Exploring the neurophysiological effects of trataka as ayogic neuro ophthalmic examination technique within Ayurveda interventions A pilot study - NIL

开始日期2024-08-12

申办/合作机构

Amrita Vishwa Vidyapeetham

CTRI/2024/06/068527 / Not yet recruiting临床4期IIT

GraftRinse prior to reperfusion In LDLT, an RCT : GRIT Trial

开始日期2024-07-15

申办/合作机构

Amrita Vishwa Vidyapeetham

CTRI/2022/09/045721 / Not yet recruitingN/AIIT

A randomized control trial in second trimester termination of pregnancy with two different regimes

开始日期2022-09-21

申办/合作机构

Amrita Vishwa Vidyapeetham

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项与 Amrita Vishwa Vidyapeetham 相关的文献（医药）

2024-11-01·Biotechnology and Genetic Engineering Reviews

Functional and biotechnological cues of potassium homeostasis for stress tolerance and plant development

Review

作者: P, Suprasanna ; Kishor, P. B. Kavi ; Suravajhala, Prashanth ; Kaniganti, Sirisha ; Sudhakar Reddy, P. ; Anil Kumar, S. ; Hima Kumari, P.

Potassium (K⁺) is indispensable for the regulation of a plethora of functions like plant metabolism, growth, development, and abiotic stress responses. K⁺ is associated with protein synthesis and entangled in the activation of scores of enzymes, stomatal regulation, and photosynthesis. It has multiple transporters and channels that assist in the uptake, efflux, transport within the cell as well as from soil to different tissues, and the grain filling sites. While it is implicated in ion homeostasis during salt stress, it acts as a modulator of stomatal movements during water deficit conditions. K⁺ is reported to abate the effects of chilling and photooxidative stresses. K⁺ has been found to ameliorate effectively the co-occurrence of drought and high-temperature stresses. Nutrient deficiency of K⁺ makes leaves necrotic, leads to diminished photosynthesis, and decreased assimilate utilization highlighting the role it plays in photosynthesis. Notably, K⁺ is associated with the detoxification of reactive oxygen species (ROS) when plants are exposed to diverse abiotic stress conditions. It is irrefutable now that K⁺ reduces the activity of NADPH oxidases and at the same time maintains electron transport activity, which helps in mitigating the oxidative stress. K⁺ as a macronutrient in plant growth, the role of K⁺ during abiotic stress and the protein phosphatases involved in K⁺ transport have been reviewed. This review presents a holistic view of the biological functions of K⁺, its uptake, translocation, signaling, and the critical roles it plays under abiotic stress conditions, plant growth, and development that are being unraveled in recent times.

2024-09-01·Journal of Ayurveda and Integrative Medicine

An exploratory single-arm open-label clinical study to evaluate the combined effect of Vamana and Sarasvata Churna in reducing excessive daytime sleepiness

Article

作者: Sreejith, K ; Chacko, James ; Soman, Devipriya ; Menon, Arathy ; Sreejith, K. ; Anandaraman, P.V. ; Kundagol, Mahesh C ; Kundagol, Mahesh C. ; Anandaraman, P V

