flow, its potential to mitigate the clinical signs of segmental facilitation is uncertain.
Therefore, this project aims to investigate whether DN applied at a facilitated segment could normalize blood flow to its associated muscles. Specifically, this study will explore whether DN at the C5-6 level improves blood flow in the infraspinatus muscle, enhances shoulder range of motion, and influences muscle strength over time. The secondary purpose is to determine whether C5-6 DN will reduce the number of tender points in the muscles supplied by C5-6.

开始日期2024-12-01

申办/合作机构

Texas Woman's University

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项与 Texas Woman's University 相关的文献（医药）

2025-06-01·Musculoskeletal Science and Practice

Differences in non-weight-bearing and weight-bearing measures of lower leg muscle elasticity using shear wave elastography

Article

作者: Brewer, Wayne ; Mitchell, Katy ; Bickley, Christina ; Kempfert, David J

INTRODUCTIONElasticity is a biomechanical property of muscle necessary for physical function and can be measured with shear wave elastography (SWE). SWE may be useful in diagnosing pathology, predicting injury, and monitoring rehabilitation. This would be beneficial for smaller muscles working synergistically to resist external loads during functional activities. Establishing clinical measures of elasticity in larger sample sizes is necessary prior to its use in assessing pathology and guiding intervention.PURPOSEThe study's primary aim was to investigate differences in elasticity for the tibialis anterior (TA), tibialis posterior (TP), peroneal longus (PL), and peroneal brevis (PB) muscles. It was hypothesized that there would be a statistically-significant difference in muscle elasticity both within and between non-weight-bearing (NWB) and weight-bearing (WB) positions.METHODSSame-day, repeated-measures, cross-sectional design incorporating 109 healthy, recreationally active adults. Elasticity (kPa) was measured in NWB and 90 % WB.RESULTSThere was a statistically-significant interaction between muscle (TA, TP, PL, PB) and position (NWB, WB). Utilizing pairwise simple effects with Bonferroni correction, there was a significant (p ≤ 0.001-0.007) difference within muscles for NWB measures. WB measures revealed a significant (p ≤ 0.001) difference within muscles, except the TA-PB (p = 1.000). A significant (p ≤ 0.001-0.018) difference was found between NWB and WB positions for the TA, TP, and PB but not the PL (p = 0.140).CONCLUSIONThe utility of SWE may help describe how the biomechanical property of elasticity differs between resting positions and functional states of muscle contraction. These findings may aid future clinical applications of SWE for injury prevention, rehabilitation, and physical performance.

2025-05-01·Dementia

Experiences of African American caregivers providing care for family living with Alzheimer’s disease: A descriptive phenomenological study

Article

作者: Carson, LaGaryion ; McFarlane, Judith

This study aimed to describe how African American family caregivers of people living with Alzheimer’s disease manage caregiving. A qualitative study design using a descriptive phenomenological approach was used to understand the lived experiences of African American family caregivers. Fifteen individual semi-structured and in-depth interviews were conducted via telephone or videoconference between January and June 2023 to address the research question. Guided by Swanson’s theory of caring, the data transcribed verbatim from the audio-recorded interviews were analyzed using Colaizzi’s methodology. Eight themes emerged from the data: (a) Parenting all over again, (b) Self-sacrifice, (c) Caring for the caregiver, (d) Connecting to God, (e) Responsibility to care, (f) Trapped, (g) Beyond exhaustion, and (h) Loss of self. The findings of the study indicate that African American family caregivers of people living with Alzheimer’s disease often experience physical, mental, and emotional exhaustion while managing care. Thus, there is a considerable need for greater support, health promotion, and development of appropriate interventions to alleviate the challenges experienced so that they can continue in their caregiving role with some respite.

