A multi-centre, randomized, parallel-group, double-blind, controlled, exploratory clinical trial is conducted to assess the positive effect of feeding a formula containing synbiotics (pre- and probiotics) on the composition of the gut microbiota in caesarean section (CS) born healthy term infants within the first 6 months of life.

开始日期2021-09-23

申办/合作机构

HiPP GmbH & Co. Vertrieb KG

NCT04736082 / CompletedN/A

Safety and Suitability of an Infant Formula Manufactured From Extensively Hydrolysed Protein in Healthy Term Infants

A multi-centre, randomised, double-blind, parallel-group, controlled, prospective, non-inferiority intervention clinical trial is performed to assess the safety and suitability of an infant formula manufactured from extensively hydrolysed protein by showing normal growth of healthy term infants during the first 120 days of life with an optional follow up until 180 days of life.

开始日期2021-03-16

申办/合作机构

HiPP GmbH & Co. Vertrieb KG

[+2]

NCT03489733 / Active, not recruitingN/A

The Effect of Low Protein, Extensively Hydrolyzed Infant Formula on Allergy Prevention in At-risk Infants up to 1 Year of Age: a Randomized, Double-blind, Controlled Intervention Study and the Long-term Effect on Allergy Prevention of Early Nutrition Given in the First 120 Days of Life in At-risk Infants Until the Child is 6 Years of Age

A multi-center, prospective, randomized, controlled, doubleblind intervention clinical Trial is performed to proof the efficiency of hydrolyzed infant formula showing a risk reduction of developing an allergy.

开始日期2018-07-09

申办/合作机构

HiPP GmbH & Co. Vertrieb KG

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项与 HiPP GmbH & Co. Vertrieb KG 相关的文献（医药）

2024-12-01·Microbiological Research

Bifidobacterium breve DSM 32583 and Limosilactobacillus fermentum CECT5716 postbiotics attenuate S. aureus and IL-33-induced Th2 responses

Article

作者: Köberle, Martin ; Biedermann, Tilo ; Volz, Thomas ; Grube, Jana ; Schaubeck, Monika ; Amar, Yacine

Over the past decades, the prevalence of allergic diseases noticeably increased in industrialized countries. The Th2 immune response plays a central role in these pathologies and its modulation using pro-/postbiotics constitutes a promising approach to prevent or alleviate disease symptoms. The aim of this in vitro study, was to investigate the ability of human milk-derived Bifidobacterium breve DSM 32583 (Bb) and Limosilactobacillus fermentum CECT5716 (Lf), to modulate the Th2 induced responses. To this end, Th2 cells were generated by co-culturing of human naïve Th cells with monocyte-derived dendritic cells (moDCs) either stimulated with Staphylococcus aureus or IL-33. The immunomodulatory effects of pro-/postbiotic preparations of Bb and Lf on moDCs and Th2 cells were evaluated in terms of maturation markers expression and cytokines production. Remarkably, the tested strains induced the anti-inflammatory cytokine IL-10 in moDCs, in a strain-, dose- and viability-dependent manner with no significant upregulation of IL-12p70 nor CD83, CD86 or HLA-DR. Interestingly, Bb and Lf postbiotics were able to dampen the Th2/Th1 response induced upon S. aureus- or IL-33 stimulation. They were also able to synergistically induce IL-10 in moDCs and T cells, upon co-stimulation with LPS. Finally, we observed that live probiotics triggered a mild Th1 response that was attenuated in the presence of galacto-oligosaccharides. Altogether, Bb and Lf pro-/postbiotics exhibited remarkable immune regulatory effects on both moDCs and Th2 cells. Therefore, further in vivo studies should be considered to validate these findings and assess their ability to prevent allergy or alleviate its symptoms in affected patients.

2024-11-01·Food Research International

Home practices can mitigate furan and derivatives in vegetable-based infant meals

Article

作者: Kondjoyan, Nathalie ; Ratel, Jeremy ; Sandjong Sayon, Donnelle Roline ; Beyer, Claudia ; Fuchsbauer, Norbert ; Engel, Erwan ; Meurillon, Maia ; Fakih, Aya ; Thomopoulos, Rallou ; Mercier, Frederic

