Delving into the Latest Updates on Universidade Da Beira Interior with Synapse

概览

疾病领域	数量

神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

NOX(NADPH氧化酶家族)	1

关联

1

项与 Universidade Da Beira Interior 相关的药物

US20240415815

专利挖掘

靶点

NOX

作用机制

NOX抑制剂

在研机构

Universidade Da Beira Interior [+1]

原研机构

University of Aveiro [+1]

在研适应症

认知功能障碍 [+1]

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

1

项与 Universidade Da Beira Interior 相关的临床试验

ISRCTN32617901

/ CompletedN/AIIT

Effects of supervised physical exercise on cardiotoxicity and cardiac health in women breast cancer survivors during anthracycline-containing chemotherapy: a randomised controlled trial

开始日期2018-11-01

申办/合作机构

Universidade Da Beira Interior

100 项与 Universidade Da Beira Interior 相关的临床结果

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0 项与 Universidade Da Beira Interior 相关的专利（医药）

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1,584

项与 Universidade Da Beira Interior 相关的文献（医药）

2025-12-01·Journal of Industrial Textiles

Effect of solution concentration, process parameters and a second electric field on electrospun polyamide-11 fibers

作者: Belino, Nuno JR ; Paul, Roshan ; Barata, Teresa Raquel A

The electrospinning process parameters for producing polyamide 11 (PA11) nanofibers using formic acid (FA) as the solvent were investigated. Key variables such as solution concentration, tip-to-collector distance, applied voltage, flow rate, and the introduction of a second electric field were optimized to produce uniform, bead-free nanofibers. Preliminary studies indicated that a 10% (w/v) PA11/FA solution concentration, a 25 kV voltage applied to the collector, a 12 cm tip-to-collector distance and a flow rate of 0.03 mL/min yielded the most consistent results in a conventional nozzle electrospinning setup. The effects of distance, voltage, and flow rate on fiber morphology were examined, with increased distance producing thinner fibers due to improved solvent evaporation, while higher voltages resulted in thicker fibers, highlighting the complex interplay between these parameters. Flow rate also played a significant role in fiber formation. The incorporation of charged metallic rings along the jet path, introducing a second electric field, further improved fiber uniformity. The most significant effect on the morphology of electrospun PA11 fibers was observed with rings connected to increasing voltage values, resulting in fibers with an average diameter of 145.7 ± 23.7 nm, minimal bead formation, and uniform circular cross-section. These optimized electrospinning parameters and the application of a second electric field show potential for improving fiber quality in applications such as filtration, textiles, and tissue engineering, contributing to a deeper understanding of PA11 electrospinning.

2025-12-01·Current Pain and Headache Reports

Neuroimage Signature in Post-Stroke Pain: A Systematic Review

Review

作者: Lapa, Teresa ; Duarte, Isabel Catarina ; Castelo-Branco, Miguel ; Abejas, Abel ; Donato, Helena ; Patto, Assunção Vaz ; Buzhanskyy, Andriy

INTRODUCTIONCentral Post-Stroke Pain (CPSP) is a debilitating condition with a significant prevalence in stroke survivors. Set apart by its refractory to treatment neuropathic pain, it appears to arise from lesions in the spino-thalamo-cortical pathways, particularly in the thalamus. Despite advances in neuroimaging techniques, the pathophysiology of CPSP remains poorly understood, with limited diagnostic criteria and therapeutic approaches.OBJECTIVEThis systematic review aims to identify neuroimaging markers associated with CPSP, establish correlations between brain lesions and CPSP development, and explore the utility of neuroimaging techniques for diagnosis and prognosis. Secondary objectives involve establishing a link between CPSP and secondary brain area lesions and what type of pain patients with CPSP are more likely to experience.METHODSA systematic review was conducted following PRISMA guidelines. Relevant articles were sourced from PubMed, Embase, and Web of Science, using a predefined search strategy targeting CPSP and neuroimaging studies (MRI, PET, SPECT). Studies involving adult CPSP patients with post-stroke neuroimaging were included. Data from 14 studies was analyzed, focusing on lesion locations, neuroimaging findings, and functional connectivity. Risk of bias was assessed using the QUADAS-2 tool.RESULTSKey findings highlighted the association of CPSP with lesions in the ventral posterolateral and the ventral medial nuclei of the thalamus, spinothalamic pathway, and cortical areas like the insula and operculum. Functional connectivity studies highlighted the role of disrupted neural networks in pain perception. Limitations in the reviewed studies included small sample sizes, selection bias, and heterogeneity in study designs.CONCLUSIONSNeuroimaging findings confirm the significance of thalamic and spinothalamic pathway lesions in CPSP pathophysiology. Despite these insights, gaps in research underline the need for larger, multicenter trials to identify reliable biomarkers for diagnosis and therapeutic targets. Advanced neuroimaging combined with machine learning could be the key to understanding and managing CPSP.

2025-07-01·Journal of Fluids Engineering

New Electro-Active Polymers-Based Plasma Actuators for Simultaneous Flow Control and Ice Protection

作者: Rodrigues, F. F. ; Mbanguine, L. A. ; Páscoa, J. C.

AbstractThe current work introduces a new device for effective flow control and ice removal applications based on the combination of a nonthermal plasma discharge with the excitation of an electro-active polymer membrane. This new device designated electro-active polymer (EAP) plasma actuator is particularly interesting for aeronautic and wind power applications since it allows to perform simultaneous flow control and ice removal operations. To prove the concept, in the current work, an electro-active polymer-based plasma actuator device is fabricated and experimentally tested. For the initial tests a “VHB 4910” from 3 M was used as dielectric layer and electrically conductive grease was utilized to fabricate the flexible electrodes. The results demonstrate that this new concept is feasible, and the EAP plasma actuator is able to elongate up to 80% for an applied voltage of 7 kV. In addition, it is proved it can generate induced flow velocities above 2 m/s and, simultaneously, it is able to increase the surface temperature above 100 °C. In comparison to conventional plasma actuator, the new EAP actuator brings several other advantages mainly for de-icing purposes since the electro-active polymer movement will difficult the ice adhesion and help to expel the ice from the surface.

100 项与 Universidade Da Beira Interior 相关的药物交易

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100 项与 Universidade Da Beira Interior 相关的转化医学

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