2025-04-21·Cancer Research

Abstract 3728: Extracellular vesicle dynamics in alternate-day fasting combined with low-carbohydrate weight loss intervention

作者: Dorayappan, Kalpana Deepa ; Akasheh, Rand T. ; Kalam, Faiza ; Tao, Zhipeng ; Karuppaiyah, Selvendiran ; David Cheng, Ting-Yuan ; Varady, Krista

AbstractBackground:Obesity is associated with systemic metabolic dysregulation and chronic inflammation, which are reflected in alterations in extracellular vesicles (EVs) that mediate intercellular communication. EVs, marked by CD9 and CD63, may also play a critical role in cancer risk by mediating pro-inflammatory and metabolic signaling. This study investigates how an alternate-day fasting and low-carbohydrate (ADF-LC) intervention impact EV secretion and subpopulation dynamics, exploring their potential as candidates for further protein-level investigations to delineate functional roles in inflammation and metabolic dysfunction.Methods:Serum samples were analyzed from 10 participants with obesity enrolled in a 24-week ADF-LC intervention, comprising of a 12-week weight loss phase and a 12-week weight maintenance phase. EVs were isolated from serum collected at baseline (Week 0), after weight loss (Week 12), and after weight maintenance (Week 24). EV quantification and characterization were performed using ImageStream flow cytometry, focusing on EV surface markers CD9 and CD63. Fluorescent antibody labeling was used to detect these tetraspanins, allowing precise measurement of EV subpopulations. Total EV concentrations and subpopulation dynamics were assessed, while protein cargo consistency was evaluated to identify functional shifts.Results:Body weight significantly decreased during the weight loss period (-5.5 ± 0.5%; p < 0.001) and stabilized during the weight maintenance phase (p = 0.57). Net weight loss by Week 24 was -6.3 ± 1.0%, accompanied by a significant reduction in fat mass (p < 0.01). Total EV concentrations significantly declined from baseline to Week 24 (p < 0.05), with notable reductions in CD9+ EV populations at Weeks 12 and 24 (p < 0.05) and CD63+ EV populations at Week 24 (p < 0.05). Despite these changes, EV protein cargo remained consistent, suggesting shifts in specific EV populations and EV-mediated signaling rather than alterations in total protein load. These findings support the need for further investigation into protein changes within EVs to better understand their functional roles in inflammation and metabolic dysfunction.Conclusions:This study highlights significant changes in EV dynamics and subpopulations during ADF-LC, providing novel insights into metabolic adaptations associated with obesity and weight loss interventions. EVs, particularly CD9+ and CD63+ subpopulations, emerge as potential candidates for further exploration of protein-level changes to better delineate their functional roles in mediating inflammation and metabolic dysfunction, and potential involvement in the obesity-cancer connection.Citation Format:Faiza Kalam, Kalpana Deepa Dorayappan, Rand T. Akasheh, Zhipeng Tao, Ting-Yuan David Cheng, Krista Varady, Selvendiran Karuppaiyah. Extracellular vesicle dynamics in alternate-day fasting combined with low-carbohydrate weight loss intervention [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 3728.

项与 Texas Woman's University 相关的新闻（医药）

2023-01-11

·PRNewswire

Nurse Practitioner Sues CVS for Revoking Longstanding Religious Accommodation for Prescribing Contraception

First Liberty Institute files federal lawsuit claiming religious discrimination WASHINGTON, Jan. 11, 2023 /PRNewswire/ -- First Liberty Institute and the law firm Boyden Gray & Associates today filed a federal lawsuit against CVS Pharmacy on behalf of Robyn Strader, a nurse practitioner in Texas. CVS terminated Strader's employment because she sought a religious accommodation from prescribing any medication that could intentionally end the development or life of an unborn child, an accommodation CVS had granted for the previous six years. The complaint, filed in the Northern District of Texas, is available here. "After accommodating Robyn for six and a half years without a single complaint, CVS fired her because it simply did not like her pro-life religious beliefs," said Christine Pratt, Counsel for First Liberty Institute. "It is illegal to issue a blanket revocation of all religious accommodations when it is so easy for CVS to accommodate its employees. CVS is sending a message that religious health care workers are not welcome and need not apply." Jonathan Berry, Partner at Boyden Gray & Associates and former head of rulemaking at the U.S. Department of Labor, added, "Our employment laws protect religious freedom in the workplace. No one should have to choose between her faith and her job, especially where it would be easy to continue a longstanding religious accommodation. Boyden Gray & Associates looks forward to vigorously defending Robyn's rights in court." Robyn Strader, a nurse practitioner, worked at a CVS MinuteClinic in Keller, Texas since 2015. For six and a half years she operated under a religious accommodation not to prescribe hormonal contraception. On the few occasions someone requested such a prescription from her, she would simply refer them to another nurse practitioner at her location or to another CVS MinuteClinic located 2 miles away. Then, in August 2021, CVS suddenly announced that it would no longer honor religious accommodations related to "pregnancy prevention services" regardless of circumstances. CVS could have accommodated Ms. Strader in several ways, such as transferring her to another position or continuing to honor the religious accommodation that worked successfully for years. Instead, on October 31, 2021, CVS fired Robyn. In Robyn's case, out of the thousands of patients she saw each year, only a tiny percentage (less than an estimated 0.2%) sought a prescription she could not personally provide due to her faith. Robyn has an extensive background in health care and education. She taught science at the high school and pre-professional levels, and she has multiple degrees, including a PhD in Education, Health Promotion, and Human Performance, and Medical Physiology from the University of Toledo Medical Center; a Doctor of Chiropractic from Parker University; a Master of Science in Nursing, Nursing Education, and Family Nurse Practitioner from Texas Woman's University; and an MBA, also from Texas Woman's University. In the complaint attorneys state, "In addition to prospectively preempting all requests for religious accommodations, CVS unlawfully derided Ms. Strader's religious beliefs, pressured her to change her beliefs, refused to consider her multiple requests for a religious accommodation, failed to engage with her about possible accommodations, and terminated her because of her religious beliefs." About First Liberty Institute First Liberty Institute is a non-profit public interest law firm and the largest legal organization in the nation dedicated exclusively to defending religious freedom for all Americans. SOURCE First Liberty Institute

