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Prolyl oligopeptidase from pig muscle has been crystallized in complex with an inhibitor, using PEG 8000 and calcium acetate as precipitants. The crystals are orthorombic and the space group is P212121 with cell dimensions a = 111.8, b = 101.8, c = 72.4 Å. The asymmetric unit contains a single chain of prolyl oligopeptidase, corresponding to a specific volume of 2.55 Å3 Da−1 and a solvent content of 52%. The observed diffraction pattern extends to 2.3 Å resolution and the native crystals are well suited for structural analysis by X-ray diffraction methods.

1998-06-15·Acta Crystallographica Section C Crystal Structure Communications

Isostructural Metabolites of Two Anti-Parkinson Drugs

作者: Torok, Zoltan ; Simon, Kalman ; Bocskei, Zsolt ; Harmat, Veronika ; Hermecz, Istvan

The absolute configurations of desmethylselegiline hydrochloride [(R)-(-)-1-benzyl-N-(2-propynyl)ethyl-ammonium chloride, C₁₂H₁₆N⁺.Cl^-], (1), and p-fluoro-desmethylselegiline hydrochloride [(R)-(-)-1-(4-fluorobenzyl)-N-(2-propynyl)ethylammonium chloride, C₁₂H₁₅FN⁺.Cl^-], (2), were determinedThe two compounds are metabolites of the anti-Parkinson agent selegiline and its backup, p-fluoroselegiline.The two crystal structures are highly isostructural.Crystallog. data are given.

1998-06-15·Acta Crystallographica Section C Crystal Structure Communications

Irbesartan Crystal Form B

作者: Rodger, Charles A. ; Bauer, Michel ; Caron, Antoine ; Simon, Kalman ; Bocskei, Zsolt ; Rao, Renee

Irbesartan (2-butyl-3-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diaaspiro[4.4]non-1-en-4-one, C₂₅H₂₈-N₆O), a highly selective angiotensin II receptor (AT₁) antagonist was found to exist in two distinct crystal forms (A and B).This paper describes the crystal structure of irbesartan form B.Crystallog. data are given.

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