The effect of ozoralizumab on glucocorticoid reduction and its safety in patients with rheumatoid arthritis - The effect of ozoralizumab on glucocorticoid reduction and its safety in patients with rheumatoid arthritis

开始日期2024-06-19

申办/合作机构

Graduate School of Engineering Kyoto University

JPRN-UMIN000054176

/ SuspendedN/AIIT

Effectiveness of retraining on CPR skills using digital self-learning materials - a randomized controlled trial - Liv RCT

开始日期2024-04-22

申办/合作机构

Graduate School of Engineering Kyoto University

JPRN-UMIN000054118

/ SuspendedN/AIIT

Metabolic kinetics of glyceraldehyde and investigation of the relationship between glyceraldehyde and liver steatosis in patients with diabetes. - Metabolic kinetics of glyceraldehyde and investigation of the relationship between glyceraldehyde and liver steatosis in patients with diabetes.

开始日期2024-04-18

申办/合作机构

Graduate School of Engineering Kyoto University

100 项与 Graduate School of Engineering Kyoto University 相关的临床结果

登录后查看更多信息

0 项与 Graduate School of Engineering Kyoto University 相关的专利（医药）

登录后查看更多信息

161

项与 Graduate School of Engineering Kyoto University 相关的文献（医药）

2025-05-01·Journal of Gastroenterology

Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization

Article

作者: Shimonosono, Masataka ; Hirohashi, Kenshiro ; Tamaoki, Masashi ; Kondo, Yuki ; Oryu, Kohei ; Nakai, Yukie ; Yamada, Atsushi ; Uneno, Yu ; Vu, Trang H Nguyen ; Nakagawa, Hiroshi ; Kikuchi, Osamu ; Matsubara, Junichi ; Mitani, Yosuke ; Matsuda, Tomonari ; Naganuma, Seiji ; Flashner, Samuel ; Yamamoto, Yoshihiro ; Saito, Tomoki ; Sunami, Tomohiko ; Ohashi, Shinya ; Kataoka, Shigeki ; Muto, Manabu ; Katada, Chikatoshi ; Kondo, Tomohiro ; Yokoyama, Akira

AbstractBackgroundField cancerization defined by multiple development of squamous cell carcinomas (SCCs) in upper aerodigestive tract was explained by excessive alcohol intake. A dysfunctional mitochondrial aldehyde dehydrogenase 2 (Aldh2) delays the clearance of acetaldehyde, a genotoxic alcohol metabolite, and increases SCC risks. TP53 plays key roles in squamous carcinogenesis. However, the mechanism of alcohol-mediated squamous field cancerization has not been clearly elucidated.MethodsWe developed a novel genetically engineered mouse strain KTPA–/– (Krt5CreERT2; Trp53loxp/loxp; Aldh2–/–) featuring Aldh2-loss concurrent with epithelial-specific Trp53 deletion. These mice were given 10%-EtOH, and we evaluated the development of squamous cell carcinogenesis histologically and genetically.ResultsWidespread multifocal rete ridges (RRs), characterized by downward growth of proliferative preneoplastic cells, were found only in Aldh2+/– and Aldh2–/– mice with keratin5-specific Trp53 deletion (KTPA+/– and KTPA–/– mice, respectively), and alcohol drinking apparently increased RR formation rate. SCC occurred only in KTPA–/– (Aldh2 loss/TP53 loss) mice with alcohol drinking (15/18: 83%). Total alcohol consumption volume was significantly higher in KTPA–/– (Aldh2 loss/TP53 loss) mice with SCCs than those without SCCs. Further, target sequence revealed the occurrence of genetic abnormalities including Trp53 mutations in the esophageal epithelium of Aldh2–/– mice with alcohol drinking, suggesting direct mutagenic effects of alcohol drinking to the esophageal epithelium.ConclusionThis study provides for the first time the evidence that alcohol drinking, Aldh2 dysfunction and Trp53 loss cooperate in squamous field cancerization. Alcohol consumption volume affects the SCCs development, even in the same genotype.

2025-04-07·Inorganic Chemistry

Epitaxial Growth of Triple-Layered Brownmillerite Cobalt Oxide Sr₄Co₃O₉

Article

作者: Chen, Binjie ; Kageyama, Hiroshi ; Hattori, AzusaNakamoto ; Namba, Morito ; Tanaka, Hidekazu ; Wang, Wei-Hua ; Kotani, Yoshinori ; Ohta, Hiromichi ; Yan, Weitao ; Kuwabara, Akihide ; Terashima, Takahito ; Takatsu, Hiroshi ; Li, Hao-Bo ; Kobayashi, Shunsuke ; Nakayama, Kei ; Zhu, Tong

Layered perovskite oxides with the Ruddlesden-Popper (RP) structure exhibit diverse functionalities, yet the synthesis of cobalt-based RP oxides is hindered by competing phase formation. In this study, we successfully synthesized Sr₄Co₃O₉, a triple-layered cobalt oxide with a layered brownmillerite structure, as an epitaxial thin film on a LaAlO₃ substrate. Soft X-ray absorption spectra confirmed oxygen nonstoichiometry and a mixed-valence state of Co^3.3+ while scanning transmission electron microscopy revealed the presence of a tetrahedral layer in the central perovskite block. The structural comparison indicates that unlike conventional brownmillerite A₂B₂O₅, the triple-layered A₄B₃O₉ phase features axially elongated octahedra with significant B-site off-centering, driven by Coulomb repulsion from the tetrahedral B cations. Density functional calculations suggest a charge-ordered antiferromagnetic state. The thermal power of Sr₄Co₃O₉ is lower compared to other layered cobalt oxides, such as Na_xCoO₂. Our results demonstrate the impact of structural modulation in layered brownmillerite oxides, offering a perspective for designing functional materials.

2025-04-01·IEEJ Transactions on Electrical and Electronic Engineering

Self‐Assembling Design Method of Stator Slots for AC Rotating Machines

作者: Nakamura, Taketsune ; Kido, Yushi

To maximize the performance of rotating machines, it is essential to establish a design method with minimal arbitrariness. This paper proposes a self‐assembling method to design stator slots for alternating current (AC) rotating machines. First, we develop a line‐current approximation model of the stator winding using pulse‐width modulation technique and realize an ideal spatial magnetic flux density distribution. Subsequently, we design the realistic stator with an acceptable current density of the winding by forming unique slot shapes in a self‐assembling manner under two synthetic conditions using the developed line‐current approximation model as the starting model. The designed stator realizes a rotating magnetic field similar to the conventional design results. Additionally, we perform an analysis of motor rotation characteristics by combining the self‐assembled stator with a surface‐mounted permanent magnet rotor to determine the possibility of a higher output compared to that when using a conventional stator. The self‐assembled motor without relying on empirical rules shows a possibility of further improving the torque characteristics, thereby contributing to designing the AC rotating machines. © 2024 The Author(s). IEEJ Transactions on Electrical and Electronic Engineering published by Institute of Electrical Engineers of Japan and Wiley Periodicals LLC.

100 项与 Graduate School of Engineering Kyoto University 相关的药物交易

登录后查看更多信息

100 项与 Graduate School of Engineering Kyoto University 相关的转化医学

登录后查看更多信息