Sequential imaging for suspicion of Prostate cancer Reducing Overdiagnosis and Unnecessary biopsy with Timely diagnosis of significant cancer - SPROUT

开始日期2025-03-01

申办/合作机构

Sint Antonius Ziekenhuis

NL-OMON57425

/ Suspended临床4期

DosemeLOL - Exploring differences in metoprolol concentrations between sexes, a pilot study - DoseMeLol

开始日期2025-02-01

申办/合作机构

Sint Antonius Ziekenhuis

100 项与 Sint Antonius Ziekenhuis 相关的临床结果

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0 项与 Sint Antonius Ziekenhuis 相关的专利（医药）

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项与 Sint Antonius Ziekenhuis 相关的文献（医药）

2016-09-01·European Respiratory Journal1区 · 医学

Defining a standard set of patient-centred outcomes for lung cancer

1区 · 医学

Article

作者: Annelotte C.M. Van Bommel ; Caleb Stowell ; David P. Carbone ; Aileen B. Chen ; David R. Baldwin ; Matthew Baker ; Jesme Fox ; Reza John Mehran ; Michel W.J.M. Wouters ; Tom Haswell ; Jan P. Van Meerbeeck ; Marianna Koczywas ; Suresh Senan ; Kimberley S. Mak ; Diana Borthwick ; Robert G. Stirling ; Michael D. Peake ; Benjamin D. Kozower ; Clarissa S. Baldotto ; Janet L. Abrahm ; Franz M. Schramel

In lung cancer, outcome measurement has been mostly limited to survival. Proper assessment of the value of lung cancer treatments, and the performance of institutions delivering care, requires more comprehensive measurement of standardised outcomes.The International Consortium for Health Outcomes Measurement convened an international, multidisciplinary working group of patient representatives, medical oncologists, surgeons, radiation oncologists, pulmonologists, palliative care specialists, registry experts and specialist nurses to review existing data and practices. Using a modified Delphi method, the group developed a consensus recommendation (“the set”) on the outcomes most essential to track for patients with lung cancer, along with baseline demographic, clinical and tumour characteristics (case-mix variables) for risk adjustment.The set applies to patients diagnosed with nonsmall cell lung cancer and small cell lung cancer. Our working group recommends the collection of the following outcomes: survival, complications during or within 6 months of treatment and patient-reported domains of health-related quality of life including pain, fatigue, cough and dyspnoea. Case-mix variables were defined to improve interpretation of comparisons.We defined an international consensus recommendation of the most important outcomes for lung cancer patients, along with relevant case-mix variables, and are working to support adoption and reporting of these measures globally.

2014-04-01·Critical Care

Plat op de buik gaan!

作者: Esther van Pijkeren

2012-10-09·Neurology1区 · 医学

Adjunctive dexamethasone in adults with meningococcal meningitis

1区 · 医学

Article

作者: Huisman, UW ; Struys, MA ; Jansen, C ; van Zuilen, EV ; Zorgdrager, AN ; Broere, D ; Herderschee, D ; Wieringa, EJ ; Stevens, M ; van Domburg, PHMF ; de Steen, Avan ; Fennis, TFM ; Anten, HWM ; Wennekes, MJ ; Don, JA ; Berendes, JN ; Enting, RH ; van der Kamp, W ; Bollen, AE ; Lohman, HJMM ; Jacobs, BC ; Mauser, HW ; Schiphof, PR ; Visee, HF ; van Raak, EPM ; Heerema, J ; van Dijk, GW ; Snoek, JW ; van der Ende, Arie ; Knibbeler, JGM ; Keunen, RWM ; Zegerius, L ; Dunnewold, RJW ; Grosveld, WJHM ; Admiraal, P ; Bienfait, HP ; Schipper, JP ; Wessels, PH ; Brekelmans, GFJ ; Krooman, JP ; Berntsen, PJIM ; Wouda, EJ ; Reijneveld, JC ; Medaer, RHJ ; van Schaik, IN ; Oonk, JGW ; Vrooland, L ; Pop, PHM ; Meijer, RJ ; Molenaar, DSM ; Saxena, R ; Prick, JJW ; Koppenaal, A ; Verheul, GAM ; Keuter, EJV ; Duyff, RF ; Geelen, JAG ; Holscher, RS ; Alting van Geusau, RB ; van Lieshout, HBM ; Hoefnagels, W ; de Jong, PJ ; van Spreeken, A ; Gijsbers, CJ ; van de Beek, Diederik ; Witteveen, RJW ; Brouwer, Matthijs C. ; Heckenberg, Sebastiaan G.B. ; Kerkhoff, H ; Kok, AJM ; Christiaans, MH ; de Graaf, RJ ; Taphoorn, MJB ; Kwa, IH ; van den Berg, JSP ; Beintema, KD ; Boon, AM ; ten Houten, R ; Koeman, JP ; Weisfelt, M ; Esselink, RAJ ; van der Plas, JPL ; Baart, JC ; Straathof, CSM ; van de Vlasakker, CJW ; Smits, RCF ; ter Spill, HW ; Roebroek, RMJA ; Hoogerwaard, EM ; Leenders, EM ; Vermeij, AJ ; Gerrits, M ; Blankevoort, JP ; Bülens, C ; Oerlemans, WGH

OBJECTIVESWe evaluated the implementation and effectiveness of adjunctive dexamethasone in adults with meningococcal meningitis.METHODSWe compared 2 Dutch prospective nationwide cohort studies on community-acquired meningococcal meningitis. A total of 258 patients with CSF culture-proven meningitis were enrolled between 1998 and 2002, before routine dexamethasone therapy was introduced, and 100 patients from March 2006 to January 2011, after guidelines recommended dexamethasone.RESULTSDexamethasone was administered in 43 of 258 (17%) patients in the 1998-2002 cohort and in 86 of 96 (90%) patients in the 2006-2011 cohort (p < 0.001), and was started with or before the first dose of antibiotics in 12 of 258 (5%) and 85 of 96 (89%) patients (p < 0.001). Rates of unfavorable outcome were similar between cohorts (12 of 100 [12%] vs 30 of 258 [12%]; p = 0.67), also after correction for meningococcal serogroup. The rates of hearing loss (3 of 96 [3%] vs 19 of 237 [8%]; p = 0.10) and death (4 of 100 [4%] vs 19 of 258 [7%]; p = 0.24) were lower in the 2006-2011 cohort, but this did not reach significance. The rate of arthritis was lower in patients treated with dexamethasone (32 of 258 [12%] vs 5 of 96 [5%], p = 0.046). Dexamethasone was not associated with adverse events.CONCLUSIONSAdjunctive dexamethasone is widely prescribed for patients with meningococcal meningitis and is not associated with harm. The rate of arthritis has decreased after the implementation of dexamethasone.CLASSIFICATION OF EVIDENCEThis study provides Class III evidence that adjuvant dexamethasone in adults with meningococcal meningitis does not increase negative outcomes such as deafness, death, or negative Glasgow Outcome Scale measures.

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100 项与 Sint Antonius Ziekenhuis 相关的转化医学

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