The rare autoimmune rheumatic diseases (RAIRDs) are life-long multi-system diseases that are life or organ threatening. RAIRDs can impair quality of life similar to chronic diseases such as heart failure. The aim of the study is to explore content and structure of a support programme for people with RAIRDs in focus groups and survey meetings.

开始日期2024-10-01

申办/合作机构

University of the West of England

[+1]

NCT06412341 / Active, not recruitingN/AIIT

A Feasibility Study to Inform an RCT to Evaluate 'Accepting Your Body After Cancer', an Online-delivered, Group-based CBT Body Image Intervention, for Women Who Have Received Treatment for Breast Cancer

The investigators aim to assess the feasibility and acceptability of conducting a randomised controlled trial (RCT) to test whether receiving ABC (an online-delivered, Cognitive Behavioural Therapy [CBT], group-based, body image programme) alongside a psychoeducational body image booklet provides greater benefits to women treated for breast cancer compared to a receiving a psychoeducational body image booklet alone.
Results from this feasibility study will inform the design, management, and future delivery of a definitive randomised controlled trial to assess effectiveness and cost-effectiveness of ABC.
Specific objectives are to:
* Establish appropriate, inclusive, and acceptable methods of participant recruitment, retention, and management procedures.
* Establish the feasibility and acceptability of quantitative data collection, including determining appropriate primary and secondary outcome measures.
* Adapt and test a measure of health and social care service use, to inform a future economic evaluation.
* Establish intervention adherence and acceptability (of online setting) among participants and ABC facilitators.
Participants will be randomised to either the intervention or control arm. The control arm will receive the Macmillan Cancer Support psychoeducational body image booklet. The intervention arm will receive the Macmillan booklet and the ABC programme, a 7-session, CBT group-based programme delivered online. All participants will complete self-report validated outcome measures at weeks 1 (T1; baseline/pre-intervention), 9 (T2; immediate post-intervention), 20 (T3; three-month post intervention), and 32 (T4; six-month post intervention). Following drop-out or completion of all study procedures, a subset of participants will be invited to take part in interviews.

开始日期2024-07-23

申办/合作机构

University of the West of England

ISRCTN88199566 / RecruitingN/AIIT

A feasibility study to inform a Randomised Controlled Trial to evaluate ‘Accepting your Body after Cancer’ (ABC), an online-delivered group-based cognitive behavioural therapy (CBT) body image intervention, for women who have received treatment for breast cancer

开始日期2024-07-10

申办/合作机构

University of the West of England

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2024-12-31·Health Psychology and Behavioral Medicine

More than my Appearance: a pilot evaluation of the Expand Your Horizon online functionality-based writing programme for adults with visible differences

Article

作者: Halliwell, Emma ; Alleva, Jessica ; Harcourt, Diana ; Mathews, Abbi ; Guest, Ella

Background:

Adults with conditions that affect their appearance, known as visible differences, can experience appearance concerns, social anxiety, and depression. Interventions have been developed for this population to facilitate adjustment and coping skills; however, they have limited evidence of efficacy. The Expand Your Horizon [Alleva, J. M., Martijn, C., Van Breukelen, G. J., Jansen, A., & Karos, K. (2015). Expand Your Horizon: A programme that improves body image and reduces self-objectification by training women to focus on body functionality. Body Image, 15, 81-89. https://doi-org.libproxy1.nus.edu.sg/10.1016/j.bodyim.2015.07.001] online functionality-based writing programme was adapted for adults with visible differences.

Method:

A pilot randomised controlled trial with a wait-list control group was carried out to assess preliminary intervention efficacy and gain information about the acceptability and feasibility of the programme. Forty-four adults aged 21-63 years (M = 40.21; SD = 12.05) with visible differences took part. Various facets of body image (i.e. functionality appreciation and body appreciation) as well as depression and anxiety were assessed immediately pre- and post-intervention and at three-months.

Results:

Participants reported enjoying the programme, felt that the format was acceptable, and it significantly increased functionality appreciation, which was maintained at three-months. However, there were no improvements in body appreciation, depression, and anxiety.

Conclusions:

In future, a full trial should be carried out with an active control group.

