Delving into the Latest Updates on Hirosaki University with Synapse

概览

疾病领域	数量

免疫系统疾病	1
神经系统疾病	1

排名前五的药物类型	数量

合成多肽	1

排名前五的靶点	数量

HMGB1(高迁移率族蛋白B1)	1

关联

1

项与 Hirosaki University 相关的药物

PJ1-01

靶点

HMGB1

作用机制

HMGB1抑制剂

在研机构

Hirosaki University [+4]

原研机构

StemRIM, Inc.

在研适应症

脑梗塞 [+4]

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期-

31

项与 Hirosaki University 相关的临床试验

JPRN-UMIN000054529

/ SuspendedN/AIIT

Measurement of the effects of foods containing processed whey protein on metabolism in healthy subjects - Measurement of the effects of foods containing processed whey protein on metabolism in healthy subjects

开始日期2024-06-03

申办/合作机构

Hirosaki University

JPRN-UMIN000052252

/ SuspendedN/AIIT

Examining the association between mitochondrial dysfunction and indeterminate physical complaints - Mitochondrial dysfunction and indeterminate physical complaints

开始日期2023-10-16

申办/合作机构

Hirosaki University

JPRN-UMIN000053070

/ CompletedN/AIIT

Research on the physical abilities, activity patterns, and mental and physical health of the elderly using wearable devices - Research on the physical abilities, activity patterns, and mental and physical health of the elderly using wearable devices

开始日期2023-09-08

申办/合作机构

Hirosaki University

100 项与 Hirosaki University 相关的临床结果

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0 项与 Hirosaki University 相关的专利（医药）

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18,442

项与 Hirosaki University 相关的文献（医药）

2025-07-01·Journal of Colloid and Interface Science

New fluorine-free low surface energy surfactants and surfaces

Review

作者: Darmanin, Thierry ; Guittard, Frédéric ; Sagisaka, Masanobu ; Eastoe, Julian

Modification and control of surface properties, such as surface tension γ at air-liquid (AL) interfaces and surface energy at solid-liquid (SL) surfaces, are at the heart of colloid and interface science. Certain applications require low or very low surface tensions γ_AL and surface energies γ_SL, for example and not limited to: microemulsification, aqueous foams for fire-fighting, hydrophobic, superhydrophobic and oleophobic surfaces to control spreading and wetting of aqueous and oily liquids on solids. In many cases low surface tensions/energies can only be obtained by employing perfluoroalkyl substances (PFAS) as surfactant or polymer additives or surface treatments. Although fluorocarbons and polymers have been employed for over 80 years, with many industrial and commercial benefits, it is now recognized that PFAS are very hazardous to the environment and health. Hence, in the coming years it will be necessary to phase out PFAS entirely, however, at present, there are very few viable alternatives available. This article outlines the chemical principles for designing F-free low surface energy (LSE) additives, and also covers the most recent advances in the quest for non-fluorinated surfactants and polymeric surface coatings.

2025-07-01·Archives of Gerontology and Geriatrics

Understanding physical aging in relation to biological aging, telomere length: A systematic review

Review

作者: Paing, Arkar Min ; Wai, Kyi Mar ; Swe, Thinzar

BACKGROUNDTelomere length (TL) serves as a marker for biological aging, influenced by chronological aging but distinct from it. This systematic review aims to synthesize the evidence on the associations between components of physical aging and TL in the elderly population.METHODSA comprehensive search was conducted in online databases of PubMed, Web of Science, ProQuest, and ScienceDirect to identify the eligible papers published until 1st August 2024. The authors independently extracted data using the standardized form. The quality of the included studies was evaluated for the risks of biases.RESULTSA total of 1080 records were initially identified using the predefined search strategy. A total of 40 eligible records were included in this review. When assessing physical aging, the nature and type of measurements across studies vary, including subjective, objective, and a combination of both approaches. Subjective assessments of general health or physical limitations may be linked with TL, while frailty, whether measured subjectively or objectively, shows associations with TL in less than 35 percent of total studies. In contrast, composite measures of physical performance/ability are consistently associated with TL in the elderly population.CONCLUSIONSIn conclusion, we demonstrated that the associations between physical aging and TL varies depending on the type and nature of physical aging assessments. Composite measures of physical performance/ability demonstrate a strong and consistent parameter of physical aging to link with TL. Future research should prioritize standardized, multidimensional approaches to measure physical aging to understand better its association with TL to support healthy aging strategies.

2025-07-01·Journal of Materials Science & Technology

Highly effective CO2 electroreduction to formate boosted by Ce-doping on Indium oxide electrocatalysts

作者: Zhang, Juan ; Jin, Yuxia ; Ramli, Yusrin ; An, Xiaowei ; Feng, Zhongbao ; Li, Shasha ; Yang, Ziyuan ; Hao, Xiaogang ; Zhou, Yifan ; Guan, Guoqing ; Abudula, Abuliti ; Feng, Changrui ; Luo, Peng ; Du, Xiao ; Wang, Peifen

Electrocatalytic reduction of carbon dioxide (CO₂) with high selectivity to generate value-added chem. products and fuels, utilizing renewable electricity sources, offers an effective approach to address the continued increase in atm. CO₂.Here, we report cerium (Ce)-doped indium oxide (In₂ O₃) electro-catalyst generated in situ on carbon paper (Ce-In₂ O₃ /CP), and its application in the electrochem. reduction of CO₂ (CO₂ RR) to formate formation with high Faradaic efficiency (FE) (reaching 97.6% at -1.7 V vs.Ag/AgCl) and excellent stability.Exptl. anal. and d. functional theory (DFT) calculations indicate that doping Ce onto the (222) plane of In₂ O₃ induces lattice distortion, which promotes electron transfer from Ce to In while adjusting the local electronic structure of the In atoms around Ce, making them more favorable for the adsorption of *OOCH intermediates and effectively lowering the energy bar-rier of the rate-determining step.Furthermore, Ce doping lowers the overpotential required for formate production and suppresses the hydrogen evolution reaction (HER), effectively enhancing the selectivity of formate.

100 项与 Hirosaki University 相关的药物交易

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100 项与 Hirosaki University 相关的转化医学

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