BACKGROUNDExcessive Daytime Sleepiness (EDS) is inferred as persistent sleepiness and often a general lack of energy during the day even after apparently adequate or even prolonged nighttime sleep. The subjects may not be identifying excessive daytime sleepiness but may present as feeling tired, lack of energy etc. They may seem apparently healthy and without any other systemic illness. The prevalence was found to be as high as 18 % in 2012 in United Kingdom. Also, it is a risk factor for diseases like Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases. Conventional management (Modafinil, Sodium Oxybate and Stimulants) addresses only the subjective condition in EDS and is associated with adverse effects compromising the quality of life. In the current health scenario there is a need for alternative interventions to manage this disease. On analyzing this condition through Ayurveda, we could understand it as Nidradhikya (Excessive daytime sleepiness) which is caused due to vitiated Kapha Dosha along with Vriddha Tamoguna (increased Tamoguna) that can be managed by Shodhana (biopurification) followed Shamana (pacification) therapies.OBJECTIVEThis study was aimed to assess the combined effect of Vamana (therapeutic vomiting) and Sarasvata Churna in reducing Excessive Daytime Sleepiness.MATERIALS AND METHODSThis was a single-arm exploratory open-label clinical trial. 10 subjects having EDS diagnosed using Modified Epworth Sleepiness Scale (MESS) with a score of 10-24 with proper exclusion were recruited from OPD and IPD, Department of Kāyacikitsa, Amrita School of Ayurveda. All the participants were clinically examined, sought for medical history and further checked biochemically to exclude any other systemic illness that may lead to this condition. Only healthy subjects with quality night sleep (assessed by PSQI) and without any other systemic illness were selected. The treatment protocol adopted was Vamana Karma followed by 30 days of Sarasvata Churna as Shamana Aushadha (medicine for pacification). Assessment was done using MESS on 0^th day and after 30 days of Shamana Aushadha Sevana. After completion of treatment, the results were statistically analysed using Wilcoxon Signed Rank Test and final conclusion was drawn.RESULTSOn analysis of the symptoms using Modified Epworth Sleepiness Scale, the mean total score reduced from 14.8 to 2.8 with 81.08 % relief in these 10 subjects and a significant p value < 0.05 after Vamana followed by 30 days of Shamana Aushadha Sevana.DISCUSSIONVamana helps in Kapha Nirharana (expelling) which removes the Avarana (occlusion) of Manas seen in Nidradhikya. This results in Hrit Shuddhi (purity of heart) that helps in bringing the equilibrium of Mano Gunas (qualities of mind) (Satvoudaryam Tamojayaha) which forms the line of management. Sarasvata Churna which was administered as Shamana Aushadha possesses Medhya (Nootropic), Buddhi Smriti Dhriti Vardhaka (intellect, memory and patience promoting) attributes and is being indicated in Vicetas. Most of the drugs in Sarasvata Churna are Rasayana (rejuvenation) that imparts Indriya Bala (strengthening of senses) and Priti (contempt) to Manas by Prinana (nourishing) of Rasa Dhatu.CONCLUSIONFrom this study, we could conclude that the combination of Vamana Karma followed by Sarasvata Churna administration is effective in reducing EDS.

2024-08-01·Current Reviews in Clinical and Experimental Pharmacology

A Short Review on Obeticholic Acid: An Effective Modulator of Farnesoid X Receptor

Review

作者: Surendran, Sudhindran ; Valsan, Arun ; Watson, Christopher John Edward ; Philips, Cyriac Abby ; Narayanan, Anila Kutty ; Balakrishnan, Dinesh ; Malick, Shweta ; Gopalakrishnan, Unnikrishnan

Abstract:Farnesoid X receptor (FXR) was identified as an orphan nuclear receptor resembling the steroid receptor in the late ’90s. Activation of FXR is a crucial step in many physiological functions of the liver. A vital role of FXR is impacting the amount of bile acids in the hepatocytes, which it performs by reducing bile acid synthesis, stimulating the bile salt export pump, and inhibiting its enterohepatic circulation, thus protecting the hepatocytes against the toxic accumulation of bile acids. Furthermore, FXR mediates bile acid biotransformation in the intestine, liver regeneration, glucose hemostasis, and lipid metabolism. In this review, we first discuss the mechanisms of the disparate pleiotropic actions of FXR agonists. We then delve into the pharmacokinetics of Obeticholic acid (OCA), the first-in-class selective, potent FXR agonist. We additionally discuss the clinical journey of OCA in humans, its current evidence in various human diseases, and its plausible roles in the future.

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2023-03-21

·PRNewswire

Internet of Things (IoT) in Healthcare Market Worth $861.3 Billion by 2030: Grand View Research, Inc.