2024-12-31·Plant signaling & behavior

Synergistic interplay between melatonin and hydrogen sulfide enhances cadmium-induced oxidative stress resistance in stock ( Matthiola incana L.)

Article

作者: Yong, Jean Wan Hong ; Ali, Hayssam M ; Zulfiqar, Faisal ; Moosa, Anam ; Hancock, John T

Ornamental crops particularly cut flowers are considered sensitive to heavy metals (HMs) induced oxidative stress condition. Melatonin (MLT) is a versatile phytohormone with the ability to mitigate abiotic stresses induced oxidative stress in plants. Similarly, signaling molecules such as hydrogen sulfide (H₂S) have emerged as potential options for resolving HMs related problems in plants. The mechanisms underlying the combined application of MLT and H₂S are not yet explored. Therefore, we evaluated the ability of individual and combined applications of MLT (100 μM) and H₂S in the form of sodium hydrosulfide (NaHS), a donor of H₂S, (1.5 mM) to alleviate cadmium (Cd) stress (50 mg L^-1) in stock (Matthiola incana L.) plants by measuring various morpho-physiological and biochemical characteristics. The results depicted that Cd-stress inhibited growth, photosynthesis and induced Cd-associated oxidative stress as depicted by excessive ROS accumulation. Combined application of MLT and H₂S efficiently recovered all these attributes. Furthermore, Cd stress-induced oxidative stress markers including electrolyte leakage, malondialdehyde, and hydrogen peroxide are partially reversed in Cd-stressed plants by MLT and H₂S application. This might be attributed to MLT or H₂S induced antioxidant plant defense activities, which effectively reduce the severity of oxidative stress indicators. Overall, MLT and H₂S supplementation, favorably regulated Cd tolerance in stock; yet, the combined use had a greater effect on Cd tolerance than the independent application.

2024-12-01·SLEEP MEDICINE

Video gaming and sleep in adults: A systematic review

Review

作者: Baker, Fiona C ; Ficca, Gianluca ; Baker, Fiona C. ; de Zambotti, Massimiliano ; Barresi, Giacinto ; De Rosa, Oreste ; Conte, Francesca

Video games (VGs) are one of the most common forms of entertainment and their diffusion is constantly increasing. Although largely studied in the framework of their relationship with mental and physical health, the relationship of VGs with sleep are not yet fully understood. This review provides a systematic assessment of the studies that investigated the relationships between video gaming and sleep in adults. The review search included both online databases (PubMed, Scopus, and PsycInfo) and citation tracking. Twenty-six studies were included in the final qualitative analysis. Findings are described separately for subjective and objective sleep measures and then discussed considering exposure levels and VG typology. Observational studies showed an association between excessive video gaming, poor sleep quality, and delayed sleep timing, whereas habitual and/or casual use was not associated with poor sleep and some studies even showed a beneficial effect on daytime functioning. Experimental evidence shows that playing an arousing VG before sleep delays sleep onset with possible alteration of sleep structure, whereas non-arousing cognitively challenging video gaming resulted in improved sleep continuity, stability, and organization. Overall, these findings show that the effect of VGs on sleep depends on the level of arousal associated with gaming, gaming sessions' duration, and frequency of gaming.

项与 University of the West of England 相关的新闻（医药）

2024-09-17

·PRNewswire

14th Annual Nikon Small World in Motion Competition Winner Captures Embryonic Development in Fruit Flies

