An evaluation of opioid sparing effects of intravenous diclofenac - acetaminophen combination when compared to diclofenac alone in patients undergoing inguinal hernia repair - A double blinded randomised trial - NIL

开始日期2025-03-24

申办/合作机构

Rabindranath Tagore Medical College

CTRI/2024/10/075045

/ Not yet recruitingN/AIIT

Evaluation of Leg Wrapping for the Prevention of Postspinal Hypotension In Cesarean Section under Spinal Anaesthesia-A Prospective,Randomised,control study - Nil

开始日期2024-10-18

申办/合作机构

Rabindranath Tagore Medical College

CTRI/2024/08/073124

/ Not yet recruiting临床4期IIT

Comparison of efficacy of sugammadex versus neostigmine for reversal of neuromuscular blockade in patients undergoing non-cardiac thoracic surgery:a prospective, randomised, double-blind study - NIL

开始日期2024-09-16

申办/合作机构

Rabindranath Tagore Medical College

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0 项与 Rabindranath Tagore Medical College 相关的专利（医药）

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502

项与 Rabindranath Tagore Medical College 相关的文献（医药）

2025-04-21·Cancer Research

Abstract 6510: The study of the potential role of K21 in cardiovascular genomics and its application cardio-oncology experimental therapeutics by using zebrafish model

作者: Jain, Kuntal ; Nasanally, Sai ; Jain, Kailash ; Mishra, Arishia ; Pasi, Rohan ; Rajpurohit, Surendra ; Manhiani, Devan ; Rajpurohit, Shubhra ; Arora, Vishal

Cardio-oncology is an emerging field that studies cancer therapy-associated cardiotoxicities. Cardiotoxicity is the second leading cause of death among cancer survivors. Developing reliable and effective preclinical models for cardiotoxicity prediction and prevention is essential to improving the long-term cardiac health of cancer patients. Zebrafish is an established model, to study cancer therapeutics for potential cardiovascular toxicity. In this study, we are developing zebrafish pharmacogenomics and experimental therapeutics to address cardiovascular complications induced by cancer drugs and identification and evaluation of potential drug candidates that can mimic the cancer-induced cardio-vascular complexity and mortality of cardio-oncology patients to identify co-treatments that might alleviate the heart disease risk in cancer survivors. K21 is an established antimicrobial drug known for its antimicrobial activity. In this study, we have studied K21 drug impact on zebrafish genomic common pathway enrichment analysis and comparison of Gene set enrichment analysis (GSEA) between control and K21 drug-treated larvae to define activated and suppressed gene ratio. The novel finding reveals the Significant Activated group: regulated to DNA templated transcription, brain development, regulation of transcription by RNA-polymerase-II, monoatomic ion transport, nervous system development, neuron differentiation, monoatomic ion transmembrane transport, anterior/ posterior pattern specification, neuropeptide signaling pathway, chemical synaptic transmission. Significant Suppressed Group: intracellular signal transduction, lipid metabolic process, protein transport, steroid biosynthetic process, endoplasmic reticulum to Golgi vesicle-mediated transport, intermediate filament cytoskeletal, keratinocyte differentiation, and keratinization. In zebrafish, a significant over-expressed GSEA K21 drug has an increased number of genes associated with the development of heart and blood vessels. Some of the gene sets were also associated with heart development in the initial stages. The presence of genes that engage in cardiovascular events is an important indication of cardiotoxicity and vessel damage as a part of cancer treatment. K21 also shows significant over-expressed GSEA like significant suppression of innate immune response, T-cell co-stimulation, apoptotic process, and lipid metabolism. These significant activations and suppression will be helpful to establish a potential therapeutic application of K21 in glioblastoma TME and associated ramifications to serve as potential cardioprotective agents during cancer treatment.Citation Format:Surendra Rajpurohit, Sai Nasanally, Shubhra Rajpurohit, Rohan Pasi, Arishia Mishra, Devan Manhiani, Kailash Jain, Kuntal Jain, Vishal Arora. The study of the potential role of K21 in cardiovascular genomics and its application cardio-oncology experimental therapeutics by using zebrafish model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 6510.

2025-04-01·The Journal of the Association of Physicians of India

Correlation of Serum Vitamin B₁₂ and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure.

Article

作者: Jatav, Vinod Singh ; Bhushan, Bharat ; Somvanshi, Vaibhav ; Lathiya, Ashwin ; Sardana, Vijay ; Maheshwari, Dilip ; Garg, Subham

BACKGROUNDGuillain-Barré syndrome (GBS) is an acute-onset polyneuropathy. Several biomarkers have been identified to monitor prognosis in GBS, including serum folate, serum albumin, blood glucose, serum sodium, and plasma cortisol levels.OBJECTIVESTo study the prevalence of serum vitamin B₁₂ deficiency and increased creatine kinase (CK-NAC) levels in GBS patients and ascertain if the levels of serum CK-NAC and vitamin B₁₂ can serve as prognostic indicators in GBS patients.MATERIALS AND METHODSThe research recruited 50 patients with GBS from the neurology department of a tertiary care hospital between 2020 and 2021. The study assessed the patients' motor function deficits using the MRC (Medical Research Council) scale as well as the HDS (Hughes Disability Scale). Vitamin B₁₂ and CK-NAC levels were measured, and patients were divided into four groups, one of which had a deficiency in vitamin B₁₂ and a raised CK-NAC level, while another group had normal serum vitamin B₁₂ and CK-NAC levels. Clinical characteristics were compared. Serum vitamin B₁₂ and CK-NAC levels were associated with GBS severity based on HDS and MRC scales, autonomic dysfunction, and respiratory failure.RESULTSSerum vitamin B₁₂ deficiency along with elevated CK-NAC levels was discovered in 44 and 14% of GBS patients, respectively. Serum vitamin B₁₂ deficiency correlated significantly with GBS severity, including progression duration, admission and nadir HDS scores, and autonomic dysfunction (p < 0.05). CK-NAC level did not correlate with the severity of GBS (p > 0.05).CONCLUSIONVitamin B₁₂ levels can predict prognosis in GBS patients.

2025-03-01·Indian Dermatology Online Journal

Eosinophilic Dermatosis of Hematological Malignancy

Article

作者: Solanki, Naresh ; Mittal, Asit ; Balai, Manisha ; Sahani, Shaurya

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100 项与 Rabindranath Tagore Medical College 相关的转化医学

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