专利侵权高管变更

2021-01-26

·医学新视点

两篇NEJM：不止BRCA！这些关键基因都和乳腺癌风险密切相关

▎药明康德内容团队编辑 20世纪90年代，乳腺癌易感基因BRCA1和BRCA2先后被发现。此后，大量高风险人群进行了相关基因检测，以了解相关癌症风险并采取药物或手术等预防措施。 BRCA1 20世纪90年代，乳腺癌易感基因BRCA1和BRCA2先后被发现。此后，大量高风险人群进行了相关基因检测，以了解相关癌症风险并采取药物或手术等预防措施。 BRCA2 20世纪90年代，乳腺癌易感基因BRCA1和BRCA2先后被发现。此后，大量高风险人群进行了相关基因检测，以了解相关癌症风险并采取药物或手术等预防措施。而两篇最新发表在《新英格兰医学杂志》（NEJM）的论文，现在将继续拓展我们对于乳腺癌相关基因的认知，为乳腺癌筛查提供更多洞见。 NEJM 而两篇最新发表在《新英格兰医学杂志》（NEJM）的论文，现在将继续拓展我们对于乳腺癌相关基因的认知，为乳腺癌筛查提供更多洞见。在美国、欧洲和亚洲女性中开展的两项大型乳腺癌病例对照研究，识别出了与乳腺癌风险有关的多个变异。其中8个基因在两项研究中都表现出显著关联：BRCA1、BRCA2、PALB2、BARD1、RAD51C、RAD51D、ATM和CHEK2。其中8个基因在两项研究中都表现出显著关联： BRCA1 在美国、欧洲和亚洲女性中开展的两项大型乳腺癌病例对照研究，识别出了与乳腺癌风险有关的多个变异。其中8个基因在两项研究中都表现出显著关联：BRCA1、BRCA2、PALB2、BARD1、RAD51C、RAD51D、ATM和CHEK2。 BRCA2 在美国、欧洲和亚洲女性中开展的两项大型乳腺癌病例对照研究，识别出了与乳腺癌风险有关的多个变异。其中8个基因在两项研究中都表现出显著关联：BRCA1、BRCA2、PALB2、BARD1、RAD51C、RAD51D、ATM和CHEK2。 PALB2 在美国、欧洲和亚洲女性中开展的两项大型乳腺癌病例对照研究，识别出了与乳腺癌风险有关的多个变异。其中8个基因在两项研究中都表现出显著关联：BRCA1、BRCA2、PALB2、BARD1、RAD51C、RAD51D、ATM和CHEK2。 BARD1 在美国、欧洲和亚洲女性中开展的两项大型乳腺癌病例对照研究，识别出了与乳腺癌风险有关的多个变异。其中8个基因在两项研究中都表现出显著关联：BRCA1、BRCA2、PALB2、BARD1、RAD51C、RAD51D、ATM和CHEK2。 RAD51C 在美国、欧洲和亚洲女性中开展的两项大型乳腺癌病例对照研究，识别出了与乳腺癌风险有关的多个变异。其中8个基因在两项研究中都表现出显著关联：BRCA1、BRCA2、PALB2、BARD1、RAD51C、RAD51D、ATM和CHEK2。 RAD51D 在美国、欧洲和亚洲女性中开展的两项大型乳腺癌病例对照研究，识别出了与乳腺癌风险有关的多个变异。其中8个基因在两项研究中都表现出显著关联：BRCA1、BRCA2、PALB2、BARD1、RAD51C、RAD51D、ATM和CHEK2。 ATM 在美国、欧洲和亚洲女性中开展的两项大型乳腺癌病例对照研究，识别出了与乳腺癌风险有关的多个变异。其中8个基因在两项研究中都表现出显著关联：BRCA1、BRCA2、PALB2、BARD1、RAD51C、RAD51D、ATM和CHEK2。 CHEK2 在美国、欧洲和亚洲女性中开展的两项大型乳腺癌病例对照研究，识别出了与乳腺癌风险有关的多个变异。其中8个基因在两项研究中都表现出显著关联：BRCA1、BRCA2、PALB2、BARD1、RAD51C、RAD51D、ATM和CHEK2。截图来源：New England Journal of Medicine 第一项研究来自妙佑医疗国际（Mayo Clinic）团队，对美国64719名女性（包括32247名乳腺癌患者和32544名对照女性）进行28种癌症易感基因的检测，并通过对比分析找出与乳腺癌风险有关的可遗传致病变异（germline pathogenic variants）。对美国 64719名女性第一项研究来自妙佑医疗国际（Mayo Clinic）团队，对美国64719名女性（包括32247名乳腺癌患者和32544名对照女性）进行28种癌症易感基因的检测，并通过对比分析找出与乳腺癌风险有关的可遗传致病变异（germline pathogenic variants）。