Detailing the intricate process of early embryogenesis, this year's winning video provides insights into fundamental biological processes with far-reaching implications. MELVILLE, N.Y., Sept. 17, 2024 /PRNewswire/ -- Nikon Instruments Inc. today unveiled the winners of its 14th annual Nikon Small World in Motion Video Competition, an integral component of the Nikon Small World competition, which is celebrating its 50th anniversary this year. The first-place prize was awarded to Dr. Bruno Vellutini of the Max Planck Institute of Molecular Cell Biology and Genetics for his video of mitotic waves in the embryo of a fruit fly (Drosophila melanogaster). The video reveals the dynamic processes of fly embryogenesis, crucial for uncovering genetic pathways that mirror those in humans and other mammals, with applications for cancer research, birth defects, and potential treatment development. Continue Reading Nikon Small World in Motion Video Competition (PRNewsfoto/Nikon Instruments Inc.) As a zoologist with a background in evolutionary and developmental biology, Dr. Vellutini is dedicated to advancing our understanding of how embryos build themselves from a single cell—a process fundamental to all animal life. His research, while focused on evolutionary questions, has broader implications for medical science, specifically rare neurological disorders and limb malformations in humans. "The beauty of basic research in biology," says Dr. Vellutini, "is that what we learn in one organism is often applicable to others and has the potential to contribute to the understanding of human diseases." Dr. Vellutini's winning video captures the rhythmic waves of division and tissue movements critical to proper embryonic formation in fruit flies. These processes are linked to mechanisms that can go awry, leading to the development of cancer and other diseases. For instance, during normal development, cells must organize precisely within tissues, a process maintained by cell-cell communication and mechanical feedback. Disruptions in these processes, such as the epithelial-mesenchymal transition—a process normal in embryogenesis but problematic when occurring unexpectedly—are known to contribute to the invasiveness of lung, liver, and breast cancer. Dr. Vellutini adds depth to his video, saying, "Fruit fly embryos are in our homes, developing in our kitchens and our trash bins, are undergoing the same processes as shown in the video. I believe the video is particularly impactful because it shows us how these fascinating cellular and tissue dynamics are happening every day, all around us—even in the most mundane living beings." To capture this dynamic development, Dr. Vellutini used light sheet microscopy, a technique that allows for gentle imaging of live embryos while minimizing potential damage. "The biggest challenges I encountered were in mounting the embryos correctly and optimizing imaging conditions to capture clear, high-quality footage over an extended period. Balancing light exposure to avoid harming the samples was crucial," Dr. Vellutini explained. "For the last 50 years, Nikon Small World has been a leading showcase of cutting-edge microscopy and artistic imaging. Since its inception in 2011, Small World in Motion has been a vital component of this gallery," said Eric Flem, Senior Manager, Communications and CRM at Nikon Instruments. "As we enter a new era of the competition, we remain committed to highlighting the boundaries of innovation in scientific imaging. Nikon's dedication to advancing science and art is especially evident in Dr. Vellutini's winning entry, which stands as a testament to this legacy, capturing a mesmerizing movement within the microscopic world that helps deepen our understanding of a process that shapes life itself." Second place was awarded to Jay McClellan for his video of water droplets evaporating from the wing scales of a peacock butterfly (Aglais io). The final product used image stacking and a custom CNC motion control system to handle evaporating droplets and ensure smooth, rapid image capture. Third place was awarded to Dr. Jiaxing Li for his video of an oligodendrocyte precursor cell in the spinal cord of a zebrafish. The 2024 judging panel included: Adrian Coakley, Director of Photography at National Geographic Books Michelle S. Itano, Ph.D., Assistant Professor of Cell Biology and Physiology and Director of the Neuroscience Microscopy Core at the University of North Carolina at Chapel Hill Emily