This study assessed the impact of current home practices including reheating, standing, and stirring on mitigation of furan and its derivatives in vegetable-based infant meals. Three vegetable-based infant meals (vegetables alone, with fish, with meat) underwent different home practices including reheating, post-reheating standing (60, 120 and 240 s) and post-reheating stirring (30, 60, 120 and 240 s). Targeted quantification of furan, 2-methylfuran (2-MF) and 3-methylfuran (3-MF) and exploration of additional furan derivatives were undertaken in treated and untreated vegetable-based infant meals using SHS-GC-Q Exactive-Orbitrap-MS. For the three compounds, the quality of the measurements was first validated with suitable linearity, limits of quantification, precision and recoveries. A second step highlighted high concentrations of furan (78.5-103.9 µg/kg), 2-MF (4.8-10.1 µg/kg) and 3-MF (3.4-5.8 µg/kg) in the three vegetable-based infant meals before preparation and the assessment of the cumulative risk related to these three furan compounds confirmed the relevance of studying home mitigation strategies. The third step showed that post-reheating stirring was the most effective home practice for mitigation, with maximum observed reductions of 66.3, 59.9 and 57.7 % for furan, 2-MF and 3-MF, respectively. In a fourth step, a suspect screening approach carried out on SHS-GC-Q Exactive-Orbitrap MS data revealed the presence of 2-ethyl-, 2-ethyl-5-methyl-, 2-butyl- and 2-vinyl-furan in vegetable-based meals and showed a similar mitigation trend of home practices on the relative concentrations of these four additional furan derivatives. Finally, despite a significant mitigation reaching 69 % of the furan concentration, the combined effect of home practices on furan compounds was not sufficient to rule out the risk associated with the consumption of vegetable-based infant foods and additional options are discussed.

2024-05-01·The American Journal of Clinical Nutrition

Efficacy and safety of a synbiotic infant formula for the prevention of respiratory and gastrointestinal infections: a randomized controlled trial

Article

作者: Gillaizeau, Florence ; Berding, Kirsten ; Piloquet, Hugues ; Vrignaud, Bénédicte ; Regimbart, Christine ; Hecht, Christina ; Capronnier, Odile ; Günther, Julia

BACKGROUNDEarly life nutrition is crucial for the development of the gut microbiota that, in turn, plays an essential role in the maturation of the immune system and the prevention of infections.OBJECTIVESThe aim of this study was to investigate whether feeding synbiotic infants and follow-on formulas during the first year of life reduces the incidence rate (IR) of infectious diarrhea compared with standard formulas. Secondary endpoints included the IR of other infectious diseases as well as fecal milieu parameters.METHODSIn this double-blind, controlled trial, 460 healthy, 1-mo-old infants were randomly assigned to receive a synbiotic [galacto-oligosaccharides (GOS)/Limosilactobacillus fermentum CECT 5716] (IF, n = 230) or a control formula (CF, n = 230) until 12 mo of age. A reference group of breastfed infants (HM, n = 80) was included. Data on infections were recorded throughout the study period and stool samples were collected at 4 and 12 mo of age.RESULTSIR of infectious diarrhea during the first year of life was 0.60 (CF), 0.56 (IF), and 0.29 (HM), with no statistically significant difference between groups. The IR of lower respiratory tract infections, 1 of the secondary endpoints, however, was lower in IF than in CF [0.79 compared with 1.01, IR ratio = 0.77 (0.60-1.00)]. Additionally, fecal pH was significantly lower at 4 mo (P < 0.0001), whereas secretory IgA was significantly higher at 12 mo of age (P = 0.015) in IF compared with CF.CONCLUSIONSAlthough no difference is observed in the incidence of diarrhea, consumption of a synbiotic formula containing L. fermentum CECT5716 and GOS in infancy may reduce the incidence of lower respiratory tract infections and affect the immune system and fecal milieu. Additional research is warranted to further investigate the potential interaction of the gut-lung axis. This trial was registered at clinicaltrials.gov as NCT02221687.

项与 HiPP GmbH & Co. Vertrieb KG 相关的新闻（医药）

2021-08-18

·GlobeNewswire

The infant nutrition market by revenue is expected to grow

New York, Aug. 18, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Infant Nutrition Market - Global Outlook & Forecast 2021-2026" - 70% during the period 2020–2026. Every infant and child has the right to good nutrition under the Convention on the Child’s Rights. In recent years, the increasing consumer awareness of health, a better understanding of the health and fitness of their children, and increasing adoption of natural and organic infant nutrition products are the major factors driving the market. First infant formula has high potential in APAC as the segment accounts for 47.81% of the market share due to increasing health awareness and personalized nutrition for infants. Rapid modernization and rising disposable income are the prominent reasons for the growing demand for infant nutrition solutions in developing and developed nations. Urbanization is predicted to increase the market potential for the market during the forecast period. The following factors are likely to contribute to the growth of the infant nutrition market during the forecast period: • Rising Demand for Natural & Organic Products • Personalization In Infant Nutrition • Increasing Consumer Shift Toward Plant-Based Products • Rising Awareness for Infant Nutrition The study considers the infant nutrition market’s present scenario and its market dynamics for the period 2020?2026. It covers a detailed overview of several market growth enablers, restraints, and trends. The report offers both the demand and supply aspects of the market. It profiles and examines leading companies and other prominent ones operating in the market. KEY HIGHLIGHTS • Parent’s keen interest in organic nutrition for infants and sustainability are driving the growth of organic infant formula. 47% of global consumers seek organic food and drinks because of environmental concerns. • The increasing number of working mothers across the world and the substantial rises in their spending create an opportunity for players to boost up the sales of organic infant nutrition products. • Nowadays, parents are looking and selecting formulas based on their infants’ needs and preferences, surging the growth of the personalized market. China has the highest potential in this market. • Nestle, one of the prominent players, goes vegan with plant-based infant formula. • Rising e-commerce platforms have helped increase the demand for infant food enriched with vitamins such as vitamin D. • The trend of using probiotic supplements in infant formula, baby food, and supplements for healthy early life is driving the growth of the infant nutrition market. • Product innovation plays a significant role in the growth of the baby nutrition market. • In 2020, the APAC infant nutrition market share accounted for the largest share of 44.69%. • The infant nutrition trend in North America is toward customizing infant nutrition products. MARKET SHARE AND SEGMENTS • Follow-on formula is the fastest-growing category of breastmilk substitutes. • Growing-up formula and toddlers’ milk are marketed as an alternative to whole cow’s milk for children over one year. • The powder formula segment is expected to add USD 22.70 billion to the market by 2026. • APAC and Middle East & Africa are expected to witness high traction for powder formula. • The demand for concentrated liquid formula products is likely to gain momentum as they are easy to mix and more sterilized than powdered formula in the baby nutrition market. • The global ready-to-feed formula segment will grow at a CAGR of 8.69% in upcoming years. Market Segmentation by Product Type • First Infant Formula • Follow-On Formula • Growing-Up Formula • Specialty Baby Formula Market Segmentation by Forms • Powder Formula • Concentrated Liquid Formula • Ready-To-Feed Formula Market Segmentation by Distribution Channels • Supermarket & Hypermarkets • Pharmacies & Drugstores • Online Channels • Convenience Stores • Others GEOGRAPHIC ANALYSIS The large base and rapidly increasing number of consumer’s purchasing power is attracting many multinational brands to invest in the APAC region. For instance, Nestle, one of the key players, entered the third and fourth-tier cities of China and its substitution strategy, contributing to its sales recovery in 2020. Innovative packaging of baby nutrition products is driving infant formula growth, thereby contributing to the development of infant nutrition in the region. In APAC, the players focus on goat milk for producing infant formula, which is augmenting the region’s infant formula market, thereby supporting the growth of infant nutrition. The development of infant nutrition products sales is expected to be higher in lower-tier cities than first and second-tier cities of APAC. Market Segmentation by Geography • APAC o China o Japan o Australia o South Korea o India • North America o US o Canada • Europe o Germany o UK o France o Spain o Italy • Middle East & Africa o South Africa o UAE • Latin America o Brazil o Mexico o Argentina VENDOR LANDSCAPE The infant nutrition market is highly competitive with the presence of numerous players. The global market is dominated by vendors that have an international presence. International players are expected to expand their reach worldwide, especially in the fast-developing countries of the APAC region and Latin America, to boost their market share. According to the companies, China and India are the most lucrative and significant markets for a plant-based diet. For instance, Else Nutrition Holdings, an organization to target the baby formula segment of the plant-based market by offering 100% non-soy, non-dairy, plant-based baby formula. Players are manufacturing infant nutrition with innovative product specifications to have a competitive advantage over other vendors. Prominent Vendors • Abbott • Danone • Nestle • Mead Johnson & Company • Perrigo Company Other Prominent Vendors • Meiji Holdings Company • Reckitt Benckiser • Arla Foods • Bellamy’s Organic • FrieslandCampina • Parent’s Choice Infant Formula • The Kraft Heinz Company • Beinmei Company • Glanbia • Dana Dairy Group • GCMMF • HiPP • Hero Group • Ausnutria Dairy Company • Babynat • Earth’s Best • FASSKA • Yashili International Holdings • Happy Family Organics • Holy baby food • Else • MORINAGA MILK INDUSTRY COMPANY KEY QUESTIONS ANSWERED: 1. What is the growth rate of the Infant Nutrition Market? 2. Which region has the largest share in Global Infant Nutrition Market? 3. Who are the key players in Infant Nutrition Market? 4. What are the different types of products in Infant Nutrition? 5. Which distribution channel will have the highest market share in Infant Nutrition?Read the full report: ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.__________________________

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