进行28种癌症易感基因的检测第一项研究来自妙佑医疗国际（Mayo Clinic）团队，对美国64719名女性（包括32247名乳腺癌患者和32544名对照女性）进行28种癌症易感基因的检测，并通过对比分析找出与乳腺癌风险有关的可遗传致病变异（germline pathogenic variants）。研究发现，有5.03%的乳腺癌患者体内检出12个已知的乳腺癌易感基因变异，而对照组中这一比例为1.63%。携带BRCA1和BRCA2致病变异的女性，乳腺癌风险尤其高，是普通女性的7.62倍和5.23倍。携带PALB2致病变异的女性乳腺癌风险中度升高，为普通女性的3.83倍。 BARD1、RAD51C和RAD51D的致病变异与雌激素受体（ER）阴性乳腺癌和三阴性乳腺癌风险增加有关。 ATM、CDH1和CHEK2的致病变异与ER阳性乳腺癌风险增加有关。由于特定样本量不足，这项分析未能评估PTEN或TP53变异与乳腺癌的关联。截图来源：New England Journal of Medicine 第二项研究由剑桥大学（University of Cambridge）团队领衔，对来自欧洲和亚洲共25个国家超过11.3万名女性（60466名乳腺癌患者和53461名对照女性）的34个潜在易感基因进行了检测。对来自欧洲和亚洲共25个国家超过11.3万名女性第二项研究由剑桥大学（University of Cambridge）团队领衔，对来自欧洲和亚洲共25个国家超过11.3万名女性（60466名乳腺癌患者和53461名对照女性）的34个潜在易感基因进行了检测。的34个潜在易感基因进行了检测。有5个基因的蛋白截短变异（Protein-truncating variants）与乳腺癌风险显著相关： ATM ATM、BRCA1、BRCA2、CHEK2和PALB2。相较于普通女性，影响程度从ATM变异的2.1倍风险至BRCA1变异的10.57倍风险不等。 BRCA1 ATM、BRCA1、BRCA2、CHEK2和PALB2。相较于普通女性，影响程度从ATM变异的2.1倍风险至BRCA1变异的10.57倍风险不等。 BRCA2 ATM、BRCA1、BRCA2、CHEK2和PALB2。相较于普通女性，影响程度从ATM变异的2.1倍风险至BRCA1变异的10.57倍风险不等。 CHEK2 ATM、BRCA1、BRCA2、CHEK2和PALB2。相较于普通女性，影响程度从ATM变异的2.1倍风险至BRCA1变异的10.57倍风险不等。 PALB2 ATM、BRCA1、BRCA2、CHEK2和PALB2。相较于普通女性，影响程度从ATM变异的2.1倍风险至BRCA1变异的10.57倍风险不等。 ATM ATM、BRCA1、BRCA2、CHEK2和PALB2。相较于普通女性，影响程度从ATM变异的2.1倍风险至BRCA1变异的10.57倍风险不等。 BRCA1变异的10.57倍风险 ATM、BRCA1、BRCA2、CHEK2和PALB2。相较于普通女性，影响程度从ATM变异的2.1倍风险至BRCA1变异的10.57倍风险不等。有7个基因的蛋白截短变异与乳腺癌风险有着中等相关性：携带BARD1：风险是普通女性的2.09倍携带RAD51C：1.93倍风险携带RAD51D：1.80倍风险携带PTEN：2.25倍风险携带NF1：1.76倍风险携带TP53：3.06倍风险携带MSH6：1.96倍风险相似地，这项研究也发现ATM和CHEK2蛋白截短变异与ER阳性乳腺癌风险增加有关；而BARD1、BRCA1、BRCA2、PALB2、RAD51C和RAD51D的蛋白截短变异与ER阴性乳腺癌风险升高有关。 ATM 和 CHEK2 相似地，这项研究也发现ATM和CHEK2蛋白截短变异与ER阳性乳腺癌风险增加有关；而BARD1、BRCA1、BRCA2、PALB2、RAD51C和RAD51D的蛋白截短变异与ER阴性乳腺癌风险升高有关。 BARD1 相似地，这项研究也发现ATM和CHEK2蛋白截短变异与ER阳性乳腺癌风险增加有关；而BARD1、BRCA1、BRCA2、PALB2、RAD51C和RAD51D的蛋白截短变异与ER阴性乳腺癌风险升高有关。 BRCA1 、 BRCA2 、 PALB2 、 RAD51C 相似地，这项研究也发现ATM和CHEK2蛋白截短变异与ER阳性乳腺癌风险增加有关；而BARD1、BRCA1、BRCA2、PALB2、RAD51C和RAD51D的蛋白截短变异与ER阴性乳腺癌风险升高有关。 RAD51D 相似地，这项研究也发现ATM和CHEK2蛋白截短变异与ER阳性乳腺癌风险增加有关；而BARD1、BRCA1、BRCA2、PALB2、RAD51C和RAD51D的蛋白截短变异与ER阴性乳腺癌风险升高有关。 ATM 、 CHEK2 、 TP53 、 BRCA1 、 BRCA2 中的罕见错义变异也与乳腺癌总体风险相关。图片来源： 123RF 在同期刊发的NEJM社论文章中，多伦多女子学院研究所（Women’s College Research Institute）Steven A. Narod博士指出，尽管这两项研究采用的可能不是最佳分析方法，但研究结果有助于我们了解哪些基因与乳腺癌易感性有关。 NEJM 在同期刊发的NEJM社论文章中，多伦多女子学院研究所（Women’s College Research Institute）Steven A. Narod博士指出，尽管这两项研究采用的可能不是最佳分析方法，但研究结果有助于我们了解哪些基因与乳腺癌易感性有关。 “根据这些结果，我们将扩大基因组检测的适用范围。那些从家族史来看具有乳腺癌中度风险的女性也被纳入其中，我们可能也会越来越多为携带CHEK2和ATM突变的女性提供咨询。尽管此前BRCA1或BRCA2突变远远更受关注，ATM和CHEK2被归‘其他基因’。” 我们将扩大基因组检测的适用范围 “根据这些结果，我们将扩大基因组检测的适用范围。那些从家族史来看具有乳腺癌中度风险的女性也被纳入其中，我们可能也会越来越多为携带CHEK2和ATM突变的女性提供咨询。尽管此前BRCA1或BRCA2突变远远更受关注，ATM和CHEK2被归‘其他基因’。” 我们可能也会越来越多为携带CHEK2和ATM突变的女性提供咨询 “根据这些结果，我们将扩大基因组检测的适用范围。那些从家族史来看具有乳腺癌中度风险的女性也被纳入其中，我们可能也会越来越多为携带CHEK2和ATM突变的女性提供咨询。尽管此前BRCA1或BRCA2突变远远更受关注，ATM和CHEK2被归‘其他基因’。” BRCA1 “根据这些结果，我们将扩大基因组检测的适用范围。那些从家族史来看具有乳腺癌中度风险的女性也被纳入其中，我们可能也会越来越多为携带CHEK2和ATM突变的女性提供咨询。尽管此前BRCA1或BRCA2突变远远更受关注，ATM和CHEK2被归‘其他基因’。” BRCA2 “根据这些结果，我们将扩大基因组检测的适用范围。那些从家族史来看具有乳腺癌中度风险的女性也被纳入其中，我们可能也会越来越多为携带CHEK2和ATM突变的女性提供咨询。尽管此前BRCA1或BRCA2突变远远更受关注，ATM和CHEK2被归‘其他基因’。” ATM “根据这些结果，我们将扩大基因组检测的适用范围。那些从家族史来看具有乳腺癌中度风险的女性也被纳入其中，我们可能也会越来越多为携带CHEK2和ATM突变的女性提供咨询。尽管此前BRCA1或BRCA2突变远远更受关注，ATM和CHEK2被归‘其他基因’。” CHEK2 “根据这些结果，我们将扩大基因组检测的适用范围。那些从家族史来看具有乳腺癌中度风险的女性也被纳入其中，我们可能也会越来越多为携带CHEK2和ATM突变的女性提供咨询。尽管此前BRCA1或BRCA2突变远远更受关注，ATM和CHEK2被归‘其他基因’。” 相关阅读不同癌症和人群，热门KRAS G12C突变有多常见？NEJM发表3万患者分析带来精准治疗新洞见！JCO发表近6000例复发难治癌症基因组研究里程碑参考资料 [1] Chunling Hu, et al., (2021). population-based study of genes previously implicated in breast cancer. N Engl M Med,DOI: 10.1056/nejmoa2005936. [2] Breast cancer risk genes. (2021). Breast Cancer Association Consortium "Breast cancer risk genes -- association analysis in more than 113,000 women. N Engl M Med, DOI: 10.1056/nejmoa1913948. [3] Steven A. Narod. (2021). Which genes for hereditary breast cancer?. N Engl J Med, DOI: 10.1056/nejmoa2035083. [4] Not Just BRCA: Large Studies ID Other Key Breast Cancer Risk Genes. Retrieved January 21, 2020, from https://www.medpagetoday.com/hematologyoncology/breastcancer/90803 注：本文旨在介绍医药健康研究进展，不是治疗方案推荐。如需获得治疗方案指导，请前往正规医院就诊。版权说明：本文来自药明康德微信团队，欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载授权请在「医学新视点」微信公众号后台回复“转载”，获取转载须知。如有其他合作需求，请联系wuxi_media@wuxiapptec.com 点“在看”，分享医学新知

2021-01-15

·Beckers Hospital Review

Memorial Hermann names new rehab hospital CEO

Rhonda Abbott was chosen by Memorial Hermann Health System as senior vice president and CEO of TIRR Memorial Hermann, according to a Jan. 12 news release. The Houston-based health system said Ms. Abbott will oversee TIRR Memorial Hermann, an acute rehabilitation hospital, as well as TIRR Memorial Hermann's outpatient medical clinic and TIRR Memorial Hermann adult and pediatric outpatient rehabilitation locations. Ms. Abbott is a 19-year veteran of TIRR Memorial Hermann, according to the release. Most recently, she has served as interim senior vice president and CEO of the hospital, succeeding Jerry Ashworth, who was named senior vice president and CEO of Memorial Hermann Cypress and Memorial Hermann Katy hospitals in September. She also held roles at TIRR Memorial Hermann as director of therapy services and director of clinical programs and vice president of operations. Ms. Abbott earned her MBA from West Texas A&M University in Canyon and her master's degree in science in physical therapy from Texas Woman's University in Denton.

100 项与 Texas Woman's University 相关的药物交易

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100 项与 Texas Woman's University 相关的转化医学

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