Petersen, Photography Managing Editor at Science Magazine Clare Waterman, Ph.D., Cell Biologist and Member of the National Academy of Sciences Jennifer C. Waters, Ph.D., Director of the Core for Imaging Technology & Education at Harvard Medical School Samantha Yammine, Ph.D., Neuroscientist and Science Communicator For additional information, please visit , or follow the conversation on Facebook, X @NikonSmallWorld, and Instagram @NikonInstruments. NIKON SMALL WORLD IN MOTION WINNERS 1st Place Dr. Bruno Vellutini Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Saxony, Germany Mitotic waves in the embryo of a fruit fly (Drosophila melanogaster) Light Sheet 20X (Objective Lens Magnification) 2nd Place Jay McClellan Saranac, Michigan, USA Water droplets evaporating from the wing scales of a peacock butterfly (Aglais io) Image Stacking, Timelapse 5X (Objective Lens Magnification) 3rd Place Dr. Jiaxing Li Portland, Oregon, USA An oligodendrocyte precursor cell in the spinal cord of a zebrafish Confocal 20X (Objective Lens Magnification) 4th Place Dr. Ignasi Vélez Ceron, Dr. Francesc Sagués & Dr. Jordi Ignés-Mullol University of Barcelona Department of Materials Science and Physical Chemistry Barcelona, Spain Friction transition in a microtubule-based active liquid crystal Fluorescence 20X (Objective Lens Magnification) 5th Place Quinten Geldhof Winthrop, Massachusetts, USA A baby tardigrade riding a nematode Darkfield 10X (Objective Lens Magnification) HONORABLE MENTIONS Richard J. Albrecht Altenstadt, Bavaria, Germany Molting mayfly Brightfield 2X (Objective Lens Magnification) Thomas Barlow & Connor Gibbons Columbia University Department of Neurobiology and Behavior New York, New York, USA Spontaneous activity of pigment-filled chromatophores in the skin of the dwarf cuttlefish (Sepia bandensis) Reflected Light 20X (Objective Lens Magnification) Thomas Barlow & Connor Gibbons Columbia University Department of Neurobiology and Behavior New York, New York, USA Movement and chromatophore activity in a developing octopus embryo (Octopus hummelincki) Darkfield, Stereomicroscopy 8X (Objective Lens Magnification) Dr. Ailen Cervino Baylor College of Medicine Center for Precision Environmental Health (CPEH) Houston, Texas, USA Frog (Xenopus laevis) dorsal mesoderm cells Confocal 40X (Objective Lens Magnification) Dr. Luis Carlos Cesteros Durango, Bizkaia, Spain Algae (Synura uvella) Differential Interference Contrast (DIC) 10X, 20X and 40X (Objective Lens Magnifications) Nikky Corthout & Dr. Francesca Rizzollo VIB Center for Brain and Disease Research Leuven, Vlaams-Brabant, Belgium Melanoma cells showing mitochondria and lysosome dynamics Confocal, Fluorescence 60X (Objective Lens Magnification) Samantha Fallacaro, Dr. Apratim Mukherjee & Puttachai Ratchasanmuang University of Pennsylvania Department of Cell and Developmental Biology Philadelphia, Pennsylvania, USA Three views of a fruit fly (Drosophila melanogaster): adult, embryo, and histones tagged with GFP marking nuclei Brightfield, Fluorescence, and Light Sheet 10X-100X (Objective Lens Magnification) Dr. KrassiMira A. Garbett & Richard Sando Vanderbilt University Department of Pharmacology Nashville, Tennessee, USA Live mouse neurons with fluorescently labeled points of connection (7 hour time-lapse) Confocal 60X (Objective Lens Magnification) Quinten Geldhof Winthrop, Massachusetts, USA Mosquito larva feeding Darkfield 4X (Objective Lens Magnification) Dr. Saikat Ghosh National Institutes of Health NICHD Bethesda, Maryland, USA Dynamic trafficking of mitochondria and lysosomes along microtubule tracks of neuronal highways Confocal 63X (Objective Lens Magnification) Cora A. Harris Charlotte, North Carolina, USA Crystallization of magnesium sulfate (MgSO4) salt crystals Polarized Light 10X (Objective Lens Magnification) Bre Hewitt Drexel University Department of Biology Philadelphia, Pennsylvania, USA Human fibroblast climbing a 3D 'rope' of extracellular matrix (gray) by squeezing the nucleus (cyan) through tight spaces. Actin cytoskeleton (orange). Confocal, Fluorescence 60X (Objective Lens Magnification) Dr. Patrick Colin Hickey NIPHT LIMITED Edinburgh, Midlothian, United Kingdom Dynamics of hyphal growth, cytoplasmic flow and movement of nuclei within a colony of filamentous fungus (Neurospora crassa). Time elapsed: 1.5 hours Confocal 40X (Objective Lens Magnification) Dr. Alvaro Migotto Centro de Biologia Marinha São Sebastião, São Paulo, Brazil Parchment worm larva