Delving into the Latest Updates on Technische Universität Wien with Synapse

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1

项与 Technische Universität Wien 相关的药物

GE-68

靶点

Sodium channels

作用机制

钠通道阻滞剂

在研机构-

原研机构

University of Vienna

在研适应症-

非在研适应症

心律失常

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

3

项与 Technische Universität Wien 相关的临床试验

CTIS2023-507878-41-00

/ Not yet recruiting临床2期IIT

Sequential Gilteritinib in Combination with Venetoclax and Azacitidine for Patients with Newly Diagnosed Acute Myeloid Leukemia and FLT3 Mutations Ineligible for Intensive Treatment (SEQUENCE) - TUD-SEQUNC-081

开始日期-

申办/合作机构

Technische Universität Wien

CTIS2023-507879-21-00

/ Not yet recruiting临床2期IIT

Randomized Evaluation of Treosulfan versus Melphalan conditioning fol-lowed by PTCY in Patients with AML and MDS undergoing allogeneic Transplantation (RELEVANT) - TUD-ETAL-5-084

开始日期-

申办/合作机构

Technische Universität Wien

CTIS2022-502807-31-00

/ Not yet recruiting临床2期IIT

Exploratory pilot study to determine the tolerability and effectiveness of Tirbanibulin in the treatment of Actinic Cheilitis - TUD-AKTCHE-082

开始日期2023-11-23

申办/合作机构

Technische Universität Wien

100 项与 Technische Universität Wien 相关的临床结果

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0 项与 Technische Universität Wien 相关的专利（医药）

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47,293

项与 Technische Universität Wien 相关的文献（医药）

2025-12-31·European Journal of Materials

Intermetallic phases and element distribution in carbon-free PM high-speed steels of the Fe-Co-Mo type

作者: Danninger, Herbert ; Eitenberger, Elisabeth ; Dlapka, Magdalena ; Hradil, Klaudia

2025-08-01·Journal of Mathematical Logic

On the consistency of ZF with an elementary embedding from Vλ+2 into Vλ+2

作者: Schlutzenberg, Farmer

According to a theorem due to Kenneth Kunen, under ZFC, there is no ordinal [Formula: see text] and nontrivial elementary embedding [Formula: see text]. His proof relied on the Axiom of Choice (AC), and no proof from ZF alone is has been discovered. [Formula: see text] is the assertion, introduced by Hugh Woodin, that [Formula: see text] is an ordinal and there is an elementary embedding [Formula: see text] with critical point [Formula: see text]. And [Formula: see text] asserts that [Formula: see text] holds for some [Formula: see text]. The axiom [Formula: see text] is one of the strongest large cardinals not known to be inconsistent with AC. It is usually studied assuming ZFC in the full universe V (in which case [Formula: see text] must be a limit ordinal), but we assume only ZF. We prove, assuming [Formula: see text] “[Formula: see text] is an even ordinal”, that there is a proper class transitive inner model M containing [Formula: see text] and satisfying [Formula: see text] “there is an elementary embedding [Formula: see text]”; in fact we will have [Formula: see text], where j witnesses [Formula: see text] in M. This result was first proved by the author under the added assumption that [Formula: see text] exists; Gabe Goldberg noticed that this extra assumption was unnecessary. If also [Formula: see text] is a limit ordinal and [Formula: see text] holds in V, then the model M will also satisfy [Formula: see text]. We show that [Formula: see text] “[Formula: see text] is even” [Formula: see text] implies [Formula: see text] exists for every [Formula: see text], but if consistent, this theory does not imply [Formula: see text] exists.

2025-06-01·Materials Today Bio

Advanced liver-on-chip model mimicking hepatic lobule with continuous microvascular network via high-definition laser patterning

Article

作者: Markovic, Marica ; Salvadori, Alice ; Watanabe, Masafumi ; Sudo, Ryo ; Ovsianikov, Aleksandr

There is a great demand for development of advanced in vitro liver models to predict the efficacy and safety of drug candidates accurately in the preclinical drug development. Despite the great efforts to develop biomimetic models, it remains challenging to precisely mimic a functional unit of the liver (i.e., hepatic lobule) with a continuous microvascular network. Recent progress in laser patterning has allowed us to create arbitrary biomimetic structures with high resolution. Here, we propose an advanced liver-on-chip model mimicking the hepatic lobule with a continuous microvascular network, ranging from the microvessels to the central vein of the liver, utilizing femtosecond laser patterning. Firstly, we optimize the laser power to pattern microchannels mimicking the microvessel and central vein of the hepatic lobule by using a femtosecond laser within a collagen-based hydrogel containing hepatic cells. Secondly, we construct continuous microvessels with luminal structures by comparing different microchannel sizes in diameter. Finally, we assemble a millimeter-scale hepatic lobule-like structure with multiple layers of microvascular networks in the liver-on-chip. Furthermore, our liver-on-chip model exhibits major liver functions and drug-induced hepatotoxicity, as evidenced by albumin and urea productions and by a toxic response to acetaminophen, respectively. Our approach provides valuable strategies for the development of advanced physiological and pathological liver-on-chip models for pharmaceutical and toxicological studies.

100 项与 Technische Universität Wien 相关的药物交易

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100 项与 Technische Universität Wien 相关的转化医学

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