Indira Gandhi Institute of Medical Sciences (Indira Gandhi Institute of Medical Sciences)

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127

项与 Indira Gandhi Institute of Medical Sciences 相关的临床试验

CTRI/2025/03/083757

/ Not yet recruiting临床4期

Comparison of effect of two different doses of intraoperative Dexmedetomidine infusion on recovery of gastrointestinal movement in adult patients undergoing emergency abdominal surgery : A randomised clinical trial - NIL

开始日期2025-05-01

申办/合作机构

Indira Gandhi Institute of Medical Sciences

CTRI/2024/11/077242

/ Not yet recruiting临床3期

Randomised control trial comparing eTEP (extended totally extraperitoneal repair) vs IPOM (intraperitoneal onlay mesh) for ventral hernia repair.

开始日期2024-12-07

申办/合作机构

Indira Gandhi Institute of Medical Sciences

CTRI/2024/10/074892

/ Not yet recruiting临床3期

Early hydrocortisone in neonatal shock versus standard care,a randomized control trial - NIL

开始日期2024-10-15

申办/合作机构

Indira Gandhi Institute of Medical Sciences

100 项与 Indira Gandhi Institute of Medical Sciences 相关的临床结果

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0 项与 Indira Gandhi Institute of Medical Sciences 相关的专利（医药）

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1,054

项与 Indira Gandhi Institute of Medical Sciences 相关的文献（医药）

2025-05-01·International Journal of Pediatric Otorhinolaryngology

The intricate interrelationship of cochlear aperture and internal auditory canal diameter in pediatric normal petrous structures

Article

作者: Kumari, Diksha ; Prasad, Umakant ; Sinha, Richi ; Singh, Rakesh Kumar

PURPOSEThe cochlear aperture and internal auditory canal dimensions play a pivotal role in cochlear nerve health, yet their normative data exhibit significant variability. This study seeks to establish definitive normative ranges for these dimensions and investigate their interrelationship in the context of normally developed pediatric temporal bones.METHODSThis prospective study included seventy-eight children under fifteen years, diagnosed with bilateral severe-to-profound sensorineural hearing loss and free from temporal bone deformities. Utilizing high-resolution computed tomography scans, we measured the diameters of the cochlear aperture at the mid-modiolar level and the internal auditory canal at the porus, midsection, and fundus. The associations between these dimensions were analyzed using Spearman's rank correlation and linear regression.RESULTSThe mean cochlear aperture diameter was 2.16 mm, while the internal auditory canal diameters at the porus, midsection, and fundus were 6.60 mm, 4.27 mm, and 3.88 mm, respectively. Significant positive correlations were observed between the cochlear aperture and internal auditory canal diameters at the midsection (rs = 0.246, p = 0.029) and fundus (rs = 0.338, p = 0.002), as well as the average internal auditory canal diameter (rs = 0.233, p = 0.039). Regression analysis indicated that the internal auditory canal diameter at the fundus explained 17.5 % of the variance in cochlear aperture diameter (β = 0.179, p < 0.001).CONCLUSIONThis study established normative ranges for cochlear aperture and internal auditory canal dimensions in children, addressing past variability. These findings support cochlear implant planning, with a regression model offering a noninvasive tool to estimate cochlear aperture size. We also identified a unique, significant correlation between the two, highlighting a shared developmental pathway.

2025-04-28·IP Archives of Cytology and Histopathology Research

Ibrutinib in hematology

作者: Jamal, Iffat

2025-04-01·Journal of Pediatric Urology

Intraoperative urinary ACR as a prognostic biomarker in unilateral pelviureteric junction obstruction in paediatric population-an observational study

Article

作者: Kumar, Amit ; Sinha, Amit Kumar ; Kumar, Bindey ; Bachala, Keerthana ; Mahto, Mala ; Rashi, Rashi

BACKGROUNDMany urinary biomarkers like MCP1, EGF, KIM1, CCL5/RANTES, CA19.9, NAG, TTF and micro albumin have been used as indicators of renal damage in HDN patients. Urine albumin-to-creatinine ratio (ACR) is widely used to detect renal damage in systemic diseases like diabetes and hypertension. While extensively studied in medical renal diseases, its role as an intraoperative prognostic biomarker for renal damage remains unexplored. ACR offers advantages such as low cost, easy availability, and spot testing.AIMSTo determine the correlation between urinary ACR from obstructed pelvis in the prognostication of renal function of children with unilateral pelviureteric junction obstruction.METHODSThis prospective observational pilot study included 30 patients with unilateral PUJO, aged over six months, undergoing Anderson-Hynes pyeloplasty. Patients underwent a standardized diagnostic protocol, including USG-KUB and technetium-99m DTPA renal scans. Preoperative urinary ACR from voided urine was measured. During surgery, urine from the obstructed pelvis was aspirated for ACR analysis. Data analysis compared preoperative and postoperative variables and intra-operative urinary ACR levels were correlated with change in differential renal function on DTPA.DISCUSSIONPostoperative outcomes currently rely on dynamic nuclear renal scans and USG performed 3 months after surgery. Intraoperative urinary ACR from the obstructed renal pelvis shows promise as an early biomarker for predicting renal function outcomes after pyeloplasty. It provides immediate results, alleviating parental anxiety by eliminating the usual delay in postoperative assessments.CONCLUSIONThis study highlights the potential role of urinary ACR for peri-operative prognostication in children with PUJO, though larger studies are required to confirm these findings.LEVEL OF EVIDENCELevel 2B - Prospective observational study.

100 项与 Indira Gandhi Institute of Medical Sciences 相关的药物交易

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100 项与 Indira Gandhi Institute of Medical Sciences 相关的转化医学

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