eating a copepod Darkfield 4X (Objective Lens Magnification) Dr. Andrew Moore Howard Hughes Medical Institute Janelia Research Campus Ashburn, Virginia, USA Crawling tissue culture cell Confocal 63X (Objective Lens Magnification) Dr. Andrew Moore Howard Hughes Medical Institute Janelia Research Campus Ashburn, Virginia, USA Time-lapse of cultured cells crawling and exploring Confocal 63X (Objective Lens Magnification) Rogelio Moreno Panama, Panama Sea angel (Pterapod sp.) Darkfield 4X (Objective Lens Magnification) Irina Petrova Adamatzky University of the West of England Bristol College of Arts, Technology and Environment Bristol, Somerset, United Kingdom Malaysian flower mantis (Creobroter urbanus) Reflected Light 5X (Objective Lens Magnification) Benedikt Pleyer Kirchberg, Bavaria, Germany White blood cells in menstrual blood consuming uterus mucosa cells Differential Interference Contrast (DIC) 60X (Objective Lens Magnification) Benedikt Pleyer Kirchberg, Bavaria, Germany Chemical reactions within a single drop of water Darkfield 25X - 50X (Objective Lens Magnification) Catherine Porter, Aria Huang, Hunter Nichols & Dr. Alex Hughes University of Pennsylvania Department of Bioengineering Philadelphia, Pennsylvania, USA Time-lapse of canine kidney cells, precisely arranged by photopatterned DNA tethers, creating a replica of Vermeer's painting, "Girl with a Pearl Earring" Confocal, Fluorescence 4x (Objective Lens Magnification) Jan Rosenboom Rostock, Mecklenburg Vorpommern, Germany Ignition of an arc lighter Darkfield, Reflected Light 4X (Objective Lens Magnification) Jennifer Silverman Vanderbilt University Cell & Developmental Biology Nashville, Tennessee, USA Two HeLa cells expressing an actin binding protein generate large numbers of dynamic protrusions, which are evident in the space between the cells Confocal 100X (Objective Lens Magnification) Sebastian Sparenga McCrone Research Institute Chicago, Illinois, USA Dinitronaphthalene (a chemical compound) recrystallizing upon cooling Polarized Light 4X (Objective Lens Magnification) Sanjay Sunil Kumar & Steven Reger Schulte-Merker Lab, Institute for Cardiovascular Organogenesis and Regeneration University Hospital, Muenster, Germany Muenster, NRW, Germany Blood endothelial cells forming a lumen during zebrafish development Confocal 63X (Objective Lens Magnification) Dr. Wim van Egmond Micropolitan Museum Berkel en Rodenrijs, Zuid Holland, Netherlands Starfish gastrula, escaping from the egg Darkfield, Differential Interference Contrast (DIC) 16X (Objective Lens Magnification) Dr. Daniel Wehner & Nora John Max Planck Institute for the Science of Light Department of Biological Optomechanics Erlangen, Bavaria, Germany Immune response (neutrophils, cyan; macrophages, orange) to spinal cord injury in zebrafish Confocal 10X (Objective Lens Magnification) Dr. Cara Winter Duke University Department of Biology Durham, North Carolina, USA 17-hour time-lapse of a growing thale cress (Arabidopsis thaliana) root showing induction of a gene that controls stem cell division, SHR (green), nuclei (red) Confocal 40X (Objective Lens Magnification) Chew Yen Fook Woodend, Waimakiriri, New Zealand Oligochaete worm (Chaetogaster sp.) feeding on a water flea (Chydrorus sp.) Darkfield, Polarized Light 4X (Objective Lens Magnification) Wenting Zhu Beauty of Science Hefei, Anhui Province, China Electrodeposition of silver on copper Reflected Light, Stereomicroscopy 2.5X (Objective Lens Magnification) Wenting Zhu Beauty of Science Hefei, Anhui Province, China Convection cells in a paint-alcohol mixture Reflected Light, Stereomicroscopy 5X (Objective Lens Magnification) About Nikon Small World Photomicrography Competition The Nikon Small World Competition is open to anyone with an interest in photography or video. Participants may upload digital images and videos directly at . For additional information, contact Nikon Small World, Nikon Instruments Inc., 1300 Walt Whitman Road, Melville, NY 11747, USA, or phone (631) 547-8569. Entry forms for Nikon's 2025 Small World and Small World in Motion Competitions are available at . About Nikon Instruments Inc. Nikon Instruments Inc. is the US microscopy arm of Nikon Healthcare, a world leader in the development and manufacturing of optical, digital imaging technology and software for biomedical applications. For more information, please visit or contact us at 1-800-52-NIKON. SOURCE Nikon Instruments Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED