Streamlined Geriatric and Oncological Evaluation Based on IC Technology for Holistic Patient-oriented Healthcare Management for Older Multimorbid Patients. TWOBE Study

The GerOnTe TWOBE study aims to evaluate the effectiveness of the GerOnTe intervention, consisting of a renewed, patient-centred, care pathway coordinated by an APN and supported by a Health Professional Consortium and IC Technology, compared to the current standard of care in the eight different Belgian and Dutch hospitals.

开始日期2024-06-01

申办/合作机构

Diakonessenhuis Utrecht

[+11]

NCT06082492

/ RecruitingN/AIIT

The Beneficial Value of 18F FDG PET/CT in the Follow-up of Stage III Non-small Cell Lung Cancer Patients: the NVALT31-PET Study

The primary objective of this study is to compare the 3-year overall survival of stage III NSCLC patients during follow-up surveillance with 18F-Fluorodeoxyglucose Positron Emission Tomography/ Computerized Tomography (18F FDG PET/CT) versus follow-up with conventional CT surveillance.
Participants will receive usual care until 3 years of follow-up (control group) with additional whole-body 18F FDG PET/CT scans during follow-up visits at 6 months, 12 months, 18 months, 24 months, and 36 months of follow-up in the intervention group.
Other tasks include:
* filling in quality of life (QOL) questionnaires at every time point;
* participating in an interview evaluating the addition of the 18F FDG PET/CT scans (optional);
* collecting blood at the follow-up time points for our secondary endpoint (optional).
Researchers will compare the usual care control group with the intervention group to see if the additional 18F FDG PET/CT scans are (cost-)effective.

开始日期2024-03-19

申办/合作机构

Radboud University Medical Center

[+17]

NCT06677216

/ Enrolling by invitationN/A

Botulinum Toxin in the Management of Temporo-mandibular Related Myalgia: a Prospective Study

The aim of this study was to evaluate the clinical course in terms of pain, function and quality of life of patients with TMD-related myalgia during six months after receiving BTX-A injections. The research question was: What are the outcomes in pain, quality of life and function of patients with TMD-related myalgia receiving BTX-A during 6 months? The hypothesis to be tested was that patients receiving a BTX-A injection due to TMD-related myalgia will have a reduction in pain and increase in quality of life and function after one, three- and six- months.

开始日期2024-01-26

申办/合作机构

Diakonessenhuis Utrecht

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项与 Diakonessenhuis Utrecht 相关的文献（医药）

2020-10-01·EUROPEAN JOURNAL OF CANCER

The impact of the COVID-19 pandemic on quality of life, physical and psychosocial wellbeing in breast cancer patients – a prospective, multicenter cohort study

作者: W. Maarse ; H. Verkooijen ; R. Bijlsma ; D. Young-Afat ; I. van Dam ; C. Bargon ; D. Mink van der Molen ; E. Schoenmaeckers ; I. Baas ; N. Vermulst ; T. van Dalen ; F. van der Leij ; L. van Stam ; A. Doeksen ; M. Batenburg ; M. Ernst

The impact of the COVID-19 pandemic on quality of life, phys. and psychosocial wellbeing in breast cancer patients - a prospective, multicenter cohort study.

2016-01-01·Rheumatology (Oxford, England)2区 · 医学

Does disease activity add to functional disability in estimation of utility for rheumatoid arthritis patients on biologic treatment?

2区 · 医学

Article

作者: Sijtsma, Paulina ; Nair, Sandhya C ; Bijlsma, Johannes W J ; van Laar, Jacob M ; Welsing, Paco M J ; de Wit, G Ardine ; Lafeber, Floris P J G ; Marijnissen, Anne Karien C A

OBJECTIVE:

Treatment in general is mostly directly aimed at disease activity, and measures such as the DAS28 might therefore present important additional information. Our aim was to develop and validate a model that uses a combination of disease activity (DAS28) and HAQs to estimate EuroQoL 5-dimension scale (EQ5D) utilities.

METHODS:

Longitudinal data from a cohort study in RA patients from the Utrecht Rheumatoid Arthritis Cohort study Group (Stichting Reumaonderzoek Utrecht) who started treatment with a biologic drug were used for mapping and validation. All 702 observations, including DAS28, HAQ and EQ5D assessed at the same time points, were used. The observations were randomly divided into a subset for development of the model (n = 428 observations) and a subset for validation (n = 274). A stepwise multivariable regression analysis was used to test the association of DAS28 (components) and HAQ (domains) with EQ5D. Model performance was assessed using the explained variance (R(2)) and root mean square errors. Observed and predicted utility scores were compared to check for under- or overestimation of the scores. Finally, the performance of the model was compared with published mapping models.

RESULTS:

Lower DAS28 score and HAQ items dressing and grooming, arising, eating, walking and activities were associated with higher EQ5D scores. The final model had an explained variance of 0.35 and a lower root mean square error as compared with other models tested. The agreement between predicted and observed scores was fair.

CONCLUSION:

HAQ components estimate EQ5D better than total HAQ. Adding DAS28 to HAQ components does not result in better utility estimations.

2014-11-12·The British journal of surgery1区 · 医学

Oncological outcome of malignant colonic obstruction in the Dutch Stent-In 2 trial

1区 · 医学

Article

作者: van den Berg, M W ; Witteman, P ; Naber, A H ; Nieuwenhuijzen, G A ; Veenendaal, R A ; van Milligen de Wit, M ; Tanis, P J ; Tollenaar, R A ; van Geloven, A A ; Perk, L ; van Hooft, J E ; Sloothaak, D A M ; Cense, H ; Gilissen, L P ; van Hilligersberg, R ; Steup, W H ; Heisterkamp, J ; Havenga, K ; Lutke Holzik, M F ; van Wagensveld, B ; van Berkel, A ; Jansen, J M ; Dijkgraaf, M G ; Bemelman, W A ; Koopal, S A ; Grubben, M J ; Davids, P H ; Derksen, E ; Buskens, C J ; Koornstra, J J ; van der Linde, K ; Breumelhof, R ; Baas, P C ; Timmer, R ; Houben, M H ; Scholten, P ; Depla, A C ; Bakker, C M ; van der Zaag, E ; Dijkgraaf, M G W ; Akol, H ; Sosef, M ; Tseng, L N ; Patijn, G A ; Cazemier, M ; Sprangers, M A ; Kruyt, P ; Fockens, P ; van der Waaij, L A ; ten Hove, W R ; Gerhards, M F ; Marinelli, A W ; Schenk, E ; Guicherit, O R ; Oldenburg, B ; Rijken, A M ; van Ramshorst, B

Abstract:

Background:

The Stent-In 2 trial randomized patients with malignant colonic obstruction to emergency surgery or stent placement as a bridge to elective surgery. The aim of this study was to compare the oncological outcomes.

Methods:

Disease recurrence, and disease-free, disease-specific and overall survival were evaluated, including a subgroup analysis of patients with a stent- or guidewire-related perforation.

Results:

Of 98 patients included in the original Stent-In 2 trial, patients with benign (16) or incurable (23) disease were excluded from this study, along with a patient who had withdrawn from the trial. Of the remaining 58 patients, 32 were randomized to emergency surgery (31 resection, 1 stoma only) and 26 to stenting. Unsuccessful stenting required emergency surgery in six patients owing to wire or stent perforation. Locoregional or distant disease recurrence developed in nine of 32 patients in the emergency surgery group and 13 of 26 in the stent group. Disease-free survival was worse in the subgroup with stent- or guidewire-related perforation. Five of six patients in this subgroup developed a recurrence, compared with nine of 32 in the emergency surgery group and eight of 20 who had unperforated stenting.

Conclusion:

Stent placement for malignant colonic obstruction was associated with a risk of recurrence in this trial, but the numbers are small. There is not enough evidence to refute the approach strongly. Registration number: ISRCTN46462267 (http://www.controlled-trials.com).

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