SAN FRANCISCO, March 21, 2023 /PRNewswire/ -- The global internet of things in healthcare market size is expected to reach USD 861.3 billion by 2030 and is expected to expand at 16.8% CAGR from 2023 to 2030, according to a new report by Grand View Research, Inc. High penetration of smartphones is one of the significant factors boosting the growth of market. As per the statistics published in GSM Association's report, The Mobile Economy 2018, the number of people connected to mobile services surpassed 5 billion in 2017 and the number of unique mobile subscribers is expected to reach 5.9 billion by 2030 (71% of the global population). Key Industry Insights & Findings from the report: Medical devices segment held the largest share of 2022 owing to the growing demand for self-monitoring devices and launch of novel instruments. For instance, in March 2022, Amrita University introduced Amrita Spandanam, a wearable non-prick health monitoring device that can monitor blood pressure and measure blood glucose without pressure cuffs By connectivity technology, the cellular network segment accounted for the largest share in 2022. This can be attributed to the benefits of cellular network including increased capacity, less power consumption, and reduced interference. By application, telemedicine segment dominated the market in 2022 owing to the increasing number of patients suffering from conditions requiring Long-Term Care (LTC), including Alzheimer's disease, cancer, diabetes, and cardiovascular diseases. Based on end-use, hospitals and clinics segment dominated the market in 2022. Rising investments by hospitals for accelerating the adoption of IoT solutions is a key factor propelling the segment growth. Due to the rising adoption of electronic health records, increasing government support for internet of things in healthcare and growing usage of e-prescribing, telehealth, and other HC IT technologies in North America, the region had the largest market share. Read 100-page market research report, "Internet of Things in Healthcare Market Size, Share & Trends Analysis Report By Component (Medical Devices, System & Software, Services), By Connectivity Technology, By Application, By End-use, By Region, And Segment Forecasts, 2023 - 2030", published by Grand View Research. Internet of Things in Healthcare Market Growth & Trends There is rising awareness among the people for self-health monitoring and diagnosis due to the increase in the burden of various health issues at the early component of life. Rising awareness regarding healthy lifestyle among the young and adult population to adopt smart wearables to remotely monitor the health activities and track them and monitor health issues is driving the market growth. Furthermore, many companies and healthcare institutions are launching mHealth programs for remote patient monitoring, which is leading to an increase in the adoption of IoT solutions for remote patient monitoring services. Technological advancements in healthcare IT infrastructure, including the use of IoT, AI, and big data is one of the key factors boosting the market growth. Moreover, the growing demand for efficient & effective treatment and increasing awareness among patients about upgraded technology are also some of the factors expected to boost the internet of things in healthcare market over the forecast period. Advanced technologies, such as smart sensors, robotic pills, microcontroller, digital networking, automotive microcontrollers, radiofrequency, and sensors, play a significant role in driving the market. Rise in healthcare spending across the globe is driving the demand for implementation of IoT solutions in healthcare sector. According to estimates published by WHO in 2020, global spending on healthcare witnessed a significant surge, accounting for 11% of the global GDP or USD 9 trillion. The healthcare industry is evolving from fee-for-service model to value-based model, wherein treatment outcomes are reimbursed. The pressure of reducing healthcare costs is escalating globally as its cost is increasing faster than the growth of economies. Furthermore, IoT solutions enabled clinical trials also offer an opportunity for cost reduction as IoT simplifies the overall process and captures sophisticated endpoints. Remote patient monitoring solutions help in handling of noncritical patients at home, which eventually reduces hospital admissions and improves workflow efficiency. In addition, IoT solutions also enhance clinical operations through asset tracking and improvement in data capturing helps in significant cost savings. Thus, the demand for the development of internet of things in healthcare is rising globally. Internet of Things in Healthcare Market Segmentation Grand view research has segmented the global internet of things in healthcare market based on component, connectivity technology, application, end-use, and region IoT in Healthcare Market - Component Outlook (Revenue, USD Million, 2018 - 2030) Medical Devices Wearable External Devices Implanted Medical Devices Stationary Medical Devices System and Software Remote Device Management Network Bandwidth Management Data Analytics Application Security Network Security Services System Integration Services Consulting, Training, and Education Support and Maintenance Services IoT in Healthcare Market - Connectivity Technology Outlook (Revenue, USD Million, 2018 - 2030) Cellular Wi-Fi Bluetooth LPWANs Zigbee RFID IoT in Healthcare Market - Application Outlook (Revenue, USD Million, 2018 - 2030) Telemedicine Patient Monitoring Connected Imaging Clinical Operations Medical Management Others IoT in Healthcare Market - End-use Outlook (Revenue, USD Million, 2018 - 2030) Hospitals and Clinics Clinical Research Organizations Research and Diagnostic Laboratories Others IoT in Healthcare Market - Regional Outlook (Revenue, USD Million, 2018 - 2030) North America U.S. Canada Europe U.K. Germany France Italy Spain Sweden Norway Denmark Asia Pacific Japan China India South Korea Australia Thailand Latin America Brazil Mexico Argentina MEA South Africa Saudi Arabia UAE Kuwait List of Key Players in the IoT in Healthcare Market Medtronic Cisco Systems, Inc. IBM Corporation GE Healthcare Microsoft Corporation SAP SE Infosys Limited Cerner Corporation QUALCOMM Incorporated Amazon Intel corporation Wipro ltd Check out more related studies published by Grand View Research: Medical Supply Delivery Service Market - The global medical supply delivery service market size is expected to reach USD 101.3 billion by 2028, according to a new report by Grand View Research, Inc. It is expected to expand at a CAGR of 9.3% from 2021 to 2028. The growing need for ensuring quick, safe, and secure transportation of samples and specimens for testing, reducing logistics costs, and increasing focus on improving the healthcare system is increasing the demand for medical supply delivery services. The increasing incidence of road accidents owing to various factors leading to blood loss and immediate requirement for blood is boosting the market growth. Furthermore, the growing geriatric population, rising incidence of diabetes and hypertension, and the rising surgical procedures for organ transplants are driving the market growth. U.S. Integrated Operating Rooms Market - The U.S. integrated operating rooms market size is anticipated to reach USD 3.72 billion by 2028, registering a CAGR of 10.1% over the forecast period, according to a new report by Grand View Research, Inc. The key factors driving the market growth include the rising number of Ambulatory Surgery Centers (ASCs), technologically advanced healthcare IT infrastructure, the growing popularity of integrated ORs, and increasing demand for minimally invasive & image-guided procedures. Healthcare Video Conferencing Solutions Market - The global healthcare video conferencing solutions market size is expected to reach USD 114.46 million by 2028, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 4.9% from 2021 to 2028. The key factors driving the market include robust urbanization and increasing penetration of telemedicine solutions. Furthermore, technological advancements by market players are anticipated to positively influence the market growth. Browse through Grand View Research's Healthcare IT Industry Research Reports. About Grand View Research Grand View Research, U.S.-based market research and consulting company, provides syndicated as well as customized research reports and consulting services. Registered in California and headquartered in San Francisco, the company comprises over 425 analysts and consultants, adding more than 1200 market research reports to its vast database each year. These reports offer in-depth analysis on 46 industries across 25 major countries worldwide. With the help of an interactive market intelligence platform, Grand View Research Helps Fortune 500 companies and renowned academic institutes understand the global and regional business environment and gauge the opportunities that lie ahead. Contact: Sherry James Corporate Sales Specialist, USA Grand View Research, Inc. Phone: 1-415-349-0058 Toll Free: 1-888-202-9519 Email: [email protected] Web: Grand View Compass | Astra ESG Solutions Follow Us: LinkedIn | Twitter Logo: SOURCE Grand View Research, Inc.

2022-10-11

·mobihealthnews

Indian researchers develop smartphone app that predicts optimal insulin amount

Researchers from the Indian Institute of Science's Robert Bosch Centre for Cyber-Physical Systems have teamed up with doctors from MS Ramaiah Medical College to develop an artificial pancreas system that monitors and controls blood sugar levels in real time. WHAT IT'S ABOUT According to a press release, this system mimics the human body's closed-loop system for regulating insulin production. It has three components: a sensor, an insulin pump, and an Android app. The coin-size sensor with a tiny needle-like extension is stuck onto a skin like a patch and continuously monitors glucose concentration in the subcutaneous tissue. It is connected to an insulin pump that infuses insulin underneath a user's skin. The smartphone app, which controls both the sensor and the pump, determines how much insulin needs to be injected into the body. At the core of the mobile app is a model predictive control, an algorithm which the researchers found to be a good fit for their artificial pancreas system. Using the sensor's data, it predicts how much insulin a user needs and interfaces with the pump to signal insulin infusion. Early this year, the research team conducted a pilot study of the system involving 10 Type 1-diabetes patients at MS Ramaiah Medical College. During the trial, it was found that the use of the system helped four out of 10 participants to successfully keep their blood glucose level within the normal range. Currently, the system runs over one meal cycle in a day. The researchers seek to make the system fully automated to work around the clock. They plan to use AI techniques to improve the app's algorithm, and develop another app for caregivers to remotely monitor their patients. Moreover, the researchers are working with Amrita University to develop a low-cost insulin pump with the aim to make the artificial pancreas system cost-effective and truly customised for Indian patients. WHY IT MATTERS In 2021, around 74 million people in India had diabetes, according to data from the International Diabetes Federation’s Diabetes Atlas; this number is expected to increase to 125 million by 2045. The artificial pancreas system was developed to help patients, especially those with Type 1 diabetes – an autoimmune disorder where the body's own immune cells attack insulin-producing cells in the pancreas – to regularly take insulin and maintain their blood sugar levels to ensure it doesn't go too low or too high, leading to further complications. MARKET SNAPSHOT Health2Sync, a well-known player in digital diabetes management from Taiwan, has been working with Sanofi since last year to develop new insulin management solutions, including a titration alert feature to resolve the suboptimal use of insulin among diabetes patients in Asia. Meanwhile, in 2019, researchers from Harvard developed a similar artificial pancreas system that can also help maintain or improve glycemic control. In the same year, an automated glycemic controller device by US-based medical device maker Tandem Diabetes Care was given a De Novo clearance by the US Food and Drug Administration. It has algorithms that allow an insulin pump and its connected system to automatically adjust insulin delivery.