更新于：2024-11-01

Kyungpook National University Hospital

更新于：2024-11-01

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201

项与 Kyungpook National University Hospital 相关的临床试验

NCT06622967 / Active, not recruitingN/AIIT

Multinational Clinical Trial of Real-time Artificial Intelligence System (CadAI-B) for Breast Ultrasound: Prospective Clinical Validation Study

The CadAI-B (Computer Aided Design Artificial Intelligence-Breast) system is a real-time AI diagnostic tool for breast ultrasound. It integrates with ultrasound devices to detect suspicious lesions, providing size, BI-RADS, and malignancy probability. After installation and user training, the system displays real-time breast conditions and automatically analyzes lesions when a freeze frame is set, showing results in seconds. This study will assess CadAI-B's accuracy and reliability by comparing its findings with biopsy results.

开始日期2024-09-15

申办/合作机构

Kyungpook National University Hospital

[+1]

KCT0009613 / Not yet recruitingN/AIIT

Comparative analysis of inhibitory concentration 50 on EEG Approximate entropy between males and females: Prospective cohort study

开始日期2024-09-01

申办/合作机构

Kyungpook National University Hospital

NCT06578676 / Recruiting临床1期

A Clinical Study to Evaluate the Safety and Pharmacokinetic Interaction Between HODO-22251 and HODO-22252 in Healthy Adults

The purpose of this study is to evaluate pharmacokinetic interaction and safety of co-administrated 25mg of Empagliflozin and 10/10mg Ezetimibe/Rosuvastatin in steady state in healthy volunteers.

开始日期2024-06-20

申办/合作机构

Hyundai Pharmaceutical Co., Ltd.

[+1]

100 项与 Kyungpook National University Hospital 相关的临床结果

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0 项与 Kyungpook National University Hospital 相关的专利（医药）

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4,820

项与 Kyungpook National University Hospital 相关的文献（医药）

2024-12-31·Computer Assisted Surgery

Flexible endoscope manipulating robot using quad-roller friction mechanism

Article

作者: Shim, Seongbo ; Lee, Hyun-Joo ; Byeon, Jaehyeon ; Hong, Jaesung ; Kim, Hyeonwook ; Lee, Subin

A robotic system for manipulating a flexible endoscope in surgery can provide enhanced accuracy and usability compared to manual operation. However, previous studies require large-scale, complex hardware systems to implement the rotational and translational motions of the soft endoscope cable. The conventional control of the endoscope by actuating the endoscope handle also leads to undesired slack between the endoscope tip and the handle, which becomes more problematic with long endoscopes such as a colonoscope. This study proposes a compact quad-roller friction mechanism that enables rotational and translational motions triggered not from the endoscope handle but at the endoscope tip. Controlling two pairs of tilted rollers achieves both types of motion within a small space. The proposed system also introduces an unsynchronized motion strategy between the handle and tip parts to minimize the robot's motion near the patient by employing the slack positively as a control index. Experiments indicate that the proposed system achieves accurate rotational and translational motions, and the unsynchronized control method reduces the total translational motion by up to 88% compared to the previous method.

2024-12-01·Clinical Biomechanics

An acoustic bellows-type round window transducer for middle-ear implants

Article

作者: Shin, Dong Ho ; Seong, Ki Woong ; Lee, Kyu-Yup

BACKGROUNDThis study describes the development of output devices for round window middle-ear. To overcome the problems of output devices that apply sound pressure directly to the round window, an acoustic bellows-type round window transducer was implemented by combining a small bellows, acoustic tube, and balanced armature driver.METHODSThe output characteristics of the proposed acoustic bellows-type round window transducer were confirmed through bench tests and distortion measurements. To compare the vibration transmission characteristics of the proposed transducer with those of sound pressure stimulation devices, an experiment was performed using four human temporal bones.FINDINGSThe average output magnitude of the acoustic bellows-type round window transducer was equivalent to sound pressure levels of 92, 96, and 108 dB for frequency ranges of <1, 1-2, and > 2 kHz, respectively. The results showed that the proposed transducer delivered vibration consistently without reducing the sound pressure level due to leakage, unlike the sound pressure stimulation device.INTERPRETATIONTherefore, the acoustic bellows-type round window transducer is a more stable and suitable output device for round window middle-ear implants than a sound pressure stimulation device. It is expected to overcome the limitations of sound pressure stimulation devices and to contribute to new technical solutions in the field of round window middle-ear implants development.

2024-12-01·European Journal of Medicinal Chemistry

Discovery of the therapeutic potential of PPARδ agonist bearing 1,3,4- thiadiazole in inflammatory disorders

Article

作者: Kwon, Sugyeong ; Kwon, Oh-bin ; Jung, Kyungjin ; Hwang, Ji Sun ; Kadayat, Tara Man ; Kim, Ye Jin ; Hwang, Hayoung ; Lee, Taeho ; Choi, Yeon-Kyung ; Kim, Jina ; Cho, Sung Jin ; Park, Keun-Gyu ; Jeon, Yong Hyun ; Lee, Jae-Eon ; Chin, Jungwook ; Kwon, Oh-Bin

As a defense mechanism against deleterious stimuli, inflammation plays a vital role in the development of many disorders, including atherosclerosis, inflammatory bowel disease, experimental autoimmune encephalomyelitis, septic and non-septic shock, and non-alcoholic fatty liver disease (NAFLD). Despite the serious adverse effects of extended usage, traditional anti-inflammatory medications, such as steroidal and non-steroidal anti-inflammatory medicines (NSAIDs), are commonly used for alleviating symptoms of inflammation. The PPARδ subtype of peroxisome proliferator-activated receptors (PPARs) has attracted interest because of its potential for reducing inflammation and related disorders. In this study, a series of 1,3,4-thiadiazole derivatives were designed, synthesized, and evaluated. Compound 11 exhibited potent PPARδ agonistic activity with EC₅₀ values 20 nM and strong selectivity over PPARα and PPARγ. Furthermore, compound 11 demonstrated favorable in vitro and in vivo pharmacokinetic properties. In vivo experiments using labeled macrophages and paw thickness measurements confirmed compound 11's potential to reduce macrophage infiltration and alleviate inflammation. These findings highlight compound 11 as a potent and promising therapeutic candidate for the treatment of acute inflammatory diseases and warrant further investigation to explore various biological roles.

100 项与 Kyungpook National University Hospital 相关的药物交易

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100 项与 Kyungpook National University Hospital 